Alteraciones alveolo-intersticiales en el fumador pasivo. Modelo morfometrico experimental
Alveolo-interstitial alterations in passive smoking. Morphometric experimental model
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"tienePdf" => "es" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "1" "paginaFinal" => "2" ] ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Cortijo Gimeno" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Cortijo Gimeno" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317750?idApp=UINPBA00003Z" "url" => "/03002896/0000002500000001/v1_201509151056/S0300289615317750/v1_201509151056/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Alteraciones alveolo-intersticiales en el fumador pasivo. Modelo morfometrico experimental" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "3" "paginaFinal" => "9" ] ] "autores" => array:2 [ 0 => array:3 [ "autoresLista" => "A.I. Maurain Viloria, J. de D. Escolar Castellón, M.D. Ariño Matín, P. Miñana Amada, P. Roche Roche" "autores" => array:5 [ 0 => array:2 [ "nombre" => "A.I." "apellidos" => "Maurain Viloria" ] 1 => array:2 [ "nombre" => "J. de D." "apellidos" => "Escolar Castellón" ] 2 => array:2 [ "nombre" => "M.D." "apellidos" => "Ariño Matín" ] 3 => array:2 [ "nombre" => "P." "apellidos" => "Miñana Amada" ] 4 => array:2 [ "nombre" => "P." "apellidos" => "Roche Roche" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Departamento de Ciencias Morfológicas. Facultad de Medicina. Universidad de Zaragoza" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "autoresLista" => "E. Prats Rivera" "autores" => array:1 [ 0 => array:3 [ "nombre" => "E." "apellidos" => "Prats Rivera" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0010" ] ] ] ] "afiliaciones" => array:1 [ 0 => array:3 [ "entidad" => "Servicio de Medicina Nuclear. Facultad de Medicina. Universidad de Zaragoza" "etiqueta" => "*" "identificador" => "aff0010" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Alveolo-interstitial alterations in passive smoking. Morphometric experimental model" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1988-04-06" "fechaAceptado" => "1988-10-05" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se ha realizado un modelo experimental de fumador pasivo exponiendo a ratas al humo de 10 cigarrillos al día/ dos meses. Paralelamente se estableció un grupo control. El estudio ha sido fundamentalmente morfológico, dividiendo los hallazgos en: a) citológicos del lavado broncoalveolar (LBA) (linfocitos, macrófagos y polimorfonucleares); b) morfométricos (hiperinsuflación pulmonar, engrosamiento septal, hemosiderina, área linfática, epitelio en contacto (Ep C), epitelio plano (Ep P) y alveolos ocupados y c) isotópicos (captación de Ga67 por el pulmón y cociente pulmón/hígado). El LBA presentó un aumento significativo de linfocitos (x¯ = 27,1%) y polimorfo-nucleares (x¯ = 5,6%) (p < 0,001). El estudio morfométrico mostró un aumento de todas las variables, que fue significativo (p < 0,01) a excepción del engrosamiento septal. La captación de Ga67 fue menor en los pulmones de los animales expuestos a humo de tabaco, habiendo diferencias significativas en el cociente P/H. Se concluye que la exposición de forma pasiva a humo de tabaco produce alteraciones alveolo-intersticiales similares a las descritas en los modelos experimentales en rata de fumador activo.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">A passive smoking experimental model was designed by exposing rats to the smoke of 10 cigarettes/day for 2 months. A control group was established parallel to the former. This study consisted chiefly of measurement of morphologic parameters which were divided into: a) cytologic parameters at bronchoalveolar lavage (lymphocytes, macrophages and polymorphonuclears); b) morphometric parameters (hyperinflation of the lung, septal thickening, deposition of hemosiderin, lymphatic area, epithelium in contact, flat epithelium, and occupied alveoli); and c) isotopic parameters (pulmonary uptake of 67Gallium and lung/liver ratio). Bronchoalveolar lavage revealed a significant increase in the number of lymphocytes (x¯ = 27.1%) and polymorphonuclears (x¯ = 5.6%) (p < 0.001). The morphometric study disclosed an increase in all variables which was significant (p < 0.01) except for septal thickening. The 67Gallium uptake was lower in the lungs of the animals exposed to tobacco smoke and there were significant differences in liver/lung ratio. It is concluded that passive exposure to tobacco smoke produces alveolo-interstitial alterations which are similar to those reported in experimental models of active smoking in rats.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:51 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 4 | 8 |
| 2024 October | 32 | 15 | 47 |
| 2024 September | 35 | 19 | 54 |
| 2024 August | 48 | 34 | 82 |
| 2024 July | 59 | 21 | 80 |
| 2024 June | 43 | 21 | 64 |
| 2024 May | 110 | 41 | 151 |
| 2024 April | 27 | 15 | 42 |
| 2024 March | 25 | 23 | 48 |
| 2024 February | 30 | 35 | 65 |
| 2023 December | 0 | 3 | 3 |
| 2023 November | 0 | 3 | 3 |
| 2023 October | 0 | 6 | 6 |
| 2023 September | 0 | 9 | 9 |
| 2023 July | 0 | 2 | 2 |
| 2023 March | 15 | 3 | 18 |
| 2023 February | 36 | 25 | 61 |
| 2023 January | 21 | 32 | 53 |
| 2022 December | 69 | 21 | 90 |
| 2022 November | 32 | 18 | 50 |
| 2022 October | 30 | 49 | 79 |
| 2022 September | 24 | 29 | 53 |
| 2022 August | 29 | 35 | 64 |
| 2022 July | 23 | 33 | 56 |
| 2022 June | 33 | 33 | 66 |
| 2022 May | 19 | 27 | 46 |
| 2022 April | 25 | 26 | 51 |
| 2022 March | 28 | 33 | 61 |
| 2022 February | 22 | 22 | 44 |
| 2022 January | 29 | 26 | 55 |
| 2021 December | 11 | 31 | 42 |
| 2021 November | 12 | 26 | 38 |
| 2021 October | 11 | 36 | 47 |
| 2021 September | 16 | 37 | 53 |
| 2021 August | 25 | 39 | 64 |
| 2021 July | 9 | 35 | 44 |
| 2021 June | 16 | 36 | 52 |
| 2021 May | 18 | 23 | 41 |
| 2021 April | 18 | 57 | 75 |
| 2021 March | 28 | 17 | 45 |
| 2021 February | 33 | 20 | 53 |
| 2021 January | 27 | 17 | 44 |
| 2020 December | 22 | 22 | 44 |
| 2020 November | 17 | 14 | 31 |
| 2020 October | 12 | 12 | 24 |
| 2020 September | 3 | 8 | 11 |
| 2020 August | 24 | 17 | 41 |
| 2020 July | 31 | 14 | 45 |
| 2020 June | 13 | 17 | 30 |
| 2020 May | 20 | 10 | 30 |
| 2020 April | 18 | 10 | 28 |
| 2020 March | 22 | 23 | 45 |
| 2020 February | 20 | 23 | 43 |
| 2020 January | 24 | 17 | 41 |
| 2019 December | 31 | 23 | 54 |
| 2019 November | 10 | 9 | 19 |
| 2019 October | 16 | 19 | 35 |
| 2019 September | 30 | 30 | 60 |
| 2019 August | 16 | 4 | 20 |
| 2019 July | 13 | 31 | 44 |
| 2019 June | 13 | 23 | 36 |
| 2019 May | 16 | 30 | 46 |
| 2019 April | 23 | 70 | 93 |
| 2019 March | 17 | 21 | 38 |
| 2019 February | 8 | 10 | 18 |
| 2019 January | 9 | 3 | 12 |
| 2018 December | 12 | 13 | 25 |
| 2018 November | 9 | 15 | 24 |
| 2018 October | 22 | 9 | 31 |
| 2018 September | 10 | 4 | 14 |
| 2018 May | 4 | 1 | 5 |
| 2018 April | 4 | 7 | 11 |
| 2018 March | 7 | 11 | 18 |
| 2018 February | 8 | 6 | 14 |
| 2018 January | 7 | 10 | 17 |
| 2017 December | 11 | 13 | 24 |
| 2017 November | 10 | 6 | 16 |
| 2017 October | 13 | 24 | 37 |
| 2017 September | 7 | 5 | 12 |
| 2017 August | 10 | 12 | 22 |
| 2017 July | 8 | 24 | 32 |
| 2017 June | 5 | 8 | 13 |
| 2017 May | 15 | 14 | 29 |
| 2017 April | 7 | 6 | 13 |
| 2017 March | 3 | 6 | 9 |
| 2017 February | 2 | 9 | 11 |
| 2017 January | 3 | 4 | 7 |
| 2016 December | 7 | 6 | 13 |
| 2016 November | 12 | 7 | 19 |
| 2016 October | 18 | 20 | 38 |
| 2016 September | 16 | 10 | 26 |
| 2016 August | 12 | 6 | 18 |
| 2016 July | 18 | 4 | 22 |
| 2016 June | 24 | 14 | 38 |
| 2016 May | 14 | 2 | 16 |
| 2016 April | 6 | 0 | 6 |
| 2016 March | 8 | 0 | 8 |
| 2016 February | 10 | 1 | 11 |
| 2016 January | 27 | 12 | 39 |
| 2015 December | 28 | 15 | 43 |
| 2015 November | 28 | 7 | 35 |
| 2015 October | 7 | 2 | 9 |
| 2015 September | 2 | 0 | 2 |
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