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Journal Information
Vol. 39. Issue 4.
Pages 184-186 (April 2003)
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Vol. 39. Issue 4.
Pages 184-186 (April 2003)
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Calcificación pulmonar metastásica: una rara causa de enfermedad pulmonar intersticial
Metastatic pulmonary calcification: a rare cause of interstitial lung disease
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R. Santiago Villalobosa,
Corresponding author
rsantiago_villalobos@hotmail.com

Correspondencia: Bami, 27, 4.° D. 41013 Sevilla. España
, E. Rodríguez Becerraa, F. Borderas Naranjob, J. Martín Juana
a Unidad Médico-Quirúrgica de Enfermedades Respiratorias. Hospital Universitario Virgen del Rocío. Sevilla
b Departamento de Anatomía Patológica. Hospital Universitario Virgen del Rocío. Sevilla. España
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Article information

Presentamos el caso de una paciente de 58 años diagnosti-cada de calcinosis pulmonar metastásica. Clínicamente refe-ría síntomas de hiperreactividad bronquial. Tras tiroidecto-mía total bilateral con paratiroidectomía, estaba en tratamiento sustitutivo con calcio y vitamina D, y presentó 4 episodios de hipercalcemia sintomática secundaria a admi-nistración exógena. Las pruebas de función pulmonar evi-denciaban un patrón obstructivo leve con reversibilidad tras broncodilatadores. Las pruebas de imagen ponían de mani-fiesto un patrón micronodular bilateral de predominio en campos superiores (radiografía y tomografía computarizada de alta resolución de tórax), y depósito patológico de calcio en el pulmón (gammagrafía ósea). El diagnóstico se estable-ció mediante biopsia transbronquial. La evolución de la pa-ciente fue favorable

La calcinosis pulmonar metastásica es una afección rara, generalmente asintomática y de buena evolución, que habría que tener presente en el diagnóstico diferencial de las neu-mopatías intersticiales de morfología micronodular en pa-cientes con factores de riesgo para su desarrollo

Palabras clave:
Enfermedad pulmonar intersticial
Calcificación pulmonar metastásica
Calcinosis pulmonar metastásica

We report the case of a 58-year-old woman with metasta-tic pulmonary calcinosis who presented with bronchial hy-perreactivity. She was receiving calcium and vitamin D sup-plementation following total bilateral thyroidectomy with parathyroidectomy and had a history of episodes of sympto-matic hypercalcemia secondary to exogenous administra-tion. Lung function testing showed slight obstruction that was reversed by bronchodilators. Images showed a bilateral micronodular pattern mainly in the upper fields (x-ray and high resolution computed tomography of the thorax) and abnormal calcium deposition in the lungs (bone scinti-graphy). The diagnosis was established by transbronchial biopsy. The clinical course was favorable. Metastatic pulmo-nary calcinosis is rare and usually asymptomatic and evolu-tion is good. This entity should be taken into account in the differential diagnosis of interstitial lung diseases involving micronodular infiltrates in patients at risk

Keywords:
Interstitial pulmonary disease
Metastatic pulmo-nary calcification
Metastatic pulmonary calcinosis
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Bibliografía
[1.]
E. Ulmer, H. Borer, P. Sandoz, et al.
Diffuse pulmonary nodular infiltrates in a renal transplant recipient.
Chest, 120 (2000), pp. 1394-1398
[2.]
R.K. Lingam, J. The, A. Sharma, E. Friedman.
Case report. Metastatic pulmonary calcification in renal failure: a new HRCT pattern.
Br J Radiol, 75 (2002), pp. 74-77
[3.]
M. Romagnoli, G. Mourad, I. Serre, J.P. Senac, L. Paradis, P. Godard, et al.
Diffuse pulmonary calcinosis without calcium metabolism abnormalities in a renal transplant recipient.
Eur Respir J, 10 (1997), pp. 958-960
[4.]
E.D. Chan, D.V. Morales, C.H. Welsh, M.T. McDermott, M.I. Schwarz.
State of the art: calcium deposition with or without bone formation in the lung.
Am J Respir Crit Care Med, 165 (2002), pp. 1654-1669
Copyright © 2003. Sociedad Española de Neumología y Cirugía Torácica
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