array:23 [
  "pii" => "S1579212906603066"
  "issn" => "15792129"
  "doi" => "10.1016/S1579-2129(06)60306-6"
  "estado" => "S300"
  "fechaPublicacion" => "2004-07-01"
  "aid" => "60306"
  "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
  "copyrightAnyo" => "2004"
  "documento" => "article"
  "crossmark" => 0
  "subdocumento" => "fla"
  "cita" => "Arch Bronconeumol. 2004;40:301-3"
  "abierto" => array:3 [
    "ES" => false
    "ES2" => false
    "LATM" => false
  ]
  "gratuito" => false
  "lecturas" => array:2 [
    "total" => 2714
    "formatos" => array:3 [
      "EPUB" => 73
      "HTML" => 1873
      "PDF" => 768
    ]
  ]
  "itemSiguiente" => array:18 [
    "pii" => "S1579212906603078"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(06)60307-8"
    "estado" => "S300"
    "fechaPublicacion" => "2004-07-01"
    "aid" => "60307"
    "copyright" => "Sociedad Española de Neumología y Cirugía Torácica (SEPAR)"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:304-10"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 1730
      "formatos" => array:3 [
        "EPUB" => 88
        "HTML" => 1080
        "PDF" => 562
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "Lung Cancer Incidence in the Province of Avila&#44; Spain&#44; in 2002 and Decade-Long Trends"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "304"
          "paginaFinal" => "310"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;R&#46; Hern&#225;ndez Hern&#225;ndez, J&#46;A&#46; Tapias del Pozo, P&#46; Moreno Canelo, A&#46; Rodr&#237;guez Puebla, S&#46; Paniagua Tejo, J&#46;C&#46; S&#225;nchez Marcos"
          "autores" => array:6 [
            0 => array:3 [
              "preGrado" => "Dr&#46;"
              "nombre" => "J&#46;R&#46;"
              "apellidos" => "Hern&#225;ndez Hern&#225;ndez"
            ]
            1 => array:2 [
              "nombre" => "J&#46;A&#46;"
              "apellidos" => "Tapias del Pozo"
            ]
            2 => array:2 [
              "nombre" => "P&#46;"
              "apellidos" => "Moreno Canelo"
            ]
            3 => array:2 [
              "nombre" => "A&#46;"
              "apellidos" => "Rodr&#237;guez Puebla"
            ]
            4 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Paniagua Tejo"
            ]
            5 => array:2 [
              "nombre" => "J&#46;C&#46;"
              "apellidos" => "S&#225;nchez Marcos"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603078?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004000000007/v1_201305150100/S1579212906603078/v1_201305150100/en/main.assets"
  ]
  "itemAnterior" => array:18 [
    "pii" => "S1579212906603054"
    "issn" => "15792129"
    "doi" => "10.1016/S1579-2129(06)60305-4"
    "estado" => "S300"
    "fechaPublicacion" => "2004-07-01"
    "aid" => "60305"
    "copyright" => "Sociedad Espa&#241;ola de Neumolog&#237;a y Cirug&#237;a Tor&#225;cica &#40;SEPAR&#41;"
    "documento" => "article"
    "crossmark" => 0
    "subdocumento" => "fla"
    "cita" => "Arch Bronconeumol. 2004;40:295-300"
    "abierto" => array:3 [
      "ES" => false
      "ES2" => false
      "LATM" => false
    ]
    "gratuito" => false
    "lecturas" => array:2 [
      "total" => 3301
      "formatos" => array:3 [
        "EPUB" => 101
        "HTML" => 2559
        "PDF" => 641
      ]
    ]
    "en" => array:10 [
      "idiomaDefecto" => true
      "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
      "titulo" => "In-Hospital and 2-Year Survival of Patients Treated With Mechanical Ventilation for Acute Exacerbation of COPD"
      "tienePdf" => "en"
      "tieneTextoCompleto" => 0
      "tieneResumen" => array:2 [
        0 => "en"
        1 => "es"
      ]
      "paginas" => array:1 [
        0 => array:2 [
          "paginaInicial" => "295"
          "paginaFinal" => "300"
        ]
      ]
      "contieneResumen" => array:2 [
        "en" => true
        "es" => true
      ]
      "contienePdf" => array:1 [
        "en" => true
      ]
      "autores" => array:1 [
        0 => array:2 [
          "autoresLista" => "J&#46;M&#46; Raurich, J&#46; P&#233;rez, J&#46; Ib&#225;&#241;ez, S&#46; Roig, S&#46; Batle"
          "autores" => array:5 [
            0 => array:3 [
              "preGrado" => "Dr&#46;"
              "nombre" => "J&#46;M&#46;"
              "apellidos" => "Raurich"
            ]
            1 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "P&#233;rez"
            ]
            2 => array:2 [
              "nombre" => "J&#46;"
              "apellidos" => "Ib&#225;&#241;ez"
            ]
            3 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Roig"
            ]
            4 => array:2 [
              "nombre" => "S&#46;"
              "apellidos" => "Batle"
            ]
          ]
        ]
      ]
    ]
    "idiomaDefecto" => "en"
    "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603054?idApp=UINPBA00003Z"
    "url" => "/15792129/0000004000000007/v1_201305150100/S1579212906603054/v1_201305150100/en/main.assets"
  ]
  "en" => array:15 [
    "idiomaDefecto" => true
    "cabecera" => "<span class="elsevierStyleTextfn">Original Articles</span>"
    "titulo" => "Conservation of Purified Protein Derivative RT-23 Tuberculin"
    "tieneTextoCompleto" => 0
    "paginas" => array:1 [
      0 => array:2 [
        "paginaInicial" => "301"
        "paginaFinal" => "303"
      ]
    ]
    "autores" => array:1 [
      0 => array:4 [
        "autoresLista" => "A&#46; Fern&#225;ndez-Villar, A&#46; Gor&#237;s, M&#46; Otero, N&#46; Chouci&#241;o, R&#46; V&#225;zquez, M&#46;J&#46; Mu&#241;oz, L&#46; Pi&#241;eiro"
        "autores" => array:7 [
          0 => array:5 [
            "preGrado" => "Dr&#46;"
            "nombre" => "A&#46;"
            "apellidos" => "Fern&#225;ndez-Villar"
            "email" => array:1 [
              0 => "jfv01po&#64;saludalia&#46;com"
            ]
            "referencia" => array:1 [
              0 => array:2 [
                "etiqueta" => "<span class="elsevierStyleSup">&#42;</span>"
                "identificador" => "cor1"
              ]
            ]
          ]
          1 => array:2 [
            "nombre" => "A&#46;"
            "apellidos" => "Gor&#237;s"
          ]
          2 => array:2 [
            "nombre" => "M&#46;"
            "apellidos" => "Otero"
          ]
          3 => array:2 [
            "nombre" => "N&#46;"
            "apellidos" => "Chouci&#241;o"
          ]
          4 => array:2 [
            "nombre" => "R&#46;"
            "apellidos" => "V&#225;zquez"
          ]
          5 => array:2 [
            "nombre" => "M&#46;J&#46;"
            "apellidos" => "Mu&#241;oz"
          ]
          6 => array:2 [
            "nombre" => "L&#46;"
            "apellidos" => "Pi&#241;eiro"
          ]
        ]
        "afiliaciones" => array:1 [
          0 => array:1 [
            "entidad" => "Unidad de Tuberculosis de Vigo&#44; Servicio de Neumolog&#237;a&#44; Complejo Hospitalario Universitario Xeral-C&#237;es&#44; Vigo&#44; Pontevedra&#44; Spain"
          ]
        ]
        "correspondencia" => array:1 [
          0 => array:3 [
            "identificador" => "cor1"
            "etiqueta" => "&#42;"
            "correspondencia" => "Correspondence&#58; Dr&#46; A&#46; Fern&#225;ndez-Villar&#46; Joaqu&#237;n Costa&#44; 60&#44; 6&#176; C&#46; 36004 Pontevedra&#46; Espa&#241;a"
          ]
        ]
      ]
    ]
    "pdfFichero" => "main.pdf"
    "tienePdf" => true
    "fechaRecibido" => "2003-10-28"
    "fechaAceptado" => "2004-01-01"
    "PalabrasClave" => array:2 [
      "en" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Key Words"
          "identificador" => "xpalclavsec153494"
          "palabras" => array:5 [
            0 => "Tuberculin"
            1 => "Tuberculin test"
            2 => "Conservation"
            3 => "Knowledge"
            4 => "Nursing"
          ]
        ]
      ]
      "es" => array:1 [
        0 => array:4 [
          "clase" => "keyword"
          "titulo" => "Palabras clave"
          "identificador" => "xpalclavsec153493"
          "palabras" => array:4 [
            0 => "Tuberculina"
            1 => "Prueba Conservaci&#243;n"
            2 => "Conocimientos"
            3 => "Enfermer&#237;a"
          ]
        ]
      ]
    ]
    "tieneResumen" => true
    "resumen" => array:2 [
      "en" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Recommendations that purified protein derivative &#40;PPD&#41; RT-23 tuberculin should not be kept and used more than 24 to 48 hours after opening are rarely complied with&#46; The aim of this study was to determine whether using PPD RT-23 tuberculin from vials that had been open for a longer time could affect results of tuberculin tests and whether the solution could become contaminated&#46;</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective cross-sectional study was carried out&#46; Two tuberculin tests were simultaneously administered&#44; one in each forearm&#44; to adult contacts of patients with active tuberculosis&#44; one test using a recently opened vial of tuberculin &#40;control&#41; and the other using tuberculin that had been opened a week before &#40;first phase&#41; or a month before &#40;second phase&#41; &#40;study tuberculin&#41;&#46; Leftover tuberculin from several of the vials was cultured&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">For the 127 patients in the first group &#40;tuberculin opened 1 week&#41;&#44; the mean &#40;SD&#41; diameter of the induration was 6&#46;2 &#40;6&#46;9&#41; mm for the study tuberculin and 6&#46;3 &#40;6&#46;9&#41; mm for the control &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;3&#41;&#46; For the 83 patients in the second group &#40;tuberculin opened 1 month&#41;&#44; the mean diameter of the induration was 5&#46;5 &#40;7&#46;3&#41; mm for the study tuberculin and 5&#46;7 &#40;7&#46;3&#41; mm for the control &#40;<span class="elsevierStyleItalic">P</span> &#61; &#46;5&#41;&#46; There were no differences between the number of positive tests found&#46; None of the cultured tuberculins produced bacterial growth&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">PPD RT-23 tuberculin does not appear to lose potency or sterility when vials have been opened for a week or a month&#46;</p>"
      ]
      "es" => array:1 [
        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque se recomienda que tras la apertura y utilizaci&#243;n de los viales de tuberculina PPD RT-23 el producto restante no debe usarse pasadas 24-48 h&#44; esto habitualmente no se cumple&#46; El prop&#243;sito de este estudio es evaluar si el mantenimiento de los frascos de tuberculina PPD RT-23 abiertos durante m&#225;s tiempo de lo recomendado puede influir en los resultados de la prueba de la tuberculina o en la posibilidad de la contaminaci&#243;n microbiana del producto&#46;</p> <span class="elsevierStyleSectionTitle">M&#233;todos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo transversal&#46; Se realizaron de forma sincr&#243;nica 2 pruebas de la tuberculina en distintos antebrazos a contactos adultos de enfermos con tuberculosis activa&#44; una con la tuberculina reci&#233;n abierta &#40;control&#41; y otra con tuberculina de un frasco abierto una semana &#40;en una primera fase&#41; o un mes antes &#40;en una segunda fase&#41; &#40;tuberculina estudio&#41;&#46; Se cultiv&#243; la tuberculina sobrante de varios de los viales utilizados&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En los 127 pacientes del primer grupo &#40;una semana&#41;&#44; la media &#40;&#177; desviaci&#243;n est&#225;ndar&#41; del di&#225;metro de la induraci&#243;n fue de 6&#44;2 &#177; 6&#44;7 mm con la tuberculina estudio y de 6&#44;3 &#177; 6&#44;9 mm con la control &#40;p &#61; 0&#44;3&#41;&#46; En los 81 pacientes del segundo grupo &#40;un mes&#41; fue de 5&#44;5 &#177; 7&#44;3 mm con la tuberculina estudio y de 5&#44;7 &#177; 7&#44;3 mm con la control &#40;p &#61; 0&#44;5&#41;&#46; No se observaron diferencias en la frecuencia de pruebas positivas&#46; En ninguna de las tuberculinas cultivadas se obtuvo crecimiento bacteriano&#46;</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Parece que la tuberculina PPD RT-23 2UT no pierde potencia ni se contamina&#44; aunque se mantengan abiertos los frascos durante una semana o un mes&#46;</p>"
      ]
    ]
    "NotaPie" => array:1 [
      0 => array:1 [
        "nota" => "<p class="elsevierStyleNotepara">Part of this study was presented at the 36th National Congress of the Spanish Society of Pulmonology and Thoracic Surgery &#40;SEPAR&#41; in Zaragoza&#44; June&#44; 2003&#46;</p>"
      ]
    ]
    "bibliografia" => array:2 [
      "titulo" => "REFERENCES"
      "seccion" => array:1 [
        0 => array:1 [
          "bibliografiaReferencia" => array:11 [
            0 => array:3 [
              "identificador" => "bib1"
              "etiqueta" => "1"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberculin surveys-why&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D Menzies"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "1998"
                        "volumen" => "2"
                        "paginaInicial" => "263"
                        "paginaFinal" => "264"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9559395"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            1 => array:3 [
              "identificador" => "bib2"
              "etiqueta" => "2"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conocimientos de los profesionales de enfermer&#237;a de atenci&#243;n primaria con relaci&#243;n a la prueba de intradermorreacci&#243;n de Mantoux"
                      "autores" => array:1 [
                        0 => array:3 [
                          "colaboracion" => "y grupo de trabajo ECPT"
                          "etal" => true
                          "autores" => array:6 [
                            0 => "MP C&#243;rcoles"
                            1 => "T Moreno"
                            2 => "P Comet"
                            3 => "MI Orts"
                            4 => "I G&#243;mez"
                            5 => "MA Mart&#237;nez"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Enfermer&#237;a Cl&#237;nica"
                        "fecha" => "2002"
                        "volumen" => "12"
                        "paginaInicial" => "135"
                        "paginaFinal" => "142"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            2 => array:3 [
              "identificador" => "bib3"
              "etiqueta" => "3"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberculina 5 UT PPD RT-23&#46; &#191;Se usa correctamente&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "V Cabriada"
                            1 => "JI Villate"
                            2 => "C Cara"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Med Clin &#40;Barc&#41;"
                        "fecha" => "2000"
                        "volumen" => "114"
                        "paginaInicial" => "119"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            3 => array:3 [
              "identificador" => "bib4"
              "etiqueta" => "4"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Guidelines for conducting tuberculin skin test surveys in high prevalence countries"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "T Arnadottir"
                            1 => "HL Rieder"
                            2 => "A Trebucq"
                            3 => "HT Waaler"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Tubercle Lung Dis"
                        "fecha" => "1996"
                        "volumen" => "77"
                        "numero" => "Suppl"
                        "paginaInicial" => "1"
                        "paginaFinal" => "20"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            4 => array:3 [
              "identificador" => "bib5"
              "etiqueta" => "5"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberculin for Mantoux testing&#46; Tuberculin PPD RT 23 SSI &#91;consulted 4&#47;2&#47;2002&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Statens Serum Institute"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available at&#58; http&#58;&#47;&#47;www&#46;serum&#46;dk&#47;sw378&#46;asp"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            5 => array:3 [
              "identificador" => "bib6"
              "etiqueta" => "6"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Tuberculina PPD Evans"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "V-I Vademecum Internacional"
                        "paginaInicial" => "454"
                        "serieFecha" => "1998"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            6 => array:3 [
              "identificador" => "bib7"
              "etiqueta" => "7"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conocimientos de los profesionales de enfermer&#237;a sobre la prueba de la tuberculina"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A rn&#225;ndez-Villar"
                            1 => "MJ Mu&#241;oz"
                            2 => "V Leiro"
                            3 => "M N&#250;&#241;ez"
                            4 => "R V&#225;zquez"
                            5 => "M Mosteiro"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2003"
                        "volumen" => "39"
                        "numero" => "Supl2"
                        "paginaInicial" => "130"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Recomendaciones SEPAR&#46; Normativa sobre la prevenci&#243;n de la tuberculosis"
                      "autores" => array:1 [
                        0 => array:2 [
                          "colaboracion" => "Grupo TIR de SEPAR"
                          "etal" => false
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Arch Bronconeumol"
                        "fecha" => "2002"
                        "volumen" => "38"
                        "paginaInicial" => "441"
                        "paginaFinal" => "451"
                        "itemHostRev" => array:3 [
                          "pii" => "S0161642010008596"
                          "estado" => "S300"
                          "issn" => "01616420"
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tuberculin PPD RT23&#58; still going strong"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "K Haslov"
                            1 => "S Ponce de Le&#243;n Rosales"
                            2 => "S Rangel-Frausto"
                            3 => "S Olesen Larsen"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Int J Tuberc Lung Dis"
                        "fecha" => "1998"
                        "volumen" => "2"
                        "paginaInicial" => "793"
                        "paginaFinal" => "795"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9783524"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Aventis Pasteur &#91;consulted 20&#47;8&#47;2003&#93;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "Tuberculin Turbesol"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "WWW" => array:1 [
                        "link" => "Available at&#58; http&#58;&#47;aventispasteur&#46;com&#47;usa&#47;pdffiles&#47;2000125&#37;20Turbesol&#37;20vs&#46;pdf"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Interpretation of repeated tuberculin tests&#46; Boosting&#44; conversion&#44; and reversion"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "D Menzies"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/ajrccm.159.1.9801120"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Respir Crit Care Med"
                        "fecha" => "1999"
                        "volumen" => "159"
                        "paginaInicial" => "15"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872812"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
    ]
  ]
  "idiomaDefecto" => "en"
  "url" => "/15792129/0000004000000007/v1_201305150100/S1579212906603066/v1_201305150100/en/main.assets"
  "Apartado" => null
  "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004000000007/v1_201305150100/S1579212906603066/v1_201305150100/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/"
  "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603066?idApp=UINPBA00003Z"
]
Share
Journal Information
Vol. 40. Issue 7.
Pages 301-303 (July 2004)
Share
Share
Download PDF
More article options
Vol. 40. Issue 7.
Pages 301-303 (July 2004)
Original Articles
Full text access
Conservation of Purified Protein Derivative RT-23 Tuberculin
Visits
5082
A. Fernández-Villar
Corresponding author
jfv01po@saludalia.com

Correspondence: Dr. A. Fernández-Villar. Joaquín Costa, 60, 6° C. 36004 Pontevedra. España
, A. Gorís, M. Otero, N. Chouciño, R. Vázquez, M.J. Muñoz, L. Piñeiro
Unidad de Tuberculosis de Vigo, Servicio de Neumología, Complejo Hospitalario Universitario Xeral-Cíes, Vigo, Pontevedra, Spain
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Objective

Recommendations that purified protein derivative (PPD) RT-23 tuberculin should not be kept and used more than 24 to 48 hours after opening are rarely complied with. The aim of this study was to determine whether using PPD RT-23 tuberculin from vials that had been open for a longer time could affect results of tuberculin tests and whether the solution could become contaminated.

Methods

A prospective cross-sectional study was carried out. Two tuberculin tests were simultaneously administered, one in each forearm, to adult contacts of patients with active tuberculosis, one test using a recently opened vial of tuberculin (control) and the other using tuberculin that had been opened a week before (first phase) or a month before (second phase) (study tuberculin). Leftover tuberculin from several of the vials was cultured.

Results

For the 127 patients in the first group (tuberculin opened 1 week), the mean (SD) diameter of the induration was 6.2 (6.9) mm for the study tuberculin and 6.3 (6.9) mm for the control (P = .3). For the 83 patients in the second group (tuberculin opened 1 month), the mean diameter of the induration was 5.5 (7.3) mm for the study tuberculin and 5.7 (7.3) mm for the control (P = .5). There were no differences between the number of positive tests found. None of the cultured tuberculins produced bacterial growth.

Conclusions

PPD RT-23 tuberculin does not appear to lose potency or sterility when vials have been opened for a week or a month.

Key Words:
Tuberculin
Tuberculin test
Conservation
Knowledge
Nursing
Objetivo

Aunque se recomienda que tras la apertura y utilización de los viales de tuberculina PPD RT-23 el producto restante no debe usarse pasadas 24-48 h, esto habitualmente no se cumple. El propósito de este estudio es evaluar si el mantenimiento de los frascos de tuberculina PPD RT-23 abiertos durante más tiempo de lo recomendado puede influir en los resultados de la prueba de la tuberculina o en la posibilidad de la contaminación microbiana del producto.

Métodos

Estudio prospectivo transversal. Se realizaron de forma sincrónica 2 pruebas de la tuberculina en distintos antebrazos a contactos adultos de enfermos con tuberculosis activa, una con la tuberculina recién abierta (control) y otra con tuberculina de un frasco abierto una semana (en una primera fase) o un mes antes (en una segunda fase) (tuberculina estudio). Se cultivó la tuberculina sobrante de varios de los viales utilizados.

Resultados

En los 127 pacientes del primer grupo (una semana), la media (± desviación estándar) del diámetro de la induración fue de 6,2 ± 6,7 mm con la tuberculina estudio y de 6,3 ± 6,9 mm con la control (p = 0,3). En los 81 pacientes del segundo grupo (un mes) fue de 5,5 ± 7,3 mm con la tuberculina estudio y de 5,7 ± 7,3 mm con la control (p = 0,5). No se observaron diferencias en la frecuencia de pruebas positivas. En ninguna de las tuberculinas cultivadas se obtuvo crecimiento bacteriano.

Conclusiones

Parece que la tuberculina PPD RT-23 2UT no pierde potencia ni se contamina, aunque se mantengan abiertos los frascos durante una semana o un mes.

Palabras clave:
Tuberculina
Prueba Conservación
Conocimientos
Enfermería
Full text is only aviable in PDF
REFERENCES
[1]
D Menzies.
Tuberculin surveys-why?.
Int J Tuberc Lung Dis, 2 (1998), pp. 263-264
[2]
MP Córcoles, T Moreno, P Comet, MI Orts, I Gómez, MA Martínez, y grupo de trabajo ECPT, et al.
Conocimientos de los profesionales de enfermería de atención primaria con relación a la prueba de intradermorreacción de Mantoux.
Enfermería Clínica, 12 (2002), pp. 135-142
[3]
V Cabriada, JI Villate, C Cara.
Tuberculina 5 UT PPD RT-23. ¿Se usa correctamente?.
Med Clin (Barc), 114 (2000), pp. 119
[4]
T Arnadottir, HL Rieder, A Trebucq, HT Waaler.
Guidelines for conducting tuberculin skin test surveys in high prevalence countries.
Tubercle Lung Dis, 77 (1996), pp. 1-20
[5]
Statens Serum Institute.
Tuberculin for Mantoux testing. Tuberculin PPD RT 23 SSI [consulted 4/2/2002].
[6]
Tuberculina PPD Evans.
V-I Vademecum Internacional, pp. 454
[7]
A rnández-Villar, MJ Muñoz, V Leiro, M Núñez, R Vázquez, M Mosteiro, et al.
Conocimientos de los profesionales de enfermería sobre la prueba de la tuberculina.
Arch Bronconeumol, 39 (2003), pp. 130
[8]
Grupo TIR de SEPAR.
Recomendaciones SEPAR. Normativa sobre la prevención de la tuberculosis.
Arch Bronconeumol, 38 (2002), pp. 441-451
[9]
K Haslov, S Ponce de León Rosales, S Rangel-Frausto, S Olesen Larsen.
Tuberculin PPD RT23: still going strong.
Int J Tuberc Lung Dis, 2 (1998), pp. 793-795
[10]
Tuberculin Turbesol.
Aventis Pasteur [consulted 20/8/2003].
[11]
D Menzies.
Interpretation of repeated tuberculin tests. Boosting, conversion, and reversion.
Am J Respir Crit Care Med, 159 (1999), pp. 15-21

Part of this study was presented at the 36th National Congress of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) in Zaragoza, June, 2003.

Copyright © 2004. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?