Survival Analysis of Resection of Lung Metastases From Colorectal Cancer

Poce, Roberto Mongil; Navarrete, Carlos Pagés; Navarrete, José Antonio Ruiz; Fernández, Javier Roca; Sánchez, Ricardo Arrabal; Doménech, Agustín Benítez; de Rota Avecilla, Antonio Fernández; Bermúdez, José Luis Fernández

doi:10.1016/S1579-2129(09)72154-8

Archivos de Bronconeumología

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Vol. 45. Issue 5.

Pages 235-239 (May 2009)

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Pages 235-239 (May 2009)

Original article

DOI: 10.1016/S1579-2129(09)72154-8

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Survival Analysis of Resection of Lung Metastases From Colorectal Cancer

Analisis de supervivencia de la cirugía de resección de metastasis pulmonares de cáncer colorrectal

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Roberto Mongil Poce

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robertomongil@hotmail.com

Corresponding author.

, Carlos Pagés Navarrete, José Antonio Ruiz Navarrete, Javier Roca Fernández, Ricardo Arrabal Sánchez, Agustín Benítez Doménech, Antonio Fernández de Rota Avecilla, José Luis Fernández Bermúdez

Servicio de Cirugía Torácica, Hospital Regional Universitario Carlos Haya, Málaga, Spain

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Abstract

Introduction

The publication of the International Registry of Lung Metastases (IRLM) in 1997 was a turning point in favor of surgical resection of lung metastases. Prognostic groups were defined according to resectability, number of metastases, and disease-free interval. The objective of this study was to determine survival in patients who underwent resection of lung metastases from colorectal carcinoma and to evaluate how applicable the prognostic factors established by the IRLM are in this specific patient group.

Patients and Methods

Patients with lung metastases from colorectal carcinoma who underwent resection between January 1, 2000, and November 30, 2006, were retrospectively analyzed. Survival was calculated using the Kaplan-Meier method, with log-rank comparisons between groups.

Results

Survivals at 1, 3, 5, and 6 years was 92%, 75%, 54%, and 43%, respectively. The main finding was that 3-year survival was better in patients who underwent atypical resection of the metastasis (75%) than those who required lobectomy (55%). There were no significant differences in survival in terms of number of lung metastases resected or disease-free interval.

Conclusions

Survival in patients requiring lobectomy for resection of lung metastases from colorectal carcinoma was worse than in those who underwent atypical resection. The number of metastases and disease-free interval may be questionable prognostic factors in the case of lung metastases from colorectal carcinoma.

Keywords:

Lung metastasis

Colorectal carcinoma

Surgery

Resumen

Introducción

La publicación del Registro Internacional de Metástasis Pulmonares (IRLM, de International Registry of Lung Metastases) en 1997 supuso un punto de inflexión a favor de la cirugía de resección de metástasis pulmonares (MP). Se establecieron grupos pronósticos en función de la resecabilidad, el número de MP y el intervalo libre de enfermedad (ILE). El objetivo de este trabajo ha sido determinar la supervivencia de los pacientes intervenidos con resección de MP de carcinoma colorrectal y evaluar la aplicabilidad de los factores pronósticos establecidos por el IRLM a este grupo concreto de pacientes.

Pacientes y métodos

Se ha realizado un trabajo retrospectivo recogiendo los casos de MP de carcinoma colorrectal intervenidos entre el 1 de enero de 2000 y el 30 de noviembre de 2006. Para calcular la supervivencia se empleó el método de Kaplan-Meier con el test de rangos logarítmicos.

Resultados

La supervivencia a 1; 3; 5, y 6 años fue del 92, el 75, el 54 y el 43%, respectivamente. Como principal hallazgo, se observó que los pacientes a quienes se realizó resección atípica de las metástasis tuvieron mayor supervivencia que aquellos que necesitaron lobectomía: un 75% de supervivencia a los 3 años frente al 55%, respectivamente. No se encontraron diferencias significativas de supervivencia en cuanto al número de MP resecadas ni en cuanto al ILE.

Conclusiones

Los pacientes que requieren lobectomía para la resección de MP de carcinoma colorrectal presentan peor supervivencia que aquellos a los que se realiza resección atípica. El número de metástasis y el ILE pueden ser factores pronósticos cuestionables en el caso de MP de carcinoma colorrectal.

Palabras clave:

Metástasis pulmonar

Carcinoma colorectal

Tratamiento quirúrgico

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References

[1.]

K. Krishnan, C. Khanna, L.J. Herman.

The molecular biology of pulmonary metastasis.

Thorac Surg Clin, 16 (2006), pp. 115-124

http://dx.doi.org/10.1016/j.thorsurg.2005.12.003 | Medline

[2.]

J. Torres Lanzas, A. Ríos Zambudio.

La cirugía de las metástasis pulmonares.

Arch Bronconeumol, 38 (2002), pp. 403-405

Medline

[3.]

U. Pastorino, M. Buyse, G. Friedel, R.J. Ginsberg, P. Girard, P. Goldstraw, et al.

Longterm results of lung metastasectomy: prognostic analyses based on 5206 cases.

J Thorac Cardiovasc Surg, 113 (1997), pp. 37-49

Medline

[4.]

R.M. Goldberg, T.R. Fleming, C.M. Tangen, C.G. Moertel, J.S. Macdonald, D.G. Haller, et al.

Surgery for recurrent colon cancer: strategies for identifying respectable recurrence and success rates after resection. Eastern Cooperative Oncology Group, the North Central Cancer Treatment Group, and the Southwest Oncology Group.

Ann Intern Med, 129 (1998), pp. 27-35

Article | Medline

[5.]

R. Midgley, D. Kerr.

Colorectal cancer.

Lancet, 353 (1999), pp. 391-399

http://dx.doi.org/10.1016/S0140-6736(98)07127-X | Medline

[6.]

A. Jemal, R. Siegel, E. Ward, T. Murray, J. Xu, C. Smigal, et al.

Cancer statistics 2006.

CA Cancer J Clin, 56 (2006), pp. 106-130

Medline

[7.]

S.J. Brister, B. De Varennes, P.H. Gordon, N.M. Sheiner, J. Pym.

Contemporary operative management of pulmonary metastases of colorectal origin.

Dis Colon Rectum, 31 (1988), pp. 786-792

Medline

[8.]

J.E. Meyerhardt, R.J. Mayer.

Systemic therapy for colorectal cancer.

N Engl J Med, 352 (2005), pp. 476-487

http://dx.doi.org/10.1056/NEJMra040958 | Medline

[9.]

T. Iizasa, M. Suzuki, S. Yoshida, S. Motohashi, K. Yasufuku, A. Iyoda, et al.

Prediction of prognosis and surgical indications for pulmonary metastasectomy from colorectal cancer.

Ann Thorac Surg, 82 (2006), pp. 254-260

http://dx.doi.org/10.1016/j.athoracsur.2006.02.027 | Medline

[10.]

A. Muñoz Llarena, S. Carrera Revilla, A. Gil-Negrete Laborda, J. Pac Ferrer, R. Barceló Galíndez, G. López Vivanco.

Factores pronósticos de metástasis pulmonares resecables de carcinoma colorrectal.

Arch Bronconeumol, 43 (2007), pp. 309-316

Medline

[11.]

C. Pagés Navarrete, J. Ruiz Zafra, C. Simón Adiego, J.M. Díez Pina, A. Cueto Ladrón de Guevara, A. Sánchez-Palencia Ramos.

Tratamiento quirúrgico de las metastasis pulmonares: estudio de supervivencia.

Arch Bronconeumol, 36 (2000), pp. 569-573

Medline

[12.]

A.M. Parsons, F.C. Detterbeck, L.A. Parker.

Accuracy of helical CT in the detection of pulmonary metastases: is intraoperative palpation still necessary?.

Ann Thorac Surg, 78 (2004), pp. 1910-1918

http://dx.doi.org/10.1016/j.athoracsur.2004.05.065 | Medline

[13.]

S. Margaritora, V. Porziella, A. D’Andrilli, A. Cesario, D. Galetta, G. Macis, et al.

Pulmonary metastases: can accurate radiological evaluation avoid thoracotomic approach?.

Eur J Cardiothorac Surg, 21 (2002), pp. 1111-1114

Medline

[14.]

M.L. Kayton, A.G. Huvos, J. Casher, S.J. Abramson, N.S. Rosen, L.H. Wexler, et al.

Computed tomographic scan of the chest underestimates the number of metastatic lesions in osteosarcoma.

J Ped Surg, 41 (2006), pp. 200-206

[15.]

R.J. Landreneau, T. De Giacomo, M.J. Mack, S.R. Hazelrigg, P.F. Ferson, R.J. Keenan, et al.

Therapeutic video-assisted thoracoscopic surgical resection of colorectal pulmonary metastases.

Eur J Cardiothorac Surg, 18 (2000), pp. 671-676

Medline

[16.]

M.F. Jiménez, The Spanish Video-Assisted Thoracic Surgery Study Group.

Prospective study on video-assisted thoracoscopic surgery in the resection of pulmonary nodules: 209 cases from the Spanish Video-assisted Thoracic Surgery Study Group.

Eur J Cardiothorac Surg, 19 (2001), pp. 562-565

Medline

[17.]

P.M. McCormack, M.S. Bains, C. Begg, M.E. Burt, R.J. Downey, D.M. Panicek, et al.

Role of video-assisted thoracic surgery in the treatment of pulmonary metastases: results of a prospective trial.

Ann Thorac Surg, 62 (1996), pp. 213-217

Medline

[18.]

J.A. Roth, H.I. Pass, M.N. Wesley, D. White, J.B. Putman, C. Seipp.

Comparison of median sternotomy and thoracotomy for resection of pulmonary metastases in patients with adult soft tissue sarcomas.

Ann Thorac Surg, 42 (1986), pp. 134-138

Medline

[19.]

D.J. Beech, R.E. Pollock, I.J. Fidler, J.E. Putnam Jr, S.R. Patel, J.A. Roth, et al.

Treatment of the patient with lung metastases.

Curr Probl Surg, 33 (1996), pp. 885-952

[20.]

H.P. Liu, P.J. Lin, M.J. Hsieh, J.P. Chang, C.H. Chang.

Application of thoracoscopy for lung metastases.

Chest, 107 (1995), pp. 266-268

Medline

[21.]

J.C. Lin, R.J. Wiechmann, M.F. Szwerc, S.R. Hazelrigg, P.F. Ferson, K.S. Naunheim, et al.

Diagnostic and therapeutic video-assisted thoracic surgery resection of pulmonary metastases.

Surgery, 126 (1999), pp. 636-641

Medline

[22.]

J. Nakajima, T. Murakawa, T. Fukami, S. Takamoto.

Is thoracoscopic surgery justified to treat pulmonary metastasis from colorectal cancer?.

Interact Cardiovasc Thorac Surg, 7 (2008), pp. 212-217

http://dx.doi.org/10.1510/icvts.2007.167239Article | Medline

[23.]

J. Pfannschmidt, H. Dienemann, H. Hoffmann.

Surgical resection of pulmonary metastases from colorectal cancer: a systematic review of published series.

Ann Thorac Surg, 84 (2007), pp. 324-338

http://dx.doi.org/10.1016/j.athoracsur.2007.02.093 | Medline

[24.]

K. Shirozu, H. Isomoto, A. Hayashi, Y. Nagamatsu, T. Kakegawa.

Surgical treatment for patients with pulmonary metastases after resection of colorectal carcinoma.

Cancer, 76 (1995), pp. 393-398

Medline

[25.]

V.W. Rusch.

Pulmonary metastasectomy: current indications.

Chest, 107 (1995), pp. 322-331

[26.]

H. Vogelsang, S. Haas, C. Hierholzer, U. Berger, J.R. Siewert, H. Prauer.

Factors influencing survival after resection of pulmonary metastases from colorectal cancer.

Br J Surg, 91 (2004), pp. 1066-1071

http://dx.doi.org/10.1002/bjs.4602 | Medline

[27.]

Y. Tanaka, Y. Maniwa, W. Nishio, M. Yoshimura, Y. Okita.

The optimal timing to resect pulmonary metastasis.

Eur J Cardiothiorac Surg, 33 (2008), pp. 1135-1138

[28.]

T. Treasure.

Pulmonary metastasectomy for colorectal cancer: weak evidence and no randomized trials.

Eur J Cardiothorac Surg, 33 (2008), pp. 300-302

http://dx.doi.org/10.1016/j.ejcts.2007.10.015 | Medline

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