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Vol. 41. Issue 11.
Pages 618-624 (November 2005)
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Vol. 41. Issue 11.
Pages 618-624 (November 2005)
Review ArticleS
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Molecular Epidemiology of Tuberculosis: Main Findings and Their Application in Spain
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E. García-Pachóna,
Corresponding author
egpachon@hotmail.com

Correspondence: Dr. E. García-Pachón. Sección de Neumología. Hospital General Universitario. 03203 Elche. Alicante. España
, J.C. Rodríguezb
a Sección de Neumología, Hospital General Universitario, Elche, Alicante, Spain
b Sección de Microbiología, Hospital General Universitario, Elche, Alicante, Spain
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REFERENCES
[1]
D van Soolingen, PW Hermans, PE de Haas, DR Soll, JD van Embden.
Occurrence and stability of insertion sequences in Mycobacterium tuberculosis complex strains: evaluation of an insertion sequence-dependent DNA polymorphism as a tool in the epidemiology of tuberculosis.
J Clin Microbiol, 29 (1991), pp. 2578-2586
[2]
MD Cave, KD Eisenach, PF McDermott, JH Bates, JT Crawford.
IS6110 conservation of sequence in the Mycobacterium tuberculosis complex and its utilization in DNA fingerprinting.
Moll Cell Prob, 5 (1991), pp. 73-80
[3]
JR Glynn, J Bauer, AS de Boer, MW Borgdorff, PE Fine, P Godfrey-Faussett, et al.
Interpreting DNA fingerprint clusters of Mycobacterium tuberculosis. European Concerted Action on Molecular Epidemiology and Control of Tuberculosis.
Int J Tuberc Lung Dis, 3 (1999), pp. 1055-1060
[4]
E Kanduma, TD McHugh, SH Gillespie.
Molecular methods for Mycobacterium tuberculosis strain typing: a user's guide.
J Appl Microbiol, 94 (2003), pp. 781-791
[5]
LN Nguyen, GL Gilbert, GB Marks.
Molecular epidemiology of tuberculosis and recent developments in understanding the epidemiology of tuberculosis.
Respirology, 9 (2004), pp. 313-319
[6]
PF Barnes, MD Cave.
Molecular epidemiology of tuberculosis.
N Engl J Med, 349 (2003), pp. 1149-1156
[7]
JDA van Embden, MD Cave, JT Crawford, JW Dale, KD Eisenach, B Gicquel, et al.
Strain identification of Mycobacterium tuberculosis by DNA fingerprinting: recommendations for a standardized methodology.
J Clin Microbiol, 31 (1993), pp. 406-409
[8]
H Soini, X Pan, L Teeter, JM Musser, EA Graviss.
Transmission dynamics and molecular characterization of Mycobacterium tuberculosis isolates with low copy numbers of IS6110.
J Clin Microbiol, 39 (2001), pp. 217-221
[9]
M Ruiz, JC Rodríguez, S Samper, G Royo.
Caracterización genómica de cepas de Mycobacterium tuberculosis con menos de 5 copias de IS6110: utilidad de amplified-fragment length polymorphism (AFLP), variable number tandem repeat (VTNR) y spoligotyping.
Med Clin (Barc), 124 (2005), pp. 75-76
[10]
D van Soolingen.
Molecular epidemiology of tuberculosis and other mycobacterial infections: main methodologies and achievements.
J Intern Med, 249 (2001), pp. 1-26
[11]
I Filliol, JR Driscoll, D van Soolingen, BN Kreiswirth, K Kremer, G Valetudie, et al.
Global distribution of Mycobacterium tuberculosis spoligotypes.
Emerg Infect Dis, 8 (2002), pp. 1347-1349
[12]
JW Dale, D Brittain, AA Cataldi, D Cousins, JT Crawford, JJ Driscoll, et al.
Spacer oligonucleotide typing of bacteria of the Mycobacterium tuberculosis complex: recommendations for standardised nomenclature.
Int J Lung Dis, 5 (2001), pp. 216-219
[13]
E Mazars, S Lesjean, AL Banuls, M Gilbert, V Vincent, B Gicquel, et al.
High-resolution minisatellite-based typing as a portable approach to global analysis of Mycobacterium tuberculosis molecular epidemiology.
Proc Natl Acad Sci USA, 98 (2001), pp. 1901-1906
[14]
P Supply, S Lesjean, E Savine, K Kremer, D van Soolingen, C Locht.
Automated high-throughput genotyping for study of global epidemiology of Mycobacterium tuberculosis based on mycobacterial interspersed repetitive units.
J Clin Microbiol, 39 (2001), pp. 3563-3571
[15]
M Ruiz, JC Rodríguez, F Rodríguez-Valera, G Royo.
Amplified fragment length polymorphism as a complement to IS16110 restriction fragment length polymorphism analysis for molecular typing of Mycobacterium tuberculosis..
J Clin Microbiol, 41 (2003), pp. 4820-4822
[16]
F Fernández Cuenca.
Aplicación de técnicas de PCR en la epidemiología molecular de las enfermedades infecciosas.
Enferm Infecc Microbiol Clin, 22 (2004), pp. 355-360
[17]
RW Yeh, A Ponce de León, CB Agasino, JA Hahn, CL Daley, CP Hopewell, et al.
Stability of Mycobacterium tuberculosis DNA genotypes.
J Infect Dis, 177 (1998), pp. 1107-1111
[18]
AS de Boer, MW Borgdorff, PE de Haas, NJ Nagelkerke, JD van Embden, D van Soolingen.
Analysis of rate of change of IS6110 RFLP patterns of Mycobacterium tuberculosis based on serial patient isolates.
J Infect Dis, 180 (1999), pp. 1238-1244
[19]
RM Warren, GD van der Spuy, M Richardson, N Beyers, MW Borgdorff, MA Behr, et al.
Calculation of the stability of the IS6110 banding pattern in patients with persistent Mycobacterium tuberculosis disease.
J Clin Microbiol, 40 (2002), pp. 1705-1708
[20]
T Lillebaek, A Dirksen, E Vynnycky, I Baess, VO Thomsen, AB Andersen.
Stability of DNA patterns as evidence of Mycobacterium tuberculosis reactivation occurring decades after the initial infection.
J Infect Dis, 188 (2003), pp. 1032-1039
[21]
A Siedler, A Nienhaus, R Diel.
The transmission of tuberculosis in the light of new molecular biological approaches.
Occup Environ Med, 61 (2004), pp. 96-102
[22]
D Alland, GE Kalkut, AR Moss, RA McAdam, JA Hahn, W Bosworth, et al.
Transmission of tuberculosis in New York City. An analysis by DNA fingerprinting and conventional epidemiologic methods.
N Engl J Med, 330 (1994), pp. 1710-1716
[23]
PM Small, PC Hopewell, SP Singh, A Paz, J Parsonnet, DC Ruston, et al.
The epidemiology of tuberculosis in San Francisco. A population-based study using conventional and molecular methods in the 1990s.
N Engl J Med, 330 (1994), pp. 1703-1709
[24]
MW Borgdorff, N Nagelkerke, D van Soolingen, PE de Hass, J Veen, JD van Embden.
Analysis of tuberculosis transmission between nationalities in the Netherlands in the period 1993-1995 using DNA fingerprinting.
Am J Epidemiol, 147 (1998), pp. 187-195
[25]
GE Pfyffer, A Strassle, N Rose, R Wirth, O Brandli, H Shang, et al.
Transmission of tuberculosis in the metropolitan area of Zurich: a 3 year survey based on DNA fingerprinting.
Eur Respir J, 11 (1998), pp. 804-808
[26]
M Murray, E Nardell.
Molecular epidemiology of tuberculosis. Achievements and challenges to current knowledge.
Bull World Health Organ, 80 (2002), pp. 477-482
[27]
L Pineda-García, A Ferrera, SE Hoffner.
DNA fingerprinting of Mycobacterium tuberculosis strains from patients with tuberculsis in Honduras.
J Clin Microbiol, 35 (1997), pp. 2393-2397
[28]
M Doroudchi, K Kremer, EA Basiri, MR Kadivar, D van Soolingen, AA Ghaderi, et al.
IS6110-RFLP and spoligotyping of Mycobacterium tuberculosis isolates in Iran.
Scan J Infect Dis, 32 (2000), pp. 663-668
[29]
JR Glynn, E Vynnycky, PE Fine.
Influence of sampling on estimates of clustering and recent transmission of Mycobacterium tuberculosis derived from DNA fingerprinting techniques.
Am J Epidemiol, 149 (1999), pp. 366-371
[30]
H Safi, J Aznar, JC Palomares.
Molecular epidemiology of Mycobacterium tuberculosis strains isolated during a 3-year period (1993-1995) in Seville, Spain.
J Clin Microbiol, 35 (1997), pp. 2472-2476
[31]
S Samper, MJ Iglesias, MJ Rabanaque, MA Lezcano, LA Vitoria, MC Rubio, et al.
The molecular epidemiology of tuberculosis in Zaragoza, Spain: a retrospective epidemiological study in 1993.
Int J Tuberc Lung Dis, 2 (1998), pp. 281-287
[32]
J Íñigo Martínez, F Chaves Sánchez, A Arce Arnáez, M Alonso Sanz, E Palenque Mataix, F Jaén Herreros, et al.
Transmisión reciente de tuberculosis en Madrid: utilidad de las técnicas moleculares.
Med Clin (Barc), 115 (2000), pp. 241-245
[33]
J Solsona, JA Cayla, E Verdü, MP Estrada, S García, D Roca, et al.
Molecular and conventional epidemiology of tuberculosis in an inner city district.
Int J Tuberc Lung Dis, 5 (2001), pp. 724-731
[34]
K Fernández de la Hoz, J Íñigo, JI Fernández Martín, A Arce, M Alonso Sanz, P Gómez Pintado, et al.
The influence of HIV infection and imprisonment on dissemination of Mycobacterium tuberculosis in a large Spanish city.
Int J Tuberc Lung Dis, 5 (2001), pp. 696-702
[35]
J Elizaga, P Carrero, J Íñigo, F Chaves.
Transmisión reciente de la tuberculosis en un área con baja incidencia: estudio epidemiológico y molecular.
Med Clin (Barc), 118 (2002), pp. 645-649
[36]
M Ruiz, JC Rodríguez, JF Navarro, S Samper, C Martín, G Royo.
Molecular epidemiology of tuberculosis in Elche, Spain: a 7-year study.
J Med Microbiol, 51 (2002), pp. 273-277
[37]
MJ Pena, JA Caminero, MI Campos Herrero, JC Rodríguez Gallego, ML García Laorden, P Cabrera, et al.
Epidemiology of tuberculosis on Gran Canaria: a 4-year population study using traditional and molecular approaches.
Thorax, 58 (2003), pp. 618-622
[38]
J Íñigo Martínez, A Arce Arnáez, F Chaves Sánchez, E Palenque Mataix, M Burgoa Arenales.
Patrones de transmisión de la tuberculosis en un área sanitaria de Madrid.
Rev Esp Salud Püblica, 77 (2003), pp. 541-551
[39]
B Perfecto, JR Sánchez, AI González, I López, I Dorronsoro.
Brote de tuberculosis multiresistente.
An Sist Sanit Navar, 23 (2000), pp. 257-263
[40]
RM Jasmer, JA Hahn, PM Small, CL Daley, MA Behr, AR Moss, et al.
A molecular epidemiologic analysis of tuberculosis trends in San Francisco.
Ann Intern Med, 130 (1999), pp. 971-978
[41]
BJ van Wolleswinkel, NJ Nagelkerke, JF Broekmans, MW Borgdorff.
The impact of immigration on the elimination of tuberculosis in The Netherlands: a model based approach.
Int J Tuberc Lung Dis, 6 (2002), pp. 130-136
[42]
M Murray.
Determinants of cluster distribution in the molecular epidemiology of tuberculosis.
Proc Natl Acad Sci USA, 99 (2002), pp. 1538-1543
[43]
CR Braden, GL Templeton, MD Cave, S Valway, IM Onorato, KG Castro, et al.
Interpretation of restriction fragment length polymorphism analysis of Mycobacterium tuberculosis isolates from a state with a large rural population.
J Infect Dis, 175 (1997), pp. 1446-1452
[44]
M Murray, DA Alland.
Methodological problems in the molecular epidemiology of tuberculosis.
Am J Epidemiol, 155 (2002), pp. 565-571
[45]
E Heldal, UR Dahle, P Sandven, DA Caugant, N Brattaas, HT Waaler, et al.
Risk factors for recent transmission of Mycobacterium tuberculosis..
Eur Respir J, 22 (2003), pp. 637-642
[46]
TP Giordano, H Soini, LD Teeter, GJ Adams, JM Musser, EA Graviss.
Relating the size of molecularly defined clusters of tuberculosis to the duration of symptoms.
Clin Infect Dis, 38 (2004), pp. 10-16
[47]
E Hernández-Garduno, V Cook, D Kunimoto, RK Elwood, WA Black, JM FitzGerald.
Transmission of tuberculosis from smear negative patients: a molecular epidemiology study.
Thorax, 59 (2004), pp. 286-290
[48]
M Ruiz, JF Navarro, JC Rodríguez, JA Larrosa, G Royo.
Effect of clinical and socio-economic factors on the rate of clustering of Mycobacterium tuberculosis clinical isolates in Elche (Spain).
Epidemiol Infect, 131 (2003), pp. 1077-1083
[49]
JL Calpe, E Chiner, J Martínez Pardo, A Calpe, V Armero.
Impact of the human immunodeficiency virus on the epidemiology of tuberculosis in area 15 of the Valencian community in Spain.
Int J Tuberc Lung Dis, 8 (2004), pp. 1204-1212
[50]
JJ Camarena, A Artero, JM Nogueira, JC Navarro, A Olmos, R Blanquer.
Tuberculosis en pacientes con sida: aportación del análisis de los fragmentos de restricción de longitud polimórfica de aislados de Mycobacterium tuberculosis..
Med Clin (Barc), 111 (1998), pp. 721-724
[51]
D van Soolingen, MW Borgdorff, PE de Haas, MM Sebek, J Veen, M Dessens, et al.
Molecular epidemiology of tuberculosis in The Netherlands: a nationwide study from 1993 through 1997.
J Infect Dis, 18 (1999), pp. 726-736
[52]
SI McLaughlin, P Spradling, D Drociuk, R Ridzon, CJ Pozsik, I Onorato.
Extensive transmission of Mycobacterium tuberculosis among congregated, HIV-infected prison inmates in South Carolina, United States.
Int J Tuberc Lung Dis, 7 (2003), pp. 665-672
[53]
MV Burgos, AS Pym.
Molecular epidemiology of tuberculosis.
Eur Respir J, 20 (2002), pp. 54-65
[54]
E Nardell, B McInnis, B Thomas, S Weidhaas.
Exogenous reinfection with tuberculosis in a shelter for the homeless.
N Engl J Med, 315 (1986), pp. 1570-1574
[55]
PM Small, RW Shafer, PC Hopewell, SP Singh, MJ Murphy, E Desmond, et al.
Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in patients with advanced HIV infection.
N Engl J Med, 328 (1993), pp. 1137-1144
[56]
RW Shafer, SP Singh, C Larkin, PM Small.
Exogenous reinfection with multidrug-resistant Mycobacterium tuberculosis in an immunocompetent patient.
Tuber Lung Dis, 76 (1995), pp. 575-577
[57]
A van Rie, R Warren, M Richardson, TC Victor, RP Gie, DA Enarson, et al.
Exogenous reinfection as a cause of recurrent tuberculosis after curative treatment.
N Engl J Med, 341 (1999), pp. 1174-1179
[58]
A Bandera, A Gori, L Catozzi, A Degli Esposti, G Marchetti, C Molteni, et al.
Molecular epidemiology study of exogenous reinfection in an area with a low incidence of tuberculosis.
J Clin Microbiol, 39 (2000), pp. 2213-2218
[59]
JA Caminero, MJ Pena, MI Campos-Herrero, JC Rodríguez, O Afonso, C Martín, et al.
Exogenous reinfection with tuberculosis on a European island with a moderate incidence of disease.
Am J Respir Crit Care Med, 163 (2001), pp. 717-720
[60]
D García de Viedma, M Marín, S Hernangómez, M Díaz, MJ Ruiz Serrano, E Alcalá.
Tuberculosis recurrences: reinfection plays a role in a population whose clinical/epidemiological characteristics do not favor reinfection.
Arch Intern Med, 162 (2002), pp. 1873-1879
[61]
RM Jasmer, L Bozeman, K Schwartzman, MD Cave, JJ Saukkonen, B Metchock, et al.
Recurrent tuberculosis in the United States and Canada: relapse or reinfection?.
Am J Respir Crit Care Med, 170 (2004), pp. 1360-1366
[62]
SE Weis, JM Pogoda, Z Yang, MD Cave, C Wallace, M Kelley, et al.
Transmission dynamics of tuberculosis in Tarrant County, Texas.
Am J Respir Crit Care Med, 166 (2002), pp. 36-42
[63]
SJ McNabb, JS Kammerer, AC Hickey, CR Braden, N Shang, LS Rosenblum, et al.
Added epidemiologic value to tuberculosis prevention control of the investigation of clustered genotypes of Mycobacterium tuberculosis isolates.
Am J Epidemiol, 160 (2004), pp. 589-597
[64]
H van Deutekom, SP Hoijng, PE de Haas, MW Langendam, A Horsman, D van Soolingen, et al.
Clustered tuberculosis cases: do they represent recent transmission and can they be detected earlier?.
Am J Respir Crit Care Med, 169 (2004), pp. 806-810
[65]
J Íñigo, A Arce, JM Martín-Moreno, R Herruzo, E Palanque, F Chaves.
Recent transmission of tuberculosis in Madrid: application of capture-recapture analysis to conventional and molecular epidemiology.
Int J Epidemiol, 32 (2003), pp. 763-769
[66]
E Geng, B Kreiswirth, C Driver, J Li, J Burzybski, P dellaLatta, et al.
Changes in the transmission of tuberculosis in New York City from 1990 to 1999.
N Engl J Med, 346 (2002), pp. 1453-1458
[67]
SJ McNabb, CR Braden, TR Navin.
DNA fingerprinting of Myco-bacterium tuberculosis: lessons learned and implications in the future.
Emerg Infect Dis, 8 (2002), pp. 1314-1319
[68]
J Bauer, A Kok-Jensen, P Faurschou, J Thuesen, E Taurdorf, AB Andersen.
A prospective evaluation of the clinical value of nation-wide DNA fingerprinting of tuberculosis isolates in Denmark.
Int J Tuberc Lung Dis, 4 (2000), pp. 295-299
[69]
JT Crawford, CR Braden, BA Schable, IM Onorato.
National Tuberculosis Genotyping and Surveillance Network: design and methods.
Emerg Infect Dis, 8 (2002), pp. 1 192-1 196
[70]
CS Lambregts van Weezenbeek, MM Sebek, PJ van Gerben, G de Vries, S Verver, NA Kalisvaart, et al.
Tuberculosis contact investigation and DNA fingerprinting surveillance in The Netherlands: 6 years' experience with nation-wide cluster feedback and cluster monitoring.
Int J Tuberc Lung Dis, 12 (2003), pp. 46370
[71]
A Seidler, A Nienhaus, R Diel.
The transmission of tuberculosis in the light of new molecular biological approaches.
Occup Environ Med, 61 (2004), pp. 96-201
[72]
KA Sepkowitz, CR Friedman, A Hafner, D Kwork, S Manoach, M Floris, et al.
Tuberculosis among urban health care workers: a study using restriction fragment length polymorphism typing.
Clin Infec Dis, 21 (1995), pp. 1098-1101
[73]
H van Deutekom, JJ Gerritsen, D van Soolingen, EJ van Ameijden, JD van Embden, RA Coutinho.
A molecular epidemiological approach to studying the transmission of tuberculosis in Amsterdam.
Clin Infect Dis, 25 (1997), pp. 1071-1077
[74]
G Tudó, J González, JM Gatell, JA Caylá, E Martínez, A García, et al.
Detection of unsuspected cases of nosocomial transmission of tuberculosis by use of a molecular typing method.
Clin Infect Dis, 33 (2001), pp. 453-459
[75]
X Casas, J Ruiz-Manzano, I Casas, F Andreo, J Sanz, N Rodríguez, et al.
Tuberculosis en personal sanitario de un hospital general.
Med Clin (Barc), 122 (2004), pp. 741-743
[76]
PJ Bifani, B Mathema, NE Kurepina, BN Kreiswirth.
Global dissemination of the Mycobacterium tuberculosis W-Beijing family strains.
Trends Microbiol, 10 (2002), pp. 45-52
[77]
JA Caminero, MJ Pena, MI Campos-Herrero, JC Rodríguez, I García, P Cabrera, et al.
Epidemiological evidence of spread of a Mycobacterium tuberculosis strain of the Beijing genotype on Gran Canaria Island.
Am J Respir Crit Care Med, 164 (2001), pp. 1165-1170
[78]
JR Glynn, J Whiteley, PJ Bifani, K Kremer, D van Soolingen.
Worldwide occurrence of Beijing/W strains of Mycobacterium tuberculosis: a systematic review.
Emerg Infect Dis, 8 (2002), pp. 843-849
[79]
M Zhang, J Gong, Z Yang, B Samten, MD Cave, PF Barnes.
Enhanced capacity of a widespread strain of Mycobacterium tuberculosis to grow in human macrophages.
J Infect Dis, 179 (1999), pp. 1213-1217
[80]
C Manca, L Tsenova, CE Barry, A Bergtold, S Freeman, PA Haslett, et al.
Mycobacterium tuberculosis CDC 1551 induces a more vigorous host response in vivo and in vitro, but is not more virulent than other clinical isolates.
J Immunol, 162 (1999), pp. 6740-6746
[81]
ML García-García, A Ponce de León, ME Jiménez-Corona, A Jiménez-Corona, M Palacios-Martínez, S Balandrano-Campos, et al.
Clinical consequences and transmissibility of tuberculosis in souhern Mexico.
Arch Intern Med, 160 (2000), pp. 630-636
[82]
TR Frieden, LF Sherman, KL Maw, PI Fujiwara, JT Crawford, B Nivin, et al.
A multi-institutional outbreak of highly drug-resistant tuberculosis: epidemiology and clinical outcomes.
JAMA, 276 (1996), pp. 1229-1235
[83]
A Kruuner, SE Hoffner, H Sillastu, M Danilovits, K Levina, SB Svenson, et al.
Spread of drug-resistant pulmonary tuberculosis in Estonia.
J Clin Microbiol, 39 (2001), pp. 3339-3345
[84]
PJ Bifani, B Mathema, Z Liu, SL Moghazeh, B Shopsin, B Tempalski, et al.
Identification of a W variant outbreak of Mycobacterium tuberculosis via population-based molecular epidemiology.
JAMA, 282 (1999), pp. 2321-2327
[85]
M Ruddy, TD McHugh, JW Dale, D Banerjee, H Maguire, P Wilson, et al.
Estimation of the rate of unrecognized cross-contamination with Mycobacterium tuberculosis in London microbiology laboratories.
J Clin Microbiol, 40 (2002), pp. 4100-4104
[86]
WJ Burman, RR Reves.
Review of false-positive cultures for Mycobacterium tuberculosis and recommendations for avoid unnecessary treatment.
Clin Infect Dis, 31 (2000), pp. 1390-1395
[87]
JK O'Brien, LA Sandman, BN Kreiswirth, WN Rom, NW Schluger.
DNA fingerprinting from Mycobacterium tuberculosis isolates of patients confined for therapy noncompliance show frequent clustering.
Chest, 112 (1997), pp. 387-392
[88]
AA Majeed, N Ahmed, KR Rao, S Ghousunnissa, F Kauser, B Bose, et al.
AmpliBase MT(TM): a Mycobacterium tuberculosis diversity knowledge base.
Bioinformatics, 20 (2004), pp. 989-992

This work received financial support from the Escuela Valenciana de Estudios para la Salud (Valencian School of Health Studies).

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