Etiopatogenia y fisiopatología de la hipertensión pulmonar tromboembólica crónica
Etiopathogenesis and physiopathology in chronic thromboembolic pulmonary hypertension
Remedios Otero Candelera
, Teresa Elías Hernández
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Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen de Rocío, Sevilla, España
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fisiopatología de la hipertensión pulmonar tromboembólica crónica" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "6" "paginaFinal" => "10" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Remedios Otero Candelera, Teresa Elías Hernández" "autores" => array:2 [ 0 => array:4 [ "nombre" => "Remedios Otero" "apellidos" => "Candelera" "email" => array:1 [ 0 => "rotero@separ.es" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">¿</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "Teresa Elías" "apellidos" => "Hernández" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad Médico-Quirúrgica de Enfermedades Respiratorias, Hospital Universitario Virgen de Rocío, Sevilla, España" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "⁎" "correspondencia" => "Autor para correspondencia." ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Etiopathogenesis and physiopathology in chronic thromboembolic pulmonary hypertension" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec154520" "palabras" => array:5 [ 0 => "Hipertensión pulmonar postrombótica" 1 => "Embolia pulmonar crónica" 2 => "Fisiopatología" 3 => "Enfermedad tromboembólica venosa" 4 => "Etiopathogenesis and physiopathology" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec154521" "palabras" => array:4 [ 0 => "Postthrombotic pulmonary hypertension" 1 => "Chronic pulmonary embolism" 2 => "Physiopathology" 3 => "Venous thromboembolic disease" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La hipertensión pulmonar tromboembólica crónica se caracteriza por la organización de material trombótico dentro de las arterias pulmonares. La falta de correlación entre la proporción de arterias pulmonares obliteradas y las cifras de hipertensión pulmonar sugiere que una teoría exclusivamente mecánica podría ser demasiado simplista. El embolismo pulmonar agudo podría ser el evento inicial, pero la progresión de la enfermedad resultaría del remodelado vascular progresivo de los pequeños vasos. Es posible que la trombosis arterial pulmonar no resuelta sea un factor decisivo para que células endoteliales vasculares inicien su transición mesenquimal. Se analizan los aspectos genéticos, mecanismos inflamatorios y condicionantes clínicos que influyen en el mosaico fisiopatológico de esta compleja entidad.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Chronic thromboembolic pulmonary hypertension (CTEPH) is characterized by the organization of thrombotic material within the pulmonary arteries. The lack of correlation between the proportion of obliterated pulmonary arteries and pulmonary hypertension values suggest that an exclusively mechanical theory could be too simplistic. Acute pulmonary embolism could be the initial event, but disease progression probably results from progressive vascular remodelling of the small vessels. Unresolved pulmonary arterial thrombosis may be a decisive factor in initiating endothelial-to-mesenchymal transition. The present article analyzes the genetic features, inflammatory mechanisms and clinical factors influencing the physiopathological mosaic of this complex entity.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:65 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1." 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 October | 39 | 13 | 52 |
| 2024 September | 78 | 21 | 99 |
| 2024 August | 89 | 34 | 123 |
| 2024 July | 79 | 34 | 113 |
| 2024 June | 98 | 28 | 126 |
| 2024 May | 76 | 32 | 108 |
| 2024 April | 49 | 24 | 73 |
| 2024 March | 47 | 21 | 68 |
| 2024 February | 51 | 44 | 95 |
| 2023 March | 4 | 3 | 7 |
| 2023 February | 41 | 30 | 71 |
| 2023 January | 36 | 25 | 61 |
| 2022 December | 46 | 37 | 83 |
| 2022 November | 51 | 31 | 82 |
| 2022 October | 43 | 37 | 80 |
| 2022 September | 37 | 30 | 67 |
| 2022 August | 46 | 43 | 89 |
| 2022 July | 49 | 61 | 110 |
| 2022 June | 44 | 54 | 98 |
| 2022 May | 54 | 47 | 101 |
| 2022 April | 69 | 60 | 129 |
| 2022 March | 53 | 72 | 125 |
| 2022 February | 96 | 59 | 155 |
| 2022 January | 99 | 43 | 142 |
| 2021 December | 42 | 56 | 98 |
| 2021 November | 51 | 60 | 111 |
| 2021 October | 46 | 68 | 114 |
| 2021 September | 30 | 79 | 109 |
| 2021 August | 29 | 51 | 80 |
| 2021 July | 41 | 54 | 95 |
| 2021 June | 29 | 54 | 83 |
| 2021 May | 26 | 73 | 99 |
| 2021 April | 77 | 179 | 256 |
| 2021 March | 45 | 36 | 81 |
| 2021 February | 15 | 33 | 48 |
| 2021 January | 23 | 36 | 59 |
| 2020 December | 19 | 26 | 45 |
| 2020 November | 21 | 37 | 58 |
| 2020 October | 20 | 34 | 54 |
| 2020 September | 22 | 25 | 47 |
| 2020 August | 27 | 25 | 52 |
| 2020 July | 32 | 26 | 58 |
| 2020 June | 28 | 17 | 45 |
| 2020 May | 33 | 30 | 63 |
| 2020 April | 38 | 37 | 75 |
| 2020 March | 36 | 31 | 67 |
| 2020 February | 40 | 53 | 93 |
| 2020 January | 51 | 31 | 82 |
| 2019 December | 40 | 22 | 62 |
| 2019 November | 34 | 15 | 49 |
| 2019 October | 32 | 29 | 61 |
| 2019 September | 43 | 31 | 74 |
| 2019 August | 36 | 21 | 57 |
| 2019 July | 30 | 33 | 63 |
| 2019 June | 23 | 26 | 49 |
| 2019 May | 55 | 49 | 104 |
| 2019 April | 70 | 78 | 148 |
| 2019 March | 35 | 38 | 73 |
| 2019 February | 26 | 25 | 51 |
| 2019 January | 11 | 29 | 40 |
| 2018 December | 23 | 35 | 58 |
| 2018 November | 30 | 34 | 64 |
| 2018 October | 59 | 31 | 90 |
| 2018 September | 34 | 20 | 54 |
| 2018 May | 29 | 2 | 31 |
| 2018 April | 49 | 8 | 57 |
| 2018 March | 32 | 6 | 38 |
| 2018 February | 12 | 15 | 27 |
| 2018 January | 24 | 14 | 38 |
| 2017 December | 20 | 30 | 50 |
| 2017 November | 60 | 42 | 102 |
| 2017 October | 88 | 19 | 107 |
| 2017 September | 109 | 48 | 157 |
| 2017 August | 60 | 58 | 118 |
| 2017 July | 44 | 47 | 91 |
| 2017 June | 87 | 45 | 132 |
| 2017 May | 49 | 30 | 79 |
| 2017 April | 34 | 26 | 60 |
| 2017 March | 24 | 33 | 57 |
| 2017 February | 38 | 40 | 78 |
| 2017 January | 12 | 53 | 65 |
| 2016 December | 36 | 73 | 109 |
| 2016 November | 51 | 152 | 203 |
| 2016 October | 44 | 205 | 249 |
| 2016 September | 79 | 192 | 271 |
| 2016 August | 203 | 203 | 406 |
| 2016 July | 135 | 114 | 249 |
| 2016 June | 172 | 158 | 330 |
| 2016 May | 254 | 280 | 534 |
| 2016 April | 22 | 1 | 23 |
| 2016 March | 33 | 7 | 40 |
| 2016 February | 71 | 22 | 93 |
| 2016 January | 170 | 197 | 367 |
| 2015 December | 105 | 76 | 181 |
| 2015 November | 254 | 222 | 476 |
| 2015 October | 201 | 12 | 213 |
| 2015 September | 175 | 0 | 175 |
| 2015 August | 135 | 0 | 135 |
| 2015 July | 107 | 0 | 107 |
| 2015 June | 123 | 0 | 123 |
| 2015 May | 202 | 0 | 202 |
| 2015 April | 123 | 0 | 123 |
| 2015 March | 119 | 0 | 119 |
| 2015 February | 99 | 0 | 99 |
| 2015 January | 80 | 0 | 80 |
| 2014 December | 84 | 0 | 84 |
| 2014 November | 158 | 0 | 158 |
| 2014 October | 132 | 0 | 132 |
| 2014 September | 129 | 0 | 129 |
| 2014 August | 119 | 0 | 119 |
| 2014 July | 121 | 0 | 121 |
| 2014 June | 157 | 0 | 157 |
| 2014 May | 211 | 0 | 211 |
| 2014 April | 212 | 0 | 212 |
| 2014 March | 195 | 0 | 195 |
| 2014 February | 131 | 0 | 131 |
| 2014 January | 110 | 0 | 110 |
| 2013 December | 106 | 0 | 106 |
| 2013 November | 171 | 0 | 171 |
| 2013 October | 150 | 0 | 150 |
| 2013 September | 102 | 0 | 102 |
| 2013 August | 125 | 0 | 125 |
| 2013 July | 91 | 0 | 91 |
| 2013 June | 64 | 0 | 64 |
| 2013 May | 57 | 0 | 57 |
| 2013 April | 47 | 0 | 47 |
| 2013 March | 18 | 0 | 18 |
| 2000 January | 529 | 0 | 529 |
Show all
