Journal Information
Vol. 37. Issue 1.
Pages 48-50 (January 2001)
Share
Share
Download PDF
More article options
Vol. 37. Issue 1.
Pages 48-50 (January 2001)
Full text access
Tratamiento del asma con antileucotrienos y síndrome de Churg-Strauss
Asthma treated with antileukotriene and Churg-Strauss syndrome
Visits
14427
J. Sala Félix*, M.E. Pereiro Alonso
Servicio de Neumología II. Hospital Central de Asturias. Oviedo
C. Salas Antón*
* Servicio de Anatomía Patológica. Hospital Puerta de Hierro. Madrid
This item has received
Article information

Desde la introducción de los antileucotrienos (ALT) en el tratamiento del asma existe controversia sobre si su uso pue-de dar lugar a un síndrome de Churg-Strauss (SCS) o si esta enfermedad simplemente se mantiene cohibida por el uso de esteroides, habiéndose publicado varios artículos en este sentido.

Presentamos el caso de un paciente con sospecha clínic de SCS con manifestaciones broncopulmonares, cutáneas y hematológicas, tratado con esteroides orales. Un año des-pués, tras su mejoría clínica, se sustituyó el tratamiento con esteroides orales por ALT, desarrollándose de nuevo la clí-nica y confirmándose anatomopatológicamente la vasculitis de Churg-Strauss.

Palabras clave:
Síndrome de Churg-Strauss
Asma
Antileuco-trienos
Esteroides

Since antileukotriene treatment for asthma was introdu-ced, there has been debate about whether such therapy can lead to Churg-Strauss Syndrome (CSS) or whether CSS is simply inhibited by the use of steroids, as various authors have suggested.

We report a case in which we suspected CSS in a patient with bronchopulmonary, cutaneous and analytical signs and whom we treated with oral steroids. After clinical improve-ment, one year later, steroids were replaced by antileukotrie-nes, after which the same clinical picture developed. The vas-culitis characteristic of CSS was confirmed pathologically.

Keywords:
Churg-Strauss syndrome
Asthma
Anti-leukotrienes
Steroids
Full text is only aviable in PDF
Bibliografía
[1.]
I.T. Lie.
Illustrated histopathologic classification criteria for selected vasculitis syndromes.
Arthritis Rheum, 33 (1990), pp. 1074-1087
[2.]
L.C. Chumbley, J.r. Harrison EG, R.A. DeRemee.
Allergic granulomatosis and agiitis (Churg-Strauss syndrome): report and analysis of 30 cases.
Mayo Clin Proc, 52 (1977), pp. 477-484
[3.]
J.G. Lanham, K.B. Elkon, C.D. Pusey, G.R. Hughes.
Systemic vasculitis with asthma and eosinophilia: a clinical approach to the Churg- Strauss syndrome.
Medicine, 63 (1984), pp. 65-81
[4.]
A.T. Masi, G.G. Hunder, J.T. Lie, B.A. Michel, D.A. Bloch, W.P. Arend.
The American College of Rheumatology 1990 criteria for the classification of Churg-Strauss syndrome (allergic granulomatosis and angiitis).
Arthritis Rheum, 33 (1990), pp. 1094-1100
[5.]
P.M. O'Byrne.
Leukotrienes in the pathogenesis of asthma.
Chest, 111 (1997), pp. 21-34
[6.]
P.M. O'Byrne, E. Israel, J.M. Drazen.
Antileukotrienes in the treatment of asthma.
Ann Intern Med, 127 (1997), pp. 472-480
[7.]
T.E. Reiss, P. Chervinsky, R.J. Dockhorn, S. Shingo, B. Seidenberg, T.B. Edwards.
Montelukast, a once daily leukotriene receptor antagonist in the treatment of chronic asthma: a multicenter, randomized, double-blind trial.
Arch Intern Med, 158 (1998), pp. 1213-1220
[8.]
M. Labiolette, K. Malstrom, S. Lu, P. Cherninsky, J.C. Pujet, I. Peszek, et al.
Montelukast added to inhaled beclometasone in treatment of asthma.
Am J Respir Crit Care Med, 160 (1999), pp. 1862-1868
[9.]
M. Kinoshita, T. Shiraishi, T. Koga, M. Ayabe, T. Rikimaru, K. Oizumi.
Churg-Strauss syndrome after corticosteroid withdrawal in an asthmatic patient treated with pranlukast.
J Allergy Clin Inmunol, 103 (1999), pp. 534-535
[10.]
A. Churg, M. Brallas, S.R. Cronin, J. Churg.
Formes frustrées of Churg-Strauss syndrome.
Chest, 108 (1995), pp. 320-323
[11.]
M.E. Wechsler, E. Carpestad, S.R. Flier, O. Kocher, D.A. Weiland, A.J. Polito.
Pulmonary infiltrates, eosinophilia, and cardiomyopathy following corticosteroid withdrawal in patients with asthma receiving zafirlukast.
Jama, 279 (1998), pp. 455-457
[12.]
R.S. Katz, M. Papernik.
Zafirlukast and Churg-Strauss syndrome.
Jama, 279 (1998), pp. 1949-1950
[13.]
L. Daren, Knoell, D. Pharm, J. Lucas, J.N. Allen.
Churg-Strauss syndrome associated with zafirlukast.
Chest, 114 (1998), pp. 332-334
Copyright © 2001. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
Article options
Tools

Are you a health professional able to prescribe or dispense drugs?