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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">To present our early experience in the treatment of primary malignant and metastatic lung lesions by radiofrequency ablation&#46;</p> <span class="elsevierStyleSectionTitle">Patients and methods</span><p class="elsevierStyleSimplePara elsevierViewall">From August 2004 through January 2007 we treated 19 patients &#40;in 26 procedures&#41; with curative or palliative intent&#46; None of the lesions was amenable to surgery and some had been treated previously&#46; The procedure was performed in the radiology room under conscious sedationanalgesia administered by an anesthesiologist&#46; Fourteen patients were treated for pulmonary lesions and 5 for metastatic lung disease in a context of controlled primary disease&#46; Treatment was with curative intent in 15 cases and palliative in 4&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">The radiofrequency technique was applicable in 26 procedures and the mean follow-up was 8&#46;68 months&#46; The principal complications of radiofrequency treatment were pneumothorax in 4 patients&#44; requiring drainage in only 2 cases&#59; pneumonitis in 4&#59; self-limiting pulmonary hemorrhage in 1&#59; and pleural effusion in 5&#46; There were no procedure-related deaths&#46; Six patients died during the follow-up period&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">In our experience&#44; radiofrequency offers a safe and minimally invasive option for the treatment of malignant lung lesions in appropriately selected&#44; nonsurgical patients&#46; Morbidity is low&#44; and in combination with other treatments this technique opens up a wide range of possibilities still to be explored&#46;</p>"
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                          "autores" => array:2 [
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                            5 => "N Christie"
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                        "paginaFinal" => "1148"
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                    0 => array:2 [
                      "doi" => "10.1002/cncr.10234"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "2002"
                        "volumen" => "94"
                        "paginaInicial" => "443"
                        "paginaFinal" => "451"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/11900230"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            7 => array:3 [
              "identificador" => "bib8"
              "etiqueta" => "8"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Primary lung cancer&#58; treatment with radiofrequency thermal ablation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "L Thanos"
                            1 => "S Mylona"
                            2 => "M Pomoni"
                            3 => "V Kalioras"
                            4 => "L Zoganas"
                            5 => "N Batakis"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00330-003-2189-9"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Radiol"
                        "fecha" => "2004"
                        "volumen" => "14"
                        "paginaInicial" => "897"
                        "paginaFinal" => "901"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14666377"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            8 => array:3 [
              "identificador" => "bib9"
              "etiqueta" => "9"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percutaneous radiofrequency ablation of malignancies in the lung"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "D Dupuy"
                            1 => "RJ Zagoria"
                            2 => "W Akerley"
                            3 => "WW Mayo-Smith"
                            4 => "PV Kavanagh"
                            5 => "H Safran"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.174.1.1740057"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "2000"
                        "volumen" => "174"
                        "paginaInicial" => "57"
                        "paginaFinal" => "59"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/10628454"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiofrequency ablation in lung cancer&#58; promising results in safety and efficacy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "R Suh"
                            1 => "K Reckamp"
                            2 => "M Zeidler"
                            3 => "R Cameron"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncology"
                        "fecha" => "2005"
                        "volumen" => "19"
                        "paginaInicial" => "12"
                        "paginaFinal" => "21"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16366374"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Minimally invasive techniques for managing pulmonary metastases&#58; video-assisted thoracic surgery and radiofrequency ablation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A Ketchedjian"
                            1 => "B Daly"
                            2 => "J Luketich"
                            3 => "HC Fernando"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:5 [
                        "paginaInicial" => "157"
                        "paginaFinal" => "165"
                        "serieVolumen" => "16"
                        "serieTitulo" => "Current surgical management of pulmonary metastases"
                        "serieFecha" => "2006"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percutaneous radiofrequency ablation of lung neoplasms&#58; initial therapeutic response"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Akeboshi"
                            1 => "K Yamakodo"
                            2 => "A Nakatsuka"
                            3 => "O Hataji"
                            4 => "O Taguchi"
                            5 => "M Takao"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Vasc Interv Radiol"
                        "fecha" => "2004"
                        "volumen" => "15"
                        "paginaInicial" => "463"
                        "paginaFinal" => "470"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15126656"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiofrequency ablation of primary and metastatic lung tumors&#58; preliminary experience with a single center device"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "D Lagan&#224;"
                            1 => "G Carrafiello"
                            2 => "M Mangini"
                            3 => "L Boni"
                            4 => "G Dionigi"
                            5 => "MC Fusi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Surg Endosc"
                        "fecha" => "2006"
                        "volumen" => "20"
                        "paginaInicial" => "1261"
                        "paginaFinal" => "1267"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiofrequency ablation for the treatment of stage I non-small cell lung cancer in high-risk patients"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "A Pennathur"
                            1 => "JD Luketich"
                            2 => "G Abbas"
                            3 => "M Chen"
                            4 => "HC Fernando"
                            5 => "WE Gooding"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.jtcvs.2007.04.060"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "2007"
                        "volumen" => "134"
                        "paginaInicial" => "857"
                        "paginaFinal" => "864"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17903496"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "New therapeutic approaches for early stage non-small cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "A el-Sherif"
                            1 => "JD Luketich"
                            2 => "RJ Landreneau"
                            3 => "HC Fernando"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.suronc.2004.11.002"
                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Oncol"
                        "fecha" => "2005"
                        "volumen" => "14"
                        "paginaInicial" => "27"
                        "paginaFinal" => "32"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15777887"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor ablation&#58; treatment and palliation using image-guided therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:1 [
                            0 => "DE Dupuy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncology"
                        "fecha" => "2005"
                        "volumen" => "1911"
                        "numero" => "Suppl 4"
                        "paginaInicial" => "4"
                        "paginaFinal" => "5"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases&#58; preliminary report"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "JM Lee"
                            1 => "GY Jin"
                            2 => "SH Goldberg"
                            3 => "YC Lee"
                            4 => "GH Chung"
                            5 => "YM Han"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiol.2301020934"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2004"
                        "volumen" => "230"
                        "paginaInicial" => "125"
                        "paginaFinal" => "134"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/14645875"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Ablative treatments for lung tumors&#58; radiofrequency ablation&#44; stereotactic surgery and microwave ablation"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "G Abbas"
                            1 => "MJ Schuchert"
                            2 => "A Pennathur"
                            3 => "S Gilbert"
                            4 => "J Luketich"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/j.thorsurg.2007.03.007"
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorac Surg Clin"
                        "fecha" => "2007"
                        "volumen" => "17"
                        "paginaInicial" => "261"
                        "paginaFinal" => "271"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17626404"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Current role of image-guided ablative therapies in lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "CJ Simon"
                            1 => "D Dupuy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1586/14737140.5.4.657"
                      "Revista" => array:6 [
                        "tituloSerie" => "Expert Rev Anticancer Ther"
                        "fecha" => "2005"
                        "volumen" => "5"
                        "paginaInicial" => "657"
                        "paginaFinal" => "666"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16111466"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib20"
              "etiqueta" => "20"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Radiofrequency ablation of lung malignancies&#58; where do we stand&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "R Lencioni"
                            1 => "L Crocetti"
                            2 => "R Cioni"
                            3 => "A Mussi"
                            4 => "G Fontanini"
                            5 => "M Ambrogi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1007/s00270-004-0008-6"
                      "Revista" => array:6 [
                        "tituloSerie" => "Cardiovasc Intervent Radiol"
                        "fecha" => "2004"
                        "volumen" => "27"
                        "paginaInicial" => "581"
                        "paginaFinal" => "590"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15578133"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib21"
              "etiqueta" => "21"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Conscious analgosedation for radiofrequency ablation of lung neoplasm"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Volpe"
                            1 => "O Piazza"
                            2 => "D Palumbo"
                            3 => "S Griffo"
                            4 => "M Romano"
                            5 => "G Servillo"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Minerva Anestesiol"
                        "fecha" => "2006"
                        "volumen" => "72"
                        "paginaInicial" => "111"
                        "paginaFinal" => "115"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16493387"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib22"
              "etiqueta" => "22"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percutaneous image-guided thermal ablation and radiation therapy&#58; outcomes of combined treatment for 41 patients with inoperable stage I&#47;II non-small-cell lung cancer"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "CA Grieco"
                            1 => "CJ Simon"
                            2 => "W Mayo-Smith"
                            3 => "T DiPetrillo"
                            4 => "N Ready"
                            5 => "DE Dupuy"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1097/01.RVI.0000228373.58498.6E"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Vasc Interv Radiol"
                        "fecha" => "2006"
                        "volumen" => "17"
                        "paginaInicial" => "1117"
                        "paginaFinal" => "1124"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16868164"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            22 => array:3 [
              "identificador" => "bib23"
              "etiqueta" => "23"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percutaneous radiofrequency ablation of pulmonary malignancies&#58; a prospective&#44; multicenter clinical trial"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "R Lencioni"
                            1 => "L Crocetti"
                            2 => "DW Glenn"
                            3 => "DL Morris"
                            4 => "RD Suh"
                            5 => "C Bartolozzi"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:4 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2003"
                        "volumen" => "229"
                        "paginaInicial" => "437"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            23 => array:3 [
              "identificador" => "bib24"
              "etiqueta" => "24"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Image-guided tumor ablation&#58; standardization of terminology and reporting criteria"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:8 [
                            0 => "SN Goldberg"
                            1 => "CJ Grassi"
                            2 => "JF Cardella"
                            3 => "JW Charboneau"
                            4 => "GD Dodd"
                            5 => "DE Dupuy"
                            6 => "Society of Interventional Radiology Technology Assessment Committee"
                            7 => "International Working Group on Image-Guided Tumor Ablation"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1148/radiol.2353042205"
                      "Revista" => array:6 [
                        "tituloSerie" => "Radiology"
                        "fecha" => "2005"
                        "volumen" => "235"
                        "paginaInicial" => "728"
                        "paginaFinal" => "739"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15845798"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib25"
              "etiqueta" => "25"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Percutaneous computed tomography-guided radiofrequency thermal ablation of small unresectable lung tumours"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "S Rossi"
                            1 => "D Dore"
                            2 => "A Cascina"
                            3 => "V Vespro"
                            4 => "F Garbagnati"
                            5 => "L Rosa"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1183/09031936.06.00052905"
                      "Revista" => array:6 [
                        "tituloSerie" => "Eur Respir J"
                        "fecha" => "2006"
                        "volumen" => "27"
                        "paginaInicial" => "556"
                        "paginaFinal" => "563"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16507856"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            25 => array:3 [
              "identificador" => "bib26"
              "etiqueta" => "26"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "CT imaging findings of pulmonary neoplasms after treatment with radiofrequency ablation&#58; results in 32 tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "J Bojarski"
                            1 => "DE Dupuy"
                            2 => "W Mayo-Smith"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.2214/ajr.185.2.01850466"
                      "Revista" => array:6 [
                        "tituloSerie" => "AJR Am J Roentgenol"
                        "fecha" => "2005"
                        "volumen" => "185"
                        "paginaInicial" => "466"
                        "paginaFinal" => "471"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/16037522"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The RECIST &#40;Response Evaluation Criteria in Solid Tumors&#41; criteria&#58; implications for diagnostic radiologists"
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                      "titulo" => "Radiofrequency ablation of lung malignancies"
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                            0 => "CL Nguyen"
                            1 => "W Scott"
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                        "paginaFinal" => "371"
                        "link" => array:1 [
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                ]
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                        "paginaFinal" => "644"
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Vol. 44. Issue 7.
Pages 364-370 (January 2008)
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Vol. 44. Issue 7.
Pages 364-370 (January 2008)
Original Articles
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Computed Tomography-Guided Radiofrequency Ablation of Malignant Lung Lesions: Early Experience
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José M. Galbis-Caravajala,
Corresponding author
josegalbiscar@gmail.com

Correspondence: Dr J.M. Galbis-Caravajal, Servicio de Cirugía Torácica, Hospital Universitario de La Ribera, Ctra. Corbera, km 1, 46600 Alcira, Valencia, Spain
, Yolanda Pallardó-Calatayudb, Antonio Revert-Venturab, Jesús G. Sales-Badíaa, Rafael Esturi-Navarroc, María Cuenca-Torresd
a Servicio de Cirugía Torácica, Hospital Universitario de La Ribera, Alcira, Valencia, Spain
b Servicio de Radiología, Hospital Universitario de La Ribera, Alcira, Valencia, Spain
c Servicio de Anestesia, Hospital Universitario de La Ribera, Alcira, Valencia, Spain
d Unidad de Investigatión, Hospital Universitario de La Ribera, Alcira, Valencia, Spain
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Objective

To present our early experience in the treatment of primary malignant and metastatic lung lesions by radiofrequency ablation.

Patients and methods

From August 2004 through January 2007 we treated 19 patients (in 26 procedures) with curative or palliative intent. None of the lesions was amenable to surgery and some had been treated previously. The procedure was performed in the radiology room under conscious sedationanalgesia administered by an anesthesiologist. Fourteen patients were treated for pulmonary lesions and 5 for metastatic lung disease in a context of controlled primary disease. Treatment was with curative intent in 15 cases and palliative in 4.

Results

The radiofrequency technique was applicable in 26 procedures and the mean follow-up was 8.68 months. The principal complications of radiofrequency treatment were pneumothorax in 4 patients, requiring drainage in only 2 cases; pneumonitis in 4; self-limiting pulmonary hemorrhage in 1; and pleural effusion in 5. There were no procedure-related deaths. Six patients died during the follow-up period.

Conclusions

In our experience, radiofrequency offers a safe and minimally invasive option for the treatment of malignant lung lesions in appropriately selected, nonsurgical patients. Morbidity is low, and in combination with other treatments this technique opens up a wide range of possibilities still to be explored.

Key words:
Radiofrequency ablation
Stage I lung cancer
Lung metastases
CT-guidedpuncture
Objetivo

Presentar la experiencia inicial en el tratamiento de las lesiones pulmonares malignas (primarias y metastá-sicas) mediante la ablación por radiofrecuencia (RF).

Pacientes y métodos

De agosto de 2004 a enero de 2007 tratamos a 19 pacientes (mediante 26 procedimientos) con intención curativa o paliativa. Todos los casos correspondían a lesiones no quirúrgicas, tratadas o no previamente. La técnica se practicó en la sala de radiología, con sedoanalgesia consciente Ilevada a cabo por el anestesiólogo. Se trató a 14 pacientes con lesión pulmonar y a 5 con enfermedad metástasica pulmonar, con la enfermedad primaria controlada. En 15 casos el tratamiento se realizó con intención curativa y en 4 era paliativo.

Resultados

La técnica de RF pudo realizarse en los 26 procedimientos. La media de seguimiento fue de 8,68 meses. Las principales complicaciones derivadas del tratamiento de RF fueron: neumotórax en 4 pacientes, de los que sólo 2 requirieron drenaje; neumonitis en 4; hemorragia pulmonar autolimitada en 1, y derrame pleural en 5. No hubo mortalidad en relación con el procedimiento. Durante el período de seguimiento fallecieron 6 pacientes.

Conclusiones

Según nuestra experiencia, la RF puede ser una opción segura y mínimamente invasiva para el tratamiento de las lesiones pulmonares malignas en pacientes no quirúrgicos adecuadamente seleccionados, con una baja morbilidad. La combinatión con otros tratamientos ofrece un amplio abanico de posibilidades pendientes de discernir.

Palabras clave:
Ablación por radiofrecuencia
Carcinoma pulmonar estadio I
Metástasis pulmonares
Punción dirigidapor TC
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References
[1]
S Evrard.
Controversies between surgical and percutaneous radiofrequency ablation.
Eur J Surg Oncol, 32 (2006), pp. 3-5
[2]
NS Gandhi, DE Dupuy.
Image-guided radiofrequency ablation as a new treatment option for patients with lung cancer.
Semin Roentgenol, 40 (2005), pp. 171-181
[3]
A Siperstein, A Gotomirski.
History and technological aspects of radiofrequency thermoablation.
Cancer J, 6 (2000), pp. S293-S301
[4]
LJ Herrera, HC Fernando, Y Perry, W Gooding, P Buenaventura, N Christie, et al.
Radiofrequency ablation of pulmonary malignant tumors in non-surgical candidates.
J Thorac Cardiovasc Surg, 125 (2003), pp. 929-937
[5]
DE Dupuy, SN Goldberg.
Imagine-guided radiofrequency tumor ablation: challenges and opportunities II.
J Vasc Interv Radiol, 12 (2001), pp. 1135-1148
[6]
G Belfiore, G Moggio, E Tedeschi, M Greco, R Cioffi, F Cincotti, et al.
CT-guided radiofrequency ablation: a potential complementary therapy for patients with unresectable primary lung cancers. A preliminary report of 33 patients.
AJR Am J Roentgenol, 183 (2004), pp. 1003-1011
[7]
BJ Wood, JR Ramkaransingh, T Fojo, MM Walter, S Libutti.
Percutaneous tumor ablation with radiofrequency.
Cancer, 94 (2002), pp. 443-451
[8]
L Thanos, S Mylona, M Pomoni, V Kalioras, L Zoganas, N Batakis.
Primary lung cancer: treatment with radiofrequency thermal ablation.
Eur Radiol, 14 (2004), pp. 897-901
[9]
D Dupuy, RJ Zagoria, W Akerley, WW Mayo-Smith, PV Kavanagh, H Safran.
Percutaneous radiofrequency ablation of malignancies in the lung.
AJR Am J Roentgenol, 174 (2000), pp. 57-59
[10]
R Suh, K Reckamp, M Zeidler, R Cameron.
Radiofrequency ablation in lung cancer: promising results in safety and efficacy.
Oncology, 19 (2005), pp. 12-21
[11]
A Ketchedjian, B Daly, J Luketich, HC Fernando.
Minimally invasive techniques for managing pulmonary metastases: video-assisted thoracic surgery and radiofrequency ablation.
pp. 157-165
[12]
M Akeboshi, K Yamakodo, A Nakatsuka, O Hataji, O Taguchi, M Takao, et al.
Percutaneous radiofrequency ablation of lung neoplasms: initial therapeutic response.
J Vasc Interv Radiol, 15 (2004), pp. 463-470
[13]
D Laganà, G Carrafiello, M Mangini, L Boni, G Dionigi, MC Fusi, et al.
Radiofrequency ablation of primary and metastatic lung tumors: preliminary experience with a single center device.
Surg Endosc, 20 (2006), pp. 1261-1267
[14]
A Pennathur, JD Luketich, G Abbas, M Chen, HC Fernando, WE Gooding, et al.
Radiofrequency ablation for the treatment of stage I non-small cell lung cancer in high-risk patients.
J Thorac Cardiovasc Surg, 134 (2007), pp. 857-864
[15]
A el-Sherif, JD Luketich, RJ Landreneau, HC Fernando.
New therapeutic approaches for early stage non-small cell lung cancer.
Surg Oncol, 14 (2005), pp. 27-32
[16]
DE Dupuy.
Tumor ablation: treatment and palliation using image-guided therapy.
Oncology, 1911 (2005), pp. 4-5
[17]
JM Lee, GY Jin, SH Goldberg, YC Lee, GH Chung, YM Han, et al.
Percutaneous radiofrequency ablation for inoperable non-small cell lung cancer and metastases: preliminary report.
Radiology, 230 (2004), pp. 125-134
[18]
G Abbas, MJ Schuchert, A Pennathur, S Gilbert, J Luketich.
Ablative treatments for lung tumors: radiofrequency ablation, stereotactic surgery and microwave ablation.
Thorac Surg Clin, 17 (2007), pp. 261-271
[19]
CJ Simon, D Dupuy.
Current role of image-guided ablative therapies in lung cancer.
Expert Rev Anticancer Ther, 5 (2005), pp. 657-666
[20]
R Lencioni, L Crocetti, R Cioni, A Mussi, G Fontanini, M Ambrogi, et al.
Radiofrequency ablation of lung malignancies: where do we stand?.
Cardiovasc Intervent Radiol, 27 (2004), pp. 581-590
[21]
M Volpe, O Piazza, D Palumbo, S Griffo, M Romano, G Servillo, et al.
Conscious analgosedation for radiofrequency ablation of lung neoplasm.
Minerva Anestesiol, 72 (2006), pp. 111-115
[22]
CA Grieco, CJ Simon, W Mayo-Smith, T DiPetrillo, N Ready, DE Dupuy.
Percutaneous image-guided thermal ablation and radiation therapy: outcomes of combined treatment for 41 patients with inoperable stage I/II non-small-cell lung cancer.
J Vasc Interv Radiol, 17 (2006), pp. 1117-1124
[23]
R Lencioni, L Crocetti, DW Glenn, DL Morris, RD Suh, C Bartolozzi.
Percutaneous radiofrequency ablation of pulmonary malignancies: a prospective, multicenter clinical trial.
Radiology, 229 (2003), pp. 437
[24]
SN Goldberg, CJ Grassi, JF Cardella, JW Charboneau, GD Dodd, DE Dupuy, Society of Interventional Radiology Technology Assessment Committee, International Working Group on Image-Guided Tumor Ablation, et al.
Image-guided tumor ablation: standardization of terminology and reporting criteria.
Radiology, 235 (2005), pp. 728-739
[25]
S Rossi, D Dore, A Cascina, V Vespro, F Garbagnati, L Rosa, et al.
Percutaneous computed tomography-guided radiofrequency thermal ablation of small unresectable lung tumours.
Eur Respir J, 27 (2006), pp. 556-563
[26]
J Bojarski, DE Dupuy, W Mayo-Smith.
CT imaging findings of pulmonary neoplasms after treatment with radiofrequency ablation: results in 32 tumors.
AJR Am J Roentgenol, 185 (2005), pp. 466-471
[27]
AR Padhani, L Ollivier.
The RECIST (Response Evaluation Criteria in Solid Tumors) criteria: implications for diagnostic radiologists.
Br J Radiol, 74 (2001), pp. 983-986
[28]
PE Sewell, RB Vance, YD Wang.
Assessing radiofrequency ablation of non-small cell lung cancer with positron emission tomography (PET).
Radiology, 217 (2000), pp. 334
[29]
CL Nguyen, W Scott, M Goldberg.
Radiofrequency ablation of lung malignancies.
Ann Thorac Surg, 82 (2006), pp. 365-371
[30]
HC Fernando, A de Hoyos, RJ Landreneau, S Gilbert, WE Gooding, PO Buenaventura, et al.
Radiofrequency ablation for the treatment of non small-cell lung cancer in marginal surgical patients.
J Thorac Cardiovasc Surg, 129 (2005), pp. 639-644
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