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        "titulo" => "Resumen"
        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">En Tuberculosis&#44; hoy se trata de utilizar un r&#233;gimen terap&#233;utico tan eficaz que sea capaz de curar al enfermo antes de <span class="elsevierStyleItalic">que se canse de tomar la medicaci&#243;n</span>&#46; Los Tratamientos Cortos con Rifampicina e Hidracida&#44; completados con una tercera droga&#44; son el motivo de este trabajo&#46; Se ha realizado un Estudio Controlado en 3 fases&#58; 1&#46;<span class="elsevierStyleSup">er</span><span class="elsevierStyleItalic">Estudio</span>&#44; de &#171;Aproximaci&#243;n a los Tratamientos Cortos&#187; de 12 meses de duraci&#243;n&#44; &#40;99 casos&#41; en donde se ha ido acortando el tiempo de ad ministraci&#243;n de la Rifampicina &#40;12&#44;9 y 6 <span class="elsevierStyleItalic">meses</span>&#41;&#44; pero manteniendo en todos los casos la Hidracida hasta completar el a&#241;o de tratamiento&#46; 2&#46;&#176; <span class="elsevierStyleItalic">Estudio</span>&#44; con pautas abreviadas de duraci&#243;n real de 12&#46; 9 y 6 meses &#40;133 pacientes&#41; y 3&#46;<span class="elsevierStyleSup">er</span> Estudio&#44; todav&#237;a en fase de admisi&#243;n de enfermos&#59; donde se pretende conocer qu&#233; papel juega la Pirazinamida sobre la recidiva&#44; y cual es su tolerancia&#46; Hasta ahora cuenta con 157 casos&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">En un r&#233;gimen standar&#44; que sirve como control la conversi&#243;n del esputo se consigue al final del 6&#46;&#176; mes&#59; en tanto que los que contienen R&#47;AMP lo consiguen al 3&#46;<span class="elsevierStyleSup">er</span> mes&#46; Entre 245 enfermos ha habido 5 fracasos bacteriol&#243;gicos en el transcurso del trata-miento &#40;2&#37;&#41;&#46; 3 con el r&#233;gimen standard &#40;8&#44;5&#37;&#41; y 2 con los reg&#237;menes que llevan R&#47;AMP &#40;1&#37;&#41;&#46; Hasta ahora no ha habido recidiva alguna&#44; incluso en los reg&#237;menes de 6 meses de duraci&#243;n&#44; bien es cierto que el n&#250;mero de casos es todav&#237;a reducido para poder extraer conclusiones que tengan valor estad&#237;stico&#46; Todav&#237;a es temprano para valorar los datos del 3&#46; <span class="elsevierStyleSup">er</span> Estudio&#59; s&#243;lo es destacable la toxicidad a la PZ que no es despreciable&#44; pero que podr&#237;a aceptarse si esta droga fuera capaz de reducir las recidivas y recortar a&#250;n m&#225;s el tratamiento&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Se hacen unas consideraciones sobre los tres sectores que componen la poblaci&#243;n bacilar de una cavidad &#171;no tratada&#187;&#58; La masa bacilar sensible&#44; los g&#233;rmenes inicialmente resistentes&#44; y los bacilos persistentes&#46; Se concluye que los Tratamientos Cortos act&#250;an con eficacia sobre estas 3 subpoblaciones bacilares&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Por publicarse este trabajo en una Revista de amplia difusi&#243;n entre los neum&#243;logos espa&#241;oles&#44; gran parte de los cuales viven alejados del problema de la Tuberculosis&#44; se intercalan m&#225;s comentarios de tipo pr&#225;ctico de los debidos&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">In Tuberculosis&#44; today one tries to use a therapeutical regimen so effective <span class="elsevierStyleItalic">that it is capable of curing the patient before he tires of taking the medication</span>&#46; Short term treatments with Rifampicine and Hidracide&#44; completed with a third drug are the motive of this pa per&#46; The authors have carried out a Controlled Study in 3 phases&#58; <span class="elsevierStyleItalic">1st Study&#46; of &#171;Approximation to Short Term</span> Treatments&#58; <span class="elsevierStyleItalic">12 months</span> long&#44; &#40;99 cases&#41; where the length of time of administration of Rifampicine was shortened 12&#44; 9 and 6 months&#41;&#44; but maintaining in all the cases Hidracide until completing the year of treatment&#46; <span class="elsevierStyleItalic">2nd Study</span>&#44; with abbreviated guides of real duration of 12&#46; 9 and <span class="elsevierStyleItalic">6 months</span> &#40;133 patients&#41;&#46; <span class="elsevierStyleItalic">3rd Study</span>&#44; still in the phase of admission of patients&#59; where the authors pretend to learn the role of Pirazinamide on relapse&#44; and what is its tolerance&#46; To date&#44; the authors count with 157 cases&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">In a standard regimen&#44; that serves as control&#44; the conversion of sputum was achieved at the end of the 6th month&#59; whereas those that contain R&#47;AMP achieve this conversion in the third month&#46; Out of a group of 245 patients there were 5 bacteriological failures during the course of treatment &#40;5&#37;&#41;&#59; 3 with the standard regimen &#40;8&#44;5&#37;&#41; and 2 with the regimens that include R&#47;AMP &#40;1&#37;&#41;&#46; Up to now there has been no relapse&#44; including the regimens of 6 months of duration&#46; However&#44; it is true that the number of cases is still too small to be able to offer conclusions witha statistical value&#46; It is still early to evaluate the data of the 3rd Study&#59; although the toxicity of PZ is worthy of note&#44; as it is not contemptible&#44; but could be acepted if this drug were capable of reducing the nomber of relapses and shortening the treatment even more&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The authors then comment on the three sectors that compose the bacillary population of an &#171;untreated&#187; cavity&#58; the sensitive bacillary mass&#44; initially resistant germs&#44; and persistent bacilli&#46; The authors come to the conclusion that the Short Term Treatments act effectively on these 3 bacillary subpopulations&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Finally the author add appropriate commentaries of a practical type as this paper is published in a journal of wide distribution among Spanish pneumologists&#44; many of whom do not live the problem of Tuberculosis closely&#46;</p></span>"
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Vol. 14. Issue 3.
Pages 105-117 (July - September 1978)
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Vol. 14. Issue 3.
Pages 105-117 (July - September 1978)
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Tratamientos cortos en tuberculosis pulmonar. La evolucion conceptual de la terapeutica. 3 ensayos controlados
Short term treatments for pulmonary tuberculosis
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F.J. Guerra Sanz, R. Rey Durán, J.J. Martínez Cuesta, F. Bachiller Cabezón, L. Muñoz Cabrera, R. Salama Benoliel, L. Lara Garcia, J.J. Fernández Luceño, P. Martínez Larriba
Servicio de Bronconeumologia Clínica Torácica Victoria Eugenia Madrid
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Resumen

En Tuberculosis, hoy se trata de utilizar un régimen terapéutico tan eficaz que sea capaz de curar al enfermo antes de que se canse de tomar la medicación. Los Tratamientos Cortos con Rifampicina e Hidracida, completados con una tercera droga, son el motivo de este trabajo. Se ha realizado un Estudio Controlado en 3 fases: 1.erEstudio, de «Aproximación a los Tratamientos Cortos» de 12 meses de duración, (99 casos) en donde se ha ido acortando el tiempo de ad ministración de la Rifampicina (12,9 y 6 meses), pero manteniendo en todos los casos la Hidracida hasta completar el año de tratamiento. 2.° Estudio, con pautas abreviadas de duración real de 12. 9 y 6 meses (133 pacientes) y 3.er Estudio, todavía en fase de admisión de enfermos; donde se pretende conocer qué papel juega la Pirazinamida sobre la recidiva, y cual es su tolerancia. Hasta ahora cuenta con 157 casos.

En un régimen standar, que sirve como control la conversión del esputo se consigue al final del 6.° mes; en tanto que los que contienen R/AMP lo consiguen al 3.er mes. Entre 245 enfermos ha habido 5 fracasos bacteriológicos en el transcurso del trata-miento (2%). 3 con el régimen standard (8,5%) y 2 con los regímenes que llevan R/AMP (1%). Hasta ahora no ha habido recidiva alguna, incluso en los regímenes de 6 meses de duración, bien es cierto que el número de casos es todavía reducido para poder extraer conclusiones que tengan valor estadístico. Todavía es temprano para valorar los datos del 3. er Estudio; sólo es destacable la toxicidad a la PZ que no es despreciable, pero que podría aceptarse si esta droga fuera capaz de reducir las recidivas y recortar aún más el tratamiento.

Se hacen unas consideraciones sobre los tres sectores que componen la población bacilar de una cavidad «no tratada»: La masa bacilar sensible, los gérmenes inicialmente resistentes, y los bacilos persistentes. Se concluye que los Tratamientos Cortos actúan con eficacia sobre estas 3 subpoblaciones bacilares.

Por publicarse este trabajo en una Revista de amplia difusión entre los neumólogos españoles, gran parte de los cuales viven alejados del problema de la Tuberculosis, se intercalan más comentarios de tipo práctico de los debidos.

Summary

In Tuberculosis, today one tries to use a therapeutical regimen so effective that it is capable of curing the patient before he tires of taking the medication. Short term treatments with Rifampicine and Hidracide, completed with a third drug are the motive of this pa per. The authors have carried out a Controlled Study in 3 phases: 1st Study. of «Approximation to Short Term Treatments: 12 months long, (99 cases) where the length of time of administration of Rifampicine was shortened 12, 9 and 6 months), but maintaining in all the cases Hidracide until completing the year of treatment. 2nd Study, with abbreviated guides of real duration of 12. 9 and 6 months (133 patients). 3rd Study, still in the phase of admission of patients; where the authors pretend to learn the role of Pirazinamide on relapse, and what is its tolerance. To date, the authors count with 157 cases.

In a standard regimen, that serves as control, the conversion of sputum was achieved at the end of the 6th month; whereas those that contain R/AMP achieve this conversion in the third month. Out of a group of 245 patients there were 5 bacteriological failures during the course of treatment (5%); 3 with the standard regimen (8,5%) and 2 with the regimens that include R/AMP (1%). Up to now there has been no relapse, including the regimens of 6 months of duration. However, it is true that the number of cases is still too small to be able to offer conclusions witha statistical value. It is still early to evaluate the data of the 3rd Study; although the toxicity of PZ is worthy of note, as it is not contemptible, but could be acepted if this drug were capable of reducing the nomber of relapses and shortening the treatment even more.

The authors then comment on the three sectors that compose the bacillary population of an «untreated» cavity: the sensitive bacillary mass, initially resistant germs, and persistent bacilli. The authors come to the conclusion that the Short Term Treatments act effectively on these 3 bacillary subpopulations.

Finally the author add appropriate commentaries of a practical type as this paper is published in a journal of wide distribution among Spanish pneumologists, many of whom do not live the problem of Tuberculosis closely.

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Copyright © 1978. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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