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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Bronchiectasis is a chronic inflammatory condition that causes permanent dilatation of the bronchi and bronchioles by destruction of structural components&#44; resulting in decreased mucociliary clearance and increased airway susceptibility to bacterial colonization and infection&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The diagnosis is traditionally performed using high resolution computed tomography &#40;HRCT&#41; in association with clinical signs and spirometry&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">2&#44;3</span></a> Because spirometry requires great cooperation from subjects&#44; the functional evaluation of patients with bronchiectasis can be complemented with impulse oscillometry &#40;IOS&#41;&#44; which provides compartmentalized information of the central and peripheral airways&#44; during tidal breathing&#44; with good sensitivity to identify changes in respiratory system resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinically&#44; the most frequent characteristic of this disease is an increase in the production of bronchial secretions&#46; The mucus produced is thicker and results in slower transport&#44; causing damage to the mucociliary transport&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">5</span></a> and patients may benefit from specific physiotherapy techniques for the removal of secretions from the respiratory system&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a> as well as overall exercises within pulmonary rehabilitation programs&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The functional exercise capacity of patients with respiratory diseases&#44; such as bronchiectasis&#44; may be reduced by several factors&#44; due to increase in ventilatory demand&#44; which causes an overload to the respiratory muscles&#46; During the exercise&#44; these patients have an increase in the respiratory rate which induces a dynamic hyperinflation&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Because it is difficult to use some measurements during exercise&#44; the literature describes some controlled experimental situations to simulate the increased ventilatory demand that occur during exercises&#44; using voluntary controlled respiratory rate in COPD patients&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">8</span></a> and using voluntary controlled hyperinflation in subjects with restrictive pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">9</span></a> However&#44; no similar studies were found in patients with bronchiectasis&#44; to identify how this exercise respiratory pattern can affect the respiratory system resistance and to propose respiratory control strategies that might enable less exhaustive exercise&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this study&#44; we evaluated the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system&#44; simulating what happens during exercise&#44; in bronchiectasis and healthy subjects&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">In this cross-sectional study&#44; the sample size was calculated based on pilot study by G&#42;Power &#40;3&#46;1&#46;9&#46;2&#41; using the resistance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41;&#44; resulting in 16 volunteers per group&#46; The project was approved by the Human Research Ethics Committee of the Clinical Hospital of the Ribeir&#227;o Preto Medical School&#44; University of S&#227;o Paulo&#44; CAAE 66047717&#46;2&#46;0000&#46;5440&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">There were included volunteers aged 18&#8211;70 years&#44; diagnosed with bronchiectasis not due to cystic fibrosis&#44; recruited at the pulmonology outpatient clinic of the Hospital das Cl&#237;nicas of the Medical School of Ribeir&#227;o Preto&#44; as well as healthy volunteers who were not active or ex-smokers without lung disease&#46; Participants with COPD&#44; asthma&#44; lung cancer&#44; and lobectomy&#44; active or ex-smokers&#44; and individuals with cardiovascular disease or decompensated metabolic&#44; neuromuscular&#44; or musculoskeletal diseases were excluded&#46; All participants have signed the Informed Consent Form&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The medical diagnoses were based on clinical history&#44; HRCT&#44; and spirometry&#46; In the Laboratory of Assessment Respiratory&#44; they were evaluated by sociodemographic and anthropometric data&#44; Bronchiectasis Severity Index &#40;BSI&#41; for assess the severity&#44; ventilometry&#44; spirometry&#44; and impulse oscillometry system &#40;IOS&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Protocol</span><p id="par0050" class="elsevierStylePara elsevierViewall">All the measurements were performed in a seated position&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The IOS were firstly performed using the subject normal breathing pattern&#44; 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Wurzburg&#44; Germany&#41;&#44; according to the ATS&#47;ERS guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">10</span></a> The following variables were analyzed&#58; forced vital capacity &#40;FVC&#41;&#44; forced expiratory volume in one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC and mean forced expiratory flow &#40;FEF25&#8211;75&#37;&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Impulse oscillometry</span><p id="par0095" class="elsevierStylePara elsevierViewall">Impulse oscillometry was performed by using a Jaeger impulse oscillometry system &#40;Jaeger&#44; Wurzburg&#44; Germany&#41; calibrated daily for volume and pressure by using a 3<span class="elsevierStyleHsp" style=""></span>L syringe with a reference resistance of 0&#46;2<span class="elsevierStyleHsp" style=""></span>kPa&#47;L&#47;s&#46; A freeflow mouthpiece was used to minimize the effect of malposition of the tongue&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">11</span></a> The mouthpiece contains a depressor to keep the tongue on the floor of the mouth&#44; stabilize it&#44; and reduce oral resistance&#46; Pressure pulses were applied to the airways 5 times per second for at least 60<span class="elsevierStyleHsp" style=""></span>s while the subject was breathing at the tidal volume level&#46; The pulses were performed to calculate the mean of 3 technically acceptable measurements&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Parameters were calculated by using frequencies between 5 and 35<span class="elsevierStyleHsp" style=""></span>Hz&#44; including the resistance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41; or total respiratory system resistance&#59; resistance at 20<span class="elsevierStyleHsp" style=""></span>Hz &#40;R20&#41; or central resistance&#59; R5&#8211;R20 or peripheral resistance&#59; reactance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;X5&#41;&#44; which reflects the combined effect of tissue elastance and inertance&#59; reactance area &#40;AX&#41;&#44; at which is a useful index related to respiratory compliance and therefore of small airways patency&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">12&#44;13</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Data analysis</span><p id="par0105" class="elsevierStylePara elsevierViewall">For statistical analysis&#44; the model with mixed effects&#44; using the R Core Team software &#40;Vienna&#44; Austria&#44; 2016&#41;&#44; SAS Statistical Software &#40;version 9&#46;3&#44; SAS Institute&#44; Inc&#46; Cary&#44; NC&#41; were used to compare baseline and experimental conditions&#44; with a significance level set at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0110" class="elsevierStylePara elsevierViewall">The anthropometric and evaluation data of the subjects are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; In the BSI score the patients were classified as intermediate&#44; the mean of the group is 5 points&#46; The values obtained for R5 and R5-20 were higher in subjects with bronchiectasis in all experimental conditions &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">In the bronchiectasis group&#44; R5 &#40;kPa&#47;L&#47;s&#41; showed differences between VRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; VR30 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HR30 <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0005&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; and HR30 <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">For R20 &#40;kPa&#47;L&#47;s&#41;&#44; there were differences between HRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#59; HR30 <span class="elsevierStyleItalic">versus</span> VRb &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#44; VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0004&#41;&#59; and HR40 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In R5-R20 &#40;kPa&#47;L&#47;s&#41;&#44; there were differences between VRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; VR30 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HR30 <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; VRb <span class="elsevierStyleItalic">versus</span> HR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0008&#41;&#44; and HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; and HR30 <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">In the healthy group&#44; only R20 &#40;kPa&#47;L&#47;s&#41; showed a difference when compared the HR30 <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;007&#41;&#59; and HR40 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Our results demonstrated that an increased respiratory rate promotes increases in the total&#44; central and peripheral resistances&#44; in subjects with bronchiectasis and an increase in the central resistance in healthy subjects&#46; When they were instructed to perform a voluntary controlled hyperinflation&#44; the high resistance and reactance&#44; induced by the respiratory rate increases was attenuated&#44; close to the baseline values&#44; in the bronchiectasis group&#46; Comparing bronchiectasis to the healthy group&#44; there was an increase in the total and peripheral resistance of the respiratory system in all experimental conditions&#44; which could be explained to the more compromised peripheral airways in the subjects&#8217; with bronchiectasis&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">14</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">People with bronchiectasis experience reduction in both exercise capacity and health-related quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">15</span></a> Reduction in exercise capacity has been associated with structural alterations to lung tissue&#44; progressive airflow obstruction&#44; dyspnea secondary to dynamic hyperinflation&#44; and psychological morbidity&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">15&#8211;17</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">In general&#44; dynamic hyperinflation is associated with a mechanically disadvantageous position for the respiratory muscles&#44; causing increased respiratory work and exercise limitation&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a> Nevertheless&#44; the hyperinflation mechanism&#44; as the increase in the lung volume&#44; promotes a reduction in the airways resistance because the bronchi are supported by the radial traction of surrounding lung tissue&#44; and their caliber increases as the lung expands&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">19</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The use of strategies to reduce respiratory work during exercise is widespread&#44; for example&#44; the pursed-lips breathing&#46; This maneuver maintains positive expiratory pressure on the airways&#44; increasing alveolar pressure and central displacement of the point of equal pressure&#44; avoiding alveolar collapse&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">20</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">However&#44; the effects of pursed-lips breathing during exercise capacity are still controversial&#46; Studies with COPD showed a reduction in dynamic hyperinflation and an increase in SpO2&#44; in the endurance and incremental tests&#44; after the use of a bronchodilator plus pursed-lips breathing&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a> Another study using pursed-lips breathing without bronchodilator&#44; reported a reduction of dynamic hyperinflation in the Glittre test&#44; but not in the six-minute walk test distance&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Physical activities and exercises are recommended for patients with chronic respiratory diseases because they are associated with clinical patient outcomes improvements&#46; Pulmonary rehabilitation programs for people with bronchiectasis&#44; that increases the ventilator demand during aerobic exercises&#44; aims to improve exercise capacity&#44; through effects on aerobic capacity and peripheral muscle&#44; as well as to enhance disease management and improve quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">7</span></a> Programs of pulmonary rehabilitation for stable patients have clinically significant benefits but the improvements in exercise capacity and healthy related quality of life are of a short duration&#46; Further exploration to identify the effects of these interventions on disease severity and optimal approaches to maintain positive outcomes are needed&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Our findings have shown that hyperinflation is not detrimental when we observe it effects on airway resistance&#46; In our protocol&#44; hyperinflation was beneficial even without the use of the bronchodilator&#44; reducing resistance values that were elevated by increased respiratory rate&#46; Based on these results&#44; we hypothesize that&#44; during exercise&#44; individuals with increased resistance values may benefit from voluntary control of respiratory frequency and volume of exhaled air&#44; and that this strategy could contribute to clinical improvements in dyspnea&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The exertional dyspnea for people with respiratory diseases is usually multifactorial in origin&#44; partly reflecting peripheral muscle dysfunction&#44; the consequences of dynamic hyperinflation&#44; increased respiratory load&#44; or defective gas exchange&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">24&#8211;26</span></a> Although dyspnea is not the primary symptom of bronchiectasis&#44; a reduction in dyspnea may partially contribute to the improvement in the exercise capacity and healthy related quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">In this study we had a controlled situation&#44; without other adaptations to exercise&#44; and we need to know if these physiological strategies could contribute to reduce the exercise limitation in bronchiectasis patients&#46; It is important to identify strategies that may improve exercise tolerance&#44; which need to be evaluated during exercise in patients with bronchiectasis&#44; contributing to a reduction of sedentary behavior and an improvement in the quality of life&#46; It is also important to identify whether other patients with increased respiratory system resistance&#44; such as asthma sufferers for example&#44; may also benefit&#44; since there was a decrease in central resistance in subjects with bronchiectasis and in subjects without lung disease&#46; Because the evaluation occurred in a controlled experimental setting&#44; it is necessary to know if these results could be reproduced during exercises for aerobic training&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion&#44; the tachypnea increases the resistance and reactance of the respiratory system in bronchiectasis patients&#44; and the voluntary hyperinflation caused attenuates this increase&#46; These results can guide the development of strategies to reduce the limitation of physical activity in patients with bronchiectasis</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Funding</span><p id="par0185" class="elsevierStylePara elsevierViewall">This work was supported by <span class="elsevierStyleGrantSponsor" id="gs1">S&#227;o Paulo Research Foundation</span> &#40;FAPESP process numbers 2016&#47;20077-6&#41;&#44; and <span class="elsevierStyleGrantSponsor" id="gs2">National Council for Scientific and Technological Development &#40;CNPq&#41;</span>&#46; This study was financed in part by the Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de N&#237;vel Superior &#8211; Brasil &#40;CAPES&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bronchiectasis patients may present a reduced functional capacity due to an increase in the ventilatory demand during exercise&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system&#44; simulating what happens during exercise&#44; in bronchiectasis and healthy subjects&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Bronchiectasis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>30&#41; and healthy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; subjects were evaluated by impulse oscillometry &#40;IOS&#41; during a baseline condition&#44; and in controlled conditions with baseline &#40;b&#41; tidal volume &#40;V&#41; and hyperinflation &#40;H&#41;&#44; with respiratory rates at 30&#40;R30&#41; and 40&#40;R40&#41; bpm&#44; in a random order&#46; The mixed effects and a significance level at 0&#46;05 were used for comparisons&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Resistance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41;&#44; and at minus 20<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#8211;R20&#41;&#44; in kPa&#47;L&#47;s&#44; were higher in subjects with bronchiectasis in all experimental conditions &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; For the bronchiectasis group&#44; R5 and R5-20 increased with R increase at V &#40;VRb <span class="elsevierStyleItalic">versus</span> VR30 and VR40&#59; VR30 <span class="elsevierStyleItalic">versus</span> VR40&#59; R5&#44; R20 and R5-20 increased with R increase at H &#40;HRb <span class="elsevierStyleItalic">versus</span> HR40&#59; HR30 <span class="elsevierStyleItalic">versus</span> HR40&#41;&#46; For the same R&#44; there was a decrease with H compared to V &#40;HRb <span class="elsevierStyleItalic">versus</span> VR30 and VR40&#59; and HR30 <span class="elsevierStyleItalic">versus</span> VR30 and VR40&#41;&#46; For the healthy group&#44; only R20 showed differences &#40;HR30 <span class="elsevierStyleItalic">versus</span> HR40&#59; HR40 <span class="elsevierStyleItalic">versus</span> VR40&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The tachypnea increases the resistance and reactance of the respiratory system in bronchiectasis patients&#44; and the voluntary hyperinflation caused attenuates this increase&#46; These results can guide the development of strategies to reduce the limitation of physical activity in patients with bronchiectasis&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0010"
            "titulo" => "Introduction"
          ]
          1 => array:2 [
            "identificador" => "abst0015"
            "titulo" => "Objective"
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          2 => array:2 [
            "identificador" => "abst0020"
            "titulo" => "Methods"
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          3 => array:2 [
            "identificador" => "abst0025"
            "titulo" => "Results"
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            "identificador" => "abst0030"
            "titulo" => "Conclusion"
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      "es" => array:3 [
        "titulo" => "Resumen"
        "resumen" => "<span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con bronquiectasias pueden presentar una capacidad funcional reducida debido a un aumento en la demanda ventilatoria durante el ejercicio&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar los efectos de la hiperinsuflaci&#243;n voluntaria y controlada y el aumento de la frecuencia respiratoria en la mec&#225;nica del sistema respiratorio&#44; simulando lo que sucede durante el ejercicio&#44; en sujetos sanos y en pacientes con bronquiectasias&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; a sujetos con bronquiectasia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>30&#41; y sujetos sanos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; mediante la oscilometr&#237;a de impulso &#40;IOS&#41; en situaci&#243;n basal&#44; y en condiciones controladas con basal &#40;b&#41;&#44; volumen corriente &#40;V&#41; e hiperinsuflaci&#243;n &#40;H&#41;&#44; con frecuencias respiratorias a 30 &#40;R30&#41; y 40 &#40;R40&#41; bpm&#44; en orden aleatorio&#46; Para las comparaciones se utilizaron el modelo de efectos mixtos y un nivel de significaci&#243;n de 0&#44;05&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La resistencia a 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41; y la diferencia con 20<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5-R20&#41;&#44; medida en kPa&#47;l&#47;s&#44; fue mayor en sujetos con bronquiectasias en todas las condiciones experimentales &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Para el grupo de bronquiectasias&#44; R5 y R5-R20 aumentaron con el aumento de R en V &#40;VRb versus VR30 y VR40&#59; VR30 versus VR40&#59; R5&#44; R20 y R5-R20 aumentaron con el aumento de R en H &#40;HRb versus HR40&#59; HR30 versus HR40&#46; Para el mismo R&#44; hubo una disminuci&#243;n de H en comparaci&#243;n con V &#40;HRb versus VR30 y VR40&#59; y HR30 versus VR30 y VR40&#41;&#46; Para el grupo sano&#44; solo R20 mostr&#243; diferencias &#40;HR30 versus HR40&#59; HR40 versus VR40&#41;&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La taquipnea aumenta la resistencia y la reactancia del sistema respiratorio en pacientes con bronquiectasias&#44; y la hiperinsuflaci&#243;n voluntaria generada aten&#250;a este aumento&#46; Estos resultados pueden guiar el desarrollo de estrategias para reducir la limitaci&#243;n de la actividad f&#237;sica en pacientes con bronquiectasia&#46;</p></span>"
        "secciones" => array:5 [
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            "identificador" => "abst0035"
            "titulo" => "Introducci&#243;n"
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          1 => array:2 [
            "identificador" => "abst0040"
            "titulo" => "Objetivo"
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          2 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "M&#233;todos"
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          3 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Resultados"
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          4 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "Conclusi&#243;n"
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        "etiqueta" => "Fig&#46; 1"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#42; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#59; VR30&#58; TV and RR 30 breaths&#47;min&#59; VR40&#58; TV and RR 40<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#59; HRb&#58; hyperinflation &#40;H&#41; with RR b&#59; &#40;HR30&#41;&#58; H with RR 30<span class="elsevierStyleHsp" style=""></span>breaths&#47;min and HRR40&#58; H with RR 40<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46;</p>"
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        "tipo" => "MULTIMEDIATABLA"
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Data expressed as mean and standard deviation&#59; BMI&#58; body mass index&#59; M&#58; man&#59; F&#58; female&#58; RR&#58; respiratory rate&#59; MV&#58; minute volume&#59; TV&#58; tidal volume&#59; VC&#58; vital capacity&#59; VER&#58; volume of expiratory reserve&#59; IC&#58; inspiratory capacity&#59; FVC&#58; forced vital capacity&#59; FEV<span class="elsevierStyleInf">1</span>&#58; forced expiratory volume in first second&#59; FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#58; ratio of forced expiratory volume in first second to forced vital capacity&#59; EFF<span class="elsevierStyleInf">25&#8211;75&#37;</span>&#58; expiratory mean forced flux&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bronchiectasis&#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>30&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-head\n
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                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;31&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">40&#46;19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">15&#47;15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">BMI &#40;kg&#47;m<span class="elsevierStyleSup">2</span>&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">24&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">26&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;70&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">RR &#40;rpm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">MV &#40;L&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">11&#46;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;66&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">VC predict &#40;mL&#47;kg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">0&#46;69<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">VC obtained &#40;mL&#47;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">2&#46;34<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;97&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">VER &#40;mL&#47;kg&#41;&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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          "leyenda" => "<p id="spar0075" class="elsevierStyleSimplePara elsevierViewall">Data presented in mean<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>standard derivation&#46;</p><p id="spar0080" class="elsevierStyleSimplePara elsevierViewall">R5&#58; resistance to 5<span class="elsevierStyleHsp" style=""></span>Hz&#59; R20&#58; resistance to 20<span class="elsevierStyleHsp" style=""></span>Hz&#59; R5-R20&#58; peripheral resistance&#46;</p><p id="spar0085" class="elsevierStyleSimplePara elsevierViewall">VRb&#58; tidal volume and basal frequency&#59; VR30&#58; tidal volume and respiratory rate of 30 breaths&#47;min&#59; VR40&#58; tidal volume and respiratory rate of 40<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#59; HRb&#58; hyperinflated and respiratory rate basal&#59; HR30&#58; Hyperinflated and respiratory rate of 30<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#59; HR40&#58; Hyperinflated and respiratory rate of 40<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46;</p>"
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                  \t\t\t\t">0&#46;41<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;10&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HRb&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HR30&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;0009&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HR40&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleItalic">R20 &#40;kPa&#47;L&#47;s&#41;</span></td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VRb&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VR30&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>VR40&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;33<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span> 0&#46;06&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HRb&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;08&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t"><span class="elsevierStyleHsp" style=""></span>HR30&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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Original Article
Effects of Controlled Voluntary Increase in the Ventilatory Demand on Respiratory System Resistance in Healthy and Non-Cystic Fibrosis Bronchiectasis Subjects: A Cross-Sectional Study
Efectos del aumento voluntario y controlado de la demanda ventilatoria en la resistencia del sistema respiratorio en sujetos sanos y en pacientes con bronquiectasias no debidas a fibrosis quística: un estudio transversal
Ricardo Grassi Morolia, Daniele Oliveira dos Santosa, Hugo Celso Dutra de Souzaa, Larissa Perossia, Maytê Assunção Ribeiroa, Jéssica Perossia, José Antônio Baddini-Martinezb, Ada Clarice Gastaldia,
Corresponding author
ada@fmrp.usp.br

Corresponding author.
a Department of Health Sciences, Graduate Program in Functional Performance, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil
b Department of Clinical Medicine, Ribeirão Preto Medical School, Ribeirão Preto, São Paulo, Brazil
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    "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">Bronchiectasis is a chronic inflammatory condition that causes permanent dilatation of the bronchi and bronchioles by destruction of structural components&#44; resulting in decreased mucociliary clearance and increased airway susceptibility to bacterial colonization and infection&#46;<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The diagnosis is traditionally performed using high resolution computed tomography &#40;HRCT&#41; in association with clinical signs and spirometry&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">2&#44;3</span></a> Because spirometry requires great cooperation from subjects&#44; the functional evaluation of patients with bronchiectasis can be complemented with impulse oscillometry &#40;IOS&#41;&#44; which provides compartmentalized information of the central and peripheral airways&#44; during tidal breathing&#44; with good sensitivity to identify changes in respiratory system resistance&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">4</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">Clinically&#44; the most frequent characteristic of this disease is an increase in the production of bronchial secretions&#46; The mucus produced is thicker and results in slower transport&#44; causing damage to the mucociliary transport&#44;<a class="elsevierStyleCrossRef" href="#bib0155"><span class="elsevierStyleSup">5</span></a> and patients may benefit from specific physiotherapy techniques for the removal of secretions from the respiratory system&#44;<a class="elsevierStyleCrossRef" href="#bib0160"><span class="elsevierStyleSup">6</span></a> as well as overall exercises within pulmonary rehabilitation programs&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">7</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">The functional exercise capacity of patients with respiratory diseases&#44; such as bronchiectasis&#44; may be reduced by several factors&#44; due to increase in ventilatory demand&#44; which causes an overload to the respiratory muscles&#46; During the exercise&#44; these patients have an increase in the respiratory rate which induces a dynamic hyperinflation&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">Because it is difficult to use some measurements during exercise&#44; the literature describes some controlled experimental situations to simulate the increased ventilatory demand that occur during exercises&#44; using voluntary controlled respiratory rate in COPD patients&#44;<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">8</span></a> and using voluntary controlled hyperinflation in subjects with restrictive pattern&#46;<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">9</span></a> However&#44; no similar studies were found in patients with bronchiectasis&#44; to identify how this exercise respiratory pattern can affect the respiratory system resistance and to propose respiratory control strategies that might enable less exhaustive exercise&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">In this study&#44; we evaluated the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system&#44; simulating what happens during exercise&#44; in bronchiectasis and healthy subjects&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Methods</span><p id="par0035" class="elsevierStylePara elsevierViewall">In this cross-sectional study&#44; the sample size was calculated based on pilot study by G&#42;Power &#40;3&#46;1&#46;9&#46;2&#41; using the resistance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41;&#44; resulting in 16 volunteers per group&#46; The project was approved by the Human Research Ethics Committee of the Clinical Hospital of the Ribeir&#227;o Preto Medical School&#44; University of S&#227;o Paulo&#44; CAAE 66047717&#46;2&#46;0000&#46;5440&#46;</p><p id="par0040" class="elsevierStylePara elsevierViewall">There were included volunteers aged 18&#8211;70 years&#44; diagnosed with bronchiectasis not due to cystic fibrosis&#44; recruited at the pulmonology outpatient clinic of the Hospital das Cl&#237;nicas of the Medical School of Ribeir&#227;o Preto&#44; as well as healthy volunteers who were not active or ex-smokers without lung disease&#46; Participants with COPD&#44; asthma&#44; lung cancer&#44; and lobectomy&#44; active or ex-smokers&#44; and individuals with cardiovascular disease or decompensated metabolic&#44; neuromuscular&#44; or musculoskeletal diseases were excluded&#46; All participants have signed the Informed Consent Form&#46;</p><p id="par0045" class="elsevierStylePara elsevierViewall">The medical diagnoses were based on clinical history&#44; HRCT&#44; and spirometry&#46; In the Laboratory of Assessment Respiratory&#44; they were evaluated by sociodemographic and anthropometric data&#44; Bronchiectasis Severity Index &#40;BSI&#41; for assess the severity&#44; ventilometry&#44; spirometry&#44; and impulse oscillometry system &#40;IOS&#41;&#46;</p><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Protocol</span><p id="par0050" class="elsevierStylePara elsevierViewall">All the measurements were performed in a seated position&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">The IOS were firstly performed using the subject normal breathing pattern&#44; called baseline tidal volume and respiratory rate &#40;VRb&#41;&#46; After this&#44; they were instructed to perform the following conditions&#44; in a random order&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">-</span><p id="par0060" class="elsevierStylePara elsevierViewall">Tidal volume and respiratory rate at 30<span class="elsevierStyleHsp" style=""></span>bpm &#40;VR30&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">-</span><p id="par0065" class="elsevierStylePara elsevierViewall">Tidal volume and respiratory rate at 40<span class="elsevierStyleHsp" style=""></span>bpm &#40;VR40&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">-</span><p id="par0070" class="elsevierStylePara elsevierViewall">In hyperinflation &#40;at 50&#37; of the inspiratory capacity&#41; and baseline respiratory rate &#40;HRb&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">-</span><p id="par0075" class="elsevierStylePara elsevierViewall">In hyperinflation &#40;at 50&#37; of the inspiratory capacity&#41; and respiratory rate at 30<span class="elsevierStyleHsp" style=""></span>bpm &#40;HR30&#41;&#59;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">-</span><p id="par0080" class="elsevierStylePara elsevierViewall">In hyperinflation &#40;at 50&#37; of the inspiratory capacity&#41; and respiratory rate at 40<span class="elsevierStyleHsp" style=""></span>bpm &#40;HR40&#41;&#46;</p></li></ul></p><p id="par0085" class="elsevierStylePara elsevierViewall">The hyperinflation was controlled using a ventilometer &#40;FERRARIS Wrigth Mark&#41; and to control the respiratory rate the volunteers were instructed to follow the sound of a metronome &#40;Metr&#244;nomo n-Track &#40;vers&#227;o 1&#46;2&#46;1&#46; &#169; n-Track Software&#41;&#46;</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0095">Spirometry</span><p id="par0090" class="elsevierStylePara elsevierViewall">All patients underwent spirometry to detect respiratory changes using the Jaeger MasterScreen spirometer &#40;Jaeger Co&#44; Wurzburg&#44; Germany&#41;&#44; according to the ATS&#47;ERS guidelines&#46;<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">10</span></a> The following variables were analyzed&#58; forced vital capacity &#40;FVC&#41;&#44; forced expiratory volume in one second &#40;FEV<span class="elsevierStyleInf">1</span>&#41;&#44; FEV<span class="elsevierStyleInf">1</span>&#47;FVC and mean forced expiratory flow &#40;FEF25&#8211;75&#37;&#41;&#46;</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0100">Impulse oscillometry</span><p id="par0095" class="elsevierStylePara elsevierViewall">Impulse oscillometry was performed by using a Jaeger impulse oscillometry system &#40;Jaeger&#44; Wurzburg&#44; Germany&#41; calibrated daily for volume and pressure by using a 3<span class="elsevierStyleHsp" style=""></span>L syringe with a reference resistance of 0&#46;2<span class="elsevierStyleHsp" style=""></span>kPa&#47;L&#47;s&#46; A freeflow mouthpiece was used to minimize the effect of malposition of the tongue&#46;<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">11</span></a> The mouthpiece contains a depressor to keep the tongue on the floor of the mouth&#44; stabilize it&#44; and reduce oral resistance&#46; Pressure pulses were applied to the airways 5 times per second for at least 60<span class="elsevierStyleHsp" style=""></span>s while the subject was breathing at the tidal volume level&#46; The pulses were performed to calculate the mean of 3 technically acceptable measurements&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Parameters were calculated by using frequencies between 5 and 35<span class="elsevierStyleHsp" style=""></span>Hz&#44; including the resistance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41; or total respiratory system resistance&#59; resistance at 20<span class="elsevierStyleHsp" style=""></span>Hz &#40;R20&#41; or central resistance&#59; R5&#8211;R20 or peripheral resistance&#59; reactance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;X5&#41;&#44; which reflects the combined effect of tissue elastance and inertance&#59; reactance area &#40;AX&#41;&#44; at which is a useful index related to respiratory compliance and therefore of small airways patency&#46;<a class="elsevierStyleCrossRefs" href="#bib0190"><span class="elsevierStyleSup">12&#44;13</span></a></p></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0105">Data analysis</span><p id="par0105" class="elsevierStylePara elsevierViewall">For statistical analysis&#44; the model with mixed effects&#44; using the R Core Team software &#40;Vienna&#44; Austria&#44; 2016&#41;&#44; SAS Statistical Software &#40;version 9&#46;3&#44; SAS Institute&#44; Inc&#46; Cary&#44; NC&#41; were used to compare baseline and experimental conditions&#44; with a significance level set at <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#46;</p></span></span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0110">Results</span><p id="par0110" class="elsevierStylePara elsevierViewall">The anthropometric and evaluation data of the subjects are described in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46; In the BSI score the patients were classified as intermediate&#44; the mean of the group is 5 points&#46; The values obtained for R5 and R5-20 were higher in subjects with bronchiectasis in all experimental conditions &#40;<a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><elsevierMultimedia ident="tbl0010"></elsevierMultimedia><p id="par0115" class="elsevierStylePara elsevierViewall">In the bronchiectasis group&#44; R5 &#40;kPa&#47;L&#47;s&#41; showed differences between VRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; VR30 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HR30 <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0005&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; and HR30 <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#46;</p><p id="par0120" class="elsevierStylePara elsevierViewall">For R20 &#40;kPa&#47;L&#47;s&#41;&#44; there were differences between HRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;01&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;001&#41;&#59; HR30 <span class="elsevierStyleItalic">versus</span> VRb &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#41;&#44; VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0004&#41;&#59; and HR40 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;009&#41;&#46;</p><p id="par0125" class="elsevierStylePara elsevierViewall">In R5-R20 &#40;kPa&#47;L&#47;s&#41;&#44; there were differences between VRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; VR30 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HR30 <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; VRb <span class="elsevierStyleItalic">versus</span> HR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0008&#41;&#44; and HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; HRb <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41;&#59; and HR30 <span class="elsevierStyleItalic">versus</span> VR30 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;005&#41;&#44; and VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;0001&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0130" class="elsevierStylePara elsevierViewall">In the healthy group&#44; only R20 &#40;kPa&#47;L&#47;s&#41; showed a difference when compared the HR30 <span class="elsevierStyleItalic">versus</span> HR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;007&#41;&#59; and HR40 <span class="elsevierStyleItalic">versus</span> VR40 &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;004&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#44; <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a>&#41;&#46;</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0115">Discussion</span><p id="par0135" class="elsevierStylePara elsevierViewall">Our results demonstrated that an increased respiratory rate promotes increases in the total&#44; central and peripheral resistances&#44; in subjects with bronchiectasis and an increase in the central resistance in healthy subjects&#46; When they were instructed to perform a voluntary controlled hyperinflation&#44; the high resistance and reactance&#44; induced by the respiratory rate increases was attenuated&#44; close to the baseline values&#44; in the bronchiectasis group&#46; Comparing bronchiectasis to the healthy group&#44; there was an increase in the total and peripheral resistance of the respiratory system in all experimental conditions&#44; which could be explained to the more compromised peripheral airways in the subjects&#8217; with bronchiectasis&#46;<a class="elsevierStyleCrossRef" href="#bib0200"><span class="elsevierStyleSup">14</span></a></p><p id="par0140" class="elsevierStylePara elsevierViewall">People with bronchiectasis experience reduction in both exercise capacity and health-related quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">15</span></a> Reduction in exercise capacity has been associated with structural alterations to lung tissue&#44; progressive airflow obstruction&#44; dyspnea secondary to dynamic hyperinflation&#44; and psychological morbidity&#46;<a class="elsevierStyleCrossRefs" href="#bib0205"><span class="elsevierStyleSup">15&#8211;17</span></a></p><p id="par0145" class="elsevierStylePara elsevierViewall">In general&#44; dynamic hyperinflation is associated with a mechanically disadvantageous position for the respiratory muscles&#44; causing increased respiratory work and exercise limitation&#46;<a class="elsevierStyleCrossRef" href="#bib0220"><span class="elsevierStyleSup">18</span></a> Nevertheless&#44; the hyperinflation mechanism&#44; as the increase in the lung volume&#44; promotes a reduction in the airways resistance because the bronchi are supported by the radial traction of surrounding lung tissue&#44; and their caliber increases as the lung expands&#46;<a class="elsevierStyleCrossRef" href="#bib0225"><span class="elsevierStyleSup">19</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">The use of strategies to reduce respiratory work during exercise is widespread&#44; for example&#44; the pursed-lips breathing&#46; This maneuver maintains positive expiratory pressure on the airways&#44; increasing alveolar pressure and central displacement of the point of equal pressure&#44; avoiding alveolar collapse&#46;<a class="elsevierStyleCrossRef" href="#bib0230"><span class="elsevierStyleSup">20</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">However&#44; the effects of pursed-lips breathing during exercise capacity are still controversial&#46; Studies with COPD showed a reduction in dynamic hyperinflation and an increase in SpO2&#44; in the endurance and incremental tests&#44; after the use of a bronchodilator plus pursed-lips breathing&#46;<a class="elsevierStyleCrossRef" href="#bib0235"><span class="elsevierStyleSup">21</span></a> Another study using pursed-lips breathing without bronchodilator&#44; reported a reduction of dynamic hyperinflation in the Glittre test&#44; but not in the six-minute walk test distance&#46;<a class="elsevierStyleCrossRef" href="#bib0240"><span class="elsevierStyleSup">22</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">Physical activities and exercises are recommended for patients with chronic respiratory diseases because they are associated with clinical patient outcomes improvements&#46; Pulmonary rehabilitation programs for people with bronchiectasis&#44; that increases the ventilator demand during aerobic exercises&#44; aims to improve exercise capacity&#44; through effects on aerobic capacity and peripheral muscle&#44; as well as to enhance disease management and improve quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">7</span></a> Programs of pulmonary rehabilitation for stable patients have clinically significant benefits but the improvements in exercise capacity and healthy related quality of life are of a short duration&#46; Further exploration to identify the effects of these interventions on disease severity and optimal approaches to maintain positive outcomes are needed&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a></p><p id="par0165" class="elsevierStylePara elsevierViewall">Our findings have shown that hyperinflation is not detrimental when we observe it effects on airway resistance&#46; In our protocol&#44; hyperinflation was beneficial even without the use of the bronchodilator&#44; reducing resistance values that were elevated by increased respiratory rate&#46; Based on these results&#44; we hypothesize that&#44; during exercise&#44; individuals with increased resistance values may benefit from voluntary control of respiratory frequency and volume of exhaled air&#44; and that this strategy could contribute to clinical improvements in dyspnea&#46;</p><p id="par0170" class="elsevierStylePara elsevierViewall">The exertional dyspnea for people with respiratory diseases is usually multifactorial in origin&#44; partly reflecting peripheral muscle dysfunction&#44; the consequences of dynamic hyperinflation&#44; increased respiratory load&#44; or defective gas exchange&#46;<a class="elsevierStyleCrossRefs" href="#bib0250"><span class="elsevierStyleSup">24&#8211;26</span></a> Although dyspnea is not the primary symptom of bronchiectasis&#44; a reduction in dyspnea may partially contribute to the improvement in the exercise capacity and healthy related quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0245"><span class="elsevierStyleSup">23</span></a></p><p id="par0175" class="elsevierStylePara elsevierViewall">In this study we had a controlled situation&#44; without other adaptations to exercise&#44; and we need to know if these physiological strategies could contribute to reduce the exercise limitation in bronchiectasis patients&#46; It is important to identify strategies that may improve exercise tolerance&#44; which need to be evaluated during exercise in patients with bronchiectasis&#44; contributing to a reduction of sedentary behavior and an improvement in the quality of life&#46; It is also important to identify whether other patients with increased respiratory system resistance&#44; such as asthma sufferers for example&#44; may also benefit&#44; since there was a decrease in central resistance in subjects with bronchiectasis and in subjects without lung disease&#46; Because the evaluation occurred in a controlled experimental setting&#44; it is necessary to know if these results could be reproduced during exercises for aerobic training&#46;</p><p id="par0180" class="elsevierStylePara elsevierViewall">In conclusion&#44; the tachypnea increases the resistance and reactance of the respiratory system in bronchiectasis patients&#44; and the voluntary hyperinflation caused attenuates this increase&#46; These results can guide the development of strategies to reduce the limitation of physical activity in patients with bronchiectasis</p></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0120">Funding</span><p id="par0185" class="elsevierStylePara elsevierViewall">This work was supported by <span class="elsevierStyleGrantSponsor" id="gs1">S&#227;o Paulo Research Foundation</span> &#40;FAPESP process numbers 2016&#47;20077-6&#41;&#44; and <span class="elsevierStyleGrantSponsor" id="gs2">National Council for Scientific and Technological Development &#40;CNPq&#41;</span>&#46; This study was financed in part by the Coordena&#231;&#227;o de Aperfei&#231;oamento de Pessoal de N&#237;vel Superior &#8211; Brasil &#40;CAPES&#41;&#46;</p></span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0125">Conflicts of interest</span><p id="par0190" class="elsevierStylePara elsevierViewall">The authors declare no conflicts of interest&#46;</p></span></span>"
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        "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0015">Introduction</span><p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Bronchiectasis patients may present a reduced functional capacity due to an increase in the ventilatory demand during exercise&#46;</p></span> <span id="abst0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0020">Objective</span><p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">To evaluate the effects of controlled voluntary hyperinflation and increased respiratory rate on the mechanics of the respiratory system&#44; simulating what happens during exercise&#44; in bronchiectasis and healthy subjects&#46;</p></span> <span id="abst0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Methods</span><p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">Bronchiectasis &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>30&#41; and healthy &#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; subjects were evaluated by impulse oscillometry &#40;IOS&#41; during a baseline condition&#44; and in controlled conditions with baseline &#40;b&#41; tidal volume &#40;V&#41; and hyperinflation &#40;H&#41;&#44; with respiratory rates at 30&#40;R30&#41; and 40&#40;R40&#41; bpm&#44; in a random order&#46; The mixed effects and a significance level at 0&#46;05 were used for comparisons&#46;</p></span> <span id="abst0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Results</span><p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Resistance at 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41;&#44; and at minus 20<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#8211;R20&#41;&#44; in kPa&#47;L&#47;s&#44; were higher in subjects with bronchiectasis in all experimental conditions &#40;<span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;05&#41;&#46; For the bronchiectasis group&#44; R5 and R5-20 increased with R increase at V &#40;VRb <span class="elsevierStyleItalic">versus</span> VR30 and VR40&#59; VR30 <span class="elsevierStyleItalic">versus</span> VR40&#59; R5&#44; R20 and R5-20 increased with R increase at H &#40;HRb <span class="elsevierStyleItalic">versus</span> HR40&#59; HR30 <span class="elsevierStyleItalic">versus</span> HR40&#41;&#46; For the same R&#44; there was a decrease with H compared to V &#40;HRb <span class="elsevierStyleItalic">versus</span> VR30 and VR40&#59; and HR30 <span class="elsevierStyleItalic">versus</span> VR30 and VR40&#41;&#46; For the healthy group&#44; only R20 showed differences &#40;HR30 <span class="elsevierStyleItalic">versus</span> HR40&#59; HR40 <span class="elsevierStyleItalic">versus</span> VR40&#41;&#46;</p></span> <span id="abst0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">Conclusion</span><p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">The tachypnea increases the resistance and reactance of the respiratory system in bronchiectasis patients&#44; and the voluntary hyperinflation caused attenuates this increase&#46; These results can guide the development of strategies to reduce the limitation of physical activity in patients with bronchiectasis&#46;</p></span>"
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        "resumen" => "<span id="abst0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Introducci&#243;n</span><p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Los pacientes con bronquiectasias pueden presentar una capacidad funcional reducida debido a un aumento en la demanda ventilatoria durante el ejercicio&#46;</p></span> <span id="abst0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Objetivo</span><p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">Evaluar los efectos de la hiperinsuflaci&#243;n voluntaria y controlada y el aumento de la frecuencia respiratoria en la mec&#225;nica del sistema respiratorio&#44; simulando lo que sucede durante el ejercicio&#44; en sujetos sanos y en pacientes con bronquiectasias&#46;</p></span> <span id="abst0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">M&#233;todos</span><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">Se evalu&#243; a sujetos con bronquiectasia &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>30&#41; y sujetos sanos &#40;n<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>16&#41; mediante la oscilometr&#237;a de impulso &#40;IOS&#41; en situaci&#243;n basal&#44; y en condiciones controladas con basal &#40;b&#41;&#44; volumen corriente &#40;V&#41; e hiperinsuflaci&#243;n &#40;H&#41;&#44; con frecuencias respiratorias a 30 &#40;R30&#41; y 40 &#40;R40&#41; bpm&#44; en orden aleatorio&#46; Para las comparaciones se utilizaron el modelo de efectos mixtos y un nivel de significaci&#243;n de 0&#44;05&#46;</p></span> <span id="abst0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Resultados</span><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">La resistencia a 5<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5&#41; y la diferencia con 20<span class="elsevierStyleHsp" style=""></span>Hz &#40;R5-R20&#41;&#44; medida en kPa&#47;l&#47;s&#44; fue mayor en sujetos con bronquiectasias en todas las condiciones experimentales &#40;p<span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#44;05&#41;&#46; Para el grupo de bronquiectasias&#44; R5 y R5-R20 aumentaron con el aumento de R en V &#40;VRb versus VR30 y VR40&#59; VR30 versus VR40&#59; R5&#44; R20 y R5-R20 aumentaron con el aumento de R en H &#40;HRb versus HR40&#59; HR30 versus HR40&#46; Para el mismo R&#44; hubo una disminuci&#243;n de H en comparaci&#243;n con V &#40;HRb versus VR30 y VR40&#59; y HR30 versus VR30 y VR40&#41;&#46; Para el grupo sano&#44; solo R20 mostr&#243; diferencias &#40;HR30 versus HR40&#59; HR40 versus VR40&#41;&#46;</p></span> <span id="abst0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Conclusi&#243;n</span><p id="spar0050" class="elsevierStyleSimplePara elsevierViewall">La taquipnea aumenta la resistencia y la reactancia del sistema respiratorio en pacientes con bronquiectasias&#44; y la hiperinsuflaci&#243;n voluntaria generada aten&#250;a este aumento&#46; Estos resultados pueden guiar el desarrollo de estrategias para reducir la limitaci&#243;n de la actividad f&#237;sica en pacientes con bronquiectasia&#46;</p></span>"
        "secciones" => array:5 [
          0 => array:2 [
            "identificador" => "abst0035"
            "titulo" => "Introducci&#243;n"
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          1 => array:2 [
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            "titulo" => "Objetivo"
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          2 => array:2 [
            "identificador" => "abst0045"
            "titulo" => "M&#233;todos"
          ]
          3 => array:2 [
            "identificador" => "abst0050"
            "titulo" => "Resultados"
          ]
          4 => array:2 [
            "identificador" => "abst0055"
            "titulo" => "Conclusi&#243;n"
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      0 => array:7 [
        "identificador" => "fig0005"
        "etiqueta" => "Fig&#46; 1"
        "tipo" => "MULTIMEDIAFIGURA"
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          "en" => "<p id="spar0055" class="elsevierStyleSimplePara elsevierViewall">&#42; <span class="elsevierStyleItalic">p</span><span class="elsevierStyleHsp" style=""></span>&#60;<span class="elsevierStyleHsp" style=""></span>0&#46;02&#59; VR30&#58; TV and RR 30 breaths&#47;min&#59; VR40&#58; TV and RR 40<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#59; HRb&#58; hyperinflation &#40;H&#41; with RR b&#59; &#40;HR30&#41;&#58; H with RR 30<span class="elsevierStyleHsp" style=""></span>breaths&#47;min and HRR40&#58; H with RR 40<span class="elsevierStyleHsp" style=""></span>breaths&#47;min&#46;</p>"
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      1 => array:8 [
        "identificador" => "tbl0005"
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        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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        "detalles" => array:1 [
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          "leyenda" => "<p id="spar0065" class="elsevierStyleSimplePara elsevierViewall">Data expressed as mean and standard deviation&#59; BMI&#58; body mass index&#59; M&#58; man&#59; F&#58; female&#58; RR&#58; respiratory rate&#59; MV&#58; minute volume&#59; TV&#58; tidal volume&#59; VC&#58; vital capacity&#59; VER&#58; volume of expiratory reserve&#59; IC&#58; inspiratory capacity&#59; FVC&#58; forced vital capacity&#59; FEV<span class="elsevierStyleInf">1</span>&#58; forced expiratory volume in first second&#59; FEV<span class="elsevierStyleInf">1</span>&#47;FVC&#58; ratio of forced expiratory volume in first second to forced vital capacity&#59; EFF<span class="elsevierStyleInf">25&#8211;75&#37;</span>&#58; expiratory mean forced flux&#46;</p>"
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                  \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Bronchiectasis&#40;<span class="elsevierStyleItalic">n</span><span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>30&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">Age &#40;years&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">49&#46;47<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;31&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">40&#46;19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>15&#46;74&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">Gender &#40;M&#47;F&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">15&#47;15&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">6&#47;10&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">&#8211;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">24&#46;65<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t">26&#46;24<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;70&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;13&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">RR &#40;rpm&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">17<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>3&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>4&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;29&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">MV &#40;L&#47;min&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">11&#46;32<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;91&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">10&#46;97<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>2&#46;48&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;66&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">VC predict &#40;mL&#47;kg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t">0&#46;69<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;19&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">0&#46;74<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;25&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;49&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">VC obtained &#40;mL&#47;kg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t\ttable-entry\n
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                  \t\t\t\t  " align="left" valign="\n
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                  \t\t\t\t">3&#46;28<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;92&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
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                  \t\t\t\t">0&#46;002&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">1&#46;16<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;78&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;61<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;53&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;02&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">IC &#40;mL&#47;kg&#41;&nbsp;\t\t\t\t\t\t\n
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                  \t\t\t\t  " align="left" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">1&#46;19<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;76&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
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                  \t\t\t\t">1&#46;67<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;73&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t  " align="char" valign="\n
                  \t\t\t\t\ttop\n
                  \t\t\t\t">0&#46;04&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n
                  \t\t\t\t\ttable-entry\n
                  \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n
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                  \t\t\t\t">4&#46;09<span class="elsevierStyleHsp" style=""></span>&#177;<span class="elsevierStyleHsp" style=""></span>0&#46;74&nbsp;\t\t\t\t\t\t\n
                  \t\t\t\t</td><td class="td" title="\n
                  \t\t\t\t\ttable-entry\n
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        "texto" => "<p id="par0195" class="elsevierStylePara elsevierViewall">The authors wish to thank the S&#227;o Paulo Research Foundation for their financial support and Laboratory of Assessment Respiratory for equipment available for this study&#46;</p>"
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ISSN: 15792129
Original language: English
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