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                    0 => array:2 [
                      "titulo" => "A randomized controlled trial of methylprednisolone in the emergency treatment of acute exacerbations of COPD"
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                          "etal" => true
                          "autores" => array:3 [
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                            2 => "T&#46;W&#46; Lukens"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "fecha" => "1989"
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                        "paginaInicial" => "563"
                        "paginaFinal" => "567"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2920584"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "Intravenous and oral corticosteroids for the prevention of relapse after treatment of descompesated COPD"
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                          "etal" => true
                          "autores" => array:3 [
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                            2 => "T&#46;W&#46; Chick"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Effect on patients with a history of multiples relapses&#46; Chest"
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                        "volumen" => "98"
                        "paginaInicial" => "845"
                        "paginaFinal" => "849"
                      ]
                    ]
                  ]
                ]
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                    0 => array:2 [
                      "titulo" => "V&#46; Value of serial peak expiratory flow measurements in assessing treatment responso in chronic airflow limitation"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;M&#46; Mitchell"
                            1 => "P&#46; Gilden"
                            2 => "A&#46;H&#46; Dimond"
                            3 => "J&#46; Collins"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
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                        "volumen" => "41"
                        "paginaInicial" => "606"
                        "paginaFinal" => "610"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3538487"
                            "web" => "Medline"
                          ]
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                    0 => array:2 [
                      "titulo" => "A double-blind comparison of oral prednisolone 40 mg&#47;day with inhaled beclomethasone dipropionate 1500 pg&#47;day in patients with adult onset chronic obstructive airways disease"
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                          "autores" => array:4 [
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                            1 => "R&#46;I&#46; Gove"
                            2 => "G&#46;A&#46; Wieland"
                            3 => "P&#46;S&#46; Burge"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Respir Dis"
                        "fecha" => "1986"
                        "volumen" => "146"
                        "numero" => "Supl"
                        "paginaInicial" => "565"
                        "paginaFinal" => "569"
                      ]
                    ]
                  ]
                ]
              ]
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            16 => array:3 [
              "identificador" => "bib0085"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of corticosteroids on pulmonary function in chronic bronchitis with airway obstruction"
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                          "autores" => array:3 [
                            0 => "F&#46;J&#46; Fuleihan"
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                            2 => "N&#46;N&#46; Malouf"
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                    0 => array:2 [
                      "doi" => "10.1164/arrd.1967.96.4.678"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1967"
                        "volumen" => "96"
                        "paginaInicial" => "678"
                        "paginaFinal" => "684"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6057607"
                            "web" => "Medline"
                          ]
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                ]
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            17 => array:3 [
              "identificador" => "bib0090"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A comparison of oral and inhaled steroids in patients with chronic airways obstruction&#58; features determining response"
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "S&#46;M&#46; Harding"
                            1 => "S&#46; Freedman"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Thorax"
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                        "volumen" => "33"
                        "paginaInicial" => "214"
                        "paginaFinal" => "218"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/351848"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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            18 => array:3 [
              "identificador" => "bib0095"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of sleroid responsivcness in patients with chronic airflow obstruction"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T&#46;C&#46; Stokes"
                            1 => "J&#46;M&#46; Shaylor"
                            2 => "J&#46;F&#46; O&#8217;Relly"
                            3 => "B&#46;D&#46; Harrison"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2213-2600(14)70037-2"
                      "Revista" => array:6 [
                        "tituloSerie" => "Lancet"
                        "fecha" => "1982"
                        "volumen" => "2"
                        "paginaInicial" => "345"
                        "paginaFinal" => "348"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/24815799"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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            19 => array:3 [
              "identificador" => "bib0100"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of prednisolone in chronic airflow limitation"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;M&#46; Mitchell"
                            1 => "P&#46; Gildeh"
                            2 => "M&#46; Relahn"
                            3 => "A&#46;H&#46; Dimond"
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                    ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S2215-0366(15)00046-2"
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                        "tituloSerie" => "Lancet"
                        "fecha" => "1984"
                        "volumen" => "2"
                        "paginaInicial" => "193"
                        "paginaFinal" => "196"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26359884"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0105"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response to oral corticosteroids in chronic airflow obstruction"
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "W&#46;K&#46; Lam"
                            1 => "S&#46;Y&#46; So"
                            2 => "D&#46;Y&#46; Yu"
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dis Chest"
                        "fecha" => "1983"
                        "volumen" => "77"
                        "paginaInicial" => "189"
                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6347233"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            21 => array:3 [
              "identificador" => "bib0110"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use&#46;of the 12 minutes walking test in assessing the effect of oral steroid therapy in patients with chronic airwavs obstruction"
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                          "etal" => false
                          "autores" => array:4 [
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                            2 => "K&#46;M&#46; Fromings"
                            3 => "D&#46;W&#46; Harrison"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dis Chest"
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                        "volumen" => "76"
                        "paginaInicial" => "374"
                        "paginaFinal" => "382"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6758833"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Effect of steroid therapy on exercise perfomance in patients with irreversible chronic obstructive pulmonary disease"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;S&#46; Strain"
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                            2 => "D&#46;P&#46; Franco"
                            3 => "R&#46;B&#46; George"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "718"
                        "paginaFinal" => "721"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3902388"
                            "web" => "Medline"
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            23 => array:3 [
              "identificador" => "bib0120"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Prednisone treatment for stable pulmonary cmphysema"
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                    0 => array:2 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
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                        "volumen" => "104"
                        "paginaInicial" => "264"
                        "paginaFinal" => "266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5558996"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Treatment of chronic obstructive pulmonary disease with corticoids"
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                  "host" => array:1 [
                    0 => array:1 [
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                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6383740"
                            "web" => "Medline"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Corticosteroids in chronic obstructivo pulmonary disease&#46; A clinical trial and reassesment of the literature"
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                          "etal" => false
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                            4 => "J&#46;R&#46; McCormick"
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                  "host" => array:1 [
                    0 => array:1 [
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                        "paginaInicial" => "484"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3514164"
                            "web" => "Medline"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic Corticosteroids in stable chronic obstructive pulmonary disease"
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                          "autores" => array:1 [
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                      "Revista" => array:5 [
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3542401"
                            "web" => "Medline"
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              "identificador" => "bib0140"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meta-analysis in clinical research"
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                      "Revista" => array:6 [
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                        "paginaInicial" => "224"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3300460"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral corticosteroid therapy for patients with stable chronic obstructive pulmonary disease&#58; a meta-analysis"
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                          "etal" => false
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                        "paginaInicial" => "216"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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            29 => array:3 [
              "identificador" => "bib0150"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response to corticosteroids in chronic bronchitis"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
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                        "volumen" => "62"
                        "paginaInicial" => "363"
                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/361794"
                            "web" => "Medline"
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            30 => array:3 [
              "identificador" => "bib0155"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Steroid response in stable chronic obstructive pulmonary disease"
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                          "etal" => false
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                            3 => "N&#46;R&#46; Anthonisen"
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                      "Revista" => array:6 [
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                        "paginaInicial" => "17"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7032378"
                            "web" => "Medline"
                          ]
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            31 => array:3 [
              "identificador" => "bib0160"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Bronchodilators and corticosteroids in chronic bronchitis and emphysema"
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                        "paginaFinal" => "1&#46;512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7427564"
                            "web" => "Medline"
                          ]
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            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time course of response to oral and inhaled corticosteroids in non-asthmatic chronic airflow obstruction"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;C&#46; Weir"
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                            2 => "R&#46;I&#46; Gove"
                            3 => "P&#46;S&#46; Burge"
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Thorax"
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                        "volumen" => "45"
                        "paginaInicial" => "118"
                        "paginaFinal" => "121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2180106"
                            "web" => "Medline"
                          ]
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            33 => array:3 [
              "identificador" => "bib0170"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severc chronic airflow obstruction&#58; can corticosteroids slow down progression&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;S&#46; Postma"
                            1 => "Steenhuis &#201;J"
                            2 => "T&#46;H&#46; Van Der Weeke"
                            3 => "H&#46;J&#46; Sluiter"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Respir Dis"
                        "fecha" => "1985"
                        "volumen" => "67"
                        "paginaInicial" => "56"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4054257"
                            "web" => "Medline"
                          ]
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            34 => array:3 [
              "identificador" => "bib0175"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Moderately severe chronic obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;S&#46; Postma"
                            1 => "I&#46; Peters"
                            2 => "E&#46;J&#46; Steenhuis"
                            3 => "H&#46;J&#46; Sluiter"
                          ]
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                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Can corticosteroids slow down obstruction&#63;&#46; Eur Respir J"
                        "fecha" => "1988"
                        "volumen" => "I"
                        "paginaInicial" => "22"
                        "paginaFinal" => "26"
                      ]
                    ]
                  ]
                ]
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            35 => array:3 [
              "identificador" => "bib0180"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis of chronic obstructive pulmonary disease&#58; The dutch experience"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Postma"
                            1 => "H&#46; Sluiter"
                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "100"
                        "paginaFinal" => "105"
                      ]
                    ]
                  ]
                ]
              ]
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            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rationale and use corticosteroids in&#46; chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;D&#46; Hudson"
                            1 => "C&#46;M&#46; Monti"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin North Am"
                        "fecha" => "1990"
                        "volumen" => "74"
                        "paginaInicial" => "661"
                        "paginaFinal" => "690"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2186237"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacologic therapy of obstructive airway disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46; Zimmet"
                          ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "1990"
                        "volumen" => "11"
                        "paginaInicial" => "471"
                        "paginaFinal" => "472"
                      ]
                    ]
                  ]
                ]
              ]
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            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic bronchitis in the 1990s&#58; Up-to-date treatment"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;W&#46; Clarke"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "1991"
                        "volumen" => "58"
                        "numero" => "Supl 1"
                        "paginaInicial" => "43"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1925078"
                            "web" => "Medline"
                          ]
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            39 => array:3 [
              "identificador" => "bib0200"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of reversibility of airway obstruction in patients with chronic obstructive airways disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Nisar"
                            1 => "M&#46; Walshaw"
                            2 => "J&#46;E&#46; Earis"
                            3 => "M&#46;G&#46; Pearson"
                            4 => "P&#46;M&#46;A&#46; Calverly"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
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                        "volumen" => "45"
                        "paginaInicial" => "190"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2330551"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0205"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airway disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;A&#46;M&#46; Kerstjens"
                            1 => "P&#46;L&#46;P&#46; Brand"
                            2 => "P&#46;H&#46; Quanjer"
                            3 => "B&#46;H&#46;H&#46;A&#46; Van der Bruggenbogaarts"
                            4 => "G&#46;H&#46; Ko&#235;ter"
                            5 => "D&#46;S&#46; Postma"
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Thorax"
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                        "paginaInicial" => "722"
                        "paginaFinal" => "729"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8153921"
                            "web" => "Medline"
                          ]
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              ]
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            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response to&#46; corticosteroids in chronic airflow obstruction&#58; relationship to emphvsema and airways collapse"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "A&#46;S&#46; Robertson"
                            3 => "P&#46;S&#46; Burge"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
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                        "volumen" => "4"
                        "paginaInicial" => "1&#46;185"
                        "paginaFinal" => "1&#46;190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1804678"
                            "web" => "Medline"
                          ]
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            42 => array:3 [
              "identificador" => "bib0215"
              "etiqueta" => "43&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute bronchodilator trials in chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46; Nisar"
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                            2 => "M&#46;G&#46; Pearson"
                            3 => "P&#46;M&#46;A&#46; Calverley"
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/146.3.555"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "146"
                        "paginaInicial" => "555"
                        "paginaFinal" => "559"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1387772"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0220"
              "etiqueta" => "44&#46;"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Determining optimal therapy -randomized tri&#225;is in individuals patients"
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                          "etal" => false
                          "autores" => array:6 [
                            0 => "G&#46; Guyatt"
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                            4 => "R&#46; Roberts"
                            5 => "S&#46; Pugsley"
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                        "tituloSerie" => "N Eng J Med"
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                        "volumen" => "314"
                        "paginaInicial" => "889"
                        "paginaFinal" => "892"
                      ]
                    ]
                  ]
                ]
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              "identificador" => "bib0225"
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                0 => array:2 [
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                    0 => array:2 [
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                          "etal" => false
                          "autores" => array:1 [
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                        "volumen" => "114"
                        "paginaInicial" => "704"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2003724"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effect of long term treatment with an inhaled corticosteroid &#40;budesonide&#41; on airway hyperresponsiveness and clinical asthma in non steroid-dependent asthmatics"
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                          "etal" => false
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
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                        "paginaInicial" => "832"
                        "paginaFinal" => "836"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2221590"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0235"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Effects of inhaled budesonide on spiromctric values&#44; reversibility&#46; airway responsiveness&#44; and cough threshold in smokers with chronic obstructive lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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                            2 => "J&#46;G&#46;R&#46; Monchy"
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                            4 => "M&#46; Boorsma"
                            5 => "G&#46;H&#46; Ko&#235;ter"
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                  "host" => array:1 [
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                        "paginaInicial" => "372"
                        "paginaFinal" => "377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2068695"
                            "web" => "Medline"
                          ]
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              "identificador" => "bib0240"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Corticosteroid tri&#225;is in non-asthmatic chronic airflow obstruction&#58; a comparison of oral prednisolone and inhaled beclomcthasone dipropionate"
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                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2180105"
                            "web" => "Medline"
                          ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of high dose inhaled beclomethasone dipropionate as a means of assessing steroid responsiveness in obstructive airways discase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "A&#46;J&#46; Knox"
                            3 => "R&#46;L&#46; Page"
                            4 => "J&#46; Cooke"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dis Chest"
                        "fecha" => "1988"
                        "volumen" => "82"
                        "paginaInicial" => "168"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3048365"
                            "web" => "Medline"
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              "etiqueta" => "50&#46;"
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Aerosolized beclomethasone in chronic bronchitis"
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                          "etal" => true
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                            5 => "S&#46;W&#46; Yancey"
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                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Improved pulmonary function and disminished airway inflammation&#46; Am Rev Respir Dis"
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                        "volumen" => "146"
                        "paginaInicial" => "389"
                        "paginaFinal" => "395"
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                  ]
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              "identificador" => "bib0255"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A trial of inhaled budesonide on airway responsiveness in smokers with chronic bronchitis"
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                            4 => "E&#46;R&#46; Weeke"
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                  "host" => array:1 [
                    0 => array:1 [
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                        "volumen" => "2"
                        "paginaInicial" => "935"
                        "paginaFinal" => "939"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2691278"
                            "web" => "Medline"
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            51 => array:3 [
              "identificador" => "bib0260"
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                0 => array:2 [
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Corticoides en la enfermedad pulmonar obstructiva crónica
J.J. Soler Cataluña*, M.A. Ciscar Vilanova**, J.A. Pérez Fernández***,1
* Servicios de Neumología. Hospitales La Fe, Valencia
** Servicios de Neumología. Hospitales General, Valencia
*** Servicios de Neumología. Hospitales Arnau de Vilanova. Valencia
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                            2 => "K&#46;M&#46; Britten"
                            3 => "S&#46;J&#46; Wilson"
                            4 => "A&#46;F&#46; Walls"
                            5 => "W&#46;R&#46; Roche"
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                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/145.3.669"
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                        "paginaFinal" => "674"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1546849"
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                      "titulo" => "Lung function and immunopathological changes after inhaled corticosteroids therapy in asthma"
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                            0 => "C&#46; Burke"
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                            4 => "B&#46; Schmekel"
                            5 => "L&#46;W&#46; Poulter"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "volumen" => "5"
                        "paginaInicial" => "73"
                        "paginaFinal" => "79"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1577153"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Characteristics of the inflammation in biopsies from large airways of subjects&#44; with asthma and subjects with chronic airflow limitation"
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                          "etal" => false
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/145.4_Pt_1.922"
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                        "tituloSerie" => "Am Rev Respir Dis"
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                        "volumen" => "145"
                        "paginaInicial" => "922"
                        "paginaFinal" => "927"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1348169"
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                      "titulo" => "The relation between structural changes in small airways and pulmonarv function test"
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                        "tituloSerie" => "N Engl J Med"
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                        "paginaInicial" => "1&#46;277"
                        "paginaFinal" => "1&#46;281"
                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/652006"
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                    0 => array:2 [
                      "titulo" => "European Respiratory Society study on chronic obstructive pulmonary disease &#40;EUROSCOP&#41;&#58; hypothesis and design"
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                        "link" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1486976"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Controlled clinical trial of methylprednisolone in patients with bronchitis and acute respiratory insuficiency"
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                        "tituloSerie" => "Ann Intern Med"
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                        "volumen" => "92"
                        "paginaInicial" => "753"
                        "paginaFinal" => "758"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6770731"
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                0 => array:2 [
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                      "titulo" => "A randomized controlled trial of methylprednisolone in the emergency treatment of acute exacerbations of COPD"
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                        "paginaFinal" => "567"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2920584"
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                      "titulo" => "Intravenous and oral corticosteroids for the prevention of relapse after treatment of descompesated COPD"
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                          0 => array:2 [
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                        "paginaFinal" => "684"
                        "link" => array:1 [
                          0 => array:2 [
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                        "paginaFinal" => "218"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/351848"
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                    0 => array:2 [
                      "titulo" => "Assessment of sleroid responsivcness in patients with chronic airflow obstruction"
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                        "paginaFinal" => "198"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Prednisone treatment for stable pulmonary cmphysema"
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                        "paginaFinal" => "266"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5558996"
                            "web" => "Medline"
                          ]
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            24 => array:3 [
              "identificador" => "bib0125"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment of chronic obstructive pulmonary disease with corticoids"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "G&#46;P&#46; Blair"
                            1 => "R&#46;W&#46; Light"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1984"
                        "volumen" => "86"
                        "paginaInicial" => "524"
                        "paginaFinal" => "528"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/6383740"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            25 => array:3 [
              "identificador" => "bib0130"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Corticosteroids in chronic obstructivo pulmonary disease&#46; A clinical trial and reassesment of the literature"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "O&#46; Eliasson"
                            1 => "J&#46; Hoffman"
                            2 => "D&#46; Trueb"
                            3 => "D&#46; Frederick"
                            4 => "J&#46;R&#46; McCormick"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1986"
                        "volumen" => "89"
                        "paginaInicial" => "484"
                        "paginaFinal" => "490"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3514164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            26 => array:3 [
              "identificador" => "bib0135"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Systemic Corticosteroids in stable chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46;K&#46; Stoller"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Do they work&#63;&#46; &#91;editorial&#93;&#46; Chest"
                        "fecha" => "1987"
                        "volumen" => "91"
                        "paginaInicial" => "155"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3542401"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            27 => array:3 [
              "identificador" => "bib0140"
              "etiqueta" => "28&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Meta-analysis in clinical research"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;A&#46; L&#8217;Abbe"
                            1 => "A&#46;S&#46; Detsky"
                            2 => "Y&#46; O&#8217;Rourke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1987"
                        "volumen" => "107"
                        "paginaInicial" => "224"
                        "paginaFinal" => "233"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3300460"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            28 => array:3 [
              "identificador" => "bib0145"
              "etiqueta" => "29&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Oral corticosteroid therapy for patients with stable chronic obstructive pulmonary disease&#58; a meta-analysis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Callahan"
                            1 => "R&#46; Dittus"
                            2 => "B&#46; Katz"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1991"
                        "volumen" => "114"
                        "paginaInicial" => "216"
                        "paginaFinal" => "223"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1824614"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            29 => array:3 [
              "identificador" => "bib0150"
              "etiqueta" => "30&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response to corticosteroids in chronic bronchitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "C&#46; Shim"
                            1 => "D&#46;E&#46; Stover"
                            2 => "M&#46;H&#46; Williams"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Allergy Clin Immunol"
                        "fecha" => "1978"
                        "volumen" => "62"
                        "paginaInicial" => "363"
                        "paginaFinal" => "367"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/361794"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            30 => array:3 [
              "identificador" => "bib0155"
              "etiqueta" => "31&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Steroid response in stable chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "L&#46;A&#46; Mendella"
                            1 => "J&#46; Manfreda"
                            2 => "P&#46;W&#46; Warren"
                            3 => "N&#46;R&#46; Anthonisen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1982"
                        "volumen" => "96"
                        "paginaInicial" => "17"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7032378"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            31 => array:3 [
              "identificador" => "bib0160"
              "etiqueta" => "32&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchodilators and corticosteroids in chronic bronchitis and emphysema"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "B&#46;J&#46; Freedman"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Br Med J"
                        "fecha" => "1963"
                        "paginaInicial" => "1&#46;509"
                        "paginaFinal" => "1&#46;512"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7427564"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Time course of response to oral and inhaled corticosteroids in non-asthmatic chronic airflow obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;C&#46; Weir"
                            1 => "A&#46;S&#46; Robertson"
                            2 => "R&#46;I&#46; Gove"
                            3 => "P&#46;S&#46; Burge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1990"
                        "volumen" => "45"
                        "paginaInicial" => "118"
                        "paginaFinal" => "121"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2180106"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            33 => array:3 [
              "identificador" => "bib0170"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Severc chronic airflow obstruction&#58; can corticosteroids slow down progression&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;S&#46; Postma"
                            1 => "Steenhuis &#201;J"
                            2 => "T&#46;H&#46; Van Der Weeke"
                            3 => "H&#46;J&#46; Sluiter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur J Respir Dis"
                        "fecha" => "1985"
                        "volumen" => "67"
                        "paginaInicial" => "56"
                        "paginaFinal" => "64"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4054257"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
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            34 => array:3 [
              "identificador" => "bib0175"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Moderately severe chronic obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;S&#46; Postma"
                            1 => "I&#46; Peters"
                            2 => "E&#46;J&#46; Steenhuis"
                            3 => "H&#46;J&#46; Sluiter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Can corticosteroids slow down obstruction&#63;&#46; Eur Respir J"
                        "fecha" => "1988"
                        "volumen" => "I"
                        "paginaInicial" => "22"
                        "paginaFinal" => "26"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            35 => array:3 [
              "identificador" => "bib0180"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prognosis of chronic obstructive pulmonary disease&#58; The dutch experience"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;S&#46; Postma"
                            1 => "H&#46; Sluiter"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1989"
                        "volumen" => "140"
                        "paginaInicial" => "100"
                        "paginaFinal" => "105"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            36 => array:3 [
              "identificador" => "bib0185"
              "etiqueta" => "37&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Rationale and use corticosteroids in&#46; chronic obstructive pulmonary disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "L&#46;D&#46; Hudson"
                            1 => "C&#46;M&#46; Monti"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Med Clin North Am"
                        "fecha" => "1990"
                        "volumen" => "74"
                        "paginaInicial" => "661"
                        "paginaFinal" => "690"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2186237"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            37 => array:3 [
              "identificador" => "bib0190"
              "etiqueta" => "38&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacologic therapy of obstructive airway disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "I&#46; Zimmet"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "1990"
                        "volumen" => "11"
                        "paginaInicial" => "471"
                        "paginaFinal" => "472"
                      ]
                    ]
                  ]
                ]
              ]
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            38 => array:3 [
              "identificador" => "bib0195"
              "etiqueta" => "39&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Chronic bronchitis in the 1990s&#58; Up-to-date treatment"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;W&#46; Clarke"
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:7 [
                        "tituloSerie" => "Respiration"
                        "fecha" => "1991"
                        "volumen" => "58"
                        "numero" => "Supl 1"
                        "paginaInicial" => "43"
                        "paginaFinal" => "46"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1925078"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
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            39 => array:3 [
              "identificador" => "bib0200"
              "etiqueta" => "40&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Assessment of reversibility of airway obstruction in patients with chronic obstructive airways disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Nisar"
                            1 => "M&#46; Walshaw"
                            2 => "J&#46;E&#46; Earis"
                            3 => "M&#46;G&#46; Pearson"
                            4 => "P&#46;M&#46;A&#46; Calverly"
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                        ]
                      ]
                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
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                        "volumen" => "45"
                        "paginaInicial" => "190"
                        "paginaFinal" => "194"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2330551"
                            "web" => "Medline"
                          ]
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                    ]
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                ]
              ]
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            40 => array:3 [
              "identificador" => "bib0205"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Variability of bronchodilator response and effects of inhaled corticosteroid treatment in obstructive airway disease"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "H&#46;A&#46;M&#46; Kerstjens"
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                            2 => "P&#46;H&#46; Quanjer"
                            3 => "B&#46;H&#46;H&#46;A&#46; Van der Bruggenbogaarts"
                            4 => "G&#46;H&#46; Ko&#235;ter"
                            5 => "D&#46;S&#46; Postma"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "tituloSerie" => "Thorax"
                        "fecha" => "1993"
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                        "paginaInicial" => "722"
                        "paginaFinal" => "729"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8153921"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            41 => array:3 [
              "identificador" => "bib0210"
              "etiqueta" => "42&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Response to&#46; corticosteroids in chronic airflow obstruction&#58; relationship to emphvsema and airways collapse"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "D&#46;C&#46; Weir"
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                            2 => "A&#46;S&#46; Robertson"
                            3 => "P&#46;S&#46; Burge"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
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                        "paginaInicial" => "1&#46;185"
                        "paginaFinal" => "1&#46;190"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1804678"
                            "web" => "Medline"
                          ]
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                ]
              ]
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            42 => array:3 [
              "identificador" => "bib0215"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Acute bronchodilator trials in chronic obstructive pulmonary disease"
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                        0 => array:2 [
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                            0 => "M&#46; Nisar"
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                            3 => "P&#46;M&#46;A&#46; Calverley"
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                      ]
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                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/146.3.555"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "146"
                        "paginaInicial" => "555"
                        "paginaFinal" => "559"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1387772"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            43 => array:3 [
              "identificador" => "bib0220"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Determining optimal therapy -randomized tri&#225;is in individuals patients"
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                          "etal" => false
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                            0 => "G&#46; Guyatt"
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                            2 => "D&#46;W&#46; Taylor"
                            3 => "J&#46; Chong"
                            4 => "R&#46; Roberts"
                            5 => "S&#46; Pugsley"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "N Eng J Med"
                        "fecha" => "1986"
                        "volumen" => "314"
                        "paginaInicial" => "889"
                        "paginaFinal" => "892"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            44 => array:3 [
              "identificador" => "bib0225"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Corticosteroids for chronic obstructive pulmonary disease &#91;carta&#93;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "R&#46; Gilbcrt"
                          ]
                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1991"
                        "volumen" => "114"
                        "paginaInicial" => "704"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2003724"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            45 => array:3 [
              "identificador" => "bib0230"
              "etiqueta" => "46&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effect of long term treatment with an inhaled corticosteroid &#40;budesonide&#41; on airway hyperresponsiveness and clinical asthma in non steroid-dependent asthmatics"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "E&#46;F&#46; Juniper"
                            1 => "P&#46;A&#46; Kline"
                            2 => "A&#46; Vanzieleghem"
                            3 => "E&#46;H&#46; Ramsdale"
                            4 => "P&#46;M&#46; O&#8217;Byrne"
                            5 => "F&#46;E&#46; Hargreave"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm/142.4.832"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1990"
                        "volumen" => "142"
                        "paginaInicial" => "832"
                        "paginaFinal" => "836"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2221590"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            46 => array:3 [
              "identificador" => "bib0235"
              "etiqueta" => "47&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Effects of inhaled budesonide on spiromctric values&#44; reversibility&#46; airway responsiveness&#44; and cough threshold in smokers with chronic obstructive lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "B&#46; Auffart"
                            1 => "D&#46;S&#46; Postma"
                            2 => "J&#46;G&#46;R&#46; Monchy"
                            3 => "Van der Mark ThW"
                            4 => "M&#46; Boorsma"
                            5 => "G&#46;H&#46; Ko&#235;ter"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1991"
                        "volumen" => "46"
                        "paginaInicial" => "372"
                        "paginaFinal" => "377"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2068695"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            47 => array:3 [
              "identificador" => "bib0240"
              "etiqueta" => "48&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Corticosteroid tri&#225;is in non-asthmatic chronic airflow obstruction&#58; a comparison of oral prednisolone and inhaled beclomcthasone dipropionate"
                      "autores" => array:1 [
                        0 => array:2 [
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                            1 => "R&#46;I&#46; Gove"
                            2 => "A&#46;S&#46; Robertson"
                            3 => "P&#46;S&#46; Burge"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1990"
                        "volumen" => "45"
                        "paginaInicial" => "112"
                        "paginaFinal" => "117"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2180105"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            48 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The use of high dose inhaled beclomethasone dipropionate as a means of assessing steroid responsiveness in obstructive airways discase"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "Wardman Ag"
                            1 => "F&#46;G&#46; Simpson"
                            2 => "A&#46;J&#46; Knox"
                            3 => "R&#46;L&#46; Page"
                            4 => "J&#46; Cooke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Br J Dis Chest"
                        "fecha" => "1988"
                        "volumen" => "82"
                        "paginaInicial" => "168"
                        "paginaFinal" => "171"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3048365"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            49 => array:3 [
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              "etiqueta" => "50&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aerosolized beclomethasone in chronic bronchitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A&#46;B&#46; Thompson"
                            1 => "M&#46;B&#46; Mueller"
                            2 => "A&#46;J&#46; Heires"
                            3 => "T&#46;L&#46; Bohling"
                            4 => "D&#46; Daughton"
                            5 => "S&#46;W&#46; Yancey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Improved pulmonary function and disminished airway inflammation&#46; Am Rev Respir Dis"
                        "fecha" => "1992"
                        "volumen" => "146"
                        "paginaInicial" => "389"
                        "paginaFinal" => "395"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            50 => array:3 [
              "identificador" => "bib0255"
              "etiqueta" => "51&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "A trial of inhaled budesonide on airway responsiveness in smokers with chronic bronchitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "T&#46; Engel"
                            1 => "J&#46;H&#46; Heining"
                            2 => "O&#46; Madsen"
                            3 => "M&#46; Hansen"
                            4 => "E&#46;R&#46; Weeke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "1989"
                        "volumen" => "2"
                        "paginaInicial" => "935"
                        "paginaFinal" => "939"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2691278"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            51 => array:3 [
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Failure of inhaled corticosteroids to modify bronchoconstrictor or bronchodilator responsiveness in middle-aged smokers with mild airflow obstruction"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            1 => "T&#46; Keang Lim"
                            2 => "H&#46; Joyce"
                            3 => "N&#46;B&#46; Pride"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                        "tituloSerie" => "Chest"
                        "fecha" => "1992"
                        "volumen" => "101"
                        "paginaInicial" => "350"
                        "paginaFinal" => "355"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1735253"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            52 => array:3 [
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                    0 => array:2 [
                      "titulo" => "Effects of high dose inhaled beclomethasone dipropionate&#44; 750 pg and 1500 pg twice daily&#44; and 40 mg per day oral prednisolone on lung function&#44; symptoms&#44; and bronchial hyperresponsiveness in patients with non-asthmatic chronic airflow obstruction"
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                    ]
                  ]
                  "host" => array:1 [
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                        "tituloSerie" => "Thorax"
                        "fecha" => "1993"
                        "volumen" => "48"
                        "paginaInicial" => "309"
                        "paginaFinal" => "316"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8511727"
                            "web" => "Medline"
                          ]
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                  ]
                ]
              ]
            ]
            53 => array:3 [
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                0 => array:2 [
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                    0 => array:2 [
                      "titulo" => "Slowing the&#46; deterioration of asthma and chronic obstructive pulmonary disease observed during bronchodilator therapy by adding inhaled corticosteroids&#46; A 4-year prospective study"
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                        0 => array:2 [
                          "etal" => true
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                            2 => "P&#46;M&#46; Van Grunsven"
                            3 => "C&#46;L&#46;A&#46; Van Herwaarden"
                            4 => "R&#46; Akkermans"
                            5 => "J&#46; Molema"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Intern Med"
                        "fecha" => "1993"
                        "volumen" => "118"
                        "paginaInicial" => "770"
                        "paginaFinal" => "778"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8470851"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                  "referenciaCompleta" => "Kerstjens HAM&#44; Brand PLP&#44; Hughes MD&#44; Robinson NJ&#44; Postma DS&#44; Sluiter HJ&#44; et al&#46; A comparison of bronchodilator therapy with or without inhaled corticosteroid therapy for obstructive airways disease&#46;"
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                    0 => array:2 [
                      "titulo" => "Inhaled corticosteroids in COPD&#58; awaiting controlled trials &#91;editorial&#93;"
                      "autores" => array:1 [
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                          "autores" => array:1 [
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                        "link" => array:1 [
                          0 => array:2 [
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                            "web" => "Medline"
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                    0 => array:2 [
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                        "tituloSerie" => "BMJ"
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                        "paginaFinal" => "1&#46;554"
                        "link" => array:1 [
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ISSN: 03002896
Original language: Spanish
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