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    "titulo" => "Operabilidad en el carcinoma broncogenico. Valoracion por estudio gammagrafico pulmonar de perfusion, cuantitativo y diferencial"
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        "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">El problema de la tolerancia funcional a una neumo-nectom&#237;a es valorado en este estudio mediante la cuantificaci&#243;n diferencial de la perfusi&#243;n pulmonar por metodolog&#237;a isot&#243;pica calculando el VEMS previsto postoperatorio&#46; Siguiendo t&#233;cnicas ya descritas&#44; en una serie de 128 pacientes con carcinoma broncog&#233;nico protocolizados prospectivamente desde 1978 a 1982&#44; en 10 pacientes se decidi&#243; inoperabilidad por encontrar un VEMS calculado postoperatorio menor de 800 ce&#59; la correlaci&#243;n entre el VEMS calculado por esta t&#233;cnica y el real postoperatorio hallado es alta en nuestra experiencia &#40;r&#58;0&#44;93&#41;&#46; En catorce neumonectom&#237;as de pacientes con VEMS real preoperatorio menor de 2&#46;000 ce&#44; que superaban el criterio anteriormente expuesto&#44; uno fallec&#237;a en el per&#237;odo postoperatorio inmediato &#40;7&#44;1&#37;&#41;&#46; Este nivel de mortalidad operatoria es similar a poblaciones neumonectomizadas por carcinoma broncog&#233;nico sin ser seleccionadas por criterio funcional&#46;</p><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Teniendo presentes estos datos en relaci&#243;n a un valor absoluto del VEMS como l&#237;mite de operabilidad&#44; se efect&#250;an diversas consideraciones acerca de si otros par&#225;metros como el porcentaje del VEMS con respecto al te&#243;rico y la combinaci&#243;n con estudios hemodin&#225;micos&#44; pueden en el futuro ser &#237;ndices mas exactos de predicci&#243;n del riesgo operatorio&#46;</p></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">The problem of the functional tolerance to pneumo-nectomy is evaluated in the present study by means of differential quantification of pulmonary perfusion by radioisotopic studies and calculation of predicted postoperative FEV<span class="elsevierStyleInf">1</span>&#46; Using already described techniques&#44; in a series of 128 patients with bronchogenic carcinoma pros-pectively undergoing a protocol study from 1978 to 1982&#44; inoperability was decided on the basis of a calculated postoperative FEV<span class="elsevierStyleInf">1</span> of less than 800 cc&#46; In our experience&#44; the correlation between the FEV<span class="elsevierStyleInf">1</span> as calculated by this technique and the real postoperative values in high &#40;r&#58;0&#46;93&#41;&#46; In 14 pneumonectomies in patients with real postoperative FEV<span class="elsevierStyleInf">1</span> of less than 2000 cc &#40;exceeding the above mentioned criteria&#41;&#44; 1 patient died in the imme-diate postoperative period &#40;7&#46;1&#37;&#41;&#46; This rate of postoperative mortality is similar to that seen in populations undergoing pneumonectomy for bronchogenic carcinoma and not being selected on the basis of functional criteria&#46;</p><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">In view of these data related to an absolute value of FEV<span class="elsevierStyleInf">1</span> as a limit to Operability&#44; some considerations are developed as to whether other parameters&#44; such as the ratio of FEV<span class="elsevierStyleInf">1</span> to its predicted value and the combination with hemodynamic studies&#44; may be in the future more occurate predictors of operative risk&#46;</p></span>"
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary function in bronchial carcinoma"
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                          "autores" => array:2 [
                            0 => "J&#46;S&#46; Legge"
                            1 => "K&#46;N&#46;V&#46; Palmer"
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                    ]
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                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Thorax"
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                        "paginaInicial" => "588"
                        "paginaFinal" => "591"
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4784380"
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                    0 => array:2 [
                      "titulo" => "Lung cancer&#58; to operate or not"
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                          "autores" => array:2 [
                            0 => "C&#46;H&#46; Mittman"
                            1 => "I&#46; Bruderman"
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                        ]
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                    ]
                  ]
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                    0 => array:2 [
                      "doi" => "10.1164/arrd.1977.116.3.477"
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                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1977"
                        "volumen" => "116"
                        "paginaInicial" => "477"
                        "paginaFinal" => "499"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/900635"
                            "web" => "Medline"
                          ]
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                ]
              ]
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              "identificador" => "bib0015"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Pulmonary function evaluation of the lung resection candidate&#58; a prospectivo study"
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                            2 => "B&#46;W&#46; Swenson"
                            3 => "J&#46;R&#46; Castle"
                            4 => "J&#46;W&#46; Wynne"
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                        ]
                      ]
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                  ]
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                      "doi" => "10.1164/arrd.1975.111.4.379"
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                        "fecha" => "1975"
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                        "paginaInicial" => "379"
                        "paginaFinal" => "387"
                        "link" => array:1 [
                          0 => array:2 [
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                      "titulo" => "Preoperative evaluation of pulmonary func tion Validity&#44; indications and benefits"
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                        "volumen" => "119"
                        "paginaInicial" => "293"
                        "paginaFinal" => "310"
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                      "titulo" => "Excercise testing in evaluation for lung resection"
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                        "paginaFinal" => "606"
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                      "Revista" => array:5 [
                        "tituloSerie" => "Arch Bronconeumol"
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                        "paginaInicial" => "243"
                        "paginaFinal" => "247"
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                      "titulo" => "Unilateral lung function Comparison of the lateral position test with radionuclide ventilation-perfusion studies"
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                      "titulo" => "Use of lateral position test and perfusion lung scan in predicting mediastinal metastases"
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                        "paginaFinal" => "104"
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                    0 => array:2 [
                      "titulo" => "A bronchospirometric method of estimating the effect of pneumonectomy on the ma ximum breathing capacity"
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                          "etal" => false
                          "autores" => array:2 [
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                            1 => "N&#46;S&#46; Cherniack"
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                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "1968"
                        "volumen" => "55"
                        "paginaInicial" => "1944"
                        "paginaFinal" => "1948"
                      ]
                    ]
                  ]
                ]
              ]
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            13 => array:3 [
              "identificador" => "bib0070"
              "etiqueta" => "14&#46;"
              "referencia" => array:1 [
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                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prediction of pulmonary function loss due to pneumonectomy using 133 Xenon radiospirometry"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "S&#46; Kristersson"
                            1 => "S&#46;B&#46; Lindell"
                            2 => "I&#46; Svenberg"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1968"
                        "volumen" => "62"
                        "paginaInicial" => "694"
                        "paginaFinal" => "698"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/4635418"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Predicting loss of pulmonary function after pulmonary resection for bronchogenic carcinoma"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Khalil Ali"
                            1 => "C&#46;F&#46; Mountain"
                            2 => "M&#46;S&#46; Ewer"
                            3 => "D&#46; Johnston"
                            4 => "T&#46;P&#46; Hayne"
                          ]
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1980"
                        "volumen" => "77"
                        "paginaInicial" => "337"
                        "paginaFinal" => "342"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7357934"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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                    0 => array:2 [
                      "titulo" => "Pulmonary function in lung cancer&#58; correlation with disease stage and post-surgical survival"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Khalil Ali"
                            1 => "C&#46;F&#46; Mountain"
                            2 => "M&#46;S&#46; Ewer"
                            3 => "M&#46;R&#46; Atallach"
                            4 => "T&#46;P&#46; Haynie"
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                      ]
                    ]
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                      "Libro" => array:4 [
                        "titulo" => "Abstracts II World Conference on Lung Cancer 1980&#46; Excerpta Medica"
                        "fecha" => "1980"
                        "editorial" => "Ed&#46; Hansen HH"
                        "editorialLocalizacion" => "Amsterdam"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            16 => array:3 [
              "identificador" => "bib0085"
              "etiqueta" => "17&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Role of pulmonary vascular resistance measurements in preoperative evaluation of candidates for pul monary resection"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "H&#46;J&#46; Fee"
                            1 => "E&#46; Carmack-Holmes"
                            2 => "H&#46;S&#46; Gewirtz"
                            3 => "K&#46;P&#46; Rawming"
                            4 => "J&#46;M&#46; Alexander"
                          ]
                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "J Thorac Cardiovasc Surg"
                        "fecha" => "1978"
                        "volumen" => "75"
                        "paginaInicial" => "519"
                        "paginaFinal" => "524"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/642548"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
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            17 => array:3 [
              "identificador" => "bib0090"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Fiberoptic bronchoscopy"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "D&#46;M&#46; Mitchell"
                            1 => "J&#46;V&#46; Collins"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
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                      "LibroEditado" => array:3 [
                        "titulo" => "Recent Advances in Respiratory Medicine"
                        "edicion" => "2&#46; Ed"
                        "serieFecha" => "1980"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            18 => array:3 [
              "identificador" => "bib0095"
              "etiqueta" => "19&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Preoperative evaluation for pulmonary resection The role of radionuclide lung scanning"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "S&#46;S&#46; Lefrak"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
                        "tituloSerie" => "Chest"
                        "fecha" => "1977"
                        "volumen" => "72"
                        "paginaInicial" => "419"
                        "paginaFinal" => "420"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/908208"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
                  ]
                ]
              ]
            ]
            19 => array:3 [
              "identificador" => "bib0100"
              "etiqueta" => "20&#46;"
              "referencia" => array:1 [
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                    0 => array:2 [
                      "titulo" => "Protocolo para el estudio y tratamiento del carcinoma broncog&#233;nico &#40;I&#41;"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "A&#46; L&#243;pez-Encuentra"
                            1 => "J&#46; Mart&#237;nez"
                            2 => "H&#46; Cort&#233;s-Funes"
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                        ]
                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:5 [
                        "tituloSerie" => "Med Clin &#40;Barcelona&#41;"
                        "fecha" => "1979"
                        "volumen" => "72"
                        "paginaInicial" => "321"
                        "paginaFinal" => "331"
                      ]
                    ]
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                ]
              ]
            ]
            20 => array:3 [
              "identificador" => "bib0105"
              "etiqueta" => "21&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Biologic phisiologic and technical determinants in surgical therapy for lung cancer"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:1 [
                            0 => "C&#46;F&#46; Mountain"
                          ]
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                    ]
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                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:3 [
                        "titulo" => "Lung Cancer"
                        "edicion" => "2&#46;<span class="elsevierStyleSup">a</span>"
                        "serieFecha" => "1983"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            21 => array:3 [
              "identificador" => "bib0110"
              "etiqueta" => "22&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Further observations on the course and prognosis of chronic obstructive lung disease"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "C&#46;F&#46; Diener"
                            1 => "B&#46; Burrows"
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                      ]
                    ]
                  ]
                  "host" => array:1 [
                    0 => array:2 [
                      "doi" => "10.1164/arrd.1975.111.6.719"
                      "Revista" => array:6 [
                        "tituloSerie" => "Am Rev Respir Dis"
                        "fecha" => "1975"
                        "volumen" => "111"
                        "paginaInicial" => "719"
                        "paginaFinal" => "724"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1137239"
                            "web" => "Medline"
                          ]
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                      ]
                    ]
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                ]
              ]
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            22 => array:3 [
              "identificador" => "bib0115"
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              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "The natural history of chronic bronchitis and emphysema"
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                          "etal" => false
                          "autores" => array:4 [
                            0 => "C&#46;M&#46; Fletcher"
                            1 => "R&#46; Peto"
                            2 => "C&#46; Tinker"
                            3 => "F&#46;E&#46; Jpeizer"
                          ]
                        ]
                      ]
                    ]
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                  "host" => array:1 [
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                      "Libro" => array:3 [
                        "fecha" => "1976"
                        "editorial" => "Oxford University Press"
                        "editorialLocalizacion" => "Oxford"
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                  ]
                ]
              ]
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            23 => array:3 [
              "identificador" => "bib0120"
              "etiqueta" => "24&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:1 [
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:2 [
                            0 => "N&#46; Care"
                            1 => "L&#46; Martin"
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                        ]
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                    ]
                  ]
                  "host" => array:1 [
                    0 => array:1 [
                      "LibroEditado" => array:2 [
                        "titulo" => "Etablisement des normes physiologiques&#46; L&#8217;exploration fonctionnelle pulmonaire"
                        "serieFecha" => "1964"
                      ]
                    ]
                  ]
                ]
              ]
            ]
            24 => array:3 [
              "identificador" => "bib0125"
              "etiqueta" => "25&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Clinical spirometric in normal men The Veteran Administration Army Cooperative&#46; Study of pulmonary function"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:4 [
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                            1 => "R&#46; Callahan"
                            2 => "H&#46;G&#46; Boren"
                            3 => "J&#46;C&#46; Symer"
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                    ]
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Am J Med"
                        "fecha" => "1961"
                        "volumen" => "30"
                        "paginaInicial" => "243"
                        "paginaFinal" => "258"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/13753281"
                            "web" => "Medline"
                          ]
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            25 => array:3 [
              "identificador" => "bib0130"
              "etiqueta" => "26&#46;"
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                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Prospective evaluation for pneumonec tomy using the 99m Technetium quantitative perfusion lung sean"
                      "autores" => array:1 [
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                          "autores" => array:6 [
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                            1 => "A&#46;J&#46; Block"
                            2 => "G&#46;N&#46; Olsen"
                            3 => "P&#46;V&#46; Moulder"
                            4 => "J&#46;O&#46; Harris"
                            5 => "R&#46;E&#46; Rawitscher"
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                    ]
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                  "host" => array:1 [
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                        "paginaInicial" => "422"
                        "paginaFinal" => "428"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/908209"
                            "web" => "Medline"
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                      "titulo" => "Prospec tive evaluation for pneumonectomy using perfusion scanning Follow-up beyond one year"
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                          "etal" => false
                          "autores" => array:4 [
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                            2 => "A&#46;J&#46; Block"
                            3 => "G&#46;M&#46; Olsen"
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                  "host" => array:1 [
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                        "paginaInicial" => "163"
                        "paginaFinal" => "166"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7249760"
                            "web" => "Medline"
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                      "titulo" => "Regional pulmonary function before and after pneumonectomy using 133 Xenon"
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                          "etal" => false
                          "autores" => array:5 [
                            0 => "M&#46; Khalil Al"
                            1 => "C&#46; Mountain"
                            2 => "J&#46;M&#46; Miller"
                            3 => "D&#46;A&#46; Johnston"
                            4 => "C&#46;C&#46; Schullenberger"
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                  "host" => array:1 [
                    0 => array:1 [
                      "Revista" => array:6 [
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                        "paginaInicial" => "288"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1157532"
                            "web" => "Medline"
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                      "titulo" => "Pulmonary resection and postoperative pulmonary function"
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                          "autores" => array:1 [
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                  "host" => array:1 [
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                        "fecha" => "1980"
                        "volumen" => "68"
                        "paginaInicial" => "288"
                        "paginaFinal" => "296"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/1157532"
                            "web" => "Medline"
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                    0 => array:2 [
                      "titulo" => "Effects of lobectomy on lung function"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "N&#46; Berend"
                            1 => "A&#46;J&#46; Woolcock"
                            2 => "G&#46;E&#46; Marlin"
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                  "host" => array:1 [
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                        "paginaInicial" => "145"
                        "paginaFinal" => "150"
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                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7376119"
                            "web" => "Medline"
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                      "titulo" => "Les scintigraphies pulmonaires de perfusion et de ventilation dans le diagnostic d&#8217;operabilit&#233; des cancers bronchiques primitifs"
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                            2 => "J&#46;P&#46; Gamondes"
                            3 => "T&#46;H&#46; Wiesendanger"
                            4 => "F&#46; Serain"
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                  "host" => array:1 [
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                      "Revista" => array:5 [
                        "tituloSerie" => "Ann Chir Thorac Cardiovasc"
                        "fecha" => "1982"
                        "volumen" => "36"
                        "paginaInicial" => "95"
                        "paginaFinal" => "101"
                      ]
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            31 => array:3 [
              "identificador" => "bib0160"
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                      "titulo" => "Complications of surgery in the treatment of carcinoma of the lung"
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                            1 => "B&#46;J&#46; Flehinger"
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                  "host" => array:1 [
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                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7083931"
                            "web" => "Medline"
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            32 => array:3 [
              "identificador" => "bib0165"
              "etiqueta" => "33&#46;"
              "referencia" => array:1 [
                0 => array:2 [
                  "contribucion" => array:1 [
                    0 => array:2 [
                      "titulo" => "Relationship between preoperative pulmonary function tests and complications after thoracotomy"
                      "autores" => array:1 [
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                          "etal" => false
                          "autores" => array:3 [
                            0 => "P&#46;G&#46; Boysen"
                            1 => "A&#46;D&#46; Block"
                            2 => "P&#46;V&#46; Moulder"
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                  "host" => array:1 [
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                      "Revista" => array:6 [
                        "tituloSerie" => "Surg Gyn Obst"
                        "fecha" => "1981"
                        "volumen" => "152"
                        "paginaInicial" => "813"
                        "paginaFinal" => "815"
                        "link" => array:1 [
                          0 => array:2 [
                            "url" => "https://www.ncbi.nlm.nih.gov/pubmed/7244959"
                            "web" => "Medline"
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              ]
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Vol. 20. Issue 5.
Pages 181-187 (September - October 1984)
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Vol. 20. Issue 5.
Pages 181-187 (September - October 1984)
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Operabilidad en el carcinoma broncogenico. Valoracion por estudio gammagrafico pulmonar de perfusion, cuantitativo y diferencial
Operability in bronchogenic carcinoma. Evaluation with scintigraphic perfusion, qualitative and differential studies
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3163
A. Lopez-Encuentra, G. Varela, P. Martin-Escribano, J. Toledo, M. Gutierrez, A. Manrique, J. Diaz-Atauri
Secciones de Neumología y Cirugía Torácica. Servicio de Medicina Nuclear. Ciudad Sanitaria Primero de Octubre. Madrid
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El problema de la tolerancia funcional a una neumo-nectomía es valorado en este estudio mediante la cuantificación diferencial de la perfusión pulmonar por metodología isotópica calculando el VEMS previsto postoperatorio. Siguiendo técnicas ya descritas, en una serie de 128 pacientes con carcinoma broncogénico protocolizados prospectivamente desde 1978 a 1982, en 10 pacientes se decidió inoperabilidad por encontrar un VEMS calculado postoperatorio menor de 800 ce; la correlación entre el VEMS calculado por esta técnica y el real postoperatorio hallado es alta en nuestra experiencia (r:0,93). En catorce neumonectomías de pacientes con VEMS real preoperatorio menor de 2.000 ce, que superaban el criterio anteriormente expuesto, uno fallecía en el período postoperatorio inmediato (7,1%). Este nivel de mortalidad operatoria es similar a poblaciones neumonectomizadas por carcinoma broncogénico sin ser seleccionadas por criterio funcional.

Teniendo presentes estos datos en relación a un valor absoluto del VEMS como límite de operabilidad, se efectúan diversas consideraciones acerca de si otros parámetros como el porcentaje del VEMS con respecto al teórico y la combinación con estudios hemodinámicos, pueden en el futuro ser índices mas exactos de predicción del riesgo operatorio.

The problem of the functional tolerance to pneumo-nectomy is evaluated in the present study by means of differential quantification of pulmonary perfusion by radioisotopic studies and calculation of predicted postoperative FEV1. Using already described techniques, in a series of 128 patients with bronchogenic carcinoma pros-pectively undergoing a protocol study from 1978 to 1982, inoperability was decided on the basis of a calculated postoperative FEV1 of less than 800 cc. In our experience, the correlation between the FEV1 as calculated by this technique and the real postoperative values in high (r:0.93). In 14 pneumonectomies in patients with real postoperative FEV1 of less than 2000 cc (exceeding the above mentioned criteria), 1 patient died in the imme-diate postoperative period (7.1%). This rate of postoperative mortality is similar to that seen in populations undergoing pneumonectomy for bronchogenic carcinoma and not being selected on the basis of functional criteria.

In view of these data related to an absolute value of FEV1 as a limit to Operability, some considerations are developed as to whether other parameters, such as the ratio of FEV1 to its predicted value and the combination with hemodynamic studies, may be in the future more occurate predictors of operative risk.

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Bibliografia
[1.]
J.S. Legge, K.N.V. Palmer.
Pulmonary function in bronchial carcinoma.
Thorax, 28 (1973), pp. 588-591
[2.]
C.H. Mittman, I. Bruderman.
Lung cancer: to operate or not.
Am Rev Respir Dis, 116 (1977), pp. 477-499
[3.]
G.N. Olsen, A.J. Block, B.W. Swenson, J.R. Castle, J.W. Wynne.
Pulmonary function evaluation of the lung resection candidate: a prospectivo study.
Am Rev Respir Dis, 111 (1975), pp. 379-387
[4.]
G.M. Tisi.
Preoperative evaluation of pulmonary func tion Validity, indications and benefits.
Am Rev Respir Dis, 119 (1979), pp. 293-310
[5.]
N.C. Colman, D.E. Schreufnagel, R.N. Rivington, R.L. Pardy.
Excercise testing in evaluation for lung resection.
Am Rev Respir Dis, 125 (1982), pp. 604-606
[6.]
P. Casan, M. Jordana, J. Sanchís, M. Ramos, I. Carrió, C. León.
Determinación espirométrica de la función pulmonar unilateral.
Arch Bronconeumol, 18 (1982), pp. 243-247
[7.]
J.M. Marion, P.O. Alderson, S.S. Lefrak, R.M. Senior, M.H. Jacobs.
Unilateral lung function Comparison of the lateral position test with radionuclide ventilation-perfusion studies.
Chest, 69 (1976), pp. 5-9
[8.]
R.N. Walkup, L.F. Vossel, J.P. Griffin, R.J. Proctor.
Prediction of postoperative pulmonary function with the lateral posi tion test. A prospective study.
Chest, 77 (1980), pp. 24-27
[9.]
S.J. Jan, R.B. Stonehill, S.O. Kiblawi, J. Norton.
Variability of the lateral position test in normal subjects.
Am Rev Respir Dis, 121 (1980), pp. 165-168
[10.]
K.R. Cooper.
Reliability of the lateral position test.
Chest, 79 (1981), pp. 494-495
[11.]
D.A. Solomon, A.L. Goldman.
Use of lateral position test and perfusion lung scan in predicting mediastinal metastases.
Chest, 79 (1981), pp. 406-408
[12.]
A. De Vega, L. Palenciano, M.C. Fernández, R. Rodríguez.
Valoración de la función pulmonar unilateral mediante broncoespirometría y gammagrafia de perfusión con macro-agregados de albúmina marcada con TC-99m.
Arch Bronco-neum, 17 (1981), pp. 99-104
[13.]
H. Neuhaus, N.S. Cherniack.
A bronchospirometric method of estimating the effect of pneumonectomy on the ma ximum breathing capacity.
J Thorac Cardiovasc Surg, 55 (1968), pp. 1944-1948
[14.]
S. Kristersson, S.B. Lindell, I. Svenberg.
Prediction of pulmonary function loss due to pneumonectomy using 133 Xenon radiospirometry.
Chest, 62 (1968), pp. 694-698
[15.]
M. Khalil Ali, C.F. Mountain, M.S. Ewer, D. Johnston, T.P. Hayne.
Predicting loss of pulmonary function after pulmonary resection for bronchogenic carcinoma.
Chest, 77 (1980), pp. 337-342
[16.]
M. Khalil Ali, C.F. Mountain, M.S. Ewer, M.R. Atallach, T.P. Haynie.
Pulmonary function in lung cancer: correlation with disease stage and post-surgical survival.
Abstracts II World Conference on Lung Cancer 1980. Excerpta Medica, Ed. Hansen HH, (1980),
[17.]
H.J. Fee, E. Carmack-Holmes, H.S. Gewirtz, K.P. Rawming, J.M. Alexander.
Role of pulmonary vascular resistance measurements in preoperative evaluation of candidates for pul monary resection.
J Thorac Cardiovasc Surg, 75 (1978), pp. 519-524
[18.]
D.M. Mitchell, J.V. Collins.
Fiberoptic bronchoscopy.
Recent Advances in Respiratory Medicine, 2. Ed,
[19.]
S.S. Lefrak.
Preoperative evaluation for pulmonary resection The role of radionuclide lung scanning.
Chest, 72 (1977), pp. 419-420
[20.]
A. López-Encuentra, J. Martínez, H. Cortés-Funes.
Protocolo para el estudio y tratamiento del carcinoma broncogénico (I).
Med Clin (Barcelona), 72 (1979), pp. 321-331
[21.]
C.F. Mountain.
Biologic phisiologic and technical determinants in surgical therapy for lung cancer.
Lung Cancer, 2.a,
[22.]
C.F. Diener, B. Burrows.
Further observations on the course and prognosis of chronic obstructive lung disease.
Am Rev Respir Dis, 111 (1975), pp. 719-724
[23.]
C.M. Fletcher, R. Peto, C. Tinker, F.E. Jpeizer.
The natural history of chronic bronchitis and emphysema.
Oxford University Press, (1976),
[24.]
N. Care, L. Martin.
Etablisement des normes physiologiques. L’exploration fonctionnelle pulmonaire,
[25.]
R.C. Kory, R. Callahan, H.G. Boren, J.C. Symer.
Clinical spirometric in normal men The Veteran Administration Army Cooperative. Study of pulmonary function.
Am J Med, 30 (1961), pp. 243-258
[26.]
P.G. Boysen, A.J. Block, G.N. Olsen, P.V. Moulder, J.O. Harris, R.E. Rawitscher.
Prospective evaluation for pneumonec tomy using the 99m Technetium quantitative perfusion lung sean.
Chest, 72 (1977), pp. 422-428
[27.]
P.G. Boysen, J.O. Harris, A.J. Block, G.M. Olsen.
Prospec tive evaluation for pneumonectomy using perfusion scanning Follow-up beyond one year.
Chest, 80 (1981), pp. 163-166
[28.]
M. Khalil Al, C. Mountain, J.M. Miller, D.A. Johnston, C.C. Schullenberger.
Regional pulmonary function before and after pneumonectomy using 133 Xenon.
Chest, 68 (1975), pp. 288-296
[29.]
P.G. Boysen.
Pulmonary resection and postoperative pulmonary function.
Chest, 68 (1980), pp. 288-296
[30.]
N. Berend, A.J. Woolcock, G.E. Marlin.
Effects of lobectomy on lung function.
Thorax, 35 (1980), pp. 145-150
[31.]
J. Brune, R. Munsch, J.P. Gamondes, T.H. Wiesendanger, F. Serain.
Les scintigraphies pulmonaires de perfusion et de ventilation dans le diagnostic d’operabilité des cancers bronchiques primitifs.
Ann Chir Thorac Cardiovasc, 36 (1982), pp. 95-101
[32.]
F. Nagasaki, B.J. Flehinger, N. Martini.
Complications of surgery in the treatment of carcinoma of the lung.
Chest, 82 (1982), pp. 25-29
[33.]
P.G. Boysen, A.D. Block, P.V. Moulder.
Relationship between preoperative pulmonary function tests and complications after thoracotomy.
Surg Gyn Obst, 152 (1981), pp. 813-815
[34.]
D.V. Bates, P.T. Macklem, R.V. Christie.
Respiratory func tion in disease..
WB Saunders Company, (1971),
[35.]
S. Boileau, J. Borge, M.C. Laxenaire.
Bilan fonctionnel pulmonaire et indications operatoires. 26eme session d’enseignement post-universitaire.
Faculté de Medicine de Nancy, Mars-Avril, (1982),
[36.]
J.I. Miller, G.D. Grossman, C.R. Hatcher.
Pulmonary function test criteria for operability and pulmonary resection.
Sur Gyn Obst, 153 (1981), pp. 893-895
[37.]
D.R. Gracey, M.B. Divertie, E.P. Didier.
Preoperative pul monary preparation of patients with chronic obstructive pulmo nary disease. A prospective study.
Chest, 76 (1979), pp. 123-129
[38.]
G.L. Snider.
Preoperative pulmonary preparation of pa tients with COPD.
Chest, 77 (1980), pp. 814-815
[39.]
H. Richelme, B. Bleine, A. Bourgeon, C. Ferrari, M. Namer, P. Chaunel, et al.
Actuarial survival of 350 cases of bronchial carcinoma treated by surgery. Symposium on Progress and Perspectives in Lung Cancer Treatment.
EORTC, (1979),
[40.]
G.A. Traver, M.G. Cline, B. Burrows.
Predictors of mortality in chronic obstructive pulmonary diseases. A 15 follow-up study.
Am Rev Respir Dis, 119 (1979), pp. 895-902
[41.]
R.J. Knudson, R.C. Stalin, M.D. Lebowitz, B. Burrows.
The maximal expiratory flow-volume curve Normal standards, variability and effects of age.
Am Rev Respir Dis, 113 (1976), pp. 587-600
[42.]
F. Paris, J. Padilla, Blasco, et al.
Prognostic factors in surgical therapy for lung cancer Abstracts Ist Convention Societas Europae Pneumologica. Sept, 1982.
Eur J Respir, 125 (1982), pp. 63
[43.]
Mountain CF. Surgery of lung cancer including adjuntive therapy. Lung Cancer, 1980. II World Congress on Lung Cancer. Copenhagen. Denmark. June 1980. Excerpta Medica. Ed. Hansen HH, Rørth M. Amsterdam 1980.
[44.]
E. Weitzenbaum, C. Hirth, A. Ducolone, R. Mirhom, J. Rasahalinjanahary, M. Erhart.
Prognostic value of pulmonary artery presure in chronic obstructive pulmonary disease.
Tho rax, 36 (1981), pp. 752-758
Copyright © 1984. Sociedad Española de Neumología y Cirugía Torácica
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