Becas Separ
Pruebas de sensibilidad a micobacterias. Desarrollo de métodos rápidos. Asociación de quimioterápicos
N. Martín Casabona
Hospital General de la Vall d’Hebron. Barcelona.
Read
3918
Timeswas read the article
2069
Total PDF
1849
Total HTML
Share statistics
array:23 [ "pii" => "S0300289615311005" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31100-5" "estado" => "S300" "fechaPublicacion" => "1994-04-01" "aid" => "71170" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "copyrightAnyo" => "1994" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 1994;30:228" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1772 "formatos" => array:3 [ "EPUB" => 73 "HTML" => 690 "PDF" => 1009 ] ] "itemSiguiente" => array:18 [ "pii" => "S0300289615311017" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31101-7" "estado" => "S300" "fechaPublicacion" => "1994-04-01" "aid" => "71171" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 1994;30:228" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1486 "formatos" => array:3 [ "EPUB" => 83 "HTML" => 739 "PDF" => 664 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Becas Separ</span>" "titulo" => "¿Es la traslocación bacteriana un mecanismo etiopatogénico de la neumonía nosocomial adquirida durante la ventilación mecánica?" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "228" ] ] "contieneResumen" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "M. El-Ebiary Alarcón" "autores" => array:1 [ 0 => array:2 [ "nombre" => "M." "apellidos" => "El-Ebiary Alarcón" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615311017?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000004/v1_201509151156/S0300289615311017/v1_201509151156/es/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S0300289615310991" "issn" => "03002896" "doi" => "10.1016/S0300-2896(15)31099-1" "estado" => "S300" "fechaPublicacion" => "1994-04-01" "aid" => "71169" "copyright" => "Sociedad Española de Neumología y Cirugía Torácica" "documento" => "article" "crossmark" => 0 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 1994;30:227-8" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 1244 "formatos" => array:3 [ "EPUB" => 57 "HTML" => 665 "PDF" => 522 ] ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Becas Separ</span>" "titulo" => "Estudio de la etiopatogenia de las neumopatías difusas no infecciosas en pacientes receptores de trasplante de médula ósea mediante hibridación in situ" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "227" "paginaFinal" => "228" ] ] "contieneResumen" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "J. Barberá Mir" "autores" => array:1 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Barberá Mir" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310991?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000004/v1_201509151156/S0300289615310991/v1_201509151156/es/main.assets" ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Becas Separ</span>" "titulo" => "Pruebas de sensibilidad a micobacterias. Desarrollo de métodos rápidos. Asociación de quimioterápicos" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "228" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "N. Martín Casabona" "autores" => array:1 [ 0 => array:2 [ "nombre" => "N." "apellidos" => "Martín Casabona" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Hospital General de la Vall d’Hebron. Barcelona." "identificador" => "aff0005" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "tieneResumen" => true "resumen" => array:1 [ "es" => array:2 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">1) Elección de medio sólido y estudio de las CMI de capas de M. tuberculosis. Comparación con el método de proporciones. 2) Aplicabilidad de sondas ADN marcadas, como método rápido de antibiograma. Correlación con el método de proporciones. 3) Estudio de antibiogramas utilizando la asociación de fármacos. 4) Estudio de cepas no M. tuberculosis (MNT). Las pruebas de sensibilidad convencionales requieren tiempo (15-21 días). El objetivo principal sería estudiar un método rápido utilizando sondas ADN marcadas. A la vez, estudio de la CMI en medios líquidos y sólidos y su correlación con el método de las proporciones de Canetti.</p></span> <span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Métodos</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se estudia la sensibilidad de 12 cepas de M. tuberculosis (cinco sensibles y siete resistentes) frente a isoniacida (H) y rifampicina (R) utilizando sondas ADN marcadas.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se ha evaluado el medio más idóneo para el estudio de la CMI en medio sólido (Middlebrook 7H10 y 7H11 con ADC y/o OADC). Se ha investigado la CMI de 34 cepas (32 resistentes y dos sensibles) frente a H y/o R, por dos métodos, dilución en agar (Middlebrook 7<span class="elsevierStyleHsp" style=""></span>H 11) y dilución en medio líquido (Middlebrook 7H9) comparándola con el método cualitativo de proporciones.</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Resultados</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se están evaluando los resultados de las 12 cepas estudiadas. En cuanto al estudio de la CMI, todas las cepas catalogadas de resistentes para H y/o R por el método de Canetti presentaron unos valores de CMI para ambos fármacos superiores a 0,2 μg/ml y l,0 μg/ml, respectivamente (concentraciones críticas).</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">El medio sólido más adecuado para el estudio de la CMI ha sido el Middlebrook 7H11 suplementado con OADC.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Existe una buena correlación entre los valores obtenidos de la CMI con el método de las proporciones.</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Los resultados preliminares indican que es posible determinar la sensibilidad o resistencia de cepas de M. tuberculosis frente a H o R utilizando sondas ADN.</p></span>" "secciones" => array:4 [ 0 => array:2 [ "identificador" => "abst0005" "titulo" => "Objetivos" ] 1 => array:2 [ "identificador" => "abst0010" "titulo" => "Métodos" ] 2 => array:2 [ "identificador" => "abst0015" "titulo" => "Resultados" ] 3 => array:2 [ "identificador" => "abst0020" "titulo" => "Conclusiones" ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/0000003000000004/v1_201509151156/S0300289615311005/v1_201509151156/es/main.assets" "Apartado" => array:4 [ "identificador" => "14738" "tipo" => "SECCION" "es" => array:2 [ "titulo" => "Información" "idiomaDefecto" => true ] "idiomaDefecto" => "es" ] "PDF" => "https://static.elsevier.es/multimedia/03002896/0000003000000004/v1_201509151156/S0300289615311005/v1_201509151156/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615311005?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 6 | 7 | 13 |
| 2024 October | 35 | 14 | 49 |
| 2024 September | 44 | 17 | 61 |
| 2024 August | 46 | 31 | 77 |
| 2024 July | 30 | 23 | 53 |
| 2024 June | 46 | 18 | 64 |
| 2024 May | 46 | 26 | 72 |
| 2024 April | 24 | 19 | 43 |
| 2024 March | 31 | 33 | 64 |
| 2024 February | 23 | 44 | 67 |
| 2024 January | 0 | 5 | 5 |
| 2023 December | 0 | 8 | 8 |
| 2023 October | 0 | 4 | 4 |
| 2023 August | 0 | 2 | 2 |
| 2023 July | 0 | 2 | 2 |
| 2023 May | 0 | 2 | 2 |
| 2023 March | 9 | 2 | 11 |
| 2023 February | 31 | 16 | 47 |
| 2023 January | 22 | 19 | 41 |
| 2022 December | 28 | 24 | 52 |
| 2022 November | 36 | 27 | 63 |
| 2022 October | 25 | 28 | 53 |
| 2022 September | 20 | 22 | 42 |
| 2022 August | 31 | 35 | 66 |
| 2022 July | 18 | 33 | 51 |
| 2022 June | 19 | 23 | 42 |
| 2022 May | 32 | 22 | 54 |
| 2022 April | 22 | 27 | 49 |
| 2022 March | 26 | 31 | 57 |
| 2022 February | 32 | 29 | 61 |
| 2022 January | 23 | 27 | 50 |
| 2021 December | 17 | 35 | 52 |
| 2021 November | 19 | 23 | 42 |
| 2021 October | 17 | 29 | 46 |
| 2021 September | 16 | 23 | 39 |
| 2021 August | 21 | 28 | 49 |
| 2021 July | 21 | 30 | 51 |
| 2021 June | 14 | 21 | 35 |
| 2021 May | 26 | 22 | 48 |
| 2021 April | 30 | 22 | 52 |
| 2021 March | 46 | 25 | 71 |
| 2021 February | 44 | 16 | 60 |
| 2021 January | 19 | 17 | 36 |
| 2020 December | 25 | 19 | 44 |
| 2020 November | 3 | 11 | 14 |
| 2020 October | 19 | 8 | 27 |
| 2020 September | 17 | 10 | 27 |
| 2020 August | 29 | 16 | 45 |
| 2020 July | 12 | 24 | 36 |
| 2020 June | 6 | 14 | 20 |
| 2020 May | 17 | 15 | 32 |
| 2020 April | 20 | 9 | 29 |
| 2020 March | 9 | 17 | 26 |
| 2020 February | 19 | 13 | 32 |
| 2020 January | 20 | 15 | 35 |
| 2019 December | 24 | 24 | 48 |
| 2019 November | 7 | 9 | 16 |
| 2019 October | 7 | 6 | 13 |
| 2019 September | 6 | 7 | 13 |
| 2019 August | 13 | 6 | 19 |
| 2019 July | 5 | 19 | 24 |
| 2019 June | 7 | 36 | 43 |
| 2019 May | 11 | 33 | 44 |
| 2019 April | 14 | 25 | 39 |
| 2019 March | 9 | 22 | 31 |
| 2019 February | 5 | 18 | 23 |
| 2019 January | 6 | 11 | 17 |
| 2018 December | 9 | 10 | 19 |
| 2018 November | 6 | 21 | 27 |
| 2018 October | 24 | 27 | 51 |
| 2018 September | 11 | 49 | 60 |
| 2018 July | 0 | 1 | 1 |
| 2018 May | 11 | 2 | 13 |
| 2018 April | 11 | 14 | 25 |
| 2018 March | 4 | 7 | 11 |
| 2018 February | 8 | 13 | 21 |
| 2018 January | 7 | 11 | 18 |
| 2017 December | 9 | 16 | 25 |
| 2017 November | 11 | 52 | 63 |
| 2017 October | 6 | 26 | 32 |
| 2017 September | 30 | 21 | 51 |
| 2017 August | 16 | 30 | 46 |
| 2017 July | 10 | 26 | 36 |
| 2017 June | 13 | 39 | 52 |
| 2017 May | 15 | 43 | 58 |
| 2017 April | 13 | 38 | 51 |
| 2017 March | 8 | 39 | 47 |
| 2017 February | 5 | 40 | 45 |
| 2017 January | 7 | 11 | 18 |
| 2016 December | 10 | 12 | 22 |
| 2016 November | 21 | 50 | 71 |
| 2016 October | 17 | 46 | 63 |
| 2016 September | 40 | 46 | 86 |
| 2016 August | 30 | 16 | 46 |
| 2016 July | 23 | 3 | 26 |
| 2016 June | 27 | 14 | 41 |
| 2016 May | 21 | 11 | 32 |
| 2016 April | 14 | 1 | 15 |
| 2016 March | 15 | 1 | 16 |
| 2016 February | 7 | 2 | 9 |
| 2016 January | 22 | 7 | 29 |
| 2015 December | 28 | 17 | 45 |
| 2015 November | 27 | 6 | 33 |
| 2015 October | 7 | 3 | 10 |
| 2015 September | 1 | 0 | 1 |
Show all
