Utilidad de la enolasa neuroespecífica sérica en el manejo clínico del carcinoma microcítico de pulmón
Serum neuron specific enolase in the clinical management of small cell lung cancer
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"apellidos" => "Sánchez de Cos Escuín" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">1</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "F." "apellidos" => "Masa Jiménez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "C." "apellidos" => "Disdier Vicente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "J.L." "apellidos" => "de la Cruz Ríos" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "C." "apellidos" => "Vergara Fiordia" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "aff0005" ] ] ] 5 => array:3 [ "nombre" => "C." "apellidos" => "Domínguez Retortillo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">**</span>" "identificador" => "aff0010" ] ] ] 6 => array:3 [ "nombre" => "F." "apellidos" => "Fuentes Otero" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">***</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Unidad de Neumología. Hospital San Pedro de Alcántara. Cáceres" "etiqueta" => "*" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Laboratorio de Bioquímica. Hospital San Pedro de Alcántara. Cáceres" "etiqueta" => "**" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Sección de Neumología. Hospital Infanta Cristina. Universidad de Extremadura. Badajoz" "etiqueta" => "***" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "1" "correspondencia" => "Correspondencia: Santa Joaquina de Vedruna 6E, l.° I. 10001 Cáceres." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Serum neuron specific enolase in the clinical management of small cell lung cancer" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1993-08-30" "fechaAceptado" => "1994-01-05" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se analiza la utilidad de la enolasa neuroespecífica (NSE) sérica en el diagnóstico y manejo del carcinoma microcítico de pulmón (CMP).</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Se efectuaron determinaciones séricas de NSE en 69 adultos sanos, 106 pacientes con neumopatías no neoplásicas (NNN), 26 con metástasis pulmonares de origen extrapulmonar (MPOE), 126 con carcinoma pulmonar no microcítico (CPNM) y 77 con CMP. En estos últimos, se realizaron determinaciones sucesivas durante y después del tratamiento y se registró el tiempo de supervivencia.</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">La NSE resultó elevada en el 77,6% de los CMP (50% en casos de enfermedad limitada [EL], y 93,6% en enfermedad extendida [EE]), en el 10,3% de los CPNM, en el 11,5% de MPOE y en el 2,8% de NNN.</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">La NSE descendió en el 100% de los CMP que obtuvieron remisión completa tras el tratamiento y en el 25% de los que no respondieron favorablemente. Posteriormente, el marcador ascendió en el 81,2% de las recidivas; en el 6,2%, dicho ascenso precedió a la sintomatología.</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">La concentración inicial de NSE demostró valor pronóstico (p = 0,003) independientemente del estadio (EL o EE).</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">La NSE es de gran valor diagnóstico y pronóstico en el CMP, refleja fielmente la masa tumoral, y los cambios postratamiento guardan estrecho paralelismo con el curso de la enfermedad.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The utility of neuron specific enolase (NSE) for the diagnosis and management of small cell lung cáncer (SCLC) is analyzed.</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Serum concentrations of NSE were measured in 69 healthy adults, 106 patients with non-neoplastic pneumopathy (NNP), 16 with pulmonary metastasis of extra-pulmonary origin (PMEO), 126 with non-small cell lung cancer (NSCLC), and 77 with SCLC. Repeated analyses were carried out for patients in the last group during and after treatment, and survival time was recorded.</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">NSE was high in 77.6% of patients with SCLC [50% in cases with limited disease (LD) and 93.6% in those with extensive disease (ED)]. NSE was high in 10.3% of those with NSCLC, in 11.5% of those with PMEO, and in 2.8% of those with NNP. NSE decreased 100% in SCLC patients achieving full remission after treatment and in 25% of those responding poorly. Later, this marker increased in 81.2% of those experiencing relapse, and in 6.2% of these the increased preceded symptoms. Initial NSE concentrations had prognostic value (p = 0.003) that was independent of disease stage (LD or ED).</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">NSE is of great diagnostic and prognostic valué in SCLC, accurately reflecting tumor size. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 10 | 5 | 15 |
| 2024 October | 90 | 35 | 125 |
| 2024 September | 64 | 25 | 89 |
| 2024 August | 87 | 36 | 123 |
| 2024 July | 56 | 29 | 85 |
| 2024 June | 72 | 36 | 108 |
| 2024 May | 63 | 45 | 108 |
| 2024 April | 44 | 41 | 85 |
| 2024 March | 42 | 46 | 88 |
| 2024 February | 75 | 61 | 136 |
| 2024 January | 0 | 16 | 16 |
| 2023 December | 0 | 3 | 3 |
| 2023 November | 0 | 1 | 1 |
| 2023 October | 0 | 6 | 6 |
| 2023 September | 0 | 1 | 1 |
| 2023 July | 0 | 21 | 21 |
| 2023 June | 0 | 3 | 3 |
| 2023 April | 0 | 2 | 2 |
| 2023 March | 6 | 6 | 12 |
| 2023 February | 29 | 25 | 54 |
| 2023 January | 25 | 49 | 74 |
| 2022 December | 35 | 29 | 64 |
| 2022 November | 34 | 22 | 56 |
| 2022 October | 31 | 40 | 71 |
| 2022 September | 30 | 29 | 59 |
| 2022 August | 29 | 35 | 64 |
| 2022 July | 30 | 48 | 78 |
| 2022 June | 23 | 33 | 56 |
| 2022 May | 35 | 29 | 64 |
| 2022 April | 30 | 34 | 64 |
| 2022 March | 38 | 40 | 78 |
| 2022 February | 51 | 34 | 85 |
| 2022 January | 35 | 31 | 66 |
| 2021 December | 32 | 48 | 80 |
| 2021 November | 23 | 61 | 84 |
| 2021 October | 75 | 58 | 133 |
| 2021 September | 40 | 54 | 94 |
| 2021 August | 48 | 65 | 113 |
| 2021 July | 30 | 53 | 83 |
| 2021 June | 42 | 65 | 107 |
| 2021 May | 67 | 56 | 123 |
| 2021 April | 39 | 77 | 116 |
| 2021 March | 34 | 46 | 80 |
| 2021 February | 54 | 30 | 84 |
| 2021 January | 34 | 33 | 67 |
| 2020 December | 39 | 35 | 74 |
| 2020 November | 27 | 29 | 56 |
| 2020 October | 21 | 37 | 58 |
| 2020 September | 78 | 20 | 98 |
| 2020 August | 79 | 38 | 117 |
| 2020 July | 75 | 22 | 97 |
| 2020 June | 103 | 28 | 131 |
| 2020 May | 95 | 29 | 124 |
| 2020 April | 33 | 23 | 56 |
| 2020 March | 22 | 38 | 60 |
| 2020 February | 31 | 40 | 71 |
| 2020 January | 55 | 31 | 86 |
| 2019 December | 114 | 45 | 159 |
| 2019 November | 88 | 22 | 110 |
| 2019 October | 67 | 39 | 106 |
| 2019 September | 63 | 62 | 125 |
| 2019 August | 65 | 18 | 83 |
| 2019 July | 37 | 41 | 78 |
| 2019 June | 26 | 43 | 69 |
| 2019 May | 48 | 40 | 88 |
| 2019 April | 73 | 91 | 164 |
| 2019 March | 14 | 26 | 40 |
| 2019 February | 10 | 29 | 39 |
| 2019 January | 10 | 22 | 32 |
| 2018 December | 10 | 28 | 38 |
| 2018 November | 27 | 24 | 51 |
| 2018 October | 25 | 28 | 53 |
| 2018 September | 24 | 27 | 51 |
| 2018 May | 6 | 1 | 7 |
| 2018 April | 8 | 32 | 40 |
| 2018 March | 15 | 18 | 33 |
| 2018 February | 7 | 30 | 37 |
| 2018 January | 7 | 22 | 29 |
| 2017 December | 13 | 24 | 37 |
| 2017 November | 8 | 17 | 25 |
| 2017 October | 10 | 21 | 31 |
| 2017 September | 10 | 25 | 35 |
| 2017 August | 10 | 25 | 35 |
| 2017 July | 4 | 13 | 17 |
| 2017 June | 31 | 48 | 79 |
| 2017 May | 11 | 20 | 31 |
| 2017 April | 4 | 16 | 20 |
| 2017 March | 6 | 38 | 44 |
| 2017 February | 6 | 21 | 27 |
| 2017 January | 6 | 13 | 19 |
| 2016 December | 13 | 16 | 29 |
| 2016 November | 22 | 21 | 43 |
| 2016 October | 24 | 34 | 58 |
| 2016 September | 33 | 33 | 66 |
| 2016 August | 25 | 15 | 40 |
| 2016 July | 29 | 15 | 44 |
| 2016 June | 35 | 17 | 52 |
| 2016 May | 53 | 39 | 92 |
| 2016 April | 29 | 0 | 29 |
| 2016 March | 4 | 1 | 5 |
| 2016 February | 19 | 2 | 21 |
| 2016 January | 22 | 8 | 30 |
| 2015 December | 20 | 13 | 33 |
| 2015 November | 26 | 4 | 30 |
| 2015 October | 4 | 1 | 5 |
| 2015 September | 2 | 0 | 2 |
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