EPOC y enfermedad cardiovascular
Chronic obstructive pulmonary disease and cardiovascular disease
José Luis Izquierdo Alonso
Servicio de Neumología, Hospital Universitario, Guadalajara, España
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"paginaFinal" => "22" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "José Luis Izquierdo Alonso" "autores" => array:1 [ 0 => array:3 [ "nombre" => "José Luis Izquierdo" "apellidos" => "Alonso" "email" => array:1 [ 0 => "jlizquierdo@sescam.org" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología, Hospital Universitario, Guadalajara, España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Chronic obstructive pulmonary disease and cardiovascular disease" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec155185" "palabras" => array:3 [ 0 => "Enfermedad pulmonar obstructiva crónica" 1 => "Enfermedad cardiovascular" 2 => "Inflamación sistémica" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec155184" "palabras" => array:3 [ 0 => "Chronic obstructive pulmonary disease" 1 => "Cardiovascular disease" 2 => "Systemic inflammation" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Durante la última década se ha indicado que la enfermedad pulmonar obstructiva crónica (EPOC) podría favorecer la aparición de cardiopatía isquémica. Varios estudios observacionales y de casos y controles han confirmado que los pacientes con EPOC tienen un riesgo mayor de presentar trastornos cardiovasculares. Sin embargo, este riesgo aumentado podría justificarse en gran parte por una prevalencia mayor de factores de riesgo clásicos. Actualmente, no hay datos que permitan establecer una relación de causalidad entre la EPOC y las enfermedades cardiovasculares, y el concepto de inflamación sistémica como mecanismo patogénico común no está demostrado. Tampoco hay suficiente evidencia para poder afirmar que ciertos fármacos, como estatinas o corticoides inhalados, a través de una reducción de la inflamación sistémica, puedan incidir de forma favorable en el riesgo cardiovascular del paciente con EPOC. Actualmente, sólo deben recomendarse cuando el paciente presente una situación específica que aconseje su uso.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">In the last decade, various studies have suggested that chronic obstructive pulmonary disease (COPD) could favor the development of ischemic heart disease. Several observational and case-control studies have confirmed that patients with COPD have a higher risk of cardiovascular disorders. However, this increased risk could be largely explained by a greater prevalence of classical risk factors. Currently, there are no data to indicate a causal relation between COPD and cardiovascular disease and the concept of systemic inflammation as a common pathogenic mechanism has not been demonstrated. Equally, there is insufficient evidence to conclude that some drugs, such as statins or inhaled corticoids, could decrease cardiovascular risk in patients with COPD by reducing systemic inflammation. Currently, these drugs should only be recommended if patients show specific indications for their use.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:45 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "La EPOC en la vida y en la muerte" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J. Soriano" 1 => "J.L. Izquierdo" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2006" "volumen" => "42" "paginaInicial" => "421" "paginaFinal" => "422" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17040655" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "B.R. Celli" 1 => "C.G. Cote" 2 => "J.M. Marin" 3 => "C. Casanova" 4 => "M. Montes de Oca" 5 => "R.A. Mendez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa021322" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2004" "volumen" => "350" "paginaInicial" => "1005" "paginaFinal" => "1012" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14999112" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Expansion of the prognostic assessment of patients with chronic obstructive pulmonary disease: the updated BODE index and the ADO index" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.A. Puhan" 1 => "J. Garcia-Aymerich" 2 => "M. Frey" 3 => "G. Ter Riet" 4 => "J.M. Antó" 5 => "A.G. Agustí" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(09)61301-5" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "2009" "volumen" => "374" "paginaInicial" => "704" "paginaFinal" => "711" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19716962" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Derivation and Validation of a Composite Index of Severity in Chronic Obstructive Pulmonary Disease - The DOSE Index" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R.C. Jones" 1 => "G.C. Donaldson" 2 => "N.H. Chavannes" 3 => "K. Kida" 4 => "M. Dickson-Spillmann" 5 => "S. Harding" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200902-0271OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2009" "volumen" => "180" "paginaInicial" => "1189" "paginaFinal" => "1195" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19797160" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Severe acute exacerbations and mortality in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.J. Soler-Cataluña" 1 => "M.A. Martínez-García" 2 => "P. Román Sánchez" 3 => "E. Salcedo" 4 => "M. Navarro" 5 => "R. Ochando" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2005.040527" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2005" "volumen" => "60" "paginaInicial" => "925" "paginaFinal" => "931" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16055622" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Need to test the arterial inflammation hypothesis" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.L. Bhatt" 1 => "E.J. Topol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2002" "volumen" => "106" "paginaInicial" => "136" "paginaFinal" => "140" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12093783" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Atherosclerotic coronary artery disease: usefulness of C-reactive protein for the identification of the vulnerable plaque and the vulnerable patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "R. Arroyo-Espliguero" 1 => "P. Avanzas" 2 => "J.C. Kaski" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Rev Esp Cardiol" "fecha" => "2004" "volumen" => "57" "paginaInicial" => "375" "paginaFinal" => "378" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15151769" "web" => "Medline" ] ] ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Why are patients with chronic obstructive pulmonary disease at increased risk of cardiovascular diseases? The potential role of systemic inflammation in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "D.D. Sin" 1 => "S.F. Man" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2003" "volumen" => "107" "paginaInicial" => "1514" "paginaFinal" => "1519" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12654609" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C-reactive protein and mortality in mild to moderate chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P. Man" 1 => "J.E. Connett" 2 => "N.R. Anthonisen" 3 => "R.A. Wise" 4 => "D.P. Tashkin" 5 => "D.D. Sin" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2006.059808" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "849" "paginaFinal" => "853" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16738034" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C-reactive Protein As a Predictor of Prognosis in Chronic Obstructive Pulmonary Disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "M. Dahl" 1 => "J. Vestbo" 2 => "P. Lange" 3 => "S.E. Bojesen" 4 => "A. Tybjaerg-Hansen" 5 => "B.G. Nordestgaard" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200605-713OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2007" "volumen" => "175" "paginaInicial" => "250" "paginaFinal" => "255" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17053205" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Wedzicha" 1 => "T.A. Seemungal" 2 => "P.K. MacCallum" 3 => "E.A. Paul" 4 => "G.C. Donaldson" 5 => "A. Bhowmik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Haemost" "fecha" => "2000" "volumen" => "84" "paginaInicial" => "210" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10959691" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib12" "etiqueta" => "12." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EPOC y riesgo Cardiovascular" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "J.L. Izquierdo Alonso" 1 => "R. Arroyo Espliguero" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2005" "volumen" => "41" "paginaInicial" => "410" "paginaFinal" => "412" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16117944" "web" => "Medline" ] ] ] ] ] ] ] ] 12 => array:3 [ "identificador" => "bib13" "etiqueta" => "13." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C-reactive protein levels and survival in patients with moderate to very severe COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.P. De Torres" 1 => "V. Pinto-Plata" 2 => "C. Casanova" 3 => "H. Mullerova" 4 => "E. Córdoba-Lanús" 5 => "M. Muros de Fuentes" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.07-2433" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2008" "volumen" => "133" "paginaInicial" => "1336" "paginaFinal" => "1343" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18339787" "web" => "Medline" ] ] ] ] ] ] ] ] 13 => array:3 [ "identificador" => "bib14" "etiqueta" => "14." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "C-Reactive Protein and Risk of Cardiovascular Disease in Men and Women From the Framingham Heart Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "P.W.F. Wilson" 1 => "B.H. Nam" 2 => "M. Pencina" 3 => "R.B. D’Agostino" 4 => "E.J. Benjamin" 5 => "C.J. O’Donnell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archinte.165.21.2473" "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "2005" "volumen" => "165" "paginaInicial" => "2473" "paginaFinal" => "2478" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16314543" "web" => "Medline" ] ] ] ] ] ] ] ] 14 => array:3 [ "identificador" => "bib15" "etiqueta" => "15." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "EPOC e inflamación sistémica. Una vía de enlace para la comorbilidad" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "A. Agustí" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0300-2896(09)72950-3" "Revista" => array:7 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2009" "volumen" => "45" "numero" => "Supl 4" "paginaInicial" => "14" "paginaFinal" => "17" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20116757" "web" => "Medline" ] ] ] ] ] ] ] ] 15 => array:3 [ "identificador" => "bib16" "etiqueta" => "16." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inflamación y estrés oxidativo en dos fenotipos de EPOC" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "J.L. Izquierdo" 1 => "C. Almonacid" 2 => "T. Parra" 3 => "J. Perez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2006" "volumen" => "42" "paginaInicial" => "332" "paginaFinal" => "337" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16945263" "web" => "Medline" ] ] ] ] ] ] ] ] 16 => array:3 [ "identificador" => "bib17" "etiqueta" => "17." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The novel role of C-reactive protein in cardiovascular disease: Risk marker or pathogen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Wilson" 1 => "M.C. Ryan" 2 => "A.J. Boyle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2005.01.068" "Revista" => array:6 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2006" "volumen" => "106" "paginaInicial" => "291" "paginaFinal" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16337036" "web" => "Medline" ] ] ] ] ] ] ] ] 17 => array:3 [ "identificador" => "bib18" "etiqueta" => "18." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Effects of a Smoking Cessation Intervention on 14.5-Year Mortality" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Nicholas" 1 => "M.D. Anthonisen" 2 => "A. Melissa" 3 => "M.S. Skeans" 4 => "M.D. Wise" 5 => "J. Manfreda" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Ann Intern Med" "fecha" => "2005" "volumen" => "142" "paginaInicial" => "233" "paginaFinal" => "239" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15710956" "web" => "Medline" ] ] ] ] ] ] ] ] 18 => array:3 [ "identificador" => "bib19" "etiqueta" => "19." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Impaired lung function and mortality risk in men and women: findings from the Renfrew and Paisley prospective population study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J. Hole" 1 => "G.C. Watt" 2 => "Davey-Smith" 3 => "C.L. Hart" 4 => "C.R. Gillis" 5 => "V.M. Hawthorne" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "BMJ" "fecha" => "1996" "volumen" => "313" "paginaInicial" => "711" "paginaFinal" => "715" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8819439" "web" => "Medline" ] ] ] ] ] ] ] ] 19 => array:3 [ "identificador" => "bib20" "etiqueta" => "20." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Symptoms of chronic bronchitis and the risk of coronary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "P. Jousilahti" 1 => "E. Vartiainen" 2 => "J. Tuomilehto" 3 => "P. Puska" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S0140-6736(96)02374-4" "Revista" => array:6 [ "tituloSerie" => "Lancet" "fecha" => "1996" "volumen" => "348" "paginaInicial" => "567" "paginaFinal" => "572" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8774568" "web" => "Medline" ] ] ] ] ] ] ] ] 20 => array:3 [ "identificador" => "bib21" "etiqueta" => "21." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Pulmonary Function Is a Long-term Predictor of Mortality in the General Population: 29-Year Follow-up of the Buffalo Health Study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "H.J. Schünemann" 1 => "J. Dorn" 2 => "B.J.B. Grant" 3 => "W. Winkelstein" 4 => "M. Trevisan" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2000" "volumen" => "118" "paginaInicial" => "656" "paginaFinal" => "664" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10988186" "web" => "Medline" ] ] ] ] ] ] ] ] 21 => array:3 [ "identificador" => "bib22" "etiqueta" => "22." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lung function and mortality in the United States: data from the First National Health and Nutrition Examination Survey follow up study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "D.M. Mannino" 1 => "A.S. Buist" 2 => "T.L. Petty" 3 => "P.L. Enright" 4 => "S.C. Redd" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2003" "volumen" => "58" "paginaInicial" => "388" "paginaFinal" => "393" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12728157" "web" => "Medline" ] ] ] ] ] ] ] ] 22 => array:3 [ "identificador" => "bib23" "etiqueta" => "23." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Occurrence and prognostic significance of ventricular arrhythmia is related to pulmonary function: a study from “men born in 1914”, Malmo, Sweden" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G. Engstrom" 1 => "P. Wollmer" 2 => "B. Hedblad" 3 => "S. Juul-Moller" 4 => "S. Valind" 5 => "L. Janzon" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2001" "volumen" => "103" "paginaInicial" => "3086" "paginaFinal" => "3091" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11425773" "web" => "Medline" ] ] ] ] ] ] ] ] 23 => array:3 [ "identificador" => "bib24" "etiqueta" => "24." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Patterns of comorbidities in newly diagnosed COPD and asthma in primary care" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J.B. Soriano" 1 => "G.T. Visick" 2 => "H. Muellerova" 3 => "N. Payvandi" 4 => "A.L. Hansell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.128.4.2099" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2005" "volumen" => "128" "paginaInicial" => "2099" "paginaFinal" => "2107" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16236861" "web" => "Medline" ] ] ] ] ] ] ] ] 24 => array:3 [ "identificador" => "bib25" "etiqueta" => "25." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Cardiovascular Disease in Patients with Chronic Obstructive Pulmonary Disease, Saskatchewan Canada cardiovascular disease in COPD patients" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "S. Curkendall" 1 => "C. DeLuise" 2 => "J.K. Jones" 3 => "S. Lanes" 4 => "M.R. Stang" 5 => "E. Goehring" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.annepidem.2005.04.008" "Revista" => array:6 [ "tituloSerie" => "Ann Epidemiol" "fecha" => "2006" "volumen" => "16" "paginaInicial" => "63" "paginaFinal" => "70" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16039877" "web" => "Medline" ] ] ] ] ] ] ] ] 25 => array:3 [ "identificador" => "bib26" "etiqueta" => "26." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lower pulmonary function and cerebral subclinical abnormalities detected by MRI: the Atherosclerosis Risk in Communities study" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Liao" 1 => "M. Higgins" 2 => "N.R. Bryan" 3 => "M.L. Eigenbrodt" 4 => "L.E. Chambless" 5 => "V. Lamar" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "1999" "volumen" => "116" "paginaInicial" => "150" "paginaFinal" => "156" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10424519" "web" => "Medline" ] ] ] ] ] ] ] ] 26 => array:3 [ "identificador" => "bib27" "etiqueta" => "27." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Coronary artery calcification in older adults to age 99: prevalence and risk factors" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A.B. Newman" 1 => "B.L. Naydeck" 2 => "K. Sutton-Tyrrell" 3 => "A. Feldman" 4 => "D. Edmundowicz" 5 => "L.H. Kuller" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Circulation" "fecha" => "2001" "volumen" => "104" "paginaInicial" => "2679" "paginaFinal" => "2684" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11723018" "web" => "Medline" ] ] ] ] ] ] ] ] 27 => array:3 [ "identificador" => "bib28" "etiqueta" => "28." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Airflow limitation in smokers is associated with subclinical aterosclerosis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Iwamoto" 1 => "A. Yokoyama" 2 => "Y. Kitahara" 3 => "N. Ishikawa" 4 => "Y. Haruta" 5 => "K. Yamane" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200804-560OC" "Revista" => array:7 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2009" "volumen" => "179" "paginaInicial" => "35" "paginaFinal" => "40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18931335" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1575092211003287" "estado" => "S300" "issn" => "15750922" ] ] ] ] ] ] ] 28 => array:3 [ "identificador" => "bib29" "etiqueta" => "29." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Relationship between lung function impairment and incidence or recurrence of cardiovascular events in a middle-aged cohort" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "A.K. Johnston" 1 => "D.M. Mannino" 2 => "G.W. Hagan" 3 => "K.J. Davis" 4 => "V.A. Kiri" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2007.088112" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2008" "volumen" => "63" "paginaInicial" => "599" "paginaFinal" => "605" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18245145" "web" => "Medline" ] ] ] ] ] ] ] ] 29 => array:3 [ "identificador" => "bib30" "etiqueta" => "30." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Asociación de factores de riesgo cardiovascular y EPOC. Resultados de un estudio epidemiológico (estudio ARCE)" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "P. Lucas-Ramos" 1 => "J.L. Izquierdo-Alonso" 2 => "J.M. Rodríguez-González Moro" 3 => "J.M. Bellón Cano" 4 => "J. Ancochea-Bermúdez" 5 => "M. Calle-Rubio" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2008" "volumen" => "238" "paginaInicial" => "233" "paginaFinal" => "238" "itemHostRev" => array:3 [ "pii" => "S1575092212000599" "estado" => "S300" "issn" => "15750922" ] ] ] ] ] ] ] 30 => array:3 [ "identificador" => "bib31" "etiqueta" => "31." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Chronic obstructive pulmonary disease does not increase the risk of ischemic heart disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "J.L. Izquierdo" 1 => "A. Martínez" 2 => "E. Guzmán" 3 => "B. Arnalich" 4 => "C. Almonacid" 5 => "P. Resano" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Eur Respir J" "fecha" => "2009" "volumen" => "34" "numero" => "Suppl 53" "paginaInicial" => "68s" ] ] ] ] ] ] 31 => array:3 [ "identificador" => "bib32" "etiqueta" => "32." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effects of fluticasone on systemic markers of inflamation in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "D.D. Sin" 1 => "P. Lacy" 2 => "E. York" 3 => "S.F.P. Man" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200404-543OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2004" "volumen" => "170" "paginaInicial" => "760" "paginaFinal" => "765" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15229100" "web" => "Medline" ] ] ] ] ] ] ] ] 32 => array:3 [ "identificador" => "bib33" "etiqueta" => "33." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "CD 14 and toll-like receptor 4: a link between infection and acute coronary events?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "R. Arroyo-Espliego" 1 => "P. Avanzas" 2 => "S. Jefery" 3 => "J.C. Kaski" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/hrt.2002.001297" "Revista" => array:6 [ "tituloSerie" => "Heart" "fecha" => "2004" "volumen" => "90" "paginaInicial" => "983" "paginaFinal" => "988" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15310678" "web" => "Medline" ] ] ] ] ] ] ] ] 33 => array:3 [ "identificador" => "bib34" "etiqueta" => "34." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Sputum and plasma endothelin-1 levels in exacerbations of chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M. Roland" 1 => "A. Bhowmik" 2 => "R.J. Sapsford" 3 => "T.A. Seemungal" 4 => "D.J. Jeffries" 5 => "T.D. Warner" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2001" "volumen" => "56" "paginaInicial" => "30" "paginaFinal" => "35" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11120901" "web" => "Medline" ] ] ] ] ] ] ] ] 34 => array:3 [ "identificador" => "bib35" "etiqueta" => "35." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Acute exacerbations of chronic obstructive pulmonary disease are accompanied by elevations of plasma fibrinogen and serum IL-6 levels" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J.A. Wedzicha" 1 => "T.A. Seemungal" 2 => "P.K. MacCallum" 3 => "E.A. Paul" 4 => "G.C. Donaldson" 5 => "A. Bhowmik" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Thromb Haemost" "fecha" => "2000" "volumen" => "84" "paginaInicial" => "210" "paginaFinal" => "215" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10959691" "web" => "Medline" ] ] ] ] ] ] ] ] 35 => array:3 [ "identificador" => "bib36" "etiqueta" => "36." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Reduction of morbidity and mortality by statins, angiotensin-converting enzyme inhibitors, and angiotensin receptor blockers in patients with chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "G.B. Mancini" 1 => "M. Etminan" 2 => "B. Zhang" 3 => "L.E. Levesque" 4 => "J.M. FitzGerald" 5 => "J.M. Brophy" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.jacc.2006.04.039" "Revista" => array:6 [ "tituloSerie" => "J Am Coll Cardiol" "fecha" => "2006" "volumen" => "47" "paginaInicial" => "2554" "paginaFinal" => "2560" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16781387" "web" => "Medline" ] ] ] ] ] ] ] ] 36 => array:3 [ "identificador" => "bib37" "etiqueta" => "37." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The novel role of C-reactive protein in cardiovascular disease: Risk marker or pathogen" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "A.M. Wilson" 1 => "M.C. Ryan" 2 => "A.J. Boyle" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ijcard.2005.01.068" "Revista" => array:6 [ "tituloSerie" => "Int J Cardiol" "fecha" => "2006" "volumen" => "106" "paginaInicial" => "291" "paginaFinal" => "297" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16337036" "web" => "Medline" ] ] ] ] ] ] ] ] 37 => array:3 [ "identificador" => "bib38" "etiqueta" => "38." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Statin use is associated with reduced mortality in COPD" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "V. Søyseth" 1 => "P.H. Brekke" 2 => "P. Smith" 3 => "T. Omland" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/09031936.00106406" "Revista" => array:6 [ "tituloSerie" => "Eur Respir J" "fecha" => "2007" "volumen" => "29" "paginaInicial" => "279" "paginaFinal" => "283" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17050558" "web" => "Medline" ] ] ] ] ] ] ] ] 38 => array:3 [ "identificador" => "bib39" "etiqueta" => "39." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Clinical practice guidelines and quality of care for older patients with multiple comorbid diseases: implications for pay for performance" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "C.M. Boyd" 1 => "J. Darer" 2 => "C. Boult" 3 => "L.P. Fried" 4 => "L. Boult" 5 => "A.W. Wu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/jama.294.6.716" "Revista" => array:6 [ "tituloSerie" => "JAMA" "fecha" => "2005" "volumen" => "294" "paginaInicial" => "716" "paginaFinal" => "724" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16091574" "web" => "Medline" ] ] ] ] ] ] ] ] 39 => array:3 [ "identificador" => "bib40" "etiqueta" => "40." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Salmeterol and fluticasone propionate and survival in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "TORCH investigators" "etal" => true "autores" => array:6 [ 0 => "P.M. Calverley" 1 => "J.A. Anderson" 2 => "B. Celli" 3 => "G.T. Ferguson" 4 => "C. Jenkins" 5 => "P.W. Jones" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa063070" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2007" "volumen" => "356" "paginaInicial" => "775" "paginaFinal" => "789" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17314337" "web" => "Medline" ] ] ] ] ] ] ] ] 40 => array:3 [ "identificador" => "bib41" "etiqueta" => "41." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The effects of fluticasone with or without salmeterol on systemic biomarkers of inflammation in chronic obstructive pulmonary disease" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D.D. Sin" 1 => "S.F. Man" 2 => "D.D. Marciniuk" 3 => "G. Ford" 4 => "M. FitzGerald" 5 => "E. Wong" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200709-1356OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2008" "volumen" => "177" "paginaInicial" => "1207" "paginaFinal" => "1214" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18310480" "web" => "Medline" ] ] ] ] ] ] ] ] 41 => array:3 [ "identificador" => "bib42" "etiqueta" => "42." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "A 4-Year Trial of Tiotropium in Chronic Obstructive Pulmonary Disease" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "for the UPLIFT Study Investigators" "etal" => true "autores" => array:6 [ 0 => "D.P. Tashkin" 1 => "B. Celli" 2 => "S. Senn" 3 => "D. Burkhart" 4 => "S. Kesten" 5 => "S. Menjoge" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/NEJMoa0805800" "Revista" => array:6 [ "tituloSerie" => "N Engl J Med" "fecha" => "2008" "volumen" => "359" "paginaInicial" => "1543" "paginaFinal" => "1554" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/18836213" "web" => "Medline" ] ] ] ] ] ] ] ] 42 => array:3 [ "identificador" => "bib43" "etiqueta" => "43." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Regular physical activity reduces hospital admission and mortality in chronic obstructive pulmonary disease: a population based cohort study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "J. Garcia-Aymerich" 1 => "P. Lange" 2 => "M. Benet" 3 => "P. Schnohr" 4 => "J.M. Anto" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2006.060145" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2006" "volumen" => "61" "paginaInicial" => "772" "paginaFinal" => "778" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16738033" "web" => "Medline" ] ] ] ] ] ] ] ] 43 => array:3 [ "identificador" => "bib44" "etiqueta" => "44." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "The Effect of Weight Loss on C-Reactive Protein. A Systematic Review" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "E. Selvin" 1 => "N.P. Paynter" 2 => "T.P. Erlinger" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1001/archinte.167.1.31" "Revista" => array:6 [ "tituloSerie" => "Arch Intern Med" "fecha" => "2007" "volumen" => "167" "paginaInicial" => "31" "paginaFinal" => "39" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17210875" "web" => "Medline" ] ] ] ] ] ] ] ] 44 => array:3 [ "identificador" => "bib45" "etiqueta" => "45." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Inverse Association between Pulmonary Function and C-Reactive Protein in Apparently Healthy Subjects" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "D. Aronson" 1 => "I. Roterman" 2 => "M. Yigla" 3 => "A. Kerner" 4 => "O. Avizohar" 5 => "R. Sella" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.200602-243OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2006" "volumen" => "174" "paginaInicial" => "626" "paginaFinal" => "632" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16778162" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "es" "url" => "/03002896/00000046000000S3/v1_201305150345/S0300289610700223/v1_201305150345/es/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/03002896/00000046000000S3/v1_201305150345/S0300289610700223/v1_201305150345/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289610700223?idApp=UINPBA00003Z" ]
| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 44 | 64 | 108 |
| 2024 September | 60 | 45 | 105 |
| 2024 August | 82 | 54 | 136 |
| 2024 July | 43 | 45 | 88 |
| 2024 June | 71 | 60 | 131 |
| 2024 May | 80 | 70 | 150 |
| 2024 April | 71 | 71 | 142 |
| 2024 March | 76 | 52 | 128 |
| 2024 February | 55 | 51 | 106 |
| 2023 December | 29 | 13 | 42 |
| 2023 November | 7 | 0 | 7 |
| 2023 October | 1 | 2 | 3 |
| 2023 September | 1 | 1 | 2 |
| 2023 May | 1 | 0 | 1 |
| 2023 March | 11 | 10 | 21 |
| 2023 February | 45 | 30 | 75 |
| 2023 January | 48 | 31 | 79 |
| 2022 December | 41 | 30 | 71 |
| 2022 November | 63 | 31 | 94 |
| 2022 October | 71 | 52 | 123 |
| 2022 September | 51 | 32 | 83 |
| 2022 August | 42 | 57 | 99 |
| 2022 July | 44 | 53 | 97 |
| 2022 June | 43 | 45 | 88 |
| 2022 May | 44 | 52 | 96 |
| 2022 April | 65 | 45 | 110 |
| 2022 March | 45 | 45 | 90 |
| 2022 February | 61 | 55 | 116 |
| 2022 January | 96 | 69 | 165 |
| 2021 December | 53 | 60 | 113 |
| 2021 November | 64 | 77 | 141 |
| 2021 October | 46 | 56 | 102 |
| 2021 September | 65 | 74 | 139 |
| 2021 August | 42 | 53 | 95 |
| 2021 July | 43 | 42 | 85 |
| 2021 June | 56 | 41 | 97 |
| 2021 May | 55 | 56 | 111 |
| 2021 April | 185 | 49 | 234 |
| 2021 March | 83 | 27 | 110 |
| 2021 February | 44 | 28 | 72 |
| 2021 January | 32 | 30 | 62 |
| 2020 December | 40 | 18 | 58 |
| 2020 November | 44 | 24 | 68 |
| 2020 October | 46 | 25 | 71 |
| 2020 September | 23 | 30 | 53 |
| 2020 August | 35 | 19 | 54 |
| 2020 July | 30 | 33 | 63 |
| 2020 June | 44 | 32 | 76 |
| 2020 May | 40 | 25 | 65 |
| 2020 April | 43 | 26 | 69 |
| 2020 March | 42 | 22 | 64 |
| 2020 February | 43 | 18 | 61 |
| 2020 January | 56 | 38 | 94 |
| 2019 December | 39 | 23 | 62 |
| 2019 November | 40 | 27 | 67 |
| 2019 October | 54 | 27 | 81 |
| 2019 September | 58 | 30 | 88 |
| 2019 August | 48 | 24 | 72 |
| 2019 July | 53 | 31 | 84 |
| 2019 June | 53 | 22 | 75 |
| 2019 May | 84 | 39 | 123 |
| 2019 April | 81 | 69 | 150 |
| 2019 March | 75 | 38 | 113 |
| 2019 February | 52 | 12 | 64 |
| 2019 January | 29 | 19 | 48 |
| 2018 December | 33 | 27 | 60 |
| 2018 November | 72 | 56 | 128 |
| 2018 October | 101 | 50 | 151 |
| 2018 September | 65 | 16 | 81 |
| 2018 May | 43 | 1 | 44 |
| 2018 April | 55 | 9 | 64 |
| 2018 March | 62 | 6 | 68 |
| 2018 February | 11 | 6 | 17 |
| 2018 January | 17 | 14 | 31 |
| 2017 December | 31 | 16 | 47 |
| 2017 November | 78 | 25 | 103 |
| 2017 October | 70 | 23 | 93 |
| 2017 September | 79 | 32 | 111 |
| 2017 August | 119 | 56 | 175 |
| 2017 July | 55 | 29 | 84 |
| 2017 June | 114 | 47 | 161 |
| 2017 May | 91 | 49 | 140 |
| 2017 April | 66 | 42 | 108 |
| 2017 March | 50 | 36 | 86 |
| 2017 February | 55 | 37 | 92 |
| 2017 January | 20 | 46 | 66 |
| 2016 December | 50 | 24 | 74 |
| 2016 November | 103 | 37 | 140 |
| 2016 October | 89 | 39 | 128 |
| 2016 September | 117 | 89 | 206 |
| 2016 August | 69 | 29 | 98 |
| 2016 July | 73 | 18 | 91 |
| 2016 June | 81 | 24 | 105 |
| 2016 May | 69 | 11 | 80 |
| 2016 April | 56 | 1 | 57 |
| 2016 March | 75 | 2 | 77 |
| 2016 February | 87 | 5 | 92 |
| 2016 January | 81 | 29 | 110 |
| 2015 December | 98 | 35 | 133 |
| 2015 November | 143 | 31 | 174 |
| 2015 October | 81 | 3 | 84 |
| 2015 September | 73 | 0 | 73 |
| 2015 August | 56 | 0 | 56 |
| 2015 July | 34 | 0 | 34 |
| 2015 June | 31 | 0 | 31 |
| 2015 May | 38 | 0 | 38 |
| 2015 April | 49 | 0 | 49 |
| 2015 March | 34 | 0 | 34 |
| 2015 February | 24 | 0 | 24 |
| 2015 January | 48 | 0 | 48 |
| 2014 December | 29 | 0 | 29 |
| 2014 November | 29 | 0 | 29 |
| 2014 October | 53 | 0 | 53 |
| 2014 September | 33 | 0 | 33 |
| 2014 August | 31 | 0 | 31 |
| 2014 July | 32 | 0 | 32 |
| 2014 June | 34 | 0 | 34 |
| 2014 May | 44 | 0 | 44 |
| 2014 April | 45 | 0 | 45 |
| 2014 March | 28 | 0 | 28 |
| 2014 February | 48 | 0 | 48 |
| 2014 January | 27 | 0 | 27 |
| 2013 December | 35 | 0 | 35 |
| 2013 November | 39 | 0 | 39 |
| 2013 October | 40 | 0 | 40 |
| 2013 September | 50 | 0 | 50 |
| 2013 August | 60 | 0 | 60 |
| 2013 July | 48 | 0 | 48 |
| 2013 June | 40 | 0 | 40 |
| 2013 May | 40 | 0 | 40 |
| 2013 April | 40 | 0 | 40 |
| 2013 March | 26 | 0 | 26 |
| 2000 January | 864 | 0 | 864 |
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