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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Uno de los requisitos esenciales en la t&#233;cnica de LBA&#44; cuando se utiliza con el fin concreto de estudiar la respuesta inmune o inflamatoria en patolog&#237;a intersticial pulmonar&#44; es que las muestras obtenidas sean representativas del tracto respiratorio inferior&#46; Por ello&#44; la selecci&#243;n de muestras adecuadas es un paso obligado en el estudio de rutina&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Valorar la incidencia de muestras de LBA no id&#243;neas para estudio citol&#243;gico y determinar la relaci&#243;n entre par&#225;metros relacionados con la t&#233;cnica y patolog&#237;a subyacente con la calidad de espec&#237;menes&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 161 pacientes&#58; 72 infectados por el VIH con infiltrados pulmonares difusos&#44; 34 fibrosis pulmonar idiop&#224;tica &#40;FPI&#41;&#44; 10 sarcoidosis&#44; 10 neumonitis por hipersensibilidad&#44; 19 con neumopat&#237;a intersticial asociada a enfermedades del col&#225;geno&#44; dos con eosinofilia pulmonar y 14 pacientes seleccionados como grupo control&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Para el estudio de calidad se realiz&#243; tinci&#243;n de muestras de LBA con t&#233;cnica de Wright-Giemsa modificada y se emplearon los criterios de selecci&#243;n descritos por Chamberlain et al&#46; &#40;1987&#41;&#46; Resultaron no &#250;tiles para estudio el 53&#37; de muestras en pacientes infectados por el VIH&#44; el 35&#37; en pacientes con fibrosis pulmonar idiop&#224;tica y el 21&#37; en neumopat&#237;a intersticial asociada a conectivopat&#237;as&#46; En el resto&#44; todas las muestras fueron &#250;tiles para estudio&#46; La intolerancia del LBA con descenso del porcentaje de fluido recuperado se asoci&#243; significativamente con la calidad de muestras sobre todo en el grupo con FPI&#46; Los hallazgos citol&#243;gicos que invalidaron las muestras fueron diferentes entre grupos&#46; Como dato com&#250;n&#44; las muestras inadecuadas mostraron una baja concentraci&#243;n celular&#46; Por otro lado&#44; la evidencia o no de infecci&#243;n asociada en pacientes infectados por el VIH&#44; al contrario que en otras neumopat&#237;as&#44; no parece ser un factor que determine por s&#237; mismo la calidad de muestras&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Es previsible la obtenci&#243;n de un porcentaje importante de muestras de LBA no id&#243;neas para estudio&#44; sobre todo en neumopat&#237;a difusa asociada a infecci&#243;n VIH&#44; FPI y neumopat&#237;a intersticial asociada a conectivopat&#237;as&#46; Por otra parte&#44; la tolerancia de la t&#233;cnica&#44; entre otros factores&#44; influye en la calidad del esp&#233;cimen y&#44; por tanto&#44; ha de tenerse en cuenta en la valoraci&#243;n de los hallazgos citol&#243;gicos&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Falta por homogeneizar la aplicaci&#243;n de criterios de calidad entre los distintos grupos de trabajo y determinar si la exclusi&#243;n de muestras no &#250;tiles repercute en la composici&#243;n final de los grupos de estudio&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Bronchoalveolar lavage &#40;BAL&#41; samples used to study immune or inflammatory response in interstitial lung disease must be representative of the lower respiratory tract&#46; Thus&#44; the selection of suitable samples must be part of routine practice&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">To assess the incidence of unsuitable BAL samples used for cytology and to determine the relation between parameters related to underlying disease and the quality of samples&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">One hundred sixty-one patients were enrolled&#46; Seventytwo were HIV positive and had diffuse pulmonary infiltrates&#44; 34 had idiopathic pulmonary fibrosis &#40;IPF&#41;&#44; 10 had sarcoidosis&#44; 10 had hypersensitivity pneumonitis&#44; 19 had interstitial lung disease and collagen diseases and 2 had pulmonary eosinophilia&#46; Fourteen individuals formed the control group&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The quality study was carried out by staining the BAL samples following a modified Wright-Giemsa technique and evaluating the samples by the selection criteria described by Chamberlain and colleagues &#40;1987&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">We identified unsuitable samples from 53&#37; of the HIV positive patients&#44; from 35&#37; of the IPF patients and from 21&#37; of the interstitial lung disease patients with associated connective tissue disease&#46; In the other groups&#44; all samples were suitable for analysis&#46; Intolerance of BAL with decreasing percentage of fluid recovered was significantly associated with sample quality&#44; particularly in the IPF group&#46; The cytology results that invalidated the samples differed by group&#46; In all groups&#44; unsuitable specimens had low cell counts&#46; The finding or not of evidence of associated infectionin HIV-infected patients&#44; on the other hand&#44; did not appear to determine sample quality in and of itself&#44; although it did in samples related to other entities&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">We can predict that a high rate of unsuitable BAL samples will come mainly from patients with diffuse lung disease associated to HIV infection&#44; IPF and interstitial lung disease with associated connective tissue disease&#46; Tolerance to the technique influences quality of the specimen obtained and&#44; therefore&#44; should be taken into account in interpreting the findings of cytology&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The criteria applied by the various teams using BAL should be unified&#44; and it should be determined whether the exclusion of inappropriate samples affects the final composition of study groups&#46;</p></span>"
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Estudio de calidad y selección de muestras de lavado broncoalveolar (LBA) en neumopatías difusas
Quality study and screening of bronchoalveolar lavage samples
J. Martín Juan*, F. Valenzuela Mateos, G. Soto Campos, A. Segado Soriano, F. Rodríguez Panadero, J. Castillo Gómez
Servicio de Respiratorio. Hospital Universitario Virgen del Rocío. Sevilla
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          "palabras" => array:3 [
            0 => "Lavado broncoalveolar"
            1 => "Calidad de muestras"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Uno de los requisitos esenciales en la t&#233;cnica de LBA&#44; cuando se utiliza con el fin concreto de estudiar la respuesta inmune o inflamatoria en patolog&#237;a intersticial pulmonar&#44; es que las muestras obtenidas sean representativas del tracto respiratorio inferior&#46; Por ello&#44; la selecci&#243;n de muestras adecuadas es un paso obligado en el estudio de rutina&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Valorar la incidencia de muestras de LBA no id&#243;neas para estudio citol&#243;gico y determinar la relaci&#243;n entre par&#225;metros relacionados con la t&#233;cnica y patolog&#237;a subyacente con la calidad de espec&#237;menes&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se incluyeron 161 pacientes&#58; 72 infectados por el VIH con infiltrados pulmonares difusos&#44; 34 fibrosis pulmonar idiop&#224;tica &#40;FPI&#41;&#44; 10 sarcoidosis&#44; 10 neumonitis por hipersensibilidad&#44; 19 con neumopat&#237;a intersticial asociada a enfermedades del col&#225;geno&#44; dos con eosinofilia pulmonar y 14 pacientes seleccionados como grupo control&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Para el estudio de calidad se realiz&#243; tinci&#243;n de muestras de LBA con t&#233;cnica de Wright-Giemsa modificada y se emplearon los criterios de selecci&#243;n descritos por Chamberlain et al&#46; &#40;1987&#41;&#46; Resultaron no &#250;tiles para estudio el 53&#37; de muestras en pacientes infectados por el VIH&#44; el 35&#37; en pacientes con fibrosis pulmonar idiop&#224;tica y el 21&#37; en neumopat&#237;a intersticial asociada a conectivopat&#237;as&#46; En el resto&#44; todas las muestras fueron &#250;tiles para estudio&#46; La intolerancia del LBA con descenso del porcentaje de fluido recuperado se asoci&#243; significativamente con la calidad de muestras sobre todo en el grupo con FPI&#46; Los hallazgos citol&#243;gicos que invalidaron las muestras fueron diferentes entre grupos&#46; Como dato com&#250;n&#44; las muestras inadecuadas mostraron una baja concentraci&#243;n celular&#46; Por otro lado&#44; la evidencia o no de infecci&#243;n asociada en pacientes infectados por el VIH&#44; al contrario que en otras neumopat&#237;as&#44; no parece ser un factor que determine por s&#237; mismo la calidad de muestras&#46;</p><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">Es previsible la obtenci&#243;n de un porcentaje importante de muestras de LBA no id&#243;neas para estudio&#44; sobre todo en neumopat&#237;a difusa asociada a infecci&#243;n VIH&#44; FPI y neumopat&#237;a intersticial asociada a conectivopat&#237;as&#46; Por otra parte&#44; la tolerancia de la t&#233;cnica&#44; entre otros factores&#44; influye en la calidad del esp&#233;cimen y&#44; por tanto&#44; ha de tenerse en cuenta en la valoraci&#243;n de los hallazgos citol&#243;gicos&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Falta por homogeneizar la aplicaci&#243;n de criterios de calidad entre los distintos grupos de trabajo y determinar si la exclusi&#243;n de muestras no &#250;tiles repercute en la composici&#243;n final de los grupos de estudio&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Bronchoalveolar lavage &#40;BAL&#41; samples used to study immune or inflammatory response in interstitial lung disease must be representative of the lower respiratory tract&#46; Thus&#44; the selection of suitable samples must be part of routine practice&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">To assess the incidence of unsuitable BAL samples used for cytology and to determine the relation between parameters related to underlying disease and the quality of samples&#46;</p><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">One hundred sixty-one patients were enrolled&#46; Seventytwo were HIV positive and had diffuse pulmonary infiltrates&#44; 34 had idiopathic pulmonary fibrosis &#40;IPF&#41;&#44; 10 had sarcoidosis&#44; 10 had hypersensitivity pneumonitis&#44; 19 had interstitial lung disease and collagen diseases and 2 had pulmonary eosinophilia&#46; Fourteen individuals formed the control group&#46;</p><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">The quality study was carried out by staining the BAL samples following a modified Wright-Giemsa technique and evaluating the samples by the selection criteria described by Chamberlain and colleagues &#40;1987&#41;&#46;</p><p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">We identified unsuitable samples from 53&#37; of the HIV positive patients&#44; from 35&#37; of the IPF patients and from 21&#37; of the interstitial lung disease patients with associated connective tissue disease&#46; In the other groups&#44; all samples were suitable for analysis&#46; Intolerance of BAL with decreasing percentage of fluid recovered was significantly associated with sample quality&#44; particularly in the IPF group&#46; The cytology results that invalidated the samples differed by group&#46; In all groups&#44; unsuitable specimens had low cell counts&#46; The finding or not of evidence of associated infectionin HIV-infected patients&#44; on the other hand&#44; did not appear to determine sample quality in and of itself&#44; although it did in samples related to other entities&#46;</p><p id="spar0060" class="elsevierStyleSimplePara elsevierViewall">We can predict that a high rate of unsuitable BAL samples will come mainly from patients with diffuse lung disease associated to HIV infection&#44; IPF and interstitial lung disease with associated connective tissue disease&#46; Tolerance to the technique influences quality of the specimen obtained and&#44; therefore&#44; should be taken into account in interpreting the findings of cytology&#46;</p><p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">The criteria applied by the various teams using BAL should be unified&#44; and it should be determined whether the exclusion of inappropriate samples affects the final composition of study groups&#46;</p></span>"
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                      "titulo" => "Assessment of interlobar variation of bronchoalveolar lavage differentials in interstial lung diseases"
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                            0 => "C&#46; Saltini"
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                          "autores" => array:6 [
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                          "autores" => array:3 [
                            0 => "R&#46; Baughman"
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                      "titulo" => "The effects of cytocentrifugation on differentia&#93; cell counts in samples obtained by bronchoalveolar lavage"
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                          "etal" => false
                          "autores" => array:5 [
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                            1 => "E&#46; Escudier"
                            2 => "M&#46;J&#46; Pocholle"
                            3 => "C&#46;H&#46; Carre"
                            4 => "J&#46;F&#46; Bernaudin"
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                      "titulo" => "Bronchoalveolar lavage in interstial lung disease&#58; effect of volumen of fluid infused"
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                          "etal" => false
                          "autores" => array:4 [
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                            3 => "G&#46;W&#46; Hunninghake"
                          ]
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
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                            2 => "P&#46;G&#46; Duncan"
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                      ]
                    ]
                  ]
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              "identificador" => "bib0065"
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                0 => array:2 [
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                      "titulo" => "Quantification of cell loss during bronchoalveolar lavage fluid processing&#46; Effects of fixation and staining methods"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:5 [
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                            2 => "P&#46; Diot"
                            3 => "E&#46; Lemarie"
                            4 => "P&#46; Anthonioz"
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                  ]
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                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.149.3.7509703"
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                        "fecha" => "1994"
                        "volumen" => "149"
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            13 => array:3 [
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              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Technical recomendations and guidelines for bronchoalveolar lavage &#40;BAL&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
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Article information
ISSN: 03002896
Original language: Spanish
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