array:23 [
  "pii" => "S1579212908600907"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(08)60090-7"
  "estado" => "S300"
  "fechaPublicacion" => "2008-01-01"
  "aid" => "60090"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2008"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "sco"
  "cita" => "Arch Bronconeumol. 2008;44:499-503"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 6053
    "formatos" => array:3 [
      "EPUB" => 117
      "HTML" => 5065
      "PDF" => 871
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212908600919"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(08)60091-9"
    "estado" => "S300"
    "fechaPublicacion" => "2008-01-01"
    "aid" => "60091"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "sco"
    "cita" => "Arch Bronconeumol. 2008;44:504-6"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2954
      "formatos" => array:3 [
        "EPUB" => 109
        "HTML" => 1924
        "PDF" => 921
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>"
      "titulo" => "Spirometric Evaluation of Respiratory Involvement in Asymptomatic Multinodular Goiter With an Intrathoracic Component"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "504"
          "paginaFinal" => "506"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Antonio R&#237;os, Jos&#233; Manuel Rodr&#237;guez, Pedro Jos&#233; Galindo, Pedro Antonio Cascales, Mar&#237;a Balsalobre, Pascual Parrilla"
          "autores" => array:6 [
            0 => array:2 [
              "nombre" => "Antonio"
              "apellidos" => "R&#237;os"
            ]
            1 => array:2 [
              "nombre" => "Jos&#233;"
              "apellidos" => "Manuel Rodr&#237;guez"
            ]
            2 => array:2 [
              "nombre" => "Pedro Jos&#233;"
              "apellidos" => "Galindo"
            ]
            3 => array:2 [
              "nombre" => "Pedro Antonio"
              "apellidos" => "Cascales"
            ]
            4 => array:2 [
              "nombre" => "Mar&#237;a"
              "apellidos" => "Balsalobre"
            ]
            5 => array:2 [
              "nombre" => "Pascual"
              "apellidos" => "Parrilla"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600919?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004400000009/v1_201305150400/S1579212908600919/v1_201305150400/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212908600890"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(08)60089-0"
    "estado" => "S300"
    "fechaPublicacion" => "2008-01-01"
    "aid" => "60089"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "rev"
    "cita" => "Arch Bronconeumol. 2008;44:493-8"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 2622
      "formatos" => array:3 [
        "EPUB" => 108
        "HTML" => 1926
        "PDF" => 588
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Review Article</span>"
      "titulo" => "Positron Emission Tomography for the Study of Solitary Pulmonary Nodules"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "493"
          "paginaFinal" => "498"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "Iv&#225;n M&#225;rquez Rodas, Javier de Miguel D&#237;ez, Jos&#233; Luis &#193;lvarez-Sala"
          "autores" => array:3 [
            0 => array:2 [
              "nombre" => "Iv&#225;n"
              "apellidos" => "M&#225;rquez Rodas"
            ]
            1 => array:2 [
              "nombre" => "Javier"
              "apellidos" => "de Miguel D&#237;ez"
            ]
            2 => array:2 [
              "nombre" => "Jos&#233; Luis"
              "apellidos" => "&#193;lvarez-Sala"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600890?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004400000009/v1_201305150400/S1579212908600890/v1_201305150400/en/main.assets"
  ]
  "en" => array:14 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Case Reports</span>"
    "titulo" => "Desquamative Interstitial Pneumonia and Respiratory Bronchiolitis-Associated Interstitial Lung Disease&#58; Data From the Spanish Patient Registry"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "499"
        "paginaFinal" => "503"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "Adolfo Baloira, Antoni Xaubet, Eulogio Rodr&#237;guez Becerra, Ana Dolores Romero, &#193;lvaro Casanova, Julio Ancochea"
        "autores" => array:6 [
          0 => array:4 [
            "nombre" => "Adolfo"
            "apellidos" => "Baloira"
            "email" => array:1 [
              0 => "adolfobaloira&#64;sogapar&#46;org"
            ]
            "referencia" => array:2 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">a</span>"
                "identificador" => "aff1"
              ]
              1 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:3 [
            "nombre" => "Antoni"
            "apellidos" => "Xaubet"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">b</span>"
                "identificador" => "aff2"
              ]
            ]
          ]
          2 => array:3 [
            "nombre" => "Eulogio"
            "apellidos" => "Rodr&#237;guez Becerra"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">c</span>"
                "identificador" => "aff3"
              ]
            ]
          ]
          3 => array:3 [
            "nombre" => "Ana Dolores"
            "apellidos" => "Romero"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">d</span>"
                "identificador" => "aff4"
              ]
            ]
          ]
          4 => array:3 [
            "nombre" => "&#193;lvaro"
            "apellidos" => "Casanova"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff5"
              ]
            ]
          ]
          5 => array:3 [
            "nombre" => "Julio"
            "apellidos" => "Ancochea"
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">e</span>"
                "identificador" => "aff5"
              ]
            ]
          ]
        ]
        "afiliaciones" => array:5 [
          0 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Complejo Hospitalario&#44; Pontevedra&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">a</span>"
            "identificador" => "aff1"
          ]
          1 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Cl&#237;nic&#44; CIBER de Enfermedades Respiratorias&#44; Barcelona&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">b</span>"
            "identificador" => "aff2"
          ]
          2 => array:3 [
            "entidad" => "Unidad M&#233;dico Quir&#250;rgica&#44; Hospital Virgen del Roc&#237;o&#44; Sevilla&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">c</span>"
            "identificador" => "aff3"
          ]
          3 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital Virgen de las Nieves&#44; Granada&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">d</span>"
            "identificador" => "aff4"
          ]
          4 => array:3 [
            "entidad" => "Servicio de Neumolog&#237;a&#44; Hospital de la Princesa&#44; Madrid&#44; Spain"
            "etiqueta" => "<span class="elsevierStyleSup">e</span>"
            "identificador" => "aff5"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr A&#46; Baloira Servicio Neumolog&#237;a&#44; Hospital Montecelo Mourente Montecelo&#44; s&#47;n 36071 Pontevedra&#44; Spain"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2007-03-15"
    "fechaAceptado" => "2007-04-05"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key words"
          "identificador" => "xpalclavsec155403"
          "palabras" => array:3 [
            0 => "Desquamative interstitial pneumonia"
            1 => "Respiratory bronchiolitis-associated interstitial lung disease"
            2 => "Smoking"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec155404"
          "palabras" => array:3 [
            0 => "Neumon&#237;a intersticial descamativa"
            1 => "Bronquiolitis respiratoria asociada a enfermedad pulmonar intersticial"
            2 => "Tabaquismo"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Among the idiopathic interstitial lung diseases&#44; respiratory bronchiolitis-associated interstitial lung disease &#40;RB-ILD&#41; and desquamative interstitial pneumonia &#40;DIP&#41; make up a subgroup of rare diseases that are clearly smoking related&#46; Few large case series have been published&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">We describe 19 cases registered in Spain&#58; 12 patients with DIP and 7 with RB-ILD&#46; Clinical and radiologic features are described along with clinical course&#44; treatments applied&#44; and outcomes&#46; With the exception of 2 patients with DIP&#44; all were smokers or ex-smokers&#46; Cough and dyspnea were the most common symptoms at onset in both diseases&#46; The most frequent radiologic findings were ground-glass opacity in DIP and pulmonary nodules in BR-ILD&#46; Most patients were treated with corticosteroids&#46; Outcomes were good in general&#59; only 1 patient&#44; with DIP&#44; died&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<p class="elsevierStyleSimplePara elsevierViewall">Dentro de las neumopat&#237;as intersticiales idiop&#225;ticas&#44; la bronquiolitis respiratoria asociada a enfermedad pulmonar intersticial &#40;BR-EPI&#41; y la neumon&#237;a intersticial descamativa &#40;NID&#41; forman un subgrupo de enfermedades raras que comparten una relaci&#243;n clara con el h&#225;bito tab&#225;quico&#46; Se han publicado pocas series con un n&#250;mero importante de pacientes&#46;</p><p class="elsevierStyleSimplePara elsevierViewall">En este trabajo se describen las caracter&#237;sticas de 19 casos &#40;12 con NID y 7 con BR-EPI&#41; recogidos en nuestro pa&#237;s&#46; Se detallan las caracter&#237;sticas cl&#237;nicas&#44; radiol&#243;gicas y evolutivas&#44; incluidos los tratamientos empleados y sus resultados&#46; Excepto 2 pacientes con NID&#44; todos eran o hab&#237;an sido fumadores&#46; Tos y disnea fueron los s&#237;ntomas de inicio m&#225;s frecuentes&#44; sin diferencias entre las 2 enfermedades&#46; La alteraci&#243;n radiol&#243;gica predominante en la NID fue el patr&#243;n en vidrio deslustrado&#44; y en la BR-EPI&#44; la presencia de n&#243;dulos pulmonares&#46; La mayor parte de los pacientes recibieron tratamiento con esteroides&#46; El pron&#243;stico en general fue bueno&#44; y falleci&#243; &#250;nicamente un paciente con NID&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "References"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:20 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Desquamative interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "AA Liebow"
                            1 => "A Steer"
                            2 => "JG Billingsley"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1965"
                        "volumen" => "38"
                        "paginaInicial" => "369"
                        "paginaFinal" => "404"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Desquamative interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "EA Gaensler"
                            1 => "AM Goff"
                            2 => "CM Prowse"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM196601202740301"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1966"
                        "volumen" => "274"
                        "paginaInicial" => "113"
                        "paginaFinal" => "128"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/5902256"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morphology and pathogenesis of desquamative interstitial pneumonitis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "E Valdivia"
                            1 => "G Hensley"
                            2 => "J Wu"
                            3 => "EP Leroy"
                            4 => "W Jaeschke"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1977"
                        "volumen" => "32"
                        "paginaInicial" => "7"
                        "paginaFinal" => "18"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/320710"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory bronchiolitis causing interstitial lung disease&#46; A clinicopathologic study of six cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "JL Myers"
                            1 => "CF Veal Jr"
                            2 => "MS Shin"
                            3 => "AL Katzenstein"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1987"
                        "volumen" => "135"
                        "paginaInicial" => "880"
                        "paginaFinal" => "884"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/3565934"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory bronchiolitisassociated interstitial lung disease and its relationship to desquamative interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "SA Yousem"
                            1 => "TV Colby"
                            2 => "EA Gaensler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Mayo Clin Proc"
                        "fecha" => "1989"
                        "volumen" => "64"
                        "paginaInicial" => "1373"
                        "paginaFinal" => "1380"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2593722"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory bronchiolitis&#44; respiratory bronchiolitisassociated interstitial lung disease&#44; and desquamative interstitial pneumonia&#58; different entities or part of the spectrum of the same disease process&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "LE Heyneman"
                            1 => "S Ward"
                            2 => "DA Lynch"
                            3 => "M Remy-Jardin"
                            4 => "T Johkoh"
                            5 => "NL M&#252;ller"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.173.6.10584810"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "1999"
                        "volumen" => "173"
                        "paginaInicial" => "1617"
                        "paginaFinal" => "1622"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10584810"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Natural history and treated course of usual and desquamative interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "CB Carrington"
                            1 => "EA Gaensler"
                            2 => "RE Coutu"
                            3 => "MX Fitzgerald"
                            4 => "RG Gupta"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1056/NEJM197804132981501"
                      "Revista" => array:6 [
                        "tituloSerie" => "N Engl J Med"
                        "fecha" => "1978"
                        "volumen" => "298"
                        "paginaInicial" => "801"
                        "paginaFinal" => "809"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/634315"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Desquamative interstitial pneumonia and respiratory bronchiolitisassociated interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "JH Ryu"
                            1 => "JL Myers"
                            2 => "SA Capizzi"
                            3 => "WW Douglas"
                            4 => "R Vassallo"
                            5 => "PA Decker"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.127.1.178"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2005"
                        "volumen" => "127"
                        "paginaInicial" => "178"
                        "paginaFinal" => "184"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15653981"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory bronchiolitis-interstitial lung disease&#46; Long-term outcome"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "J Portnoy"
                            1 => "KL Veraldi"
                            2 => "MI Schwarz"
                            3 => "CD Cool"
                            4 => "D Currant-Everett"
                            5 => "RM Cherniak"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1378/chest.06-1885"
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2007"
                        "volumen" => "131"
                        "paginaInicial" => "664"
                        "paginaFinal" => "671"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17356078"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "International multidisciplinary consensus classification of the idiopathic interstitial pneumonias"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "American Thoracic Society&#47;European Respiratory Society"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.165.2.ats01"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "2002"
                        "volumen" => "165"
                        "paginaInicial" => "277"
                        "paginaFinal" => "304"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11790668"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "J Moon"
                            1 => "RM Du Bois"
                            2 => "TV Colby"
                            3 => "DM Hansell"
                            4 => "AG Nicholson"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1999"
                        "volumen" => "54"
                        "paginaInicial" => "1009"
                        "paginaFinal" => "1014"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10525560"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Intractable desquamative pneumonia in a tattooed man"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "T Arai"
                            1 => "Y Inoue"
                            2 => "S Hayashi"
                            3 => "M Akira"
                            4 => "S Yamamoto"
                            5 => "WD Travis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Intern Med"
                        "fecha" => "2006"
                        "volumen" => "45"
                        "paginaInicial" => "1055"
                        "paginaFinal" => "1058"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17043377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Desquamative interstitial pneumonia associated with concurrent cytomegalovirus and Aspergillus pneumonia in a renal transplant recipient"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S Sung"
                            1 => "G Ko"
                            2 => "J Kim"
                            3 => "M Kim"
                            4 => "J Lee"
                            5 => "G Kim"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1093/ndt/gfh548"
                      "Revista" => array:6 [
                        "tituloSerie" => "Nephrol Dial Transplant"
                        "fecha" => "2005"
                        "volumen" => "20"
                        "paginaInicial" => "635"
                        "paginaFinal" => "638"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15735246"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Morphologic effects of cigarette smoking on airways and pulmonary parenchyma in healthy adult volunteers&#58; CT evaluation and correlation with pulmonary function tests"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "M Remy-Jardin"
                            1 => "J Remy"
                            2 => "C Boulenguez"
                            3 => "A Sobaszek"
                            4 => "JL Edme"
                            5 => "D Furon"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "1993"
                        "volumen" => "186"
                        "paginaInicial" => "105"
                        "paginaFinal" => "115"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Changes in HRCT findings in patients with respiratory bronchiolitis-associated interstitial lung disease after smoking cessation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Nakanishi"
                            1 => "Y Demura"
                            2 => "S Mizuno"
                            3 => "S Ameshima"
                            4 => "Y Chiba"
                            5 => "I Miyamori"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.00015506"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2007"
                        "volumen" => "29"
                        "paginaInicial" => "453"
                        "paginaFinal" => "461"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17135233"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "A Caminati"
                            1 => "S Harari"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1513/pats.200512-135TK"
                      "Revista" => array:6 [
                        "tituloSerie" => "Proc Am Thorac Soc"
                        "fecha" => "2006"
                        "volumen" => "3"
                        "paginaInicial" => "299"
                        "paginaFinal" => "306"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16738193"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis&#58; high-resolution CT&#44; histologic&#44; and functional correlations"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R Vassallo"
                            1 => "EA Jensen"
                            2 => "TV Colby"
                            3 => "JH Ryu"
                            4 => "WW Douglas"
                            5 => "TE Hartman"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "2003"
                        "volumen" => "124"
                        "paginaInicial" => "1199"
                        "paginaFinal" => "1205"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14555547"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory bronchiolitis associated with interstitial lung disease and desquamative interstitial pneumonia"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G Davies"
                            1 => "AU Wells"
                            2 => "RM Du Bois"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.ccm.2004.06.004"
                      "Revista" => array:6 [
                        "tituloSerie" => "Clin Chest Med"
                        "fecha" => "2004"
                        "volumen" => "25"
                        "paginaInicial" => "717"
                        "paginaFinal" => "726"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15564017"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Respiratory bronchiolitis-associated interstitial lung disease"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "AU Wells"
                            1 => "AG Nicholson"
                            2 => "DM Hansell"
                            3 => "RM Du Bois"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1055/s-2004-815606"
                      "Revista" => array:6 [
                        "tituloSerie" => "Semin Respir Crit Care Med"
                        "fecha" => "2003"
                        "volumen" => "24"
                        "paginaInicial" => "585"
                        "paginaFinal" => "594"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16088575"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recurrence of desquamative interstitial pneumonia after lung transplantation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "MB King"
                            1 => "J Jessurun"
                            2 => "MI Herzt"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.156.6.9703001"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1997"
                        "volumen" => "156"
                        "paginaInicial" => "2003"
                        "paginaFinal" => "2005"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9412587"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004400000009/v1_201305150400/S1579212908600907/v1_201305150400/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004400000009/v1_201305150400/S1579212908600907/v1_201305150400/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212908600907?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 44. Issue 9.
Pages 499-503 (January 2008)
Share
Share
Download PDF
More article options
Vol. 44. Issue 9.
Pages 499-503 (January 2008)
Case Reports
Full text access
Desquamative Interstitial Pneumonia and Respiratory Bronchiolitis-Associated Interstitial Lung Disease: Data From the Spanish Patient Registry
Visits
9276
Adolfo Baloiraa,
Corresponding author
adolfobaloira@sogapar.org

Correspondence: Dr A. Baloira Servicio Neumología, Hospital Montecelo Mourente Montecelo, s/n 36071 Pontevedra, Spain
, Antoni Xaubetb, Eulogio Rodríguez Becerrac, Ana Dolores Romerod, Álvaro Casanovae, Julio Ancocheae
a Servicio de Neumología, Complejo Hospitalario, Pontevedra, Spain
b Servicio de Neumología, Hospital Clínic, CIBER de Enfermedades Respiratorias, Barcelona, Spain
c Unidad Médico Quirúrgica, Hospital Virgen del Rocío, Sevilla, Spain
d Servicio de Neumología, Hospital Virgen de las Nieves, Granada, Spain
e Servicio de Neumología, Hospital de la Princesa, Madrid, Spain
This item has received
Article information

Among the idiopathic interstitial lung diseases, respiratory bronchiolitis-associated interstitial lung disease (RB-ILD) and desquamative interstitial pneumonia (DIP) make up a subgroup of rare diseases that are clearly smoking related. Few large case series have been published.

We describe 19 cases registered in Spain: 12 patients with DIP and 7 with RB-ILD. Clinical and radiologic features are described along with clinical course, treatments applied, and outcomes. With the exception of 2 patients with DIP, all were smokers or ex-smokers. Cough and dyspnea were the most common symptoms at onset in both diseases. The most frequent radiologic findings were ground-glass opacity in DIP and pulmonary nodules in BR-ILD. Most patients were treated with corticosteroids. Outcomes were good in general; only 1 patient, with DIP, died.

Key words:
Desquamative interstitial pneumonia
Respiratory bronchiolitis-associated interstitial lung disease
Smoking

Dentro de las neumopatías intersticiales idiopáticas, la bronquiolitis respiratoria asociada a enfermedad pulmonar intersticial (BR-EPI) y la neumonía intersticial descamativa (NID) forman un subgrupo de enfermedades raras que comparten una relación clara con el hábito tabáquico. Se han publicado pocas series con un número importante de pacientes.

En este trabajo se describen las características de 19 casos (12 con NID y 7 con BR-EPI) recogidos en nuestro país. Se detallan las características clínicas, radiológicas y evolutivas, incluidos los tratamientos empleados y sus resultados. Excepto 2 pacientes con NID, todos eran o habían sido fumadores. Tos y disnea fueron los síntomas de inicio más frecuentes, sin diferencias entre las 2 enfermedades. La alteración radiológica predominante en la NID fue el patrón en vidrio deslustrado, y en la BR-EPI, la presencia de nódulos pulmonares. La mayor parte de los pacientes recibieron tratamiento con esteroides. El pronóstico en general fue bueno, y falleció únicamente un paciente con NID.

Palabras clave:
Neumonía intersticial descamativa
Bronquiolitis respiratoria asociada a enfermedad pulmonar intersticial
Tabaquismo
Full text is only aviable in PDF
References
[1]
AA Liebow, A Steer, JG Billingsley.
Desquamative interstitial pneumonia.
Am J Med, 38 (1965), pp. 369-404
[2]
EA Gaensler, AM Goff, CM Prowse.
Desquamative interstitial pneumonia.
N Engl J Med, 274 (1966), pp. 113-128
[3]
E Valdivia, G Hensley, J Wu, EP Leroy, W Jaeschke.
Morphology and pathogenesis of desquamative interstitial pneumonitis.
Thorax, 32 (1977), pp. 7-18
[4]
JL Myers, CF Veal Jr, MS Shin, AL Katzenstein.
Respiratory bronchiolitis causing interstitial lung disease. A clinicopathologic study of six cases.
Am Rev Respir Dis, 135 (1987), pp. 880-884
[5]
SA Yousem, TV Colby, EA Gaensler.
Respiratory bronchiolitisassociated interstitial lung disease and its relationship to desquamative interstitial pneumonia.
Mayo Clin Proc, 64 (1989), pp. 1373-1380
[6]
LE Heyneman, S Ward, DA Lynch, M Remy-Jardin, T Johkoh, NL Müller.
Respiratory bronchiolitis, respiratory bronchiolitisassociated interstitial lung disease, and desquamative interstitial pneumonia: different entities or part of the spectrum of the same disease process?.
AJR Am J Roentgenol, 173 (1999), pp. 1617-1622
[7]
CB Carrington, EA Gaensler, RE Coutu, MX Fitzgerald, RG Gupta.
Natural history and treated course of usual and desquamative interstitial pneumonia.
N Engl J Med, 298 (1978), pp. 801-809
[8]
JH Ryu, JL Myers, SA Capizzi, WW Douglas, R Vassallo, PA Decker.
Desquamative interstitial pneumonia and respiratory bronchiolitisassociated interstitial lung disease.
Chest, 127 (2005), pp. 178-184
[9]
J Portnoy, KL Veraldi, MI Schwarz, CD Cool, D Currant-Everett, RM Cherniak, et al.
Respiratory bronchiolitis-interstitial lung disease. Long-term outcome.
Chest, 131 (2007), pp. 664-671
[10]
American Thoracic Society/European Respiratory Society.
International multidisciplinary consensus classification of the idiopathic interstitial pneumonias.
Am J Respir Crit Care Med, 165 (2002), pp. 277-304
[11]
J Moon, RM Du Bois, TV Colby, DM Hansell, AG Nicholson.
Clinical significance of respiratory bronchiolitis on open lung biopsy and its relationship to smoking related interstitial lung disease.
Thorax, 54 (1999), pp. 1009-1014
[12]
T Arai, Y Inoue, S Hayashi, M Akira, S Yamamoto, WD Travis, et al.
Intractable desquamative pneumonia in a tattooed man.
Intern Med, 45 (2006), pp. 1055-1058
[13]
S Sung, G Ko, J Kim, M Kim, J Lee, G Kim, et al.
Desquamative interstitial pneumonia associated with concurrent cytomegalovirus and Aspergillus pneumonia in a renal transplant recipient.
Nephrol Dial Transplant, 20 (2005), pp. 635-638
[14]
M Remy-Jardin, J Remy, C Boulenguez, A Sobaszek, JL Edme, D Furon.
Morphologic effects of cigarette smoking on airways and pulmonary parenchyma in healthy adult volunteers: CT evaluation and correlation with pulmonary function tests.
Radiology, 186 (1993), pp. 105-115
[15]
M Nakanishi, Y Demura, S Mizuno, S Ameshima, Y Chiba, I Miyamori, et al.
Changes in HRCT findings in patients with respiratory bronchiolitis-associated interstitial lung disease after smoking cessation.
Eur Respir J, 29 (2007), pp. 453-461
[16]
A Caminati, S Harari.
Smoking-related interstitial pneumonias and pulmonary Langerhans cell histiocytosis.
Proc Am Thorac Soc, 3 (2006), pp. 299-306
[17]
R Vassallo, EA Jensen, TV Colby, JH Ryu, WW Douglas, TE Hartman, et al.
The overlap between respiratory bronchiolitis and desquamative interstitial pneumonia in pulmonary Langerhans cell histiocytosis: high-resolution CT, histologic, and functional correlations.
Chest, 124 (2003), pp. 1199-1205
[18]
G Davies, AU Wells, RM Du Bois.
Respiratory bronchiolitis associated with interstitial lung disease and desquamative interstitial pneumonia.
Clin Chest Med, 25 (2004), pp. 717-726
[19]
AU Wells, AG Nicholson, DM Hansell, RM Du Bois.
Respiratory bronchiolitis-associated interstitial lung disease.
Semin Respir Crit Care Med, 24 (2003), pp. 585-594
[20]
MB King, J Jessurun, MI Herzt.
Recurrence of desquamative interstitial pneumonia after lung transplantation.
Am J Respir Crit Care Med, 156 (1997), pp. 2003-2005
Copyright © 2008. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?