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        "resumen" => "<span class="elsevierStyleSectionTitle">Objective</span><p class="elsevierStyleSimplePara elsevierViewall">TO evaluate the results of surgical treatment for lung carcinoid tumor&#46;</p> <span class="elsevierStyleSectionTitle">Patients and method</span><p class="elsevierStyleSimplePara elsevierViewall">The medical records of 62 patients who underwent surgical intervention for lung carcinoid tumor between May 1985 and October 2000 were reviewed&#46;</p> <span class="elsevierStyleSectionTitle">Results</span><p class="elsevierStyleSimplePara elsevierViewall">Fifty-two patients had typical carcinoid tumors and 10 had atypical carcinoid tumors&#46; Hilar or mediastinal lymph node metastases were present in 9 patients&#46; Distant metastasis occurred in 5 patients and was significantly more frequent in those with the atypical carcinoid histological subtype&#46; The overall survival rate at 15 years was 70&#37;&#44; with a mean survival rate of 138 &#40;SD 11&#41; months&#44; calculated with the Kaplan-Meier method&#46; We found no statistically significant correlation between smoking and the development of carcinoid tumors&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Although carcinoid tumors behave like low-grade malignant tumors&#44; they should be treated in the same way as other malignant lung tumors&#46; Curative surgical resection is the technique of choice whenever possible&#46;</p>"
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        "resumen" => "<span class="elsevierStyleSectionTitle">Objetivo</span><p class="elsevierStyleSimplePara elsevierViewall">Evaluar los resultados del tratamiento quir&#250;rgico del tumor carcinoide pulmonar&#46;</p> <span class="elsevierStyleSectionTitle">Pacientes Y M&#201;TODO</span><p class="elsevierStyleSimplePara elsevierViewall">Se han revisado las historias cl&#237;nicas de 62 pacientes intervenidos quir&#250;rgicamente por un tumor carcinoide pulmonar entre mayo de 1985 y octubre de 2000&#46;</p> <span class="elsevierStyleSectionTitle">Resultados</span><p class="elsevierStyleSimplePara elsevierViewall">Cincuenta y dos pacientes ten&#237;an un carcinoide t&#237;pico y 10 un carcinoide at&#237;pico&#46; Nueve pacientes presentaban met&#225;stasis ganglionares hiliares o mediast&#237;nicas y 5 presentaban met&#225;stasis a distancia&#46; Estas &#250;ltimas fueron m&#225;s frecuentes en el subtipo histol&#243;gico carcinoide at&#237;pico con diferencias estad&#237;sticamente significativas&#46; Cinco pacientes ten&#237;an cl&#237;nica de s&#237;ndrome carcinoide&#46; La supervivencia global a los 15 a&#241;os fue del 70&#37; y la supervivencia media de 138 &#177; 11 meses&#46; No encontramos asociaci&#243;n estad&#237;stica entre el h&#225;bito tab&#225;quico y el desarrollo de tumor carcinoide&#46;</p> <span class="elsevierStyleSectionTitle">Conclusions</span><p class="elsevierStyleSimplePara elsevierViewall">Aunque el tumor carcinoide se comporta como un tumor de bajo grado de malignidad&#44; su tratamiento debe realizarse de modo similar al del resto de los tumores malignos pulmonares&#59; la resecci&#243;n quir&#250;rgica con intenci&#243;n curativa es la t&#233;cnica de elecci&#243;n siempre que sea posible&#46;</p>"
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                      "titulo" => "The feasibility of conservative resection for carcinoid tumours&#58; is pneumonectomy ever necessary for uncomplicated cases&#63;"
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                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
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                      "autores" => array:1 [
                        0 => array:2 [
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                          "autores" => array:3 [
                            0 => "TG Sutedja"
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                            2 => "TS Werf"
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
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                        "paginaInicial" => "556"
                        "paginaFinal" => "558"
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                          0 => array:2 [
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                        "paginaFinal" => "13"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2672162"
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                        "paginaFinal" => "588"
                        "serieFecha" => "1978"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial carcinoids"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "M Ribet"
                            1 => "B Gosselin"
                            2 => "L Gambiez"
                            3 => "LE Frere"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Cardio-Thorac Surg"
                        "fecha" => "1993"
                        "volumen" => "7"
                        "paginaInicial" => "347"
                        "paginaFinal" => "350"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            9 => array:3 [
              "identificador" => "bib10"
              "etiqueta" => "10"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Limited and radical resection for tracheal and bronchopulmonary carcinoid tumour"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:3 [
                            0 => "G Stamatis"
                            1 => "L Freitag"
                            2 => "D Greschuchna"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Eur J Cardiovasc Surg"
                        "fecha" => "1990"
                        "volumen" => "4"
                        "paginaInicial" => "527"
                        "paginaFinal" => "533"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            10 => array:3 [
              "identificador" => "bib11"
              "etiqueta" => "11"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial carcinoid-twenty years experience defines a selective surgical approach"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "TS Chughtai"
                            1 => "JE Morin"
                            2 => "NM Sheiner"
                            3 => "JA Wilson"
                            4 => "DS Mulder"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Surgery"
                        "fecha" => "1997"
                        "volumen" => "122"
                        "paginaInicial" => "801"
                        "paginaFinal" => "808"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9347859"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            11 => array:3 [
              "identificador" => "bib12"
              "etiqueta" => "12"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinoid tumors of the lung&#58; do atypical features require aggressive management&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "CH Marty-Ane"
                            1 => "V Costes"
                            2 => "JL Pujol"
                            3 => "M Alauzen"
                            4 => "P Balder"
                            5 => "H Mary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0003-4975(94)00630-P"
                      "Revista" => array:6 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1995"
                        "volumen" => "59"
                        "paginaInicial" => "78"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7818364"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            12 => array:3 [
              "identificador" => "bib13"
              "etiqueta" => "13"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchial carcinoids&#46; A review of 22 cases"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "M Froudarakis"
                            1 => "P Fournel"
                            2 => "G Burgard"
                            3 => "D Bouros"
                            4 => "S Boucheron"
                            5 => "NM Siafakas"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Oncology"
                        "fecha" => "1996"
                        "volumen" => "53"
                        "paginaInicial" => "153"
                        "paginaFinal" => "158"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8604242"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            13 => array:3 [
              "identificador" => "bib14"
              "etiqueta" => "14"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Carcinoid tumors of the lung&#58; do atypical features require aggressive management&#63;"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "C Marty-Ane"
                            1 => "V Costes"
                            2 => "J Pujo"
                            3 => "M Alauzen"
                            4 => "P Baldet"
                            5 => "H Mary"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/0003-4975(94)00630-P"
                      "Revista" => array:7 [
                        "tituloSerie" => "Ann Thorac Surg"
                        "fecha" => "1995"
                        "volumen" => "59"
                        "paginaInicial" => "78"
                        "paginaFinal" => "83"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7818364"
                            "web" => "Medline"
                          ]
                        ]
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                          "pii" => "S1470204508702602"
                          "estado" => "S300"
                          "issn" => "14702045"
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                    ]
                  ]
                ]
              ]
            ]
            14 => array:3 [
              "identificador" => "bib15"
              "etiqueta" => "15"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Treatment and prognosis in bronchial carcinoid involving regional lymph nodes"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => true
                          "autores" => array:6 [
                            0 => "N Martini"
                            1 => "M Zaman"
                            2 => "SM Bain"
                            3 => "M Burt"
                            4 => "P McCormack"
                            5 => "V Rusch"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "1994"
                        "volumen" => "107"
                        "paginaInicial" => "1"
                        "paginaFinal" => "7"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/8283871"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            15 => array:3 [
              "identificador" => "bib16"
              "etiqueta" => "16"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "An analysis of 8305 cases of carcinoid tumors"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:2 [
                            0 => "I Modlin"
                            1 => "M Sandor"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cancer"
                        "fecha" => "1997"
                        "volumen" => "4"
                        "paginaInicial" => "813"
                        "paginaFinal" => "829"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib17"
              "etiqueta" => "17"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Bronchoscopic treatment of intraluminal typical carcinoid&#58; a pilot study"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:5 [
                            0 => "TJ van Boxem"
                            1 => "BJ Venmans"
                            2 => "JC van Mourick"
                            3 => "PE Postmus"
                            4 => "TG Stuteja"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1016/S0022-5223(98)70005-4"
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "1998"
                        "volumen" => "116"
                        "paginaInicial" => "402"
                        "paginaFinal" => "406"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/9731781"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            17 => array:3 [
              "identificador" => "bib18"
              "etiqueta" => "18"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Elective resection of tumours of the trachea and main carina after endoscopic laser therapy"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:4 [
                            0 => "S Shankar"
                            1 => "PJ George"
                            2 => "MR Hetzel"
                            3 => "P Goldstraw"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
                        "fecha" => "1990"
                        "volumen" => "45"
                        "paginaInicial" => "493"
                        "paginaFinal" => "495"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/2392797"
                            "web" => "Medline"
                          ]
                        ]
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib19"
              "etiqueta" => "19"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Tumor carcinoide bronquial&#46; Presentaci&#243;n at&#237;pica y tratamiento quir&#250;rgico"
                      "autores" => array:1 [
                        0 => array:2 [
                          "etal" => false
                          "autores" => array:6 [
                            0 => "JJ Fibla"
                            1 => "C Farina"
                            2 => "G G&#243;mez"
                            3 => "JC Penagos"
                            4 => "G Estrada"
                            5 => "C Le&#243;n"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Cir Esp"
                        "fecha" => "2003"
                        "volumen" => "73"
                        "paginaInicial" => "386"
                        "paginaFinal" => "387"
                      ]
                    ]
                  ]
                ]
              ]
            ]
          ]
        ]
      ]
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Vol. 40. Issue 5.
Pages 218-221 (May 2004)
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Vol. 40. Issue 5.
Pages 218-221 (May 2004)
Original Articles
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Bronchial Carcinoid Tumor: a Retrospective Analysis of 62 Surgically Treated Cases
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M. Iglesiasa,
Corresponding author
toracica@hotmail.com

Correspondence: Dra. M. Iglesias Sentís. Servei de Cirurgia Toràcica. ICPCT. Hospital Clínic. Villarroel, 170. 08036 Barcelona. España
, J. Beldaa, X. Baldób, J.M. Gimferrera, M. Catalána, M. Rubioa, M. Serrac
a Servei de Cirurgia Toràcica, ICPCT. Hospital Clínic i Provincial de Barcelona, Barcelona, Spain
b Servei de Cirurgia Toràcica, Hospital Universitari de Girona Dr. Josep Trueta, Girona, Spain
c Servei de Cirurgia Toràcica, Hospital Mútua de Terrassa, Terrassa, Barcelona, Spain
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Objective

TO evaluate the results of surgical treatment for lung carcinoid tumor.

Patients and method

The medical records of 62 patients who underwent surgical intervention for lung carcinoid tumor between May 1985 and October 2000 were reviewed.

Results

Fifty-two patients had typical carcinoid tumors and 10 had atypical carcinoid tumors. Hilar or mediastinal lymph node metastases were present in 9 patients. Distant metastasis occurred in 5 patients and was significantly more frequent in those with the atypical carcinoid histological subtype. The overall survival rate at 15 years was 70%, with a mean survival rate of 138 (SD 11) months, calculated with the Kaplan-Meier method. We found no statistically significant correlation between smoking and the development of carcinoid tumors.

Conclusions

Although carcinoid tumors behave like low-grade malignant tumors, they should be treated in the same way as other malignant lung tumors. Curative surgical resection is the technique of choice whenever possible.

Key words:
Carcinoid tumor
Carcinoid syndrome
Surgical treatment
Objetivo

Evaluar los resultados del tratamiento quirúrgico del tumor carcinoide pulmonar.

Pacientes Y MÉTODO

Se han revisado las historias clínicas de 62 pacientes intervenidos quirúrgicamente por un tumor carcinoide pulmonar entre mayo de 1985 y octubre de 2000.

Resultados

Cincuenta y dos pacientes tenían un carcinoide típico y 10 un carcinoide atípico. Nueve pacientes presentaban metástasis ganglionares hiliares o mediastínicas y 5 presentaban metástasis a distancia. Estas últimas fueron más frecuentes en el subtipo histológico carcinoide atípico con diferencias estadísticamente significativas. Cinco pacientes tenían clínica de síndrome carcinoide. La supervivencia global a los 15 años fue del 70% y la supervivencia media de 138 ± 11 meses. No encontramos asociación estadística entre el hábito tabáquico y el desarrollo de tumor carcinoide.

Conclusions

Aunque el tumor carcinoide se comporta como un tumor de bajo grado de malignidad, su tratamiento debe realizarse de modo similar al del resto de los tumores malignos pulmonares; la resección quirúrgica con intención curativa es la técnica de elección siempre que sea posible.

Palabras clave:
Tumor carcinoide
Síndrome carcinoide
Tratamiento quirúrgico
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REFERENCES
[1]
M El Jamal, AG Nicholson, P Goldstraw.
The feasibility of conservative resection for carcinoid tumours: is pneumonectomy ever necessary for uncomplicated cases?.
Eur J Cardiothorac Surg, 18 (2000), pp. 301-306
[2]
TG Sutedja, RJ Vanderschueren, TS Werf.
Bronchoscopic therapy in patients with intraluminal typical bronchial carcinoid.
Chest, 107 (1995), pp. 556-558
[3]
R García Gómez, R Texeira Fernandes, C Jara Sánchez, R González.
Carcinoide bronquial. Tumor poco frecuente. Estudio clínico de doce casos.
Rev Clin Esp, 185 (1989), pp. 9-13
[4]
FJ García-Río, IG Talavera, BG Rubio, C Prados, P Rodríguez.
Estudio clínico de veinte casos de carcinoide bronquial.
An Med Intermed (Madrid), 9 (1992), pp. 9-13
[5]
JA Domingo, E Bello, E Chacón, JA Carretero, A Hernández.
Carcinoide bronquial: diagnóstico por fibrobroncoscopia.
Arch Bronconeumol, 37 (2001), pp. 150-152
[6]
SR Bloom.
VIP and watery diarrhea in gut hormones.
Proceedings of the international symposium on gut hormones, pp. 583-588
[7]
CG Moertel.
Small intestine.
Cancer medicine, pp. 1574-1584
[8]
CM Haskell, R Tempkin, et al.
Cancer treatment.
2nd ed., pp. 585-594
[9]
M Ribet, B Gosselin, L Gambiez, LE Frere.
Bronchial carcinoids.
Eur J Cardio-Thorac Surg, 7 (1993), pp. 347-350
[10]
G Stamatis, L Freitag, D Greschuchna.
Limited and radical resection for tracheal and bronchopulmonary carcinoid tumour.
Eur J Cardiovasc Surg, 4 (1990), pp. 527-533
[11]
TS Chughtai, JE Morin, NM Sheiner, JA Wilson, DS Mulder.
Bronchial carcinoid-twenty years experience defines a selective surgical approach.
Surgery, 122 (1997), pp. 801-808
[12]
CH Marty-Ane, V Costes, JL Pujol, M Alauzen, P Balder, H Mary.
Carcinoid tumors of the lung: do atypical features require aggressive management?.
Ann Thorac Surg, 59 (1995), pp. 78-83
[13]
M Froudarakis, P Fournel, G Burgard, D Bouros, S Boucheron, NM Siafakas, et al.
Bronchial carcinoids. A review of 22 cases.
Oncology, 53 (1996), pp. 153-158
[14]
C Marty-Ane, V Costes, J Pujo, M Alauzen, P Baldet, H Mary.
Carcinoid tumors of the lung: do atypical features require aggressive management?.
Ann Thorac Surg, 59 (1995), pp. 78-83
[15]
N Martini, M Zaman, SM Bain, M Burt, P McCormack, V Rusch, et al.
Treatment and prognosis in bronchial carcinoid involving regional lymph nodes.
J Thorac Cardiovasc Surg, 107 (1994), pp. 1-7
[16]
I Modlin, M Sandor.
An analysis of 8305 cases of carcinoid tumors.
Cancer, 4 (1997), pp. 813-829
[17]
TJ van Boxem, BJ Venmans, JC van Mourick, PE Postmus, TG Stuteja.
Bronchoscopic treatment of intraluminal typical carcinoid: a pilot study.
J Thorac Cardiovasc Surg, 116 (1998), pp. 402-406
[18]
S Shankar, PJ George, MR Hetzel, P Goldstraw.
Elective resection of tumours of the trachea and main carina after endoscopic laser therapy.
Thorax, 45 (1990), pp. 493-495
[19]
JJ Fibla, C Farina, G Gómez, JC Penagos, G Estrada, C León.
Tumor carcinoide bronquial. Presentación atípica y tratamiento quirúrgico.
Cir Esp, 73 (2003), pp. 386-387
Copyright © 2004. Sociedad Española de Neumología y Cirugía Torácica (SEPAR)
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