Relación entre hiperrespuesta bronquial inespecífica, variación diaria del flujo espiratorio máximo y necesidades de medicación en pacientes con asma leve
Links between non-specific bronchial hyperreactivity, diurnal variation in peak expiratory flow and dose requirements in patients with mild asthma
Sección de Alergia. Hospital Doctor Peset. Valencia
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Análisis de 31 pacientes" "tienePdf" => "es" "tieneTextoCompleto" => 0 "tieneResumen" => array:2 [ 0 => "es" 1 => "en" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "424" "paginaFinal" => "432" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary aspergilloma. Analysis of 31 patients" ] ] "contieneResumen" => array:2 [ "es" => true "en" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:2 [ 0 => array:2 [ "autoresLista" => "J. Garrós Garay, E. Ruiz de Gordejuela" "autores" => array:2 [ 0 => array:2 [ "nombre" => "J." "apellidos" => "Garrós Garay" ] 1 => array:2 [ "nombre" => "E." "apellidos" => "Ruiz de Gordejuela" ] ] ] 1 => array:2 [ "autoresLista" => "F. Vara Quadrado" "autores" => array:1 [ 0 => array:2 [ "nombre" => "F." "apellidos" => "Vara Quadrado" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615310140?idApp=UINPBA00003Z" "url" => "/03002896/0000003000000009/v1_201509151216/S0300289615310140/v1_201509151216/es/main.assets" ] "es" => array:14 [ "idiomaDefecto" => true "titulo" => "Relación entre hiperrespuesta bronquial inespecífica, variación diaria del flujo espiratorio máximo y necesidades de medicación en pacientes con asma leve" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "433" "paginaFinal" => "439" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "L. Prieto, V. Gutiérrez, J.M. Bertó, B. Camps, M.J. Pérez" "autores" => array:5 [ 0 => array:3 [ "nombre" => "L." "apellidos" => "Prieto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:2 [ "nombre" => "V." "apellidos" => "Gutiérrez" ] 2 => array:2 [ "nombre" => "J.M." "apellidos" => "Bertó" ] 3 => array:2 [ "nombre" => "B." "apellidos" => "Camps" ] 4 => array:2 [ "nombre" => "M.J." "apellidos" => "Pérez" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Sección de Alergia. Hospital Doctor Peset. Valencia" "identificador" => "aff0005" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "*" "correspondencia" => "Correspondencia: Sección de Alergia. Hospital Doctor Peset. Gaspar Aguilar, 90. 46017 Valencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Links between non-specific bronchial hyperreactivity, diurnal variation in peak expiratory flow and dose requirements in patients with mild asthma" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1994-02-12" "fechaAceptado" => "1994-05-10" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec569880" "palabras" => array:3 [ 0 => "Hiperrespuesta bronquial" 1 => "Asma" 2 => "Flujo espiratorio máximo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key words" "identificador" => "xpalclavsec569881" "palabras" => array:3 [ 0 => "Bronchial hyperreactivity" 1 => "Asthma" 2 => "Peak expiratory flow" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Con el fin de estudiar la relación entre hiperrespuesta bronquial inespecífica, variabilidad diaria del flujo espiratorio máximo (FEM) y síntomas de asma, se seleccionaron 36 individuos con asma alérgica de intensidad leve. Los pacientes fueron sometidos a provocación con metacolina hasta inducir descensos del FEV<span class="elsevierStyleInf">1</span> mayores del 40% o administrar una concentración de 200 mg/ml. Durante los 14 días siguientes, registraron el FEM tres veces al día y anotaron los síntomas y las necesidades de salbutamol inhalado.</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En los 11 pacientes en los que se obtuvieron curvas concentración-respuesta completas, la media geométrica de la variación diaria del FEM (porcentaje de amplitud media) fue del 5,0%, mientras que en los 25 pacientes cuyas curvas no mostraban <span class="elsevierStyleItalic">plateau</span> fue del 8,3% (p < 0,01). En los 36 individuos estudiados se detectó correlación (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>–0,56; p < 0,001) entre la PC<span class="elsevierStyleInf">20</span> y el porcentaje de amplitud media del FEM. Sin embargo, en los 11 individuos con curvas completas no pudo detectarse relación entre el porcentaje de amplitud media del FEM y la PC<span class="elsevierStyleInf">20</span> (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0,31; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS) o el nivel del <span class="elsevierStyleItalic">plateau</span> (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0,19; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS) o la EC<span class="elsevierStyleInf">50</span> (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0,26; p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS). La media geométrica de la PC<span class="elsevierStyleInf">20</span> en los 12 sujetos que necesitaron salbutamol durante los 14 días posteriores a la exploración con metacolina fue de 1,06 mg/dl, mientras que en los individuos que permanecieron asintomáticos fue de 1,32 mg/ml (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS). Además, se detectó <span class="elsevierStyleItalic">plateau</span> en 2 de los 12 pacientes que presentaron síntomas de asma y en 9 de los 24 que permanecieron asintomáticos (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS).</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Concluimos que la hiperrespuesta bronquial inespecífica no es el único factor que condiciona las variaciones diarias del FEM y que, por tanto, hiperrespuesta bronquial y variabilidad de la obstrucción no son términos equivalentes. Además, en los individuos con asma leve, la determinación de la respuesta a la metacolina inhalada carece de utilidad para predecir la evolución a corto plazo de la enfermedad.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">To assess the relation between non-specific bronchial hyperreactivity, we recorded diurnal peak expiratory flow variation (PFV) and asthma symptoms in 36 individuals with mild allergic asthma. The patients were challenged with methacholine to induce decreases greater than 40% in FEV<span class="elsevierStyleInf">1</span>, or until a maximum of 200 mg/ml had been administered. Over the next 14 days, PFV was measured three times per day and symptoms and inhaled salbutamol requirements were recorded.</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In the 11 patients with complete dose-response curves, the geometric mean of diurnal PFV variation (% mean range) was 5.0%; this parameter was 8.3% (p < 0.01) in the 25 subjects whose curves did not reach a plateau. A correlation (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0.56, p < 0.001) was found between PC<span class="elsevierStyleInf">20</span> and % mean range. PFV for the sample as a whole. In the 11 patients with complete curves, however, no correlation (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0.31, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS) between % mean range of PFV and PC<span class="elsevierStyleInf">20</span> was found. Nor could the plateau (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.19, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS) or EC<span class="elsevierStyleInf">50</span> (r<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>-0.26, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS) be found for these patients. The geometric mean for PC<span class="elsevierStyleInf">20</span> in the 12 subjects who needed salbutamol throughout the 14-day study period after methacholine challenge was 1.06 mg/ml; this parameter was 1.32 mg/ml (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS) for those with no symptoms. A plateau was reached by 2 of the 12 patients who experienced asthma symptoms and in 9 of the 24 who were asymptomatic (p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>NS).</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">We conclude that non-specific bronchial hyperreactivity is not the only factor that influences diurnal PFV variation and that bronchial hyperreactivity and variability of obstruction are not equivalent terms. Moreover, determination of response to inhaled methacholine is of little use in predicting the short-term development of the condition in patients with mild asthma.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:41 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchial hyperreactivity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "H.A. Boushey" 1 => "M.J. Holtzman" 2 => "J.R. Sheller" 3 => "J.A. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 2 | 1 | 3 |
| 2024 October | 38 | 20 | 58 |
| 2024 September | 36 | 13 | 49 |
| 2024 August | 58 | 52 | 110 |
| 2024 July | 39 | 21 | 60 |
| 2024 June | 47 | 21 | 68 |
| 2024 May | 37 | 28 | 65 |
| 2024 April | 35 | 24 | 59 |
| 2024 March | 31 | 27 | 58 |
| 2024 February | 26 | 40 | 66 |
| 2024 January | 0 | 1 | 1 |
| 2023 November | 0 | 1 | 1 |
| 2023 October | 0 | 4 | 4 |
| 2023 September | 0 | 1 | 1 |
| 2023 August | 0 | 1 | 1 |
| 2023 July | 0 | 19 | 19 |
| 2023 June | 0 | 2 | 2 |
| 2023 April | 0 | 1 | 1 |
| 2023 March | 3 | 3 | 6 |
| 2023 February | 27 | 18 | 45 |
| 2023 January | 20 | 21 | 41 |
| 2022 December | 29 | 26 | 55 |
| 2022 November | 41 | 24 | 65 |
| 2022 October | 30 | 28 | 58 |
| 2022 September | 21 | 15 | 36 |
| 2022 August | 30 | 27 | 57 |
| 2022 July | 28 | 51 | 79 |
| 2022 June | 37 | 26 | 63 |
| 2022 May | 33 | 23 | 56 |
| 2022 April | 31 | 28 | 59 |
| 2022 March | 33 | 35 | 68 |
| 2022 February | 32 | 25 | 57 |
| 2022 January | 30 | 25 | 55 |
| 2021 December | 15 | 30 | 45 |
| 2021 November | 22 | 32 | 54 |
| 2021 October | 14 | 33 | 47 |
| 2021 September | 17 | 32 | 49 |
| 2021 August | 19 | 35 | 54 |
| 2021 July | 19 | 25 | 44 |
| 2021 June | 20 | 34 | 54 |
| 2021 May | 18 | 29 | 47 |
| 2021 April | 31 | 37 | 68 |
| 2021 March | 25 | 8 | 33 |
| 2021 February | 26 | 9 | 35 |
| 2021 January | 18 | 13 | 31 |
| 2020 December | 23 | 13 | 36 |
| 2020 November | 14 | 20 | 34 |
| 2020 October | 24 | 11 | 35 |
| 2020 September | 15 | 4 | 19 |
| 2020 August | 31 | 6 | 37 |
| 2020 July | 18 | 17 | 35 |
| 2020 June | 20 | 12 | 32 |
| 2020 May | 16 | 9 | 25 |
| 2020 April | 32 | 14 | 46 |
| 2020 March | 21 | 24 | 45 |
| 2020 February | 22 | 18 | 40 |
| 2020 January | 36 | 19 | 55 |
| 2019 December | 28 | 21 | 49 |
| 2019 November | 19 | 6 | 25 |
| 2019 October | 22 | 18 | 40 |
| 2019 September | 12 | 16 | 28 |
| 2019 August | 10 | 1 | 11 |
| 2019 July | 12 | 16 | 28 |
| 2019 June | 6 | 8 | 14 |
| 2019 May | 13 | 17 | 30 |
| 2019 April | 31 | 24 | 55 |
| 2019 March | 7 | 10 | 17 |
| 2019 February | 8 | 6 | 14 |
| 2019 January | 5 | 6 | 11 |
| 2018 December | 4 | 10 | 14 |
| 2018 November | 21 | 10 | 31 |
| 2018 October | 28 | 21 | 49 |
| 2018 September | 13 | 5 | 18 |
| 2018 May | 5 | 1 | 6 |
| 2018 April | 11 | 3 | 14 |
| 2018 March | 9 | 6 | 15 |
| 2018 February | 9 | 8 | 17 |
| 2018 January | 8 | 6 | 14 |
| 2017 December | 9 | 13 | 22 |
| 2017 November | 13 | 9 | 22 |
| 2017 October | 6 | 5 | 11 |
| 2017 September | 9 | 10 | 19 |
| 2017 August | 7 | 7 | 14 |
| 2017 July | 3 | 3 | 6 |
| 2017 June | 13 | 19 | 32 |
| 2017 May | 13 | 8 | 21 |
| 2017 April | 9 | 8 | 17 |
| 2017 March | 3 | 2 | 5 |
| 2017 February | 3 | 5 | 8 |
| 2017 January | 4 | 7 | 11 |
| 2016 December | 10 | 6 | 16 |
| 2016 November | 20 | 8 | 28 |
| 2016 October | 21 | 23 | 44 |
| 2016 September | 19 | 11 | 30 |
| 2016 August | 8 | 4 | 12 |
| 2016 July | 11 | 3 | 14 |
| 2016 June | 21 | 12 | 33 |
| 2016 May | 16 | 6 | 22 |
| 2016 April | 11 | 0 | 11 |
| 2016 March | 7 | 1 | 8 |
| 2016 February | 6 | 1 | 7 |
| 2016 January | 11 | 3 | 14 |
| 2015 December | 15 | 9 | 24 |
| 2015 November | 19 | 6 | 25 |
| 2015 October | 3 | 1 | 4 |
| 2015 September | 2 | 0 | 2 |
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