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Alternativa terapéutica para los aspergilomas pulmonares complicados no quirúrgicos
Therapeutic alternatives for non-operable, complicated pulmonary aspergilloma
J. Ortiz de Saracho1, E. Pérez-Rodríguez, P. Navío, J. Flores
Servicios de Neumología, Hospital Ramón y Cajal. Madrid
J. Zapatero*, J. Sánchez**
* Servicios de Cirugía Torácica, Hospital Ramón y Cajal. Madrid
** Servicios de Radiodiagnóstico. Hospital Ramón y Cajal. Madrid
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      "en" => array:1 [
        "titulo" => "Therapeutic alternatives for non-operable&#44; complicated pulmonary aspergilloma"
      ]
    ]
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    "fechaRecibido" => "1994-04-12"
    "fechaAceptado" => "1994-07-26"
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          "clase" => "keyword"
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          "palabras" => array:3 [
            0 => "Aspergiloma pulmonar"
            1 => "Tratamiento percut&#225;neo"
            2 => "Anfotericina B"
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            0 => "Pulmonary aspergilloma"
            1 => "Percutaneous treatment"
            2 => "Amphotericin B"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presentan 2 casos de aspergiloma pulmonar &#40;AP&#41; complicado por hemoptisis masiva y criterios de inoperabilidad&#44; en los que&#44; tras fracasar la embolizaci&#243;n arterial&#44; se realiz&#243; un protocolo terap&#233;utico con anfotericina B a trav&#233;s de un cat&#233;ter intracavitario&#46; A pesar del tama&#241;o de los micetomas la respuesta terap&#233;utica fue excelente con regresi&#243;n completa del aspergiloma a las 3-4 semanas de tratamiento&#44; negativiz&#225;ndose las precipitinas frente <span class="elsevierStyleItalic">Aspergillus fumigatus</span> y la presencia del hongo en las muestras del aspirado transcat&#233;ter&#46; La hemoptisis masiva fue controlada con &#225;cido &#233;psilon-aminocaproico instilado a trav&#233;s del cat&#233;ter&#46; No hubo complicaciones&#44; el tratamiento fue bien tolerado y no se observaron recidivas en el seguimiento a lo largo de 24 y 18 meses&#44; respectivamente&#46; Este tratamiento local es la mejor alternativa terap&#233;utica para los AP complicados no operables&#46;</p></span>"
      ]
      "en" => array:1 [
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">We present 2 patients with pulmonar&#41; aspergilloma complicated by massive hemoptysis who were not good candidates for surgery and were treated with intracavitary amphotericin B after arterial embolization failed&#46; In spite of the size of the mycetomas&#44; response to treatment was excellent with full regression of the aspergilloma after 3 to 4 weeks&#59; precipitins to <span class="elsevierStyleItalic">Aspergillus fumigatus</span> became negative and the fungus disappeared from transcatheter aspirate samples&#46; Massive hemoptysis was controlled with epsilon-amino-caproic acid instilled by catheter&#46; No complications were observed&#44; the treatment was well tolerated and no recurrence occurred over a follow-up period of 24 and 18 months&#44; respectively&#46; This local treatment is the best therapeutic alternative for patients with pulmonary aspergilloma who are not candidates for surgery&#46;</p></span>"
      ]
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                      "titulo" => "Pulmonary aspergilloma&#58; endobronchial treatment"
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                          "etal" => false
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                            0 => "J&#46;L&#46; Hargis"
                            1 => "C&#46;L&#46; Bone"
                            2 => "J&#46; Stewart"
                            3 => "N&#46; Rector"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M&#46;J&#46; Saphiro"
                            1 => "S&#46;M&#46; Albelda"
                            2 => "R&#46;L&#46; Mayock"
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                      "titulo" => "Percutaneous intracavitary treatment of a giant aspergilloma"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "K&#46;S&#46; Lee"
                            1 => "Y&#46;H&#46; Kim"
                            2 => "W&#46;K&#46; Bae"
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                    ]
                  ]
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                      "doi" => "10.2214/ajr.154.6.2110744"
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                        "fecha" => "1990"
                        "volumen" => "154"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spontaneous lysis of aspergillomata"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "K&#46;J&#46; Hammerman"
                            1 => "C&#46;S&#46; Christianson"
                            2 => "I&#46; Huntington"
                            3 => "G&#46;A&#46; Hurst"
                            4 => "M&#46; Zelman"
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                    ]
                  ]
                  "host" => array:1 [
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                      "titulo" => "Azole antifung al drugs&#58; old a new"
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                      "Revista" => array:6 [
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                    0 => array:2 [
                      "titulo" => "Tolerance to and efficacy of itraconazole in treatment of systemic mycoses&#58; preliminary results"
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                          "etal" => false
                          "autores" => array:5 [
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                            1 => "R&#46; Fetchick"
                            2 => "I&#46; Weisman"
                            3 => "S&#46; Foshee"
                            4 => "J&#46;R&#46; Graybill"
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                        ]
                      ]
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                  ]
                  "host" => array:1 [
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                        "fecha" => "1987"
                        "volumen" => "9"
                        "numero" => "Supl 1"
                        "paginaInicial" => "87"
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              "identificador" => "bib0065"
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                    0 => array:2 [
                      "titulo" => "Early experience with itraconazole in vitro and in patients&#58; pharmacokinetic studies and clinical results"
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                          "autores" => array:2 [
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Rev Infect Dis"
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                    0 => array:2 [
                      "titulo" => "Treatment of pulmonary aspergilloma with itraconazole"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J&#46;H&#46; Campbell"
                            1 => "J&#46;H&#46; Winter"
                            2 => "M&#46;D&#46; Richardson"
                            3 => "G&#46;S&#46; Shankland"
                            4 => "S&#46;W&#46; Banham"
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                        "tituloSerie" => "Thorax"
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              "identificador" => "bib0075"
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                    0 => array:2 [
                      "titulo" => "Topical treatment of pulmonary Aspergilloma by antifungals&#46; Relationship Between Duration of the Disease and Efficacy of Therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46; Yamada"
                            1 => "S&#46; Kohno"
                            2 => "H&#46; Koga"
                            3 => "S&#46; Maesaki"
                            4 => "M&#46; Kaku"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1993"
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                        "paginaInicial" => "1&#46;421"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8404136"
                            "web" => "Medline"
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                ]
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            15 => array:3 [
              "identificador" => "bib0080"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intracavitary Aspergilloma&#58; Transthoracic Percutaneous Injection of Amphotericin Gelatin Solution"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
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                            2 => "R&#46;N&#46; Rankin"
                            3 => "N&#46;L&#46; M&#252;ller"
                            4 => "D&#46; Ahmad"
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                      "doi" => "10.1148/radiology.188.3.8351355"
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                        "tituloSerie" => "Radiology"
                        "fecha" => "1993"
                        "volumen" => "188"
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                      "titulo" => "Inoperable Pulmonary Aspergilloma&#58; Percutaneous CT-guided Injection with Glycerin and Amphotericin B Paste in 15 cases"
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                            3 => "G&#46;B&#46; Balagner"
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                            5 => "G&#46;R&#46; Richardi"
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                        "fecha" => "1993"
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Article information
ISSN: 03002896
Original language: Spanish
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