P4 Medicine: the Future Around the Corner

Sobradillo, Patricia; Pozo, Francisco; Agustí, Álvar

doi:10.1016/S1579-2129(11)70006-4

Archivos de Bronconeumología

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Vol. 47. Issue 1.

Pages 35-40 (January 2011)

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Pages 35-40 (January 2011)

Review

DOI: 10.1016/S1579-2129(11)70006-4

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P4 Medicine: the Future Around the Corner

Isoenzimas de lactatodeshidrogenasa en el músculo esquelético de pacientes con EPOC

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Patricia Sobradilloa,b,c,

Corresponding author

psobradillo@ciberes.org

Corresponding author.

, Francisco Pozoa,d, Álvar Agustía,b,c,e

a Ciber en Enfermedades Respiratorias (CIBERES), Barcelona, Spain

b Instituto del Tórax, Hospital Clínic, Universidad de Barcelona, Spain

c Institut d’Investigacions Biomèdiques August Pi i Sunyer (IDIBAPS), Barcelona, Spain

d Hospital 12 de Octubre, Madrid, Spain

e Fundación Caubet Cimera, Mallorca, Spain

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Abstract

Traditional medical practice has always been “reactive”, meaning that the doctor intervenes when there is disease. Theoretical (scale-free networks and complex systems), technological (highly efficient “omic” technologies) and conceptual (systems biology) advances of the last decade prelude the transition towards “anticipatory” medicine centered on health and not disease. This review establishes the fundamental conceptual bases and discusses the principal aspects of this new medicine, known as “P4 Medicine” as it is personalized, predictive, preventive and participatory.

Keywords:

Systems biology

Genetics

Research

Scale-free networks

Systems biology

Resumen

La práctica médica tradicional ha sido “reactiva” (el médico interviene cuando hay enfermedad). Los avances teóricos (redes libres de escala y sistemas complejos), tecnológicos (tecnologías “ómicas” de alta eficiencia) y conceptuales (biología de sistemas) habidos en la última década permiten anticipar la transición hacia una medicina “anticipatoria”, centrada en la salud (no en la enfermedad). Esta revisión establece las bases conceptuales fundamentales y discute los principales aspectos de esta nueva medicina, denominada “Medicina P4” por ser personalizada, predictiva, preventiva y participatoria.

Palabras clave:

Biología de sistemas

Genética

Investigación

Redes libres de escala

Sistemas complejo

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