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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Se presenta el estudio de un caso de s&#237;ndrome de secreci&#243;n ect&#243;pica de ACTH como manifestaci&#243;n de un carcinoma de pulm&#243;n y caracterizado por un s&#237;ndrome de Cushing paraneopl&#225;sico&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Los datos de la cl&#237;nica manifiestan un proceso de r&#225;pida evoluci&#243;n que se expresa con una sintomatolog&#237;a de alcalosis metab&#243;lica&#44; diabetes no compensada y resistente a la insulina&#44; hiperpigmentaci&#243;n y equimosis manifiesta&#46; Asimismo&#44; aparece una alteraci&#243;n general correspondiente a la neoplasia&#46; Anal&#237;ticamente aparece una elevaci&#243;n de cortisol plasm&#225;tico&#44; con p&#233;rdida del ritmo circadiano&#59; gran eliminaci&#243;n de 17 OHS y 17 KS en orina y falta de supresi&#243;n de actividad con la administraci&#243;n de dexametasona y no est&#237;mulo con ACTH&#46;</p><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Las im&#225;genes radiogr&#225;ficas de pulm&#243;n&#44; demuestran la existencia de una tumoraci&#243;n claramente definida&#46; Anatomopatologicamente se comprueba el diagn&#243;stico de un carcinoma microcito en c&#233;lulas en avena &#40;oat-cell&#41;&#44; con met&#225;stasis a nivel hep&#225;tico&#44; medular y suprarrenal&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Se discuten los s&#237;ndromes de secreci&#243;n ect&#243;pica de ACTH&#44; que como tal ha de acompa&#241;arse de s&#237;ndrome de Cushing y se comenta la incidencia de los s&#237;ndromes paraneopl&#225;sicos en los c&#225;nceres de pulm&#243;n as&#237; como la aparici&#243;n de este s&#237;ndrome endocrino en otros tumores&#46;</p></span>"
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        "titulo" => "Summary"
        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The authors present the study of a case of syndrome of ectopic secretion of ACTH as a manifestation of lung c&#225;ncer and characterized by Cushing&#39;s paraneoplasic syndrome&#46;</p><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Data of the clinical history show a process of rapid evolution expressed with a symptomatology ofmetabolic alkalosis&#44; non compensated diabetes resistant to insulin&#44; hyperpigmentation and manifest ecchymosis&#46; There is also a general alteration corresponding to neoplasia&#46; Analytically&#44; an elevation of plasmatic cortisol appears&#44; with loss of circadian rhythm&#59; great elimination of 17 OHS and 17KS in the uri&#241;e and lack of suppression of activity with the administration of dexamethasone and non-stimulation with ACTH&#46;</p><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">The radiographic images of the lung show the existence of a tumor&#44; clearly defined&#46; The diagnosis of a microcytic carcinoma in oat-cells with met&#225;stasis at the hepatic&#44; medular and suprarenal levels is verified anatomicopathologically&#46;</p><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Finally&#44; the authors discuss the syndromes of ectopic secretion of ACTH that&#44; as such accompany Cushing&#39;s syndrome and comment on the incidence of paraneoplasic syndromes in lung cancers as well as the appearance of this endocrine syndrome in other tumors&#46;</p></span>"
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Vol. 14. Issue 1.
Pages 35-39 (January - March 1978)
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Vol. 14. Issue 1.
Pages 35-39 (January - March 1978)
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Secrecion ectopica de acth. Sindrome de cushing paraneoplasico por carcinoma de pulmon
Ectopic secretion of acth. Cushing's paraneoplasic syndrome by lung cancer
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J.R. Muñoz, A. Portolés, G. Moyano, C. Rubín de Celis, E. Navarro, J. Sardaña
Departamento de Medicina Interna. Servicio de Medicina Interna. Ciudad Sanitaria de la Seguridad Social. Zaragoza
A. Gracia*, L. Plaza*
* Servicio de Anatomía Patológica. Departamento de Medicina Interna. Servicio de Medicina Interna. Ciudad Sanitaria de la Seguridad Social. Zaragoza
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Resumen

Se presenta el estudio de un caso de síndrome de secreción ectópica de ACTH como manifestación de un carcinoma de pulmón y caracterizado por un síndrome de Cushing paraneoplásico.

Los datos de la clínica manifiestan un proceso de rápida evolución que se expresa con una sintomatología de alcalosis metabólica, diabetes no compensada y resistente a la insulina, hiperpigmentación y equimosis manifiesta. Asimismo, aparece una alteración general correspondiente a la neoplasia. Analíticamente aparece una elevación de cortisol plasmático, con pérdida del ritmo circadiano; gran eliminación de 17 OHS y 17 KS en orina y falta de supresión de actividad con la administración de dexametasona y no estímulo con ACTH.

Las imágenes radiográficas de pulmón, demuestran la existencia de una tumoración claramente definida. Anatomopatologicamente se comprueba el diagnóstico de un carcinoma microcito en células en avena (oat-cell), con metástasis a nivel hepático, medular y suprarrenal.

Se discuten los síndromes de secreción ectópica de ACTH, que como tal ha de acompañarse de síndrome de Cushing y se comenta la incidencia de los síndromes paraneoplásicos en los cánceres de pulmón así como la aparición de este síndrome endocrino en otros tumores.

Summary

The authors present the study of a case of syndrome of ectopic secretion of ACTH as a manifestation of lung cáncer and characterized by Cushing's paraneoplasic syndrome.

Data of the clinical history show a process of rapid evolution expressed with a symptomatology ofmetabolic alkalosis, non compensated diabetes resistant to insulin, hyperpigmentation and manifest ecchymosis. There is also a general alteration corresponding to neoplasia. Analytically, an elevation of plasmatic cortisol appears, with loss of circadian rhythm; great elimination of 17 OHS and 17KS in the uriñe and lack of suppression of activity with the administration of dexamethasone and non-stimulation with ACTH.

The radiographic images of the lung show the existence of a tumor, clearly defined. The diagnosis of a microcytic carcinoma in oat-cells with metástasis at the hepatic, medular and suprarenal levels is verified anatomicopathologically.

Finally, the authors discuss the syndromes of ectopic secretion of ACTH that, as such accompany Cushing's syndrome and comment on the incidence of paraneoplasic syndromes in lung cancers as well as the appearance of this endocrine syndrome in other tumors.

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Copyright © 1978. Sociedad Española de Neumología y Cirugía Torácica
Archivos de Bronconeumología
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