Eficacia broncodilatadora del clorhidrato de procaterol: analisis comparativo con salbutamol
Bronchodilating effectiveness of procaterol hydrochloride: a comparative analysis with salbutamol
A.G.N. Agustí, F. Burgos, R. Rodríguez Roisín, A. Agustí Vidal
Servei de Pneumologia. Hospital Clinic. Facultat de Medicina. Universitat de Barcelona
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Pellicer Císcar, M. Perpiñá Tordera, V. Marco Martínez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "C." "apellidos" => "Pellicer Císcar" ] 1 => array:2 [ "nombre" => "M." "apellidos" => "Perpiñá Tordera" ] 2 => array:2 [ "nombre" => "V." "apellidos" => "Marco Martínez" ] ] ] ] ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289615317610?idApp=UINPBA00003Z" "url" => "/03002896/0000002500000002/v1_201509151020/S0300289615317610/v1_201509151020/es/main.assets" ] "es" => array:13 [ "idiomaDefecto" => true "titulo" => "Eficacia broncodilatadora del clorhidrato de procaterol: analisis comparativo con salbutamol" "tieneTextoCompleto" => 0 "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "61" "paginaFinal" => "64" ] ] "autores" => array:1 [ 0 => array:3 [ "autoresLista" => "A.G.N. Agustí, F. Burgos, R. Rodríguez Roisín, A. Agustí Vidal" "autores" => array:4 [ 0 => array:2 [ "nombre" => "A.G.N." "apellidos" => "Agustí" ] 1 => array:2 [ "nombre" => "F." "apellidos" => "Burgos" ] 2 => array:2 [ "nombre" => "R." "apellidos" => "Rodríguez Roisín" ] 3 => array:2 [ "nombre" => "A." "apellidos" => "Agustí Vidal" ] ] "afiliaciones" => array:1 [ 0 => array:2 [ "entidad" => "Servei de Pneumologia. Hospital Clinic. Facultat de Medicina. Universitat de Barcelona" "identificador" => "aff0005" ] ] ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Bronchodilating effectiveness of procaterol hydrochloride: a comparative analysis with salbutamol" ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "1988-03-18" "fechaAceptado" => "1988-10-26" "tieneResumen" => true "resumen" => array:2 [ "es" => array:1 [ "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Con objeto de analizar la eficacia broncodilatadora, duración de acción y posibles efectos secundarios de un nuevo agente β<span class="elsevierStyleInf">2</span> adrenérgico en aerosol (procaterol), se diseñó un estudio abierto y cruzado de comparación entre procaterol y salbutamol. Se han incluido 20 pacientes (x¯ ± DE) (39 ± 2 años) con asma bronquial leve (FEV<span class="elsevierStyleInf">1</span> ≥= 70%) en fase de estabilidad clínica. Durante una semana, los pacientes recibieron de forma aleatoria procaterol [2 inhalaciones (20 μg) cada 8 horas] y salbutamol [2 inhalaciones (200 μg) cada 6 horas]. Antes y después de dicho período de estudio, se determinó la espirometría forzada y capacidad residual funcional (TGV) y resistencia de vías aéreas por pletismografía, expresada como conductancia específica (SGaw). Estos parámetros fueron analizados de nuevo tras 15 min, 60 min, 4 horas y 6 horas de la inhalación de cada uno de ambos broncodi-latadores. Entre ambos períodos de estudio se intercaló un período de reposo o «lavado» (<span class="elsevierStyleItalic">washout</span>) durante el cual el paciente no recibió medicación alguna. Nuestros resultados muestran que la eficacia broncodilatadora del procaterol, tanto tras su administración puntual como tras un período de tiempo más prolongado (1 semana), es equiparable a la obtenida tras el salbutamol. Destaca, además la ausencia de efectos secundarios.</p></span>" ] "en" => array:1 [ "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the bronchodilating effectiveness, duration of action and possible side effects of a new beta-2-adrenergic agent in aerosol (procaterol), an open crossover comparative study between procaterol and salbutamol was designed. Twenty patients were included (x¯ ± SD) (39 ± 2 years) with mild bronchial asthma (FEV<span class="elsevierStyleInf">1</span> ≥= 70%) in a phase of clinical stability. During one week, the patients received in random allocation either procaterol [two inhalations (20 μg) every 8 hours] and salbutamol [2 inhalations (200 μg) every 6 hours]. Before and after this study period, forced spirometry and functional residual capacity (TGV) were measured, as well as the airways resistence, evaluated with pletysmography and expressed as specific conductance (SGaw). These parameters were measured again 15 minutes, 60 minutes and 4 hours after the inhalation of each bronchodilator. A wash-out period, during which the patient did not receive any drug, was placed between both active study periods. Our results suggest that the bronchodilating effectiveness of procaterol, both measured acutely and after a more sustained period (1 week), is comparable to that of salbutamol. A remarkable finding was the absence of side effects.</p></span>" ] ] "bibliografia" => array:2 [ "titulo" => "Bibliografía" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:10 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1." 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