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Vol. 23. Issue 1.
Pages 10-14 (January - February 1987)
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Vol. 23. Issue 1.
Pages 10-14 (January - February 1987)
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Tratamiento con quimio-radioterapia en el carcinoma indiferenciado de celulas pequeñas del pulmon. Estudio prospectivo en 32 pacientes
Chemotherapy with radiotherapy in the treatment of indifferentiated small cell lung carcinoma. Prospective study on 32 patients
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L. Borderias Clau, J. Teran Santos, R. Agüero Balbin, F. Zurbano Goñi, J. Duran Cantolla, J. Barrio Soto, A. Jimenez Gomez
Servicio de Neumología. Hospital Nacional Marqués de Valdecilla. Santander
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Los autores realizan un estudio prospectivo sobre 32 pacientes afectos de carcinoma pulmonar de células pequeñas (CPCP), tratados con un régimen mixto de poliquimio-radioterapia (ciclofosfamida, adriamicina, VP-16, vincristina).

Los factores pronósticos fueron el índice de Karnofsky y la extensión tumoral. La supervivencia media fue de 56 semanas para el grupo de enfermedad localizada (EL) y de 34 semanas para los de enfermedad extendida (EE). El porcentaje de respuestas completas en pacientes con EL fue significativamente mayor que el de los que presentaban EE. En la serie hubo tres pacientes con larga supervivencia. Debido a las dosis moderadas empleadas en el protocolo, los efectos secundarios no fueron importantes y no se produjo ninguna muerte tóxica.

The authors conducted a prospective study on 32 patients with small cell lung carcinoma (CPCP) treated with a mixed regimen of polichemotherapy (cyclophosphamide, adriamycin, VP-1, vincristine) and radiotherapy.

The pronostic factors were the Karnofsky index and the spreading of the tumour. The mean survival time was 56 weeks for the group with local disease (EL) and 34 weeks for the patients with disseminated disease (EE). The percentage of complete responsos among EL patients was significatively greater than in the EE group of patients. Three patients of this series showed a long survival. Due to the moderate dosage used in the protocol, side effects were mild and no death was attributable to toxic drug effects.

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Copyright © 1987. Sociedad Española de Neumología y Cirugía Torácica
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