Original Articles
Conservation of Purified Protein Derivative RT-23 Tuberculin
A. Fernández-Villar
, A. Gorís, M. Otero, N. Chouciño, R. Vázquez, M.J. Muñoz, L. Piñeiro
Corresponding author
jfv01po@saludalia.com
Correspondence: Dr. A. Fernández-Villar. Joaquín Costa, 60, 6° C. 36004 Pontevedra. España
Correspondence: Dr. A. Fernández-Villar. Joaquín Costa, 60, 6° C. 36004 Pontevedra. España
Unidad de Tuberculosis de Vigo, Servicio de Neumología, Complejo Hospitalario Universitario Xeral-Cíes, Vigo, Pontevedra, Spain
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"apellidos" => "Fernández-Villar" "email" => array:1 [ 0 => "jfv01po@saludalia.com" ] "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor1" ] ] ] 1 => array:2 [ "nombre" => "A." "apellidos" => "Gorís" ] 2 => array:2 [ "nombre" => "M." "apellidos" => "Otero" ] 3 => array:2 [ "nombre" => "N." "apellidos" => "Chouciño" ] 4 => array:2 [ "nombre" => "R." "apellidos" => "Vázquez" ] 5 => array:2 [ "nombre" => "M.J." "apellidos" => "Muñoz" ] 6 => array:2 [ "nombre" => "L." "apellidos" => "Piñeiro" ] ] "afiliaciones" => array:1 [ 0 => array:1 [ "entidad" => "Unidad de Tuberculosis de Vigo, Servicio de Neumología, Complejo Hospitalario Universitario Xeral-Cíes, Vigo, Pontevedra, Spain" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor1" "etiqueta" => "*" "correspondencia" => "Correspondence: Dr. A. Fernández-Villar. Joaquín Costa, 60, 6° C. 36004 Pontevedra. España" ] ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2003-10-28" "fechaAceptado" => "2004-01-01" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Key Words" "identificador" => "xpalclavsec153494" "palabras" => array:5 [ 0 => "Tuberculin" 1 => "Tuberculin test" 2 => "Conservation" 3 => "Knowledge" 4 => "Nursing" ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec153493" "palabras" => array:4 [ 0 => "Tuberculina" 1 => "Prueba Conservación" 2 => "Conocimientos" 3 => "Enfermería" ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">Recommendations that purified protein derivative (PPD) RT-23 tuberculin should not be kept and used more than 24 to 48 hours after opening are rarely complied with. The aim of this study was to determine whether using PPD RT-23 tuberculin from vials that had been open for a longer time could affect results of tuberculin tests and whether the solution could become contaminated.</p> <span class="elsevierStyleSectionTitle">Methods</span><p class="elsevierStyleSimplePara elsevierViewall">A prospective cross-sectional study was carried out. Two tuberculin tests were simultaneously administered, one in each forearm, to adult contacts of patients with active tuberculosis, one test using a recently opened vial of tuberculin (control) and the other using tuberculin that had been opened a week before (first phase) or a month before (second phase) (study tuberculin). Leftover tuberculin from several of the vials was cultured.</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">For the 127 patients in the first group (tuberculin opened 1 week), the mean (SD) diameter of the induration was 6.2 (6.9) mm for the study tuberculin and 6.3 (6.9) mm for the control (<span class="elsevierStyleItalic">P</span> = .3). For the 83 patients in the second group (tuberculin opened 1 month), the mean diameter of the induration was 5.5 (7.3) mm for the study tuberculin and 5.7 (7.3) mm for the control (<span class="elsevierStyleItalic">P</span> = .5). There were no differences between the number of positive tests found. None of the cultured tuberculins produced bacterial growth.</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">PPD RT-23 tuberculin does not appear to lose potency or sterility when vials have been opened for a week or a month.</p>" ] "es" => array:1 [ "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque se recomienda que tras la apertura y utilización de los viales de tuberculina PPD RT-23 el producto restante no debe usarse pasadas 24-48 h, esto habitualmente no se cumple. El propósito de este estudio es evaluar si el mantenimiento de los frascos de tuberculina PPD RT-23 abiertos durante más tiempo de lo recomendado puede influir en los resultados de la prueba de la tuberculina o en la posibilidad de la contaminación microbiana del producto.</p> <span class="elsevierStyleSectionTitle">Métodos</span><p class="elsevierStyleSimplePara elsevierViewall">Estudio prospectivo transversal. Se realizaron de forma sincrónica 2 pruebas de la tuberculina en distintos antebrazos a contactos adultos de enfermos con tuberculosis activa, una con la tuberculina recién abierta (control) y otra con tuberculina de un frasco abierto una semana (en una primera fase) o un mes antes (en una segunda fase) (tuberculina estudio). Se cultivó la tuberculina sobrante de varios de los viales utilizados.</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">En los 127 pacientes del primer grupo (una semana), la media (± desviación estándar) del diámetro de la induración fue de 6,2 ± 6,7 mm con la tuberculina estudio y de 6,3 ± 6,9 mm con la control (p = 0,3). En los 81 pacientes del segundo grupo (un mes) fue de 5,5 ± 7,3 mm con la tuberculina estudio y de 5,7 ± 7,3 mm con la control (p = 0,5). No se observaron diferencias en la frecuencia de pruebas positivas. En ninguna de las tuberculinas cultivadas se obtuvo crecimiento bacteriano.</p> <span class="elsevierStyleSectionTitle">Conclusiones</span><p class="elsevierStyleSimplePara elsevierViewall">Parece que la tuberculina PPD RT-23 2UT no pierde potencia ni se contamina, aunque se mantengan abiertos los frascos durante una semana o un mes.</p>" ] ] "NotaPie" => array:1 [ 0 => array:1 [ "nota" => "<p class="elsevierStyleNotepara">Part of this study was presented at the 36th National Congress of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) in Zaragoza, June, 2003.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "REFERENCES" "seccion" => array:1 [ 0 => array:1 [ "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib1" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculin surveys-why?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D Menzies" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "1998" "volumen" => "2" "paginaInicial" => "263" "paginaFinal" => "264" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9559395" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib2" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conocimientos de los profesionales de enfermería de atención primaria con relación a la prueba de intradermorreacción de Mantoux" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "y grupo de trabajo ECPT" "etal" => true "autores" => array:6 [ 0 => "MP Córcoles" 1 => "T Moreno" 2 => "P Comet" 3 => "MI Orts" 4 => "I Gómez" 5 => "MA Martínez" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Enfermería Clínica" "fecha" => "2002" "volumen" => "12" "paginaInicial" => "135" "paginaFinal" => "142" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib3" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculina 5 UT PPD RT-23. ¿Se usa correctamente?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "V Cabriada" 1 => "JI Villate" 2 => "C Cara" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:4 [ "tituloSerie" => "Med Clin (Barc)" "fecha" => "2000" "volumen" => "114" "paginaInicial" => "119" ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib4" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guidelines for conducting tuberculin skin test surveys in high prevalence countries" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "T Arnadottir" 1 => "HL Rieder" 2 => "A Trebucq" 3 => "HT Waaler" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Tubercle Lung Dis" "fecha" => "1996" "volumen" => "77" "numero" => "Suppl" "paginaInicial" => "1" "paginaFinal" => "20" ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib5" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculin for Mantoux testing. Tuberculin PPD RT 23 SSI [consulted 4/2/2002]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Statens Serum Institute" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available at: http://www.serum.dk/sw378.asp" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib6" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:1 [ "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Tuberculina PPD Evans" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "LibroEditado" => array:3 [ "titulo" => "V-I Vademecum Internacional" "paginaInicial" => "454" "serieFecha" => "1998" ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib7" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Conocimientos de los profesionales de enfermería sobre la prueba de la tuberculina" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "A rnández-Villar" 1 => "MJ Muñoz" 2 => "V Leiro" 3 => "M Núñez" 4 => "R Vázquez" 5 => "M Mosteiro" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2003" "volumen" => "39" "numero" => "Supl2" "paginaInicial" => "130" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib8" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Recomendaciones SEPAR. Normativa sobre la prevención de la tuberculosis" "autores" => array:1 [ 0 => array:2 [ "colaboracion" => "Grupo TIR de SEPAR" "etal" => false ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2002" "volumen" => "38" "paginaInicial" => "441" "paginaFinal" => "451" "itemHostRev" => array:3 [ "pii" => "S0161642010008596" "estado" => "S300" "issn" => "01616420" ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib9" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Tuberculin PPD RT23: still going strong" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "K Haslov" 1 => "S Ponce de León Rosales" 2 => "S Rangel-Frausto" 3 => "S Olesen Larsen" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:6 [ "tituloSerie" => "Int J Tuberc Lung Dis" "fecha" => "1998" "volumen" => "2" "paginaInicial" => "793" "paginaFinal" => "795" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9783524" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib10" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Aventis Pasteur [consulted 20/8/2003]" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "Tuberculin Turbesol" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "WWW" => array:1 [ "link" => "Available at: http:/aventispasteur.com/usa/pdffiles/2000125%20Turbesol%20vs.pdf" ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib11" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Interpretation of repeated tuberculin tests. Boosting, conversion, and reversion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "D Menzies" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/ajrccm.159.1.9801120" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "1999" "volumen" => "159" "paginaInicial" => "15" "paginaFinal" => "21" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9872812" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000004000000007/v1_201305150100/S1579212906603066/v1_201305150100/en/main.assets" "Apartado" => null "PDF" => "https://static.elsevier.es/multimedia/15792129/0000004000000007/v1_201305150100/S1579212906603066/v1_201305150100/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212906603066?idApp=UINPBA00003Z" ]
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| 2015 February | 34 | 5 | 39 |
| 2015 January | 35 | 5 | 40 |
| 2014 December | 31 | 8 | 39 |
| 2014 November | 29 | 8 | 37 |
| 2014 October | 48 | 11 | 59 |
| 2014 September | 29 | 10 | 39 |
| 2014 August | 33 | 8 | 41 |
| 2014 July | 42 | 11 | 53 |
| 2014 June | 53 | 13 | 66 |
| 2014 May | 40 | 12 | 52 |
| 2014 April | 46 | 6 | 52 |
| 2014 March | 58 | 12 | 70 |
| 2014 February | 52 | 13 | 65 |
| 2014 January | 47 | 7 | 54 |
| 2013 December | 44 | 17 | 61 |
| 2013 November | 36 | 6 | 42 |
| 2013 October | 41 | 10 | 51 |
| 2013 September | 45 | 14 | 59 |
| 2013 August | 38 | 15 | 53 |
| 2013 July | 39 | 18 | 57 |
| 2013 June | 46 | 8 | 54 |
| 2013 May | 35 | 7 | 42 |
| 2013 April | 29 | 2 | 31 |
| 2013 March | 6 | 3 | 9 |
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