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Vol. 45. Issue S6.
Hipertensión pulmonar tromboembólica crónica
Pages 21-29 (June 2009)
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Vol. 45. Issue S6.
Hipertensión pulmonar tromboembólica crónica
Pages 21-29 (June 2009)
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Métodos de imagen en la hipertensión pulmonar tromboembólica crónica
Imaging tests in chronic thromboembolic pulmonary hypertension
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María Antonia Sánchez Nistala,
Corresponding author
masani50@yahoo.com

Autor para correspondencia.
, María Teresa Velázquez Martínb
a Servicio de Radiodiagnóstico, Hospital Universitario 12 de Octubre, Madrid, España
b Unidad de Hemodinámica, Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, España
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Las técnicas de imagen son el pilar del diagnóstico de la hipertensión pulmonar trobmboembólica crónica (HPTEC). Actualmente, se dispone de una serie de técnicas de imagen de indudable utilidad: gammagrafía ventilación/perfusión, ecocardiografía, tomografía computarizada (TC) multicorte, resonancia magnética y arteriografía pulmonar, aunque no todas están indicadas de rutina en todos los pacientes. La gammagrafía y la ecografía se utilizan como método de cribado de HPTEC tras un tromboembolismo pulmonar agudo.

La TC con multidetector (TCMD) es una herramienta eficaz en el estudio de la HPTBEC, ya que demuestra la localización, extensión y características de los trombos arteriales centrales y periféricos, además de ofrecer un estudio del vaso distal a la obstrucción. Permite valorar otros hallazgos que pueden condicionar el tratamiento médico o quirúrgico, como circulación sistémica colateral, patología parenquimatosa coincidente, patología coronaria o cardíaca. Es un método no invasivo y bien tolerado por los pacientes, por lo que puede emplearse en el seguimiento de la enfermedad o para valorar resultados posquirúrgicos.

La arteriografía pulmonar ha precedido al resto de técnicas de imagen, siendo la técnica de elección para el diagnóstico de HPTEC durante muchos años. Un acceso limitado a esta técnica, un riesgo bajo pero existente, y el desarrollo de técnicas de diagnóstico no invasivas, fundamentalmente la TCMD, han hecho que en la actualidad su principal indicación sea la valoración de la accesibilidad quirúrgica en los pacientes en los que la cirugía de tromboendarterectomía pulmonar se considera una opción terapéutica. Realizada por hemodinamistas expertos, de forma estandarizada en el laboratorio de hemodinámica, es un procedimiento seguro, incluso en pacientes con hipertensión pulmonar severa.

Palabras clave:
Hipertensión pulmonar
Hipertensión tromboembólica crónica
Trombos agudos
Tomografía Computarizada Multidetector
Angiografía pulmonar
Tromboendarterectomía
Abstract

Imaging tests are the cornerstone of the diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH). A series of imaging tests of unquestionable utility is currently available: ventilation-perfusion scintigraphy, echocardiography, multislice computed tomography (CT), magnetic resonance imaging, and pulmonary arteriography. However, not all of these techniques are routinely indicated in all patients.

Scintigraphy and echography are used to screen for CTEPH after an acute pulmonary thromboembolism.

Multidetector CT is effective in the study of CTEPH since this procedure reveals the localization, extension and characteristics of the central and peripheral arterial thrombi as well as providing data on the vessel distal to the obstruction. Other findings that can affect medical or surgical treatment can be assessed with this technique, such as collateral systemic circulation, concurrent parenchymatous abnormalities, and coronary or cardiac disease. Multidetector CT is a non-invasive method that is well tolerated by patients and consequently can be used in the follow-up of the disease or to evaluate postsurgical results.

Pulmonary arteriography predated other imaging techniques and was the technique of choice for the diagnosis of CTEPH for many years. Because of limited access to this procedure, a low but nevertheless present risk, and the development of non-invasive diagnostic techniques, mainly multidetector CT, the main indication of pulmonary arteriography is currently assessment of surgical accessibility in candidates for pulmonary thromboendarterectomy. When performed by expert hemodynamists using a standardized technique in the hemodynamic laboratory, this procedure is safe even in patients with severe pulmonary hypertension.

Keywords:
Pulmonary hypertension
Chronic thromboembolic hypertension
Acute thrombus
Multidetector computed tomography
Thromboendarterectomy
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Bibliografía
[1.]
G. Simonneau, G. Nazareno, L.J. Rubin, D. Langleben, W. Seeger, G. Domenighetti, et al.
Clinical Classification of Pulmonary Hipertensión.
J Am Coll Cardiol, 43 (2004), pp. 5S-12S
[2.]
J. Segovia, M. Gómez Bueno, P. García Pavía, et al.
Diagnóstico y clasificación. Avances en Hipertensió?.
Pulmonar, 3 (2008), pp. 1-5
[3.]
M.M. Hoeper, E. Mayer, G. Simonneau, L.J. Rubin.
Chronic trhromboembolic pulmonary hyprtension.
Circulation, 113 (2006), pp. 2011-2020
[4.]
P.F. Fedullo, W.R. Auger, K.M. Kerr, L.J. Rubin.
Chronic thromboembolic pulmonary hypertension.
N Engl J Med, (2001), pp. 345
[5.]
R. Coulden.
State-of-the-art imaging techniques in chronic thromboembolic pulmonary hypertension.
Proc Am Thorac Soc, 3 (2006), pp. 577-583
[6.]
K-F. Jakob Kreitner, S. Ley, H-U. Kauczor, E. Mayer, Th. Kramm, M.B. Pitton, et al.
Chronic thromboembolic pulmonary hypertension: pre and postoperative assessment with breath-hold MRI techniques.
Radiology, 232 (2004), pp. 535-543
[7.]
V. Fuster, J. Sanz.
Hipertensión pulmonar: nuevos conocimientos a través de la tecnología de imagen.
Rev Esp Cardiol, 60 (2007), pp. 2-9
[8.]
M. Remy-Jardin, J. Remy, L. Wattine.
Central pulmonary thromboembolism: diagnosis with spiral volumetric CT with the single- breath-hold technique: comparison with pulmonary angiography.
Radiology, 185 (1992), pp. 381-387
[9.]
B. Ghaye, A. Ghuysen, P-J. Bruyere, V. D’Orio, R.F. Dondelinger.
Can CT pulmonary angiography allow assessment of severity and prognosis in patients presenting with pulmonary embolism?. What the radiologist needs to know.
Radiographics, 26 (2006), pp. 23-40
[10.]
M-P. Revel, J-B. Faivre, M. Remy-Jardin, V. Delannoy-Deken, A. Duhamel, J. Remy.
Pulmonary hypertension: ECG- gated 64-section angiographic evaluation of new functional parameters as diagnostic criteria.
Radiology, 250 (2009), pp. 558-566
[11.]
E. Coche, S. Vynckier, Octave-Prignot.
Pulmonary embolism: radiation dose with multi-detector row CT and digital angiography for diagnosis.
Radiology, 240 (2006), pp. 690-697
[12.]
C.M. Heyer, P.S. Mohr, S.P. Lemburg, et al.
Image quality and radiation exposure at pulmonary CT angiography with 100-or-120-KVp protocol: prospective randomized study.
Radiology, 245 (2007), pp. 577-583
[13.]
J.D. MacKenzie, J. Nazario-Larrieu, T. Cai, et al.
Reduced-dose CT: effect on reader evaluation in detection of pulmonary embolism.
AJR Am J Roentgenol, 189 (2007), pp. 1371-1379
[14.]
C. Wittram.
How I do it: CT pulmonary angiography.
AJR Am J Roentgenol, 188 (2007), pp. 1255-1261
[15.]
C. Wittram, M.K. Kalra, M.M. Maher, A. Greenfield, T.h. McLoud, J-A. Shepard.
Acute and chronic pulmonary emboli: angiography-CT correlation.
AJR Am J Roentgenol, 186 (2006), pp. S421-S429
[16.]
E. Castañer, X. Gallardo, E. Ballesteros, M. Andreu, Y. Pallardó, J.M. Mata, et al.
CT diagnosis of chronic pulmonary thromboembolism.
Radiographics, 29 (2009), pp. 31-53
[17.]
C.J. Bergin, C. Sirlin, R. Deutsch, P. Fedullo, J. Hauschildt, T. Huynh, et al.
Predictors of patient response to pulmonary thromboendarterectomy.
AJR Am J Roentgenol, 174 (2000), pp. 509-515
[18.]
M. Remy-Jardin, J. Remy.
Spiral CT angiography of the pulmonary circulation.
[19.]
I. Hasegawa, P.H. Boiselle, H. Hatabu.
Bronchial artery dilatation on MDCT scans of patients with acute pulmonary embolism: Comparison with chronic or recurrent pulmonary embolism.
AJR Am J Roentgenol, 182 (2004), pp. 67-72
[20.]
M. Remy-Jardin, A. Duhamel, V. Deken, N. Bouaziz, P.h. Dumont, J. Remy.
Systemic collateral supply in patients with chronic thromboembolic and primary pulmonary hypertension: assessment with multi-detector row helical CT angiography.
Radiology, 235 (2005), pp. 274-281
[21.]
A.A. Frazier, J.R. Galvin, T.J. Franks, M. Rosado-de-Christenson.
Pulmonary vasculature: hypertension and infarction.
[22.]
M. Heinrich, M. Uder, D. Tscholl, A. Grgic, B. Kramann, H-J. Schäfers.
CT scan findings in chronic thromboembolism pulmonary hypertension: predictors of hemodynamic improvement after pulmonary thromboendarterectomy.
Chest, 127 (2005), pp. 1606-1613
[23.]
H-U. Kauczor, H.C. Schwickert, E. Mayer, F. Schweden, H.H. Schild, M. Thelen.
Spiral CT of bronchial arteries in chronic thromboembolism.
J Comp Assis Tomog, 18 (1994), pp. 855-861
[24.]
M. Remy-Jardin, J. Remy, S. Louvegny, D. Artaud, F. Deschildre, A. Duhamel.
Airway changes in chronic pulmonary embolism: CT findings in 33 patients.
Radiology, 203 (1997), pp. 355-360
[25.]
S.L. Primack, N.L. Müller, J.R. Mayo, M. Remy-Jardin, J.L. Remy.
Pulmonary parenchymal abnormalities of vascular origin: High-Resolution CT findings.
Radiographics, 14 (1994), pp. 739-746
[26.]
A.A. Tardivon, D. Musset, S. Maitre, F. Brenot, Ph. Dartevelle, G. Simonneau, M. Labrune.
Role of CT in chronic pulmonary embolism: comparison with pulmonary angiography.
J Comput Assist Tomogr, 7 (1993), pp. 345-351
[27.]
M.C. Baque-Juston, A.U. Wells, D.M. Hansell.
Pericardial thickening or effusion in patients with pulmonary artery hypertension: A CT study.
AJR Am J Roentgenol, 172 (1999), pp. 361-364
[28.]
S. Eunhee.
Tumors of the pulmonary vasculature.
Cardiol Clin, 22 (2004), pp. 431-440
[29.]
L. Manso, E. Álvarez, M. Quintela, H. Cortés-Funes, R. Hitt.
Primary pulmonary artery sarcoma: report of three cases and review of the literatura.
Clinical Lung Cancer, 8 (2007), pp. 277-281
[30.]
I. Furest, M. Marín, P. Escribano, et al.
Intimal sarcoma of the pulmonary artery: a rare cause of pulmonary hipertensión.
Arch Bronconeumol, 42 (2006), pp. 148-150
[31.]
C. Fernández-Golfín, P. Escribano, J. Cortina, R. Tello, F. Hernández, F. López-Ríos, et al.
Management of primary pulmonary artery sarcoma: Experience of a single center.
Angiology, X (2008), pp. 1-4
[32.]
K.M. Moser, L.K. Olson, M. Schlusselberg, P.O. Daily, W.P. Dembitsky.
Chronic thromboembolic occlusion in the adult can mimic pulmonary artery agenesis.
Chest, 95 (1989), pp. 503-508
[33.]
K.M. Moser, P.F. Fedullo, W.E. Finkbeiner, J. Golden.
Do patients with primary pulmonary hypertension develop extensive central thrombi?.
Circulation, 91 (1995), pp. 741-745
[34.]
P.P. Agarwal, A.L. Wolfshon, F.R. Matzinger, J.M. Seely, R.A. Peterson, C. Dennie.
In situ central pulmonary artery trombosis in primary pulmonary hipertensión.
Acta Radiologica, 7 (2005), pp. 696-700
[35.]
W.R. Auger, P.F. Fedullo, K.M. Moser, M. Buchbinder, K.L. Peterson.
Chronic mayor-vessel thromboembolic pulmonary artery obstruction: Appearance at angiography.
Radiology, 182 (1992), pp. 393-398
[36.]
I.M. Lang, W. Klepetko.
Update of chronic thromboembolic pulmonary hypertension, a frequently undiagnosed condition.
Rev Esp Cardiol, 62 (2009), pp. 120-125
[37.]
K. McNeil, J. Dunning.
Chronic thromboembolic pulmonary hypertension.
Heart, 93 (2007), pp. 1152-1158
[38.]
P. Guillinta, K.L. Peterson, O. Ben-Yehuda.
Cardiac catheterization techniques in pulmonary hypertension.
Cardiol Clin, 22 (2004), pp. 401-415
[39.]
I.M. Lang, W. Klepetko.
Chronic thromboembolic pulmonary hypertension: an updated review.
Curr Opin Cardiol, 23 (2008), pp. 555-559
Copyright © 2009. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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