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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Recommendations that purified protein derivative &#40;PPD&#41; RT-23 tuberculin should not be kept and used more than 24 to 48 hours after opening are rarely complied with&#46; The aim of this study was to determine whether using PPD RT-23 tuberculin from vials that had been open for a longer time could affect results of tuberculin tests and whether the solution could become contaminated&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective cross-sectional study was carried out&#46; Two tuberculin tests were simultaneously administered&#44; one in each forearm&#44; to adult contacts of patients with active tuberculosis&#44; one test using a recently opened vial of tuberculin &#40;control&#41; and the other using tuberculin that had been opened a week before &#40;first phase&#41; or a month before &#40;second phase&#41; &#40;study tuberculin&#41;&#46; Leftover tuberculin from several of the vials was cultured&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">For the 127 patients in the first group &#40;tuberculin opened 1 week&#41;&#44; the mean &#40;SD&#41; diameter of the induration was 6&#46;2 &#40;6&#46;9&#41; mm for the study tuberculin and 6&#46;3 &#40;6&#46;9&#41; mm for the control &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;3&#41;&#46; For the 83 patients in the second group &#40;tuberculin opened 1 month&#41;&#44; the mean diameter of the induration was 5&#46;5 &#40;7&#46;3&#41; mm for the study tuberculin and 5&#46;7 &#40;7&#46;3&#41; mm for the control &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;5&#41;&#46; There were no differences between the number of positive tests found&#46; None of the cultured tuberculins produced bacterial growth&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">PPD RT-23 tuberculin does not appear to lose potency or sterility when vials have been opened for a week or a month&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque se recomienda que tras la apertura y utilizaci&#243;n de los viales de tuberculina PPD RT-23 el producto restante no debe usarse pasadas 24-48 h&#44; esto habitualmente no se cumple&#46; El prop&#243;sito de este estudio es evaluar si el mantenimiento de los frascos de tuberculina PPD RT-23 abiertos durante m&#225;s tiempo de lo recomendado puede influir en los resultados de la prueba de la tuberculina o en la posibilidad de la contaminaci&#243;n microbiana del producto&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo transversal&#46; Se realizaron de forma sincr&#243;nica 2 pruebas de la tuberculina en distintos antebrazos a contactos adultos de enfermos con tuberculosis activa&#44; una con la tuberculina reci&#233;n abierta &#40;control&#41; y otra con tuberculina de un frasco abierto una semana &#40;en una primera fase&#41; o un mes antes &#40;en una segunda fase&#41; &#40;tuberculina estudio&#41;&#46; Se cultiv&#243; la tuberculina sobrante de varios de los viales utilizados&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En los 127 pacientes del primer grupo &#40;una semana&#41;&#44; la media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; del di&#225;metro de la induraci&#243;n fue de 6&#44;2 &#177; 6&#44;7 mm con la tuberculina estudio y de 6&#44;3 &#177; 6&#44;9 mm con la control &#40;p &#61; 0&#44;3&#41;&#46; En los 81 pacientes del segundo grupo &#40;un mes&#41; fue de 5&#44;5 &#177; 7&#44;3 mm con la tuberculina estudio y de 5&#44;7 &#177; 7&#44;3 mm con la control &#40;p &#61; 0&#44;5&#41;&#46; No se observaron diferencias en la frecuencia de pruebas positivas&#46; En ninguna de las tuberculinas cultivadas se obtuvo crecimiento bacteriano&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Parece que la tuberculina PPD RT-23 2UT no pierde potencia ni se contamina&#44; aunque se mantengan abiertos los frascos durante una semana o un mes&#46;</p>"
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Journal Information
Vol. 40. Issue 7.
Pages 301-303 (July 2004)
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Vol. 40. Issue 7.
Pages 301-303 (July 2004)
Original Articles
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Conservation of Purified Protein Derivative RT-23 Tuberculin
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A. Fernández-Villar
Corresponding author
jfv01po@saludalia.com

Correspondence: Dr. A. Fernández-Villar. Joaquín Costa, 60, 6° C. 36004 Pontevedra. España
, A. Gorís, M. Otero, N. Chouciño, R. Vázquez, M.J. Muñoz, L. Piñeiro
Unidad de Tuberculosis de Vigo, Servicio de Neumología, Complejo Hospitalario Universitario Xeral-Cíes, Vigo, Pontevedra, Spain
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Objective

Recommendations that purified protein derivative (PPD) RT-23 tuberculin should not be kept and used more than 24 to 48 hours after opening are rarely complied with. The aim of this study was to determine whether using PPD RT-23 tuberculin from vials that had been open for a longer time could affect results of tuberculin tests and whether the solution could become contaminated.

Methods

A prospective cross-sectional study was carried out. Two tuberculin tests were simultaneously administered, one in each forearm, to adult contacts of patients with active tuberculosis, one test using a recently opened vial of tuberculin (control) and the other using tuberculin that had been opened a week before (first phase) or a month before (second phase) (study tuberculin). Leftover tuberculin from several of the vials was cultured.

Results

For the 127 patients in the first group (tuberculin opened 1 week), the mean (SD) diameter of the induration was 6.2 (6.9) mm for the study tuberculin and 6.3 (6.9) mm for the control (P = .3). For the 83 patients in the second group (tuberculin opened 1 month), the mean diameter of the induration was 5.5 (7.3) mm for the study tuberculin and 5.7 (7.3) mm for the control (P = .5). There were no differences between the number of positive tests found. None of the cultured tuberculins produced bacterial growth.

Conclusions

PPD RT-23 tuberculin does not appear to lose potency or sterility when vials have been opened for a week or a month.

Key Words:
Tuberculin
Tuberculin test
Conservation
Knowledge
Nursing
Objetivo

Aunque se recomienda que tras la apertura y utilización de los viales de tuberculina PPD RT-23 el producto restante no debe usarse pasadas 24-48 h, esto habitualmente no se cumple. El propósito de este estudio es evaluar si el mantenimiento de los frascos de tuberculina PPD RT-23 abiertos durante más tiempo de lo recomendado puede influir en los resultados de la prueba de la tuberculina o en la posibilidad de la contaminación microbiana del producto.

Métodos

Estudio prospectivo transversal. Se realizaron de forma sincrónica 2 pruebas de la tuberculina en distintos antebrazos a contactos adultos de enfermos con tuberculosis activa, una con la tuberculina recién abierta (control) y otra con tuberculina de un frasco abierto una semana (en una primera fase) o un mes antes (en una segunda fase) (tuberculina estudio). Se cultivó la tuberculina sobrante de varios de los viales utilizados.

Resultados

En los 127 pacientes del primer grupo (una semana), la media (± desviación estándar) del diámetro de la induración fue de 6,2 ± 6,7 mm con la tuberculina estudio y de 6,3 ± 6,9 mm con la control (p = 0,3). En los 81 pacientes del segundo grupo (un mes) fue de 5,5 ± 7,3 mm con la tuberculina estudio y de 5,7 ± 7,3 mm con la control (p = 0,5). No se observaron diferencias en la frecuencia de pruebas positivas. En ninguna de las tuberculinas cultivadas se obtuvo crecimiento bacteriano.

Conclusiones

Parece que la tuberculina PPD RT-23 2UT no pierde potencia ni se contamina, aunque se mantengan abiertos los frascos durante una semana o un mes.

Palabras clave:
Tuberculina
Prueba Conservación
Conocimientos
Enfermería
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Part of this study was presented at the 36th National Congress of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) in Zaragoza, June, 2003.

Copyright © 2004. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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