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Se presenta una paciente diagnosticada de neumonía intersticial linfoide mediante biopsia pulmonar abierta, ante un cuadro de tos improductiva, astenia e infiltrados pulmonares bilaterales. Fue diagnosticada, así mismo, de inmunodeflciencia común variable en base a la presencia de hipogammaglobulinemia, sinusitis de repetición y síndrome diarreico. En su evolución desarrolló un linfoma no hodgkiniano que se diagnosticó mediante citología de un derrame pleural. Se revisa la asociación entre estos procesos y se considera la idea ya preconizada por otros autores de tipificar la neumonía intersticial linfoide como un proceso prelinfomatoso.
We describe a woman with lymphoid interstitial pneumonia diagnosed by open lung biopsy following a profile of unproductive cough, weakness and bilateral lung infiltrates. The patient was also diagnosed as having common variable immunodeficiency based on hypogammaglobulinemia, repeated sinusitis and persistent diarrhea. Exfoliative cytology of pleural effusion revealed the development of non-Hodgkin's lymphoma. We review the associations among these processes and consider the suggestion made by other authors that lymphoid interstitial pneumonia be considered a prelymphomatous process.
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