La respuesta a la prueba de la tuberculina en enfermos tuberculosos
Tuberculin test responses of tuberculosis patients
J.M. Pinaa,
, A. Domínguezb, J. Alcaidec, J. Álvarezd, N. Campsd, M. Díeze, P. Godoyd, J.M. Jansáf, S Minguelld, Grupo de trabajo del Proyecto Multicéntrico de Investigación en Tuberculosis (Pmit) *
Corresponding author
a Programa de la Tuberculosi de la Regió Sanitària Centre de Catalunya. Servei Català de la Salut. Institut Català de la Salut. España
b Direcció General de Salut Pública del Departament de Sanitat i Seguretat Social. España
c Programa de Prevenció i Control de la Tuberculosi de Catalunya. Departmento de Sanitat i Seguretat Social. Generaliat de Catalu nya. España
d Delegaciones Territoriales del Departamento de Sanitat i Seguretat Social de Catalunya. Barcelona, Girona, Lleida y Tarragona. España
e Unidad de Investigación en Tuberculosis. Instituto de Salud Carlos III. Madrid. España
f Instituto Municipal de la Salud. Barcelona. España
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España" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Tuberculin test responses of tuberculosis patients" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2002-06-26" "fechaAceptado" => "2002-10-15" "PalabrasClave" => array:2 [ "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec190632" "palabras" => array:2 [ 0 => "Prueba de la tuberculina" 1 => "Tuberculosis" ] ] ] "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec190631" "palabras" => array:2 [ 0 => "Tuberculin skin test" 1 => "Tuberculosis" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivos</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Conocer la respuesta a la prueba de la tuberculina (PT) en enfermos tuberculosos.</p> <span class="elsevierStyleSectionTitle">Método</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Revisión del resultado de la PT practicada en la valoración inicial de enfermos tuberculosos diagnosticados en Cataluña (Proyecto Multicéntrico de Investigación en Tuberculosis). PT negativa [PT (−)]: induración<5<span class="elsevierStyleHsp" style=""></span>mm; PT positiva [PT (+)]:<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm. Se clasificaron con y sin factores de riesgo para desarrollar la tuberculosis y estos últimos, según edad, localización y extensión de la tuberculosis.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">De los pacientes, 1.566 fueron PT (−) (23%). La PT (−) era más frecuente en enfermos con factores de riesgo: significativamente con tratamiento inmunosupresor (50%) o infección por el VIH (61%), y con menos frecuencia en enfermos sin factores de riesgo (13%) y entre éstos, en niños (1%), pacientes de 15-29 años (10%) o cuando la tuberculosis era pulmonar (10%), y significativamente más frecuente en enfermos de 60-74 años (27%), mayores de 74 (44%) y si la tuberculosis era pulmonar y extrapulmonar (26%) o diseminada (64%).</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">En enfermos sin y con factores de riesgo (incluida o no infección por el VIH) con PT (+) la diferencia de las medias de los diámetros de las induraciones no fue significativa y en todos los grupos los diámetros demostraron una distribución normal o de Gauss.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">En la valoración inicial del enfermo, la PT negativa depende de la existencia de factores de riesgo, la edad, la localización y la extensión de la tuberculosis. Cuando la PT es positiva, la respuesta es similar, exista o no cualquier factor que pueda deprimir la respuesta inmunitaria.</p>" ] "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">To determine the response of tuberculosis patients to tuberculin skin tests.</p> <span class="elsevierStyleSectionTitle">Method</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The results of skin tests used for initial assessment of tuberculosis patients in Catalonia were reviewed (Multicenter Tuberculosis Research Project). Negative skin tests were those with indurations<5<span class="elsevierStyleHsp" style=""></span>mm; positive tests were those with indurations measuring<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>5<span class="elsevierStyleHsp" style=""></span>mm. Individuals were classed as having or not having risk factors for developing tuberculosis and those without risk factors were classified by age, location and extension of tuberculosis.</p> <span class="elsevierStyleSectionTitle">Results</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Negative skin tests were seen in 1,566 patients (23%). Negative tests were more common in patients with risk factors, significantly so in those undergoing immunosup-pressant therapy (50%) or with HIV infection (61%). Negative tests were less prevalent in patients with no risk factors (13%) and, among them, in children (1%), in patients between 15 and 29 years of age (10%) or in those with non-pulmonary forms (10%). Negative tests were significantly more prevalent among patients 60 to 74 years of age (27%), those over 74 (44%), and those whose disease was pulmonary and extrapulmonary (26%) or disseminated (64%). No significant differences in induration size of positive skin tests were observed for patients with and without risk factors (including HIV infection or non-infection). A normal distribution of induration size was observed in all groups.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">A negative tuberculin skin test for initial assessment should be interpreted in function of the presence or absence of risk factors, age, location or extension of tuberculosis. When a skin test is positive, the response will be similar whether or not an immunodepressant factor is present.</p>" ] ] "NotaPie" => array:2 [ 0 => array:2 [ "etiqueta" => "*" "nota" => "<p class="elsevierStyleNotepara">El Grupo de Trabajo del Proyecto Multicéntrico de Investigación en Tuberculosis se expone al final del artículo</p>" ] 1 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">El Proyecto (PMIT) ha sido financiado (96/0064) por el Fondo de Investigación Sanitaria</p>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:23 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Story of the tuberculin test from an epidemiologic view point" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "P.Q. Edwards" 1 => "L.B. 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| Year/Month | Html | Total | |
|---|---|---|---|
| 2024 November | 4 | 1 | 5 |
| 2024 October | 34 | 19 | 53 |
| 2024 September | 39 | 15 | 54 |
| 2024 August | 50 | 42 | 92 |
| 2024 July | 37 | 27 | 64 |
| 2024 June | 42 | 36 | 78 |
| 2024 May | 49 | 35 | 84 |
| 2024 April | 19 | 26 | 45 |
| 2024 March | 39 | 31 | 70 |
| 2024 February | 28 | 35 | 63 |
| 2023 December | 0 | 1 | 1 |
| 2023 November | 0 | 10 | 10 |
| 2023 October | 0 | 3 | 3 |
| 2023 August | 0 | 3 | 3 |
| 2023 July | 0 | 13 | 13 |
| 2023 June | 0 | 16 | 16 |
| 2023 March | 3 | 5 | 8 |
| 2023 February | 20 | 17 | 37 |
| 2023 January | 31 | 21 | 52 |
| 2022 December | 28 | 32 | 60 |
| 2022 November | 27 | 26 | 53 |
| 2022 October | 28 | 31 | 59 |
| 2022 September | 19 | 25 | 44 |
| 2022 August | 30 | 45 | 75 |
| 2022 July | 27 | 35 | 62 |
| 2022 June | 18 | 41 | 59 |
| 2022 May | 25 | 38 | 63 |
| 2022 April | 29 | 23 | 52 |
| 2022 March | 24 | 29 | 53 |
| 2022 February | 34 | 29 | 63 |
| 2022 January | 24 | 31 | 55 |
| 2021 December | 13 | 44 | 57 |
| 2021 November | 20 | 28 | 48 |
| 2021 October | 30 | 50 | 80 |
| 2021 September | 22 | 54 | 76 |
| 2021 August | 14 | 44 | 58 |
| 2021 July | 14 | 35 | 49 |
| 2021 June | 28 | 38 | 66 |
| 2021 May | 19 | 36 | 55 |
| 2021 April | 37 | 56 | 93 |
| 2021 March | 47 | 21 | 68 |
| 2021 February | 46 | 22 | 68 |
| 2021 January | 32 | 33 | 65 |
| 2020 December | 26 | 27 | 53 |
| 2020 November | 19 | 19 | 38 |
| 2020 October | 29 | 15 | 44 |
| 2020 September | 19 | 12 | 31 |
| 2020 August | 19 | 22 | 41 |
| 2020 July | 29 | 22 | 51 |
| 2020 June | 11 | 23 | 34 |
| 2020 May | 15 | 19 | 34 |
| 2020 April | 16 | 17 | 33 |
| 2020 March | 16 | 17 | 33 |
| 2020 February | 13 | 19 | 32 |
| 2020 January | 18 | 16 | 34 |
| 2019 December | 25 | 41 | 66 |
| 2019 November | 10 | 28 | 38 |
| 2019 October | 5 | 37 | 42 |
| 2019 September | 15 | 27 | 42 |
| 2019 August | 11 | 29 | 40 |
| 2019 July | 15 | 21 | 36 |
| 2019 June | 13 | 17 | 30 |
| 2019 May | 29 | 30 | 59 |
| 2019 April | 11 | 38 | 49 |
| 2019 March | 7 | 26 | 33 |
| 2019 February | 8 | 22 | 30 |
| 2019 January | 5 | 16 | 21 |
| 2018 December | 10 | 30 | 40 |
| 2018 November | 13 | 28 | 41 |
| 2018 October | 27 | 15 | 42 |
| 2018 September | 17 | 13 | 30 |
| 2018 May | 6 | 1 | 7 |
| 2018 April | 7 | 7 | 14 |
| 2018 March | 7 | 14 | 21 |
| 2018 February | 12 | 9 | 21 |
| 2018 January | 8 | 10 | 18 |
| 2017 December | 10 | 9 | 19 |
| 2017 November | 7 | 4 | 11 |
| 2017 October | 14 | 9 | 23 |
| 2017 September | 6 | 7 | 13 |
| 2017 August | 10 | 9 | 19 |
| 2017 July | 3 | 26 | 29 |
| 2017 June | 16 | 22 | 38 |
| 2017 May | 13 | 13 | 26 |
| 2017 April | 9 | 26 | 35 |
| 2017 March | 10 | 10 | 20 |
| 2017 February | 1 | 6 | 7 |
| 2017 January | 5 | 4 | 9 |
| 2016 December | 22 | 12 | 34 |
| 2016 November | 27 | 19 | 46 |
| 2016 October | 29 | 21 | 50 |
| 2016 September | 29 | 15 | 44 |
| 2016 August | 21 | 7 | 28 |
| 2016 July | 21 | 8 | 29 |
| 2016 June | 24 | 10 | 34 |
| 2016 May | 22 | 11 | 33 |
| 2016 April | 9 | 1 | 10 |
| 2016 March | 14 | 5 | 19 |
| 2016 February | 19 | 3 | 22 |
| 2016 January | 29 | 18 | 47 |
| 2015 December | 27 | 10 | 37 |
| 2015 November | 33 | 8 | 41 |
| 2015 October | 57 | 1 | 58 |
| 2015 September | 47 | 0 | 47 |
| 2015 August | 52 | 0 | 52 |
| 2015 July | 53 | 0 | 53 |
| 2015 June | 47 | 0 | 47 |
| 2015 May | 59 | 0 | 59 |
| 2015 April | 45 | 0 | 45 |
| 2015 March | 35 | 0 | 35 |
| 2015 February | 32 | 0 | 32 |
| 2015 January | 31 | 0 | 31 |
| 2014 December | 26 | 0 | 26 |
| 2014 November | 32 | 0 | 32 |
| 2014 October | 49 | 0 | 49 |
| 2014 September | 34 | 0 | 34 |
| 2014 August | 35 | 0 | 35 |
| 2014 July | 35 | 0 | 35 |
| 2014 June | 51 | 0 | 51 |
| 2014 May | 51 | 0 | 51 |
| 2014 April | 42 | 0 | 42 |
| 2014 March | 53 | 0 | 53 |
| 2014 February | 48 | 0 | 48 |
| 2014 January | 36 | 0 | 36 |
| 2013 December | 31 | 0 | 31 |
| 2013 November | 33 | 0 | 33 |
| 2013 October | 35 | 0 | 35 |
| 2013 September | 45 | 0 | 45 |
| 2013 August | 66 | 0 | 66 |
| 2013 July | 46 | 0 | 46 |
| 2013 June | 40 | 0 | 40 |
| 2013 May | 34 | 0 | 34 |
| 2013 April | 18 | 0 | 18 |
| 2013 March | 9 | 0 | 9 |
| 2000 January | 3255 | 0 | 3255 |
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