array:23 [
  "pii" => "S0300289615317622"
  "issn" => "03002896"
  "doi" => "10.1016/S0300-2896(15)31762-2"
  "estado" => "S300"
  "fechaPublicacion" => "1989-03-01"
  "aid" => "71832"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
  "copyrightAnyo" => "1989"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 1989;25:61-4"
  "abierto" => array:3 [
    "ES" => true
    "ES2" => true
    "LATM" => true
  ]
  "gratuito" => true
  "lecturas" => array:2 [
    "total" => 1340
    "formatos" => array:3 [
      "EPUB" => 74
      "HTML" => 637
      "PDF" => 629
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S0300289615317634"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)31763-4"
    "estado" => "S300"
    "fechaPublicacion" => "1989-03-01"
    "aid" => "71833"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1989;25:65-8"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 2065
      "formatos" => array:3 [
        "EPUB" => 72
        "HTML" => 1023
        "PDF" => 970
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Comparacion entre procaterol y salbutamol mediante dosis-respuesta acumulada en pacientes con limitacion cronica al flujo aereo"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "65"
          "paginaFinal" => "68"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Comparison between procaterol and salbutamol by means of cumulative dose-response in patients with chronic limitation to airflow"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "M. Mayos, M. González, P. Casán, J. García-Barbal, J. Sanchís"
          "autores" => array:5 [
            0 => array:2 [
              "nombre" => "M."
              "apellidos" => "Mayos"
            ]
            1 => array:2 [
              "nombre" => "M."
              "apellidos" => "González"
            ]
            2 => array:2 [
              "nombre" => "P."
              "apellidos" => "Casán"
            ]
            3 => array:2 [
              "nombre" => "J."
              "apellidos" => "García-Barbal"
            ]
            4 => array:2 [
              "nombre" => "J."
              "apellidos" => "Sanchís"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317634?idApp=UINPBA00003Z"
    "url" => "/03002896/0000002500000002/v1_201509151020/S0300289615317634/v1_201509151020/es/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S0300289615317610"
    "issn" => "03002896"
    "doi" => "10.1016/S0300-2896(15)31761-0"
    "estado" => "S300"
    "fechaPublicacion" => "1989-03-01"
    "aid" => "71831"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 1989;25:56-60"
    "abierto" => array:3 [
      "ES" => true
      "ES2" => true
      "LATM" => true
    ]
    "gratuito" => true
    "lecturas" => array:2 [
      "total" => 1469
      "formatos" => array:3 [
        "EPUB" => 56
        "HTML" => 667
        "PDF" => 746
      ]
    ]
    "es" => array:10 [
      "idiomaDefecto" => true
      "titulo" => "Curvas dosis-respuesta a la metacolina en asmaticos y sanos: utilidad de la determinacion del punto critico de separacion entre ambas"
      "tienePdf" => "es"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "es"
        1 => "en"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "56"
          "paginaFinal" => "60"
        ]
      ]
      "titulosAlternativos" => array:1 [
        "en" => array:1 [
          "titulo" => "Dose-response curves to methacholine in asthmatic patients and in healthy individuals: usefulness of the determination of the critical separation point between both"
        ]
      ]
      "contieneResumen" => array:2 [
        "es" => true
        "en" => true
      ]
      "contienePdf" => array:1 [
        "es" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "C. Pellicer Císcar, M. Perpiñá Tordera, V. Marco Martínez"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "C."
              "apellidos" => "Pellicer Císcar"
            ]
            1 => array:2 [
              "nombre" => "M."
              "apellidos" => "Perpiñá Tordera"
            ]
            2 => array:2 [
              "nombre" => "V."
              "apellidos" => "Marco Martínez"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "es"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317610?idApp=UINPBA00003Z"
    "url" => "/03002896/0000002500000002/v1_201509151020/S0300289615317610/v1_201509151020/es/main.assets"
  ]
  "es" => array:13 [
    "idiomaDefecto" => true
    "titulo" => "Eficacia broncodilatadora del clorhidrato de procaterol: analisis comparativo con salbutamol"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "61"
        "paginaFinal" => "64"
      ]
    ]
    "autores" => array:1 [
      0 => array:3 [
        "autoresLista" => "A.G.N. Agustí, F. Burgos, R. Rodríguez Roisín, A. Agustí Vidal"
        "autores" => array:4 [
          0 => array:2 [
            "nombre" => "A.G.N."
            "apellidos" => "Agustí"
          ]
          1 => array:2 [
            "nombre" => "F."
            "apellidos" => "Burgos"
          ]
          2 => array:2 [
            "nombre" => "R."
            "apellidos" => "Rodríguez Roisín"
          ]
          3 => array:2 [
            "nombre" => "A."
            "apellidos" => "Agustí Vidal"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:2 [
            "entidad" => "Servei de Pneumologia. Hospital Clinic. Facultat de Medicina. Universitat de Barcelona"
            "identificador" => "aff0005"
          ]
        ]
      ]
    ]
    "titulosAlternativos" => array:1 [
      "en" => array:1 [
        "titulo" => "Bronchodilating effectiveness of procaterol hydrochloride: a comparative analysis with salbutamol"
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "1988-03-18"
    "fechaAceptado" => "1988-10-26"
    "tieneResumen" => true
    "resumen" => array:2 [
      "es" => array:1 [
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Con objeto de analizar la eficacia broncodilatadora&#44; duraci&#243;n de acci&#243;n y posibles efectos secundarios de un nuevo agente &#946;<span class="elsevierStyleInf">2</span> adren&#233;rgico en aerosol &#40;procaterol&#41;&#44; se dise&#241;&#243; un estudio abierto y cruzado de comparaci&#243;n entre procaterol y salbutamol&#46; Se han incluido 20 pacientes &#40;x&#175; &#177; DE&#41; &#40;39 &#177; 2 a&#241;os&#41; con asma bronquial leve &#40;FEV<span class="elsevierStyleInf">1</span> &#8805;&#61; 70&#37;&#41; en fase de estabilidad cl&#237;nica&#46; Durante una semana&#44; los pacientes recibieron de forma aleatoria procaterol &#91;2 inhalaciones &#40;20 &#956;g&#41; cada 8 horas&#93; y salbutamol &#91;2 inhalaciones &#40;200 &#956;g&#41; cada 6 horas&#93;&#46; Antes y despu&#233;s de dicho per&#237;odo de estudio&#44; se determin&#243; la espirometr&#237;a forzada y capacidad residual funcional &#40;TGV&#41; y resistencia de v&#237;as a&#233;reas por pletismograf&#237;a&#44; expresada como conductancia espec&#237;fica &#40;SGaw&#41;&#46; Estos par&#225;metros fueron analizados de nuevo tras 15 min&#44; 60 min&#44; 4 horas y 6 horas de la inhalaci&#243;n de cada uno de ambos broncodi-latadores&#46; Entre ambos per&#237;odos de estudio se intercal&#243; un per&#237;odo de reposo o &#171;lavado&#187; &#40;<span class="elsevierStyleItalic">washout</span>&#41; durante el cual el paciente no recibi&#243; medicaci&#243;n alguna&#46; Nuestros resultados muestran que la eficacia broncodilatadora del procaterol&#44; tanto tras su administraci&#243;n puntual como tras un per&#237;odo de tiempo m&#225;s prolongado &#40;1 semana&#41;&#44; es equiparable a la obtenida tras el salbutamol&#46; Destaca&#44; adem&#225;s la ausencia de efectos secundarios&#46;</p></span>"
      ]
      "en" => array:1 [
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the bronchodilating effectiveness&#44; duration of action and possible side effects of a new beta-2-adrenergic agent in aerosol &#40;procaterol&#41;&#44; an open crossover comparative study between procaterol and salbutamol was designed&#46; Twenty patients were included &#40;x&#175; &#177; SD&#41; &#40;39 &#177; 2 years&#41; with mild bronchial asthma &#40;FEV<span class="elsevierStyleInf">1</span> &#8805;&#61; 70&#37;&#41; in a phase of clinical stability&#46; During one week&#44; the patients received in random allocation either procaterol &#91;two inhalations &#40;20 &#956;g&#41; every 8 hours&#93; and salbutamol &#91;2 inhalations &#40;200 &#956;g&#41; every 6 hours&#93;&#46; Before and after this study period&#44; forced spirometry and functional residual capacity &#40;TGV&#41; were measured&#44; as well as the airways resistence&#44; evaluated with pletysmography and expressed as specific conductance &#40;SGaw&#41;&#46; These parameters were measured again 15 minutes&#44; 60 minutes and 4 hours after the inhalation of each bronchodilator&#46; A wash-out period&#44; during which the patient did not receive any drug&#44; was placed between both active study periods&#46; Our results suggest that the bronchodilating effectiveness of procaterol&#44; both measured acutely and after a more sustained period &#40;1 week&#41;&#44; is comparable to that of salbutamol&#46; A remarkable finding was the absence of side effects&#46;</p></span>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "Bibliograf&#237;a"
      "seccion" => array:1 [
        0 => array:2 [
          "identificador" => "bibs0005"
          "bibliografiaReferencia" => array:10 [
            0 => array:3 [
              "identificador" => "bib0005"
              "etiqueta" => "1&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Control of asthma by aerosols"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "M&#46;T&#46; Newhouse"
                            1 => "M&#46;B&#46; Dolovich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM198610023151406"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1986"
                        "volumen" => "315"
                        "paginaInicial" => "870"
                        "paginaFinal" => "874"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2875391"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib0010"
              "etiqueta" => "2&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Asma bronquial y broncodilatadores en aerosol&#58; empleo incorrecto en nuestro medio"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "A&#46;G&#46;N&#46; Agust&#237;"
                            1 => "P&#46; Ussetti"
                            2 => "J&#46; Roca"
                            3 => "J&#46;M&#46; Montserrat"
                            4 => "R&#46; Rodr&#237;guez-Rois&#237;n"
                            5 => "A&#46; Agust&#237;-Vidal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin"
                        "fecha" => "1983"
                        "volumen" => "81"
                        "paginaInicial" => "893"
                        "paginaFinal" => "894"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib0015"
              "etiqueta" => "3&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Broncodilatadores en aerosol"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "J&#46; Sanchis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin"
                        "fecha" => "1983"
                        "volumen" => "81"
                        "paginaInicial" => "898"
                        "paginaFinal" => "900"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib0020"
              "etiqueta" => "4&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pharmacological studies of OPC-2009&#44; a newly synthesized selective beta adrenoceptor stimulant in the bronchomotor and cardiovascular system of the anesthetized dog"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Y&#46; Yabuuchi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Phar Exp Ther"
                        "fecha" => "1977"
                        "volumen" => "202"
                        "paginaInicial" => "326"
                        "paginaFinal" => "336"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib0025"
              "etiqueta" => "5&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The &#946;-adrenoceptor stimulant action of procaterol &#40;OPC-2009&#41;&#44; a new &#40;&#946;<span class="elsevierStyleInf">2</span>-adrenoceptor stimulant&#44; on bronchial resistance and heart rate in guinea pigs"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46; Tei"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Pharmacometrics"
                        "fecha" => "1979"
                        "volumen" => "17"
                        "paginaInicial" => "335"
                        "paginaFinal" => "340"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib0030"
              "etiqueta" => "6&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respuesta al salbutamol en no fumadores sanos"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:7 [
                            0 => "C&#46; Picado"
                            1 => "F&#46; Burgos"
                            2 => "J&#46; Roca"
                            3 => "H&#46; Sala"
                            4 => "F&#46; Segarra"
                            5 => "A&#46; Agust&#237;-Vidal"
                            6 => "J&#46; Sanch&#237;s"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:2 [
                        "tituloSerie" => "Libro de comunicaciones de la 11 Reuni&#243;n Nacional SEPAR&#44; Santander"
                        "fecha" => "1981"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib0035"
              "etiqueta" => "7&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Normativa SEPAR para la espirometr&#237;a forzada"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Sanchis"
                            1 => "P&#46; Casan"
                            2 => "J&#46; Castillo"
                            3 => "N&#46; Gonz&#225;lez Mangado"
                            4 => "L&#46; Palenciano"
                            5 => "J&#46; Roca"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Libro" => array:3 [
                        "fecha" => "1985"
                        "editorial" => "Ed Doyma"
                        "editorialLocalizacion" => "Barcelona"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib0040"
              "etiqueta" => "8&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Spirometric reference values for a mediterranean population"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:8 [
                            0 => "J&#46; Roca"
                            1 => "J&#46; Sanch&#237;s"
                            2 => "A&#46; Agust&#237;-Vidal"
                            3 => "F&#46; Segarra"
                            4 => "D&#46; Navajas"
                            5 => "R&#46; Rodr&#237;guez-Rois&#237;n"
                            6 => "P&#46; Cas&#225;n"
                            7 => "S&#46; Sans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Bull Europ Physiopathol Respir"
                        "fecha" => "1986"
                        "volumen" => "22"
                        "paginaInicial" => "217"
                        "paginaFinal" => "224"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib0045"
              "etiqueta" => "9&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Static lung volumes and single-breath diffusion capacity reference values from a latin population &#40;abstract&#41;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "J&#46; Roca"
                            1 => "F&#46; Segarra"
                            2 => "R&#46; Rodr&#237;guez-Rois&#237;n"
                            3 => "E&#46; Cobo"
                            4 => "J&#46; Mart&#237;nez"
                            5 => "A&#46; Agust&#237;-Vidal"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1985.131.3.352"
                      "Revista" => array:5 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1985"
                        "volumen" => "131"
                        "paginaInicial" => "352"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3856412"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib0050"
              "etiqueta" => "10&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Comparing means of several groups"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "K&#46; Godfrey"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:4 [
                        "titulo" => "Medical uses of statistics"
                        "paginaInicial" => "205"
                        "paginaFinal" => "234"
                        "serieFecha" => "1986"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "es"
  "url" => "/03002896/0000002500000002/v1_201509151020/S0300289615317622/v1_201509151020/es/main.assets"
  "Apartado" => array:4 [
    "identificador" => "9277"
    "tipo" => "SECCION"
    "en" => array:2 [
      "titulo" => "Originales"
      "idiomaDefecto" => true
    ]
    "idiomaDefecto" => "en"
  ]
  "PDF" => "https://static.elsevier.es/multimedia/03002896/0000002500000002/v1_201509151020/S0300289615317622/v1_201509151020/es/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317622?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 25. Issue 2.
Pages 61-64 (March 1989)
Share
Share
Download PDF
More article options
Vol. 25. Issue 2.
Pages 61-64 (March 1989)
Full text access
Eficacia broncodilatadora del clorhidrato de procaterol: analisis comparativo con salbutamol
Bronchodilating effectiveness of procaterol hydrochloride: a comparative analysis with salbutamol
Visits
3705
A.G.N. Agustí, F. Burgos, R. Rodríguez Roisín, A. Agustí Vidal
Servei de Pneumologia. Hospital Clinic. Facultat de Medicina. Universitat de Barcelona
This item has received
Article information

Con objeto de analizar la eficacia broncodilatadora, duración de acción y posibles efectos secundarios de un nuevo agente β2 adrenérgico en aerosol (procaterol), se diseñó un estudio abierto y cruzado de comparación entre procaterol y salbutamol. Se han incluido 20 pacientes (x¯ ± DE) (39 ± 2 años) con asma bronquial leve (FEV1 ≥= 70%) en fase de estabilidad clínica. Durante una semana, los pacientes recibieron de forma aleatoria procaterol [2 inhalaciones (20 μg) cada 8 horas] y salbutamol [2 inhalaciones (200 μg) cada 6 horas]. Antes y después de dicho período de estudio, se determinó la espirometría forzada y capacidad residual funcional (TGV) y resistencia de vías aéreas por pletismografía, expresada como conductancia específica (SGaw). Estos parámetros fueron analizados de nuevo tras 15 min, 60 min, 4 horas y 6 horas de la inhalación de cada uno de ambos broncodi-latadores. Entre ambos períodos de estudio se intercaló un período de reposo o «lavado» (washout) durante el cual el paciente no recibió medicación alguna. Nuestros resultados muestran que la eficacia broncodilatadora del procaterol, tanto tras su administración puntual como tras un período de tiempo más prolongado (1 semana), es equiparable a la obtenida tras el salbutamol. Destaca, además la ausencia de efectos secundarios.

To evaluate the bronchodilating effectiveness, duration of action and possible side effects of a new beta-2-adrenergic agent in aerosol (procaterol), an open crossover comparative study between procaterol and salbutamol was designed. Twenty patients were included (x¯ ± SD) (39 ± 2 years) with mild bronchial asthma (FEV1 ≥= 70%) in a phase of clinical stability. During one week, the patients received in random allocation either procaterol [two inhalations (20 μg) every 8 hours] and salbutamol [2 inhalations (200 μg) every 6 hours]. Before and after this study period, forced spirometry and functional residual capacity (TGV) were measured, as well as the airways resistence, evaluated with pletysmography and expressed as specific conductance (SGaw). These parameters were measured again 15 minutes, 60 minutes and 4 hours after the inhalation of each bronchodilator. A wash-out period, during which the patient did not receive any drug, was placed between both active study periods. Our results suggest that the bronchodilating effectiveness of procaterol, both measured acutely and after a more sustained period (1 week), is comparable to that of salbutamol. A remarkable finding was the absence of side effects.

Full text is only aviable in PDF
Bibliografía
[1.]
M.T. Newhouse, M.B. Dolovich.
Control of asthma by aerosols.
N Engl J Med, 315 (1986), pp. 870-874
[2.]
A.G.N. Agustí, P. Ussetti, J. Roca, J.M. Montserrat, R. Rodríguez-Roisín, A. Agustí-Vidal.
Asma bronquial y broncodilatadores en aerosol: empleo incorrecto en nuestro medio.
Med Clin, 81 (1983), pp. 893-894
[3.]
J. Sanchis.
Broncodilatadores en aerosol.
Med Clin, 81 (1983), pp. 898-900
[4.]
Y. Yabuuchi.
Pharmacological studies of OPC-2009, a newly synthesized selective beta adrenoceptor stimulant in the bronchomotor and cardiovascular system of the anesthetized dog.
J Phar Exp Ther, 202 (1977), pp. 326-336
[5.]
S. Tei.
The β-adrenoceptor stimulant action of procaterol (OPC-2009), a new (β2-adrenoceptor stimulant, on bronchial resistance and heart rate in guinea pigs.
Pharmacometrics, 17 (1979), pp. 335-340
[6.]
C. Picado, F. Burgos, J. Roca, H. Sala, F. Segarra, A. Agustí-Vidal, J. Sanchís.
Respuesta al salbutamol en no fumadores sanos.
Libro de comunicaciones de la 11 Reunión Nacional SEPAR, Santander, (1981),
[7.]
J. Sanchis, P. Casan, J. Castillo, N. González Mangado, L. Palenciano, J. Roca.
Normativa SEPAR para la espirometría forzada.
Ed Doyma, (1985),
[8.]
J. Roca, J. Sanchís, A. Agustí-Vidal, F. Segarra, D. Navajas, R. Rodríguez-Roisín, P. Casán, S. Sans.
Spirometric reference values for a mediterranean population.
Bull Europ Physiopathol Respir, 22 (1986), pp. 217-224
[9.]
J. Roca, F. Segarra, R. Rodríguez-Roisín, E. Cobo, J. Martínez, A. Agustí-Vidal.
Static lung volumes and single-breath diffusion capacity reference values from a latin population (abstract).
Am Rev Respir Dis, 131 (1985), pp. 352
[10.]
K. Godfrey.
Comparing means of several groups.
Medical uses of statistics, pp. 205-234
Copyright © 1989. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?