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array:23 [ "pii" => "S0300289620303987" "issn" => "03002896" "doi" => "10.1016/j.arbres.2020.10.015" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "2660" "copyright" => "SEPAR" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2021;57:772-4" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "itemSiguiente" => array:19 [ "pii" => "S0300289620303999" "issn" => "03002896" "doi" => "10.1016/j.arbres.2020.10.016" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "2661" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2021;57:774-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "¿Debe incluirse la saturación basal de oxígeno en la estratificación de riesgo de la enfermedad pulmonar obstructiva crónica propuesta por GesEPOC?" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "774" "paginaFinal" => "776" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Should Pulse Oximeter Saturations Be Included in the Risk Stratification for Chronic Obstructive Pulmonary Disease Proposed by GesEPOC?" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 3491 "Ancho" => 2500 "Tamanyo" => 270259 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Curvas de supervivencia según criterios de riesgo clásicos (modelo<span class="elsevierStyleHsp" style=""></span>1) o incluyendo la variable saturación periférica de oxígeno (modelo<span class="elsevierStyleHsp" style=""></span>2).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Juan Marco Figueira Gonçalves, Rafael Golpe, Yolanda Ramallo, Ignacio García Talavera, David Dacal" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Juan Marco" "apellidos" => "Figueira Gonçalves" ] 1 => array:2 [ "nombre" => "Rafael" "apellidos" => "Golpe" ] 2 => array:2 [ "nombre" => "Yolanda" "apellidos" => "Ramallo" ] 3 => array:2 [ "nombre" => "Ignacio" "apellidos" => "García Talavera" ] 4 => array:2 [ "nombre" => "David" "apellidos" => "Dacal" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212921003785" "doi" => "10.1016/j.arbr.2021.10.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921003785?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620303999?idApp=UINPBA00003Z" "url" => "/03002896/0000005700000012/v2_202112040821/S0300289620303999/v2_202112040821/es/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S0300289621000600" "issn" => "03002896" "doi" => "10.1016/j.arbres.2021.01.034" "estado" => "S300" "fechaPublicacion" => "2021-12-01" "aid" => "2761" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "sco" "cita" => "Arch Bronconeumol. 2021;57:771" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Imagen clínica</span>" "titulo" => "Afectación pulmonar y pleural severa por osteosarcoma en mujer de 24 años. La manifestación visceral más agresiva de un tumor óseo" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "771" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Severe Lung and Pleural Involvement Due to Osteosarcoma in a 24 Year Woman. The Most Aggressive Visceral Presentation of a Bone Tumor" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 857 "Ancho" => 1300 "Tamanyo" => 112367 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Radiografía simple de tórax PA <span class="elsevierStyleBold">A)</span> y tomografía computarizada toraco-abdominal corte coronal <span class="elsevierStyleBold">B)</span> al diagnóstico, donde se objetiva derrame pleural izquierdo masivo, lesión blástica en cabeza humeral derecha, múltiples imágenes de densidad calcio en parénquima pulmonar bilateral y pleura. TC de tórax corte axial <span class="elsevierStyleBold">C1 y C2)</span> tras drenaje de derrame pleural, donde destacan múltiples metástasis bilaterales en parénquima pulmonar y en pleura, así como neumotórax izquierdo. Radiografía simple de tórax PA y lateral <span class="elsevierStyleBold">D.1 y D.2)</span> a los 10 meses desde el diagnóstico, donde se demuestra un aumento en número y tamaño de los nódulos y masas pulmonares y pleurales bilaterales, derrame pleural izquierdo y aumento de la lesión primaria en cabeza humeral derecho.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Katherin Martínez Barroso, Miguel Borregón Rivilla, Manuel Mazariegos Rubí, Javier Medina Martínez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Katherin" "apellidos" => "Martínez Barroso" ] 1 => array:2 [ "nombre" => "Miguel" "apellidos" => "Borregón Rivilla" ] 2 => array:2 [ "nombre" => "Manuel" "apellidos" => "Mazariegos Rubí" ] 3 => array:2 [ "nombre" => "Javier" "apellidos" => "Medina Martínez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212921003803" "doi" => "10.1016/j.arbr.2021.10.006" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921003803?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289621000600?idApp=UINPBA00003Z" "url" => "/03002896/0000005700000012/v2_202112040821/S0300289621000600/v2_202112040821/es/main.assets" ] "en" => array:16 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Transbronchial Cryobiopsy of Peripheral Pulmonary Lesions Guided With Real-Time Transthoracic Ultrasonography" "tieneTextoCompleto" => true "saludo" => "Dear Editor," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "772" "paginaFinal" => "774" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Felipe Andreo García, Mohamed Torky, Carmen Centeno Clemente, Pere Serra Mitjà, Antoni Rosell Gratacós, Rachid Tazi Mezalek" "autores" => array:6 [ 0 => array:4 [ "nombre" => "Felipe" "apellidos" => "Andreo García" "email" => array:1 [ 0 => "fandreo@separ.es" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">*</span>" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Mohamed" "apellidos" => "Torky" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] ] ] 2 => array:3 [ "nombre" => "Carmen" "apellidos" => "Centeno Clemente" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Pere" "apellidos" => "Serra Mitjà" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Antoni" "apellidos" => "Rosell Gratacós" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 5 => array:3 [ "nombre" => "Rachid" "apellidos" => "Tazi Mezalek" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:4 [ 0 => array:3 [ "entidad" => "Respiratory Department, Thorax Clinic Institute, Hospital Universitari Germans Trias i Pujol, Badalona, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Department of Medicine, Universitat Autònoma de Barcelona, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Ciber de Enfermedades Respiratorias (CIBERES), Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Chest Department, Tanta University, Egypt" "etiqueta" => "d" "identificador" => "aff0020" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Criobiopsia transbronquial de lesiones pulmonares periféricas guiada en tiempo real con ultrasonografía transtorácica" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 829 "Ancho" => 1255 "Tamanyo" => 135650 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Chest CT image shows a lingular mass with pleural contact and bronchus sign. (B) Flexible cryoprobe indicated for transbronchial biopsy. Outer diameter 1.9<span class="elsevierStyleHsp" style=""></span>mm, length 900<span class="elsevierStyleHsp" style=""></span>mm. (C) Transthoracic ultrasound image before performing transbronchial biopsy of the mass. (D) Transthoracic ultrasound image during the performance of transbronchial biopsy, which locates the cryoprobe within the lung mass (arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The diagnosis of peripheral pulmonary lesions (PPL) is important, especially when it is required to confirm or exclude malignancy. We present what we believe to be the first two cases of PPL diagnosed by transbronchial cryobiopsies guided by real-time transthoracic ultrasound and assisted by radial endobronchial ultrasound (r-EBUS).</p><p id="par0010" class="elsevierStylePara elsevierViewall">The first patient was a 76-year-old male, a heavy ex-smoker with a peripheral left mass on chest X-ray. Thoracic computed tomography (CT) revealed a lingular solid mass with 38<span class="elsevierStyleHsp" style=""></span>mm larger diameter, based on pleura adjacent to the anterior thoracic wall (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A) compatible with primary lung neoplasia. Chest ultrasound examination showed a nodule of 26<span class="elsevierStyleHsp" style=""></span>mm of maximum depth with pleural contact, mobile with respiratory movements and partially covered by the adjacent rib, leaving a narrow intercostal space for examination. Standard bronchoscopy with a thin bronchoscope, showed no endobronchial lesions so the endoscopic examination was carried out with r-EBUS. A 1.4<span class="elsevierStyleHsp" style=""></span>mm radial ultrasound probe (Olympus Co, Japan) was advanced through the lingula bronchi until the hypoechoic heterogeneous nodule was visualized and then we tried to reproduce the path with the 1.9<span class="elsevierStyleHsp" style=""></span>mm cryoprobe (ERBE CA, Germany) (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). Prior to transbronchial sampling, the transthoracic ultrasound (convex transducer, F2.5<span class="elsevierStyleHsp" style=""></span>MHz D9.9, MINDRAY Co, China) was applied on the anterior chest wall (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C) and was able to visualize, in real time, the transbronchial cryoprobe going through the mass and avoiding the pleura (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>D and <a class="elsevierStyleCrossRef" href="#sec0020">supplementary video 1A</a>). Curiously, applying freezing decreased the ultrasound image of the probe, except for the tip (<a class="elsevierStyleCrossRef" href="#sec0020">supplementary video 1B</a>), and allowed for the visualization of the tissue freezing process. Biopsies (4 samples, 1.1<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.9<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>0.3<span class="elsevierStyleHsp" style=""></span>cm) were positive for adenocarcinoma.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">The second case was a 39-year-old female who presented with fever and unresolved pneumonia which had resisted antibiotic therapy for a period of two months. The patient had no history of smoking and her physical examination revealed only bilateral basal fine crepitations. Thoracic CT showed bilateral basal consolidation opacities with positive air bronchogram. Microbiological examination for sputum and bronchoalveolar lavage samples were negative, including the tuberculosis work-up. For the diagnosis of the underlying pathology, the patient was subjected to r-EBUS assisted transbronchial cryobiopsy guided with transthoracic ultrasound. During the procedure, the radial probe was advanced through the lateral segment of the left lower lobe until the lesion was visible. Then, the 1.9<span class="elsevierStyleHsp" style=""></span>mm flexible cryoprobe was advanced to the target location. Simultaneously, the transthoracic ultrasound was applied on the chest wall and was able to detect the lesion. The transthoracic ultrasound was helpful in confirming that the cryoprobe was located within the lesion and distant from the pleura to avoid pneumothorax. Four transbronchial cryobiopsies were obtained and the histopathological examination revealed cryptogenic organizing pneumonia.</p><p id="par0020" class="elsevierStylePara elsevierViewall">Conventional bronchoscopy has a low diagnostic value for PPL which may be less than 20% for nodules smaller than 2<span class="elsevierStyleHsp" style=""></span>cm in diameter.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> Also, it should be noted that not all PPL can be seen by fluoroscopy, in addition to the presence of radiation hazards for the patient and the operators. Although CT guided percutaneous biopsy is a reliable technique for the diagnosis of these lesions, it is associated with a high risk of pneumothorax<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">2</span></a> and is therefore usually indicated when transbronchial procedures have proved unsuccessful. Chest ultrasound guided percutaneous biopsy is an equally long-established method but requires appropriate case selection in advance.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">3</span></a> The pleural contact length made by the mass or nodule, for example, influences diagnostic yield. Chest ultrasound and CT guided percutaneous biopsy were not considered a convenient alternative because of the ultrasound findings in our first case and because of diagnostic suspicion in the second one. Moreover, these techniques do not allow for the obtention of cryobiopsy samples.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Recent updates to bronchoscopic methods have aimed to increase the diagnostic value for PPL. Electromagnetic navigation bronchoscopy has achieved an accuracy of up to 81.7%, however, it is associated with high economic costs.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">4</span></a> R-EBUS has emerged as a safer method in comparison to CT-guided biopsy but the yield of r-EBUS remains lower than that of CT-guided biopsy, due in part to the smaller sample size.<a class="elsevierStyleCrossRefs" href="#bib0100"><span class="elsevierStyleSup">5,6</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The safety and feasibility of cryoprobes in combination with r-EBUS has also undergone a preliminary evaluation for the diagnosis of PPL and compared with forceps biopsies. Transbronchial cryobiopsy with r-EBUS assistance can obtain a better diagnostic yield and significantly larger samples.<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">7,8</span></a> Cryobiopsy could even increase the detection rate of epidermal growth factor receptor (EGFR) mutations in non-small-cell lung cancer in comparison to other tissue sampling techniques.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> However, a meta-analysis<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> reported a pneumothorax average incidence of 10% after transbronchial biopsies with a cryoprobe in interstitial lung disease. Bleeding during cryobiopsy is common and the risk is greater than with conventional forceps biopsies. Moderate bleeding after cryo-biopsy was observed in 65 cases of 383 patients in 12 studies (16.9%).<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">A main drawback regarding r-EBUS is the absence of real-time vision for biopsy. In this case report, we describe a novel technique for the biopsy of malignant and benign PPL near to pleura using transthoracic ultrasound guidance for cryobiopsies. The particular advantages of real-time guidance with external thoracic ultrasound are the ability to guide the biopsy tool directly to the lesion without C-arm fluoroscope, using echotexture to avoid necrotic areas, preventing injury to surrounding vascular structures and the pleura and to permit the exclusion of the pneumothorax.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> For instance, in the diagnosis of interstitial lung diseases, distances of the cryoprobe to the pleura of less than 1<span class="elsevierStyleHsp" style=""></span>cm are associated with a significantly increased risk of pneumothorax,<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">12</span></a> while biopsies obtained too proximally to the middle third of the lung without ultrasound assistance increase the risk of severe bleeding.</p><p id="par0040" class="elsevierStylePara elsevierViewall">Also, we hypothesize that guided real-time transthoracic ultrasound can increase the diagnostic yield of r-EBUS in a way that is similar to real-time convex EBUS transbronchial needle aspiration<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">13</span></a> when compared with non-real-time EBUS.<a class="elsevierStyleCrossRef" href="#bib0145"><span class="elsevierStyleSup">14</span></a> Nevertheless, in comparison with CT-guided biopsy, our technique may have the disadvantage of requiring two operators, one for bronchoscopy and the other for performing transthoracic ultrasound. Even though, thoracic ultrasound offers other advantages, including the lack of ionization radiation, low cost, flexibility, reproducibility of the examination and bedside availability.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In conclusion, the combination of transthoracic ultrasound and flexible cryoprobe add to r-EBUS procedure the potentiality of vision-guided transbronchial cryobiopsies for PPL lesions with pleural contact. Using percutaneous chest ultrasound has enabled us to guide the cryoprobe to the target lesion to obtain accurate samples. Further benefits are visual confirmation that it is freezing the tissue, visualization of the distance to the pleura to prevent pneumothorax and the use of the color Doppler to avoid highly vascularized areas.</p><p id="par0050" class="elsevierStylePara elsevierViewall">Our initial experience requires prospective validation in a larger patient cohort to confirm the reliability and reproducibility of these results combining transbronchial cryobiopsy with percutaneous chest ultrasound.</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Funding</span><p id="par0055" class="elsevierStylePara elsevierViewall">This study was partially supported by grants <span class="elsevierStyleGrantSponsor" id="gs1">AEER 2016</span>, <span class="elsevierStyleGrantSponsor" id="gs2">SEPAR 120/2016</span> and <span class="elsevierStyleGrantSponsor" id="gs3">FUCAP 2017</span>.</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interest</span><p id="par0060" class="elsevierStylePara elsevierViewall">The authors have reported to Archivos de Bronconeumología that no potential conflicts of interest exist with any companies/organizations whose products or services may be discussed in this article.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0005" "titulo" => "Funding" ] 1 => array:2 [ "identificador" => "sec0010" "titulo" => "Conflict of interest" ] 2 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "apendice" => array:1 [ 0 => array:1 [ "seccion" => array:1 [ 0 => array:4 [ "apendice" => "<p id="par0070" class="elsevierStylePara elsevierViewall">The following are the supplementary data to this article:<elsevierMultimedia ident="upi0005"></elsevierMultimedia></p>" "etiqueta" => "Appendix A" "titulo" => "Supplementary data" "identificador" => "sec0020" ] ] ] ] "multimedia" => array:2 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 829 "Ancho" => 1255 "Tamanyo" => 135650 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">(A) Chest CT image shows a lingular mass with pleural contact and bronchus sign. (B) Flexible cryoprobe indicated for transbronchial biopsy. Outer diameter 1.9<span class="elsevierStyleHsp" style=""></span>mm, length 900<span class="elsevierStyleHsp" style=""></span>mm. (C) Transthoracic ultrasound image before performing transbronchial biopsy of the mass. (D) Transthoracic ultrasound image during the performance of transbronchial biopsy, which locates the cryoprobe within the lung mass (arrow).</p>" ] ] 1 => array:6 [ "identificador" => "upi0005" "tipo" => "MULTIMEDIAECOMPONENTE" "mostrarFloat" => false "mostrarDisplay" => true "Ecomponente" => array:3 [ "fichero" => "mmc1.mp4" "ficheroTamanyo" => 6636811 "Video" => array:2 [ "flv" => array:5 [ "fichero" => "mmc1.flv" "poster" => "mmc1.jpg" "tiempo" => 0 "alto" => 0 "ancho" => 0 ] "mp4" => array:5 [ "fichero" => "mmc1.m4v" "poster" => "mmc1.jpg" "tiempo" => 0 "alto" => 0 "ancho" => 0 ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Supplementary Video 1. (A) On the transthoracic ultrasound screen, the cryoprobe appears from the distal part below the posterior enhancement of the mass. (B) While freezing is being applied, the cryoprobe image, except for the tip, decreases on the ultrasound screen.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Diagnostic yield of fiberoptic bronchoscopy in evaluating solitary pulmonary nodules" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "W.A. Baaklini" 1 => "M.A. Reinoso" 2 => "A.B. Gorin" 3 => "A. Sharafkaneh" 4 => "P. 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