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Vol. 56. Issue 6.
Pages 360-364 (June 2020)
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Vol. 56. Issue 6.
Pages 360-364 (June 2020)
Original Article
DOI: 10.1016/j.arbr.2019.09.015
Long Non-coding RNA LINC-PINT and LINC00599 Polymorphisms are Associated With High-altitude Pulmonary Edema in Chinese
Los polimorfismos de los ARN no codificantes de cadena larga LINC-PINT y LINC00599 se asocian al edema pulmonar de altitud en la población china
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Xue Hea,b,c, Jianwen Zhengd, Yongjun Hea,b,c, Yuhe Wange, Li Wanga,b,c, Mei Baia,b,c, Tianbo Jina,b,c,f, Dongya Yuana,b,c,
Corresponding author
dy62@163.com

Corresponding author.
a Key Laboratory of Molecular Mechanism and Intervention Research for Plateau Diseases of Tibet Autonomous Region, School of Medicine, Xianyang, Shaanxi, China
b Key Laboratory of High Altitude Environment and Genes Related to Diseases of Tibet Autonomous Region, School of Medicine, Xianyang, Shaanxi, China
c Key Laboratory for Basic Life Science Research of Tibet Autonomous Region, School of Medicine, Xizang Minzu University, Xianyang, Shaanxi, China
d Department of Internal Medicine, Affiliated Hospital of Xizang Minzu University, Xianyang, Shaanxi, China
e Department of Clinical Laboratory, Affiliated Hospital of Xizang Minzu University, Xianyang, Shaanxi, China
f Key Laboratory of Resource Biology and Biotechnology in Western China (Northwest University), Ministry of Education, School of Life Sciences, Northwest University, Xi’an, Shaanxi, China
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Tables (4)
Table 1. Characteristics of HAPE cases and healthy controls.
Table 2. Basic information of candidate single nucleotide polymorphisms (SNPs) in the study.
Table 3. Analysis of association between rs157928 of LINC-PINT and risk of HAPE.
Table 4. Stratified analysis of polymorphisms in LINC-PINT and LINC00599 on HAPE risk by age.
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Abstract
Background

High-altitude pulmonary edema (HAPE) is a kind of non-cardiogenic edema with high incidence and life-threatening. This study was designed to explore the association of LINC-PINT and LINC00599 polymorphisms with HAPE susceptibility.

Methods

This study included 244 HAPE patients and 243 age-, sex-matched healthy controls from the Chinese population. The genotypes of polymorphisms were detected using the Agena MassARRAY. The relationship between polymorphisms and HAPE risk was evaluated using a χ2 test with an odds ratio (OR) and 95% confidence intervals (CIs) in multiple genetic models.

Results

We observe a significant association between the rs157928 and decreased HAPE risk in genotype model (OR=0.65, 95% CI=0.43–0.98, p=0.038). The subgroup analysis results indicated that rs2272026 was associated with a decreased risk of HAPE in younger patients with age ≤32 (codominant model: p=0.006; recessive model: p=0.005 additive model: p=0.018; and allele model: p=0.012; rs72625676, codominant model: p=0.038; recessive model: p=0.037). Among patients older than 32 years, there was a significantly increased risk of HAPE associated with the rs2272026 and rs1962430 (rs2272026: genotype model: p=0.049; recessive model: p=0.029; rs1962430: genotype model: p=0.024; recessive model: p=0.020). Nevertheless, rs157928 had relationship with significantly reducing the risk of HAPE in the genotype model (p=0.018).

Conclusion

Our study suggests that LINC-PINT and LINC00599 polymorphisms are associated with HAPE susceptibility in Chinese population.

Keywords:
Long non-coding RNA
Polymorphisms
High-altitude pulmonary edema
Susceptibility
Resumen
Antecedentes

El edema pulmonar de altitud (EPA) es un tipo de edema no cardiogénico con una incidencia alta y es potencialmente mortal. Este estudio se diseñó para explorar la asociación entre los polimorfismos de LINC-PINT y LINC00599 y la susceptibilidad al EPA.

Métodos

Este estudio incluyó a 244 pacientes con EPA y 243 controles sanos de la misma edad y sexo, todos de origen chino. Los genotipos de los polimorfismos se detectaron utilizando el MassARRAY de Agena™. La relación entre los polimorfismos y el riesgo de EPA se evaluó utilizando el test de la χ2 con el odds ratio (OR) e intervalos de confianza (IC) del 95% en múltiples modelos genéticos.

Resultados

Observamos una asociación significativa entre el rs157928 y una disminución del riesgo de EPA en el modelo genotípico (OR=0,65, IC del 95%=0,43-0,98, p=0,038). Los resultados de los análisis por subgrupos indicaron que el rs2272026 se asociaba a una disminución del riesgo de EPA en pacientes jóvenes de ≤ 32 años (modelo codominante: p=0,006; modelo recesivo: p=0,005; modelo aditivo: p=0,018; y modelo por alelos: p=0,012 para rs72625676, modelo concomitante: p=0,038; modelo recesivo: p=0,037). Entre los pacientes mayores de 32 años, se encontró un riesgo aumentado de EPA de manera significativa asociado a los rs2272026 y rs1962430 (rs2272026: modelo genotípico: p=0,049; modelo recesivo: p=0,029; rs1962430: modelo genotípico: p=0,024; modelo recesivo: p=0,020). Sin embargo, el rs157928 tenía relación con una reducción significativa del riesgo de EPA en el modelo genotípico (p=0,018).

Conclusión

Nuestro estudio sugiere que los polimorfismos de LINC-PINT y LINC00599 están asociados a la susceptibilidad de EPA en la población china.

Palabras clave:
ARN no codificante de cadena larga
Polimorfismos
Edema pulmonar de altitud
Susceptibilidad

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