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B) Reconstrucción coronal de la TC de tórax (ventana de pulmón) que confirma la presencia de neumomediastino y enfisema subcutáneo (flechas). C) Imagen axial de la TC de tórax (ventana de pulmón) que demuestra la presencia de enfisema peribronquial izquierdo con neumomediastino (flecha), efecto Macklin. 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B) Fluoroscopic view of the 3 normally positioned stents by flexible bronchoscopy through rigid bronchoscope. C) Chest CT image without intravenous contrast, axial plane, lung window showing the presence of the 3 devices used for closing the fistula. D) Plain post-anterior chest X-ray after intervention showing correct positioning of the 3 implanted devices.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Blanca de Vega Sánchez, Carlos Disdier Vicente, Manuel Pérez-Miranda" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Blanca" "apellidos" => "de Vega Sánchez" ] 1 => array:2 [ "nombre" => "Carlos Disdier" "apellidos" => "Vicente" ] 2 => array:2 [ "nombre" => "Manuel" "apellidos" => "Pérez-Miranda" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289620300752" "doi" => "10.1016/j.arbres.2020.02.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300752?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921003104?idApp=UINPBA00003Z" "url" => "/15792129/0000005700000011/v1_202111020702/S1579212921003104/v1_202111020702/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212921003554" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.12.012" "estado" => "S300" "fechaPublicacion" => "2021-11-01" "aid" => "2710" "copyright" => "SEPAR" "documento" => "article" "crossmark" => 1 "subdocumento" => "fla" "cita" => "Arch Bronconeumol. 2021;57:690-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:14 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Original Article</span>" "titulo" => "Predictive Value of Immune Cell Functional Assay for Non-Cytomegalovirus Infection in Lung Transplant Recipients: A Multicenter Prospective Observational Study" "tienePdf" => "en" "tieneTextoCompleto" => "en" "tieneResumen" => array:3 [ 0 => "en" 1 => "en" 2 => "es" ] "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "690" "paginaFinal" => "696" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Valor predictivo del test de función de la inmunidad celular para infecciones distintas a CMV en receptores de un trasplante pulmonar: un estudio multicéntrico, prospectivo y observacional" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 1 "multimedia" => array:5 [ "identificador" => "fig0020" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => false "mostrarDisplay" => true "figura" => array:1 [ 0 => array:4 [ "imagen" => "fx1.jpeg" "Alto" => 618 "Ancho" => 1333 "Tamanyo" => 67635 ] ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Víctor Monforte, Piedad Ussetti, Raquel Castejón, Helena Sintes, Virginia Luz Pérez, Rosalía Laporta, Amparo Sole, José Manuel Cifrián, Pedro J. Marcos, Javier Redel, Ibai Los Arcos, Cristina Berastegui, Rodrigo Alonso, Silvia Rosado, Juan Escriva, David Iturbe, Juan Pablo Ovalle, José Manuel Vaquero, Manuel López-Meseguer, Alberto Mendoza, Susana Gómez-Ollés" "autores" => array:21 [ 0 => array:2 [ "nombre" => "Víctor" "apellidos" => "Monforte" ] 1 => array:2 [ "nombre" => "Piedad" "apellidos" => "Ussetti" ] 2 => array:2 [ "nombre" => "Raquel" "apellidos" => "Castejón" ] 3 => array:2 [ "nombre" => "Helena" "apellidos" => "Sintes" ] 4 => array:2 [ "nombre" => "Virginia Luz" "apellidos" => "Pérez" ] 5 => array:2 [ "nombre" => "Rosalía" "apellidos" => "Laporta" ] 6 => array:2 [ "nombre" => "Amparo" "apellidos" => "Sole" ] 7 => array:2 [ "nombre" => "José Manuel" "apellidos" => "Cifrián" ] 8 => array:2 [ "nombre" => "Pedro J." 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The Macklin effect" "tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "697" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Antía Ferreiro, Galo Granados, Ana Villar" "autores" => array:3 [ 0 => array:3 [ "nombre" => "Antía" "apellidos" => "Ferreiro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Galo" "apellidos" => "Granados" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:4 [ "nombre" => "Ana" "apellidos" => "Villar" "email" => array:1 [ 0 => "avillar@vhebron.net" ] "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitari Vall d’Hebron, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Vall d’Hebron Institut de Recerca (VHIR), Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Enfisema peribroncovascular. Efecto Macklin" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1092 "Ancho" => 1267 "Tamanyo" => 170702 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Plain chest X-ray in posteroanterior projection showing pneumomediastinum and subcutaneous emphysema (arrows). (B) Coronal reconstruction of the chest CT scan (lung window) confirming the presence of pneumomediastinum and subcutaneous emphysema (arrows). (C) Axial image of the chest CT (lung window) showing left peribronchial emphysema with pneumomediastinum (arrow) – the Macklin effect. (D) Enlarged image of peribronchial emphysema (arrow).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">A 27-year-old man with a history of asthma was seen in the emergency department for acute respiratory failure, associated with signs of bronchospasm and fever of 38.5 °C. A chest X-ray was performed, revealing pneumomediastinum associated with subcutaneous emphysema (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A), with no criteria for pleural drainage. No foci of condensation associated with pneumonia were observed. Given a diagnostic orientation of acute bronchitis, bronchodilator treatment and antibiotic therapy with amoxicillin-clavulanic acid were initiated. Although the patient showed some improvement, with resolution of bronchospasm, he continued to require supplementary low-flow oxygen therapy, so a CT angiogram was performed. This ruled out pulmonary embolism, but revealed areas of peribronchovascular emphysema, also known as the “Macklin effect” (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C and D). Mediastinal emphysema and the previously reported subcutaneous emphysema were also observed (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). The patient showed progressive clinical improvement with the previously prescribed treatment.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0010" class="elsevierStylePara elsevierViewall">The pathophysiology of spontaneous pneumomediastinum was first described in 1937 by Charles Macklin. It is caused by abrupt increases in airway pressure, which result in the rupture of the alveolar septa and subsequent gas leakage through the peribronchovascular sheaths, producing a characteristic image of peribronchial emphysema (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>C and D) and mediastinal dissection<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a>. Treatment is conservative, with oxygen therapy, rest, and analgesia.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "⋆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Ferreiro A, Granados G, Villar A. Enfisema peribroncovascular. Efecto Macklin. Arch Bronconeumol. 2021;57:697.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1092 "Ancho" => 1267 "Tamanyo" => 170702 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Plain chest X-ray in posteroanterior projection showing pneumomediastinum and subcutaneous emphysema (arrows). (B) Coronal reconstruction of the chest CT scan (lung window) confirming the presence of pneumomediastinum and subcutaneous emphysema (arrows). (C) Axial image of the chest CT (lung window) showing left peribronchial emphysema with pneumomediastinum (arrow) – the Macklin effect. (D) Enlarged image of peribronchial emphysema (arrow).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Frequent cause of the Macklin effect in spontaneous pneumomediastinum: demonstration by multidetector-row computed tomography" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "M. Sakai" 1 => "S. Murayama" 2 => "M. Gibo" 3 => "T. Akamine" 4 => "O. Nagata" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "J Comput Assist Tomogr" "fecha" => "2006" "volumen" => "30" "paginaInicial" => "92" "paginaFinal" => "94" ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Spontaneous pneumomediastinum due to the Macklin effect: less is more" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "G. Chassagnon" 1 => "O. Favelle" 2 => "V. Deroigis" 3 => "J.P. Cottier" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s11739-015-1229-1" "Revista" => array:6 [ "tituloSerie" => "Intern Emerg Med" "fecha" => "2015" "volumen" => "10" "paginaInicial" => "759" "paginaFinal" => "761" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25804499" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005700000011/v1_202111020702/S1579212921002998/v1_202111020702/en/main.assets" "Apartado" => array:4 [ "identificador" => "60604" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Clinical Images" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005700000011/v1_202111020702/S1579212921002998/v1_202111020702/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921002998?idApp=UINPBA00003Z" ]
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