Journal Information
Vol. 45. Issue S4.
EPOC y comorbilidad: una visión global
Pages 47-50 (March 2009)
Share
Share
Download PDF
More article options
Vol. 45. Issue S4.
EPOC y comorbilidad: una visión global
Pages 47-50 (March 2009)
Full text access
Impacto de la anemia en la EPOC
Impact of anemia on COPD
Visits
12869
Javier de Miguel Díeza,
Corresponding author
jmiguel.hgugm@salud.madrid.org

Autor para correspondencia.
, María Jesús Chillón Martína, Manuel Méndez Bailónb, José Luis Álvarez-Salac
a Servicio de Neumología, Hospital Universitario Gregorio Marañón, Universidad Complutense, Madrid, España
b Servicio de Medicina Interna, Hospital Infanta Leonor, Madrid, España
c Servicio de Neumología, Hospital Clínico San Carlos, Universidad Complutense, Madrid, España
This item has received
Article information
Abstract
Bibliography
Download PDF
Statistics
Resumen

La frecuencia de la anemia puede ser más elevada de lo esperado en los pacientes que padecen una enfermedad pulmonar obstructiva crónica (EPOC). En algunos estudios se han detectado prevalencias que alcanzan un 33%, lo que contrasta con la idea habitual que relaciona la EPOC con la poliglobulia secundaria. Entre los factores de riesgo que se asocian con el desarrollo de una anemia en estos pacientes se encuentran la edad avanzada, la gravedad de la obstrucción al flujo aéreo y la disminución del índice de masa corporal. La anemia es, además de un trastorno frecuente en la EPOC, un índice de mal pronóstico y determina una morbimortalidad mayor en esta enfermedad. En relación con el tratamiento, a pesar de los posibles beneficios clínicos que podrían derivarse de la corrección de la anemia en estos casos, las evidencias científicas que certifican la importancia de su efecto en el pronóstico de la EPOC son aún escasas.

Palabras clave:
Enfermedad pulmonar obstructiva crónica
Anemia de los trastornos crónicos
Pronóstico
Abstract

The frequency of anemia may be higher than expected in patients with chronic obstructive pulmonary disease (COPD). Some studies have detected a prevalence of 33%, contrasting with the common idea that associates COPD with secondary polyglobulia. Among the risk factors associated with the development of anemia in these patients are advanced age, the severity of airflow obstruction and reduction in body mass index. In addition to being a frequent disorder in COPD, anemia is also a poor prognostic factor and leads to greater morbidity and mortality in this disease. Despite the possible clinical benefits of successfully treating anemia in these patients, the scientific evidence supporting the importance of its effect on the prognosis of COPD is scarce.

Key words:
Chronic obstructive pulmonary disease
Anemia of chronic disease
Prognosis
Full text is only aviable in PDF
Bibliografía
[1.]
G. Peces-Barba, J.A. Barberá, A. Agustí, C. Casanova, A. Casas, J.L. Izquierdo, et al.
Guía clínica SEPAR-ALAT de diagnóstico y tratamiento de la EPOC.
Arch Bronconeumol, 44 (2008), pp. 271-281
[2.]
World Health Organization.
Nutritional anemia: report of a WHO scientific group. Ginebra: World Health Organization. 1968.
Tech Rep Sr, 405 (1968), pp. 5-37
[3.]
G. Weiss.
Pathogenesis and treatment of anaemia of chronic disease.
Blood Rev, 16 (2002), pp. 87-96
[4.]
R.T. Means.
Recent developments in the anemia of chronic disease.
Curr Hematol Rep, 2 (2003), pp. 116-121
[5.]
J.M. Guralnik, R.S. Eisenstaedt, L. Ferrucci, H.G. Klein, R.C. Woodman.
The prevalence of anemia in persons age 65 and older in the United States: evidence for a high rate of unexplained anemia.
Blood, 104 (2004), pp. 2263-2268
[6.]
J.A. Ezekowitz, F.A. McAlister, P.W. Armstrong.
Anemia is common in heart failure and is associated with poor outcomes: insights from a cohort of 12.065 patients with new-onset heart failure.
Circulation, 107 (2003), pp. 223-225
[7.]
E.J. Oudijk, J.W. Lammers, L. Koenderman.
Systemic inflammation in chronic obstructive pulmonary disease.
Eur Respir J, 22 (2003), pp. 5s-13s
[8.]
J.L. Álvarez-Sala Walther.
Poliglobulias secundarias hipóxicas.
Arch Bronconeumol, 25 (1989), pp. 282-294
[9.]
M. John, S. Hoernig, W. Doehner, D.D. Okonko, C. Witt, S.D. Anker.
Anemia and inflammation in COPD.
Chest, 127 (2005), pp. 825-829
[10.]
M.T. Halpern, M.D. Zilberberg, J.K. Schmier, E.C. Lau, A.F. Shorr.
Anemia, costs and mortality in chronic obstructive pulmonary disease.
Cost Eff Resour Alloc, 4 (2006), pp. 17
[11.]
M. John, A. Lange, S. Hoernig, C. Witt, S.D. Anker.
Prevalence of anemia in chronic obstructive pulmonary disease: comparison to other chronic diseases.
Int J Cardiol, 111 (2006), pp. 365-370
[12.]
A. Chambellan, E. Chailleux, T. Similowski, The Antadir observatory group.
Prognostic value of the hematocrit in patients with severe COPD receiving long-term oxygen therapy.
Chest, 128 (2005), pp. 1201-1208
[13.]
A.F. Shorr.
Anemia in chronic obstructive pulmonary disease: epidemiology and economic implications.
Curr Med Res Opin, 24 (2008), pp. 1123-1130
[14.]
J. De Miguel, A. Castuera, C. Pérez, S. Lucero, A. Ferreira, M. Fuentes, et al.
Anemia en la EPOC. Prevalencia y factores asociados.
Rev Patol Respir, 11 (2008), pp. 50
[15.]
K. Portillo, J. Belda, P. Anton, P. Casan.
Alta frecuencia de anemia en pacientes de EPOC admitidos en un hospital terciario.
Rev Clin Esp, 207 (2007), pp. 383-387
[16.]
E. Wouters.
Local and systemic inflammation in chronic obstructive pulmonary disease.
Proc Am Thorac Soc, 2 (2005), pp. 26-33
[17.]
J.R. Hurst, W.R. Perera, T.M. Wilkinson, G.C. Donaldson, J.A. Wedzicha.
Systemic and upper and lower airway inflammation at exacerbation of chronic obstructive pulmonary disease.
Am J Respir Crit Care Med, 173 (2006), pp. 71-78
[18.]
G. Weiss, L.T. Goodnough.
Anemia of chronic disease.
N Engl J Med, 352 (2005), pp. 1011-1023
[19.]
B.R. Celli, C.G. Cote, J.M. Marín, C. Casanova, M. Montes de Oca, R.A. Méndez, et al.
The body-mass index, airflow obstruction, dyspnea, and exercise capacity index in chronic obstructive pulmonary disease.
N Engl J Med, 350 (2004), pp. 1005-1012
[20.]
F.J. Martinez, F. Foster, J.L. Curtis, G. Criner, G. Weinmann, A. Fishman, et al.
Predictors of mortality in patients with emphysema and severe airflow obstruction.
Am J Respir Crit Care Med, 173 (2006), pp. 1326-1334
[21.]
M.S. Cappell, S.C. Nadler.
Increased mortality of acute upper gastrointestinal bleeding in patients with chronic obstructive pulmonary disease. A case controlled, multiyear study of 53 consecutive patients.
Dig Dis Sci, 40 (1995), pp. 256-262
[22.]
G.R. Upchruch Upchurch Jr, M.C. Proctor, P.K. Henke, P. Zajkowski, E.M. Riles, M.S. Ascher, et al.
Predictors of severe morbidity and death after elective abdominal aortic aneurysmectomy in patients with chronic obstructive pulmonary disease.
J Vasc Surg, 37 (2003), pp. 594-599
[23.]
B. Schonhofer, M. Wenzel, M. Geibel, D. Kohler.
Blood transfusion and lung function in chronically anemic patients with severe chronic obstructive pulmonary disease.
Crit Care Med, 26 (1998), pp. 1824-1828
[24.]
B. Schonhofer, H. Bohrer, D. Kohler.
Importance of blood transfusion in anemic patients with COPD and unsuccessful weaning from respirator.
Med Klin, 94 (1999), pp. 70-72
[25.]
A.P. Bolger, F.R. Bartlett, H.S. Penston, J. O’Leary, N. Pollock, R. Kaprielian, et al.
Intravenous iron alone for the treatment of anemia in patients with chronic heart failure.
J Am Coll Cardiol, 48 (2006), pp. 1225-1227
[26.]
L. Beck da Silva, L.E. Rohde, A.C. Perreira-Barretto, D. De Albuerquerque, E. Bocchi, F. Vilas-Boas, et al.
Rationale and design of the iron-Hf study: a randomized trial to assess the effects of iron supplementation in heart failure patients with anemia.
J Card Fail, 13 (2007), pp. 14-17
[27.]
R.M. Marrades, J. Roca, J.M. Campistol, O. Diaz, J.A. Barberá, J.V. Torregrosa, et al.
Effects of erythropoietin on muscle O2 transport during exercise in patients with chronic renal failure.
J Clin Invest, 97 (1996), pp. 2092-2100
Copyright © 2009. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?