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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Persulfate salts are among the most frequently implicated causes of occupational asthma&#46; The aim of this study was to describe the course of bronchial hyperresponsiveness and immunologic test results in patients with occupational asthma due to persulfate salts&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">Ten patients with occupational asthma due to persulfate salts were studied&#46; Diagnosis was based on specific bronchial challenge tests performed at least 3 years before enrollment&#46; An exhaustive medical and work history was taken during interviews with all patients&#44; and all underwent spirometry and nonspecific bronchial challenge testing&#46; Total immunoglobulin E levels were determined and skin prick tests to several persulfate salts were performed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">At the time of evaluation&#44; 7 patients had avoided workplace exposure to persulfate salts&#46; The bronchial hyperresponsiveness of 3 of those 7 patients had improved significantly&#46; No improvement was observed in patients who continued to be exposed&#46; Specific skin prick tests became negative in 3 patients who were no longer exposed at the time of the follow-up evaluation&#46; Most of the patients continued to report symptoms&#44; although improvements were noted&#46; One patient&#44; however&#44; reported worsening of symptoms in spite of avoidance of exposure&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Although asthma symptoms and bronchial hyperresponsiveness may persist for patients with occupational asthma due to persulfate salts&#44; their condition seems to improve if they avoid exposure&#46; This course does not seem to differ from that reported for other cases of occupational asthma&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Las sales de persulfato son uno de los agentes m&#225;s frecuentemente implicados en el origen del asma ocupacional &#40;AO&#41;&#46; El objetivo de este estudio ha sido establecer la evoluci&#243;n de la hiperrespuesta bronquial y de las pruebas inmunol&#243;gicas en pacientes con AO por persulfatos en funci&#243;n de que persista o no la exposici&#243;n a dichas sales&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes y m&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Se estudi&#243; a 10 pacientes con AO por exposici&#243;n a sales de persulfato&#44; diagnosticados con prueba de provocaci&#243;n bronquial espec&#237;fica&#44; en los que como m&#237;nimo hab&#237;an transcurrido 3 a&#241;os tras el diagn&#243;stico&#46; En todos los casos se realizaron un exhaustivo interrogatorio cl&#237;nico y laboral&#44; espirometr&#237;a forzada y prueba de provocaci&#243;n bronquial inespec&#237;fica con metacolina&#44; se determinaron los valores de inmunoglobulina E total y se practicaron pruebas cut&#225;neas con las distintas sales de persulfato&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En el momento del control evolutivo&#44; 7 pacientes hab&#237;an abandonado la exposici&#243;n a persulfatos&#46; De los pacientes con hiperrespuesta bronquial positiva que hab&#237;an abandonado el trabajo&#44; se observ&#243; una mejor&#237;a significativa de &#233;sta en 3 de ellos&#46; Este hecho no se observ&#243; en ninguno de los pacientes que siguieron expuestos&#46; La prueba cut&#225;nea espec&#237;fica se negativiz&#243; en 3 pacientes que no estaban expuestos en el momento del control evolutivo&#46; Desde el punto de vista cl&#237;nico&#44; la mayor&#237;a de los pacientes continuaron presentando s&#237;ntomas&#44; aunque &#233;stos hab&#237;an mejorado&#44; excepto en un caso en que&#44; a pesar de evitar la exposici&#243;n&#44; empeoraron&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque pueden persistir los s&#237;ntomas de asma y la hiperrespuesta bronquial positiva&#44; la evoluci&#243;n de los pacientes con AO por persulfato parece ser favorable si se evita la exposici&#243;n&#46; Esta respuesta no parece diferir de la comunicada en otros casos de AO&#46;</p>"
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Vol. 44. Issue 3.
Pages 140-145 (January 2008)
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Vol. 44. Issue 3.
Pages 140-145 (January 2008)
Original Articles
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Course of Bronchial Hyperresponsiveness in Patients With Occupational Asthma Caused by Exposure to Persulfate Salts
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Xavier Muñoza,b,c,
Corresponding author
xmunoz@vhebron.net

Correspondence: Dr X. Muñoz Servei de Pneumologia, Hospital General Vall d'Hebron Pg. Vall d'Hebron, 11908035 Barcelona, Spain
, Susana Gómez-Ollésa,b, María Jesús Cruza,b, María Dolores Untoriaa,b, Ramon Orriolsa,b, Ferran Morella,b
a Servei de Pneumologia, Hospital Vall d'Hebron, Barcelona, Spain
b CIBER Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III, Madrid, Spain
c Departament de Biologia Cel·lular, Fisiologia, Immunologia, Universitat Autònoma de Barcelona, Barcelona, Spain
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Article information
Objective

Persulfate salts are among the most frequently implicated causes of occupational asthma. The aim of this study was to describe the course of bronchial hyperresponsiveness and immunologic test results in patients with occupational asthma due to persulfate salts.

Patients and methods

Ten patients with occupational asthma due to persulfate salts were studied. Diagnosis was based on specific bronchial challenge tests performed at least 3 years before enrollment. An exhaustive medical and work history was taken during interviews with all patients, and all underwent spirometry and nonspecific bronchial challenge testing. Total immunoglobulin E levels were determined and skin prick tests to several persulfate salts were performed.

Results

At the time of evaluation, 7 patients had avoided workplace exposure to persulfate salts. The bronchial hyperresponsiveness of 3 of those 7 patients had improved significantly. No improvement was observed in patients who continued to be exposed. Specific skin prick tests became negative in 3 patients who were no longer exposed at the time of the follow-up evaluation. Most of the patients continued to report symptoms, although improvements were noted. One patient, however, reported worsening of symptoms in spite of avoidance of exposure.

Conclusions

Although asthma symptoms and bronchial hyperresponsiveness may persist for patients with occupational asthma due to persulfate salts, their condition seems to improve if they avoid exposure. This course does not seem to differ from that reported for other cases of occupational asthma.

Key words:
Methacholine
Skin prick test
Follow-up monitoring
Rhinitis
Hairdressers
Objetivo

Las sales de persulfato son uno de los agentes más frecuentemente implicados en el origen del asma ocupacional (AO). El objetivo de este estudio ha sido establecer la evolución de la hiperrespuesta bronquial y de las pruebas inmunológicas en pacientes con AO por persulfatos en función de que persista o no la exposición a dichas sales.

Pacientes y métodos

Se estudió a 10 pacientes con AO por exposición a sales de persulfato, diagnosticados con prueba de provocación bronquial específica, en los que como mínimo habían transcurrido 3 años tras el diagnóstico. En todos los casos se realizaron un exhaustivo interrogatorio clínico y laboral, espirometría forzada y prueba de provocación bronquial inespecífica con metacolina, se determinaron los valores de inmunoglobulina E total y se practicaron pruebas cutáneas con las distintas sales de persulfato.

Resultados

En el momento del control evolutivo, 7 pacientes habían abandonado la exposición a persulfatos. De los pacientes con hiperrespuesta bronquial positiva que habían abandonado el trabajo, se observó una mejoría significativa de ésta en 3 de ellos. Este hecho no se observó en ninguno de los pacientes que siguieron expuestos. La prueba cutánea específica se negativizó en 3 pacientes que no estaban expuestos en el momento del control evolutivo. Desde el punto de vista clínico, la mayoría de los pacientes continuaron presentando síntomas, aunque éstos habían mejorado, excepto en un caso en que, a pesar de evitar la exposición, empeoraron.

Conclusiones

Aunque pueden persistir los síntomas de asma y la hiperrespuesta bronquial positiva, la evolución de los pacientes con AO por persulfato parece ser favorable si se evita la exposición. Esta respuesta no parece diferir de la comunicada en otros casos de AO.

Palabras clave:
Metacolina
Prueba cutánea
Seguimiento
Rinitis
Profesionales de peluquería
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This study was partly funded by grant number FIS PI050100 from the Carlos III Institute of Health.

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