Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de broncopatia obstructiva cronica

Madrigal Vilata, J.A.; Llopis Llombart, R.; Merino Sesma, J.; Muñoz Gil, J.; Insa Perez, L.; Lopez Merino, V.

doi:10.1016/S0300-2896(15)32209-2

Archivos de Bronconeumología

ISSN: 0300-2896

Archivos de Bronconeumologia is an international journal that publishes original studies whose content is based upon results of research initiatives dealing with several aspects of respiratory medicine including epidemiology, respiratory physiology, pathophysiology of respiratory diseases, clinical management, thoracic surgery, pediatric lung diseases, respiratory critical care, respiratory allergy and basic research. Other types of articles such as editorials, reviews, and different types of letters are also published in the journal. Additionally, the journal expresses the voice of the following scientific societies: the Spanish Respiratory Society of Pneumology and Thoracic Surgery (SEPAR; https://www.separ.es/), the Latin American Thoracic Society (ALAT; https://alatorax.org/), and the Iberian American Association of Thoracic Surgery (AIACT; http://www.aiatorax.com/).

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Vol. 21. Issue 1.

Pages 29-33 (January - February 1985)

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Pages 29-33 (January - February 1985)

DOI: 10.1016/S0300-2896(15)32209-2

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Estudio del efecto de la nifedipina sobre las vias aereas en pacientes afectos de broncopatia obstructiva cronica

The effect of nifedipine on the airways in chronic obstructive bronchial disorders

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J.A. Madrigal Vilata, R. Llopis Llombart, J. Merino Sesma, J. Muñoz Gil, L. Insa Perez, V. Lopez Merino

Servicio de Cardiología. Hospital Clínico Universitario. Valencia

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Hemos estudiado el efecto que la nifedipina, un antagonista de los canales lentos del calcio, ejerce sobre las vías aéreas, comparándolo con el ejercido por el salbutamol, habiendo encontrado que la nifedipina mejora ligeramente la obstrucción bronquial incrementándose la VC en 6,7% (P < 0,01), el FEV1 en 9,1% (P < 0,01), el MEF50%vc en 15,8% (P < 0,01), el MMFR en 19,7% (P < 0,05), el PEF en 8,5% (P < 0,05) y la conductancia específica de vías áreas en 39,9% (P < 0,01), y disminuyendo la resistencia de vías aéreas en 25,7% (P < 0,001).

Los resultados obtenidos no justifican el uso de la nifedipina como fármaco broncodilatador, pero sí la convierten en alternativa válida a otros fármacos que pueden estar contraindicados en casos en los que se asocia una patología respiratoria a otra cardiovascular.

Nifedipine, which interferes with the passage of calcium ions was compared to salbutamol for its effect on the airways in obstructive bronchial disorders.

Nifedipine was found to slightly improve bronchial obstruction by increasing VC by 6.7% (p < 0.01); FEV1 by 9.1% (p < 0.01); MEF50%vc by 15.8% (p < 0.01); MMRF by 19.7% (p < 0.05); PEF by 8.5% (p < 0.05) and specific airways flow by 39.9% (p < 0.01) while decreasing airways resistance by 25.7% (p < 0.001). These findings do not justify the use of nifedipine as a broncbodilator although it is a valid altemative in cases where there is concommitant respiratory and cardiovascular disorder and other agents are not viable.

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