Hipertensión arterial pulmonar: un recorrido por el año 2008
Pulmonary Arterial Hypertension: a Voyage Around the Year 2008
Adolfo Baloira
Servicio de Neumología, Complexo Hospitalario de Pontevedra, Pontevedra, España
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array:12 [ "idiomaDefecto" => true "titulo" => "Hipertensión arterial pulmonar: un recorrido por el año 2008" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "43" "paginaFinal" => "48" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "Adolfo Baloira" "autores" => array:1 [ 0 => array:3 [ "nombre" => "Adolfo" "apellidos" => "Baloira" "email" => array:1 [ 0 => "adolfo.baloira.villar@sergas.es" ] ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Servicio de Neumología, Complexo Hospitalario de Pontevedra, Pontevedra, España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Pulmonary Arterial Hypertension: a Voyage Around the Year 2008" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec240606" "palabras" => array:4 [ 0 => "Hipertensión arterial pulmonar" 1 => "BMPR2" 2 => "Antiendotelina" 3 => "Sildenafilo" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec240607" "palabras" => array:4 [ 0 => "Pulmonary arterial hypertension" 1 => "BMPR2" 2 => "Anti-endothelin" 3 => "Sildenafil" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">La hipertensión arterial pulmonar (HAP) ha tenido un espectacular desarrollo, tanto en la terapéutica como en el conocimiento de su patogenia. Durante el año 2008 se han publicado algunos trabajos que ha contribuido a mejorar un poco más estos dos aspectos. En lo que se refiere a la patogenia, las mutaciones en BMPR2 siguen ganando puntos como actores fundamentales en el desarrollo de la enfermedad. Se ha podido comprobar que los pacientes que portan alguna de ellas tienen un curso clínico más rápido y grave. Existe una relación entre la vía de BMPR2 y la inflamación de árbol vascular pulmonar. En este año también ha aparecido en escena un nuevo fármaco antiendotelina: ambrisentán. Con una eficacia comparable con la de otros fármacos de su grupo, los efectos secundarios parecen ser bastante menores. Un trabajo importante ha sido la demostración de una mejoría en diversos parámetros de pacientes con HAP en clase funcional II con bosentán. También se han presentado resultados de algunas nuevas combinaciones, como sildenafilo y epoprostenol. Un tipo frecuente de HAP es el que aparece asociado a enfermedad tromboembólica. Tanto el tratamiento con sildenafilo como, en algunos casos seleccionados, la angioplastia percutánea obtienen respuestas favorables. Por último, en 2008 han visto la luz dos nuevos documentos de consenso, uno español y otro británico que, sobre la base de los conocimientos actuales, clarifican un poco más el manejo de esta grave enfermedad.</p>" ] "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">There have been spectacular developments in pulmonary arterial hypertension (PAH), both in its treatment and knowledge of its pathogenesis. Several studies have been published throughout 2008 that have contributed to improve these two aspects a little. As regards the pathogenesis, mutations in BMPR2 continue gaining points as fundamental factors in the development of the disease. It has been shown that patients who carry any of them have a more rapid and severe clinical course. There is a relationship between the BMPR2 pathway and inflammation of the pulmonary vascular tree. A new anti-endothelin drug, ambrisentan, has also appeared on the scene this year. With an efficacy comparable to other drugs of its group, the secondary effects appear to be a lot less. An important work has been the demonstration of an improvement in several parameters in functional class II in patients with PAH with bosentan. Results using new combinations, such as sildenafil and epoprostenol, have also been presented. A common type of PAH is that which seems to be associated with thromboembolic disease. Treatment with sildenafil and in some selected cases, percutaneous angioplasty, has obtained favourable responses. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 3 | 4 | 7 |
| 2024 October | 44 | 17 | 61 |
| 2024 September | 43 | 13 | 56 |
| 2024 August | 54 | 32 | 86 |
| 2024 July | 33 | 22 | 55 |
| 2024 June | 45 | 27 | 72 |
| 2024 May | 39 | 34 | 73 |
| 2024 April | 25 | 28 | 53 |
| 2024 March | 41 | 27 | 68 |
| 2024 February | 25 | 39 | 64 |
| 2023 March | 3 | 3 | 6 |
| 2023 February | 19 | 18 | 37 |
| 2023 January | 25 | 36 | 61 |
| 2022 December | 26 | 20 | 46 |
| 2022 November | 25 | 27 | 52 |
| 2022 October | 31 | 35 | 66 |
| 2022 September | 33 | 23 | 56 |
| 2022 August | 33 | 33 | 66 |
| 2022 July | 30 | 40 | 70 |
| 2022 June | 15 | 26 | 41 |
| 2022 May | 26 | 27 | 53 |
| 2022 April | 22 | 25 | 47 |
| 2022 March | 26 | 31 | 57 |
| 2022 February | 29 | 27 | 56 |
| 2022 January | 20 | 33 | 53 |
| 2021 December | 18 | 37 | 55 |
| 2021 November | 20 | 45 | 65 |
| 2021 October | 21 | 46 | 67 |
| 2021 September | 18 | 55 | 73 |
| 2021 August | 13 | 44 | 57 |
| 2021 July | 12 | 33 | 45 |
| 2021 June | 31 | 45 | 76 |
| 2021 May | 13 | 27 | 40 |
| 2021 April | 38 | 62 | 100 |
| 2021 March | 21 | 18 | 39 |
| 2021 February | 12 | 16 | 28 |
| 2021 January | 20 | 17 | 37 |
| 2020 December | 11 | 17 | 28 |
| 2020 November | 13 | 18 | 31 |
| 2020 October | 10 | 7 | 17 |
| 2020 September | 9 | 8 | 17 |
| 2020 August | 26 | 17 | 43 |
| 2020 July | 20 | 24 | 44 |
| 2020 June | 13 | 5 | 18 |
| 2020 May | 28 | 20 | 48 |
| 2020 April | 19 | 15 | 34 |
| 2020 March | 16 | 17 | 33 |
| 2020 February | 19 | 21 | 40 |
| 2020 January | 20 | 17 | 37 |
| 2019 December | 20 | 12 | 32 |
| 2019 November | 8 | 11 | 19 |
| 2019 October | 7 | 15 | 22 |
| 2019 September | 2 | 13 | 15 |
| 2019 August | 12 | 11 | 23 |
| 2019 July | 11 | 13 | 24 |
| 2019 June | 4 | 3 | 7 |
| 2019 May | 11 | 18 | 29 |
| 2019 April | 10 | 45 | 55 |
| 2019 March | 8 | 24 | 32 |
| 2019 February | 8 | 14 | 22 |
| 2019 January | 1 | 11 | 12 |
| 2018 December | 6 | 18 | 24 |
| 2018 November | 12 | 14 | 26 |
| 2018 October | 21 | 16 | 37 |
| 2018 September | 19 | 9 | 28 |
| 2018 July | 0 | 1 | 1 |
| 2018 May | 3 | 1 | 4 |
| 2018 April | 11 | 5 | 16 |
| 2018 March | 5 | 4 | 9 |
| 2018 February | 11 | 9 | 20 |
| 2018 January | 5 | 7 | 12 |
| 2017 December | 5 | 6 | 11 |
| 2017 November | 8 | 7 | 15 |
| 2017 October | 10 | 11 | 21 |
| 2017 September | 6 | 14 | 20 |
| 2017 August | 10 | 16 | 26 |
| 2017 July | 4 | 5 | 9 |
| 2017 June | 11 | 23 | 34 |
| 2017 May | 11 | 10 | 21 |
| 2017 April | 7 | 9 | 16 |
| 2017 March | 6 | 27 | 33 |
| 2017 February | 7 | 10 | 17 |
| 2017 January | 3 | 7 | 10 |
| 2016 December | 12 | 4 | 16 |
| 2016 November | 23 | 11 | 34 |
| 2016 October | 28 | 18 | 46 |
| 2016 September | 12 | 9 | 21 |
| 2016 August | 12 | 5 | 17 |
| 2016 July | 22 | 8 | 30 |
| 2016 June | 31 | 17 | 48 |
| 2016 May | 13 | 3 | 16 |
| 2016 April | 8 | 4 | 12 |
| 2016 March | 13 | 2 | 15 |
| 2016 February | 10 | 3 | 13 |
| 2016 January | 17 | 9 | 26 |
| 2015 December | 15 | 8 | 23 |
| 2015 November | 23 | 4 | 27 |
| 2015 October | 33 | 1 | 34 |
| 2015 September | 19 | 0 | 19 |
| 2015 August | 26 | 0 | 26 |
| 2015 July | 25 | 0 | 25 |
| 2015 June | 18 | 0 | 18 |
| 2015 May | 25 | 0 | 25 |
| 2015 April | 17 | 0 | 17 |
| 2015 March | 19 | 0 | 19 |
| 2015 February | 8 | 0 | 8 |
| 2015 January | 18 | 0 | 18 |
| 2014 December | 20 | 0 | 20 |
| 2014 November | 15 | 0 | 15 |
| 2014 October | 34 | 0 | 34 |
| 2014 September | 19 | 0 | 19 |
| 2014 August | 19 | 0 | 19 |
| 2014 July | 12 | 0 | 12 |
| 2014 June | 27 | 0 | 27 |
| 2014 May | 28 | 0 | 28 |
| 2014 April | 29 | 0 | 29 |
| 2014 March | 33 | 0 | 33 |
| 2014 February | 39 | 0 | 39 |
| 2014 January | 33 | 0 | 33 |
| 2013 December | 30 | 0 | 30 |
| 2013 November | 23 | 0 | 23 |
| 2013 October | 22 | 0 | 22 |
| 2013 September | 20 | 0 | 20 |
| 2013 August | 41 | 0 | 41 |
| 2013 July | 40 | 0 | 40 |
| 2013 June | 19 | 0 | 19 |
| 2013 May | 15 | 0 | 15 |
| 2013 April | 11 | 0 | 11 |
| 2013 March | 8 | 0 | 8 |
| 2000 January | 769 | 0 | 769 |
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