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Vol. 44. Issue 10.
Pages 567-570 (January 2008)
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Vol. 44. Issue 10.
Pages 567-570 (January 2008)
Case Reports
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Chronic Pulmonary Histoplasmosis Diagnosed in a Nonimmunosuppressed Patient 10 Years After Returning From an Endemic Area
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Manuel García-Marróna,
Corresponding author
mgamarron-1@yahoo.es

Correspondence: Dr M. García-Marrón Sección de Neumología, Hospital San Agustín Camino de Heros, 4 33400 Avilés, Asturias, Spain
, José María García-Garcíaa, Mercedes Pajín-Colladab, Fernando Álvarez-Navascuésa, Manuel A. Martínez-Muñiza, Andrés A. Sánchez-Antuñaa
a Sección de Neumología, Hospital San Agustín, Avilés, Asturias, Spain
b Servicio de Urgencias, Hospital San Agustín, Avilés, Asturias, Spain
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We report the case of a Spanish nonimmunosuppressed patient who was a chronic alcoholic and who developed chronic cavitary pulmonary histoplasmosis. He had been living in Venezuela until 10 years ago. The diagnosis was established when Histoplasma capsulatum was cultured from bronchoscopy samples. The patient was treated with itraconazole and progressed favorably until cure. This case suggests that histoplasmosis can reactivate years after exposure, even when significant immunodeficiency is not present. In the absence of another immunosuppressive factor, alcoholism may have played a role in the development of the condition.

Key words:
Histoplasmosis
Histoplasma capsulatum
Diagnosis
Treatment

Se presenta el caso de un paciente español, no inmunodeprimido, con alcoholismo crónico e histoplasmosis pulmonar cavitaria, crónica, que había residido 10 años antes en Venezuela. El diagnóstico se estableció por cultivo de Histoplasma capsulatum en muestras de broncoscopia y el tratamiento consistió en itraconazol, con buena evolución y curación. Este caso apoya la posibilidad de que la histoplasmosis pueda reactivarse años después de la exposición y sin que haya inmunodepresión clínicamente importante. Se plantea que, en ausencia de otro factor inmunodepresor, el alcoholismo podría haber desempeñado algún papel en el desarrollo del cuadro.

Palabras clave:
Histoplasmosis
Histoplasma capsulatum
Diagnóstico
Tratamiento
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