Journal Information
Share
Share
Download PDF
More article options
ePub
Original Article
Available online 20 January 2023
Role of Systemic Inflammatory Indices in the Prediction of Moderate to Severe Bronchopulmonary Dysplasia in Preterm Infants
Visits
...
Ufuk Cakir
Corresponding author
drufukcakir@hotmail.com

Corresponding author.
, Cuneyt Tayman, Ali Ulas Tugcu, Duran Yildiz
Division of Neonatology, Health Science University, Ankara Bilkent City Hospital, Ankara, Turkey
Received 01 December 2022. Accepted 03 January 2023
Article information
Abstract
Full Text
Bibliography
Download PDF
Statistics
Figures (3)
Show moreShow less
Abstract
Introduction

The role of systemic inflammatory indices in the diagnosis of bronchopulmonary dysplasia (BPD) is unknown. The aim of the study was to determine the possible clinical utility of systemic inflammatory indices in the prediction of moderate to severe BPD.

Methods

Premature infants<32 weeks of gestational age were included in the study. Neutrophil-to-lymphocyte ratio (NLR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), systemic immune-inflammation index (SII), pan-immune-inflammation value (PIV), and systemic inflammation response index (SIRI) were calculated at birth and at the time of diagnosis of BPD (at 36th weeks of postmenstrual age). The patients were divided into two groups as no or mild BPD and moderate or severe BPD.

Results

A total of 1146 infants were included in the study, 957 in Group 1 and 189 in Group 2. The SIRI value was significantly higher in moderate or severe BPD both at birth and at the 36th week of postmenstrual age (p<0.001 and p<0.001, respectively). The AUC value of SIRI was 0.809 and the cut-off value was>0.98 in the predictivity of BPD at birth. The AUC value of SIRI was 0.842 and the cut-off value was>1.33 for the diagnosis of BPD at 36th week of postmenstrual age. After multiple logistic regression analysis, SIRI was shown to be a significant parameter for the diagnosis of BPD (OR 2.847, 95% CI 1.557–4.875).

Conclusions

SIRI may be a useful biomarker for predicting moderate to severe BPD and a marker of clinical importance in the follow-up of infants with BPD.

Keywords:
Bronchopulmonary dysplasia
Monocyte-to-lymphocyte ratio
Neutrophil-to-lymphocyte ratio
Pan-immune-inflammation value
Platelet-to-lymphocyte ratio
Premature
Systemic inflammation response index
Systemic immune-inflammation index
Infant
Very low birth weight

Article

These are the options to access the full texts of the publication Archivos de Bronconeumología
Member
Si es usted socio de la SEPAR siga los siguientes pasos:
  • Diríjase desde aquí a la web de la >>>SEPAR<<< e inicie sesión mediante el formulario que se encuentra en la barra lateral derecha de la web de la sociedad.
Subscriber
Subscriber

If you already have your login data, please click here .

If you have forgotten your password you can you can recover it by clicking here and selecting the option “I have forgotten my password”
Subscribe
Subscribe to

Archivos de Bronconeumología

Purchase
Purchase article

Purchasing article the PDF version will be downloaded

Price 19.34 €

Purchase now
Contact
Phone for subscriptions and reporting of errors
From Monday to Friday from 9 a.m. to 6 p.m. (GMT + 1) except for the months of July and August which will be from 9 a.m. to 3 p.m.
Calls from Spain
932 415 960
Calls from outside Spain
+34 932 415 960
Email
Archivos de Bronconeumología

Subscribe to our newsletter

Article options
Tools

Are you a health professional able to prescribe or dispense drugs?