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depending on whether the vascular component is supplied from the pulmonary arteries &#40;&#60;6&#8239;s&#41; or from the bronchial arteries &#40;&#62;6&#8239;s&#41;&#46; Similarly&#44; the pattern and extent of enhancement as well as the washout time &#40;greater than 60&#8239;s&#41; in a consolidated focus or lung lesion helps differentiate between lung collapse&#44; infectious process&#47;abscess&#44; infarction&#44; and tumor&#46; In general&#44; tumors receive arterial vascular supply from the bronchial arteries&#44; as the pulmonary arteries are incapable of neoangiogenesis&#46; The delay in uptake by malignant lesions is explained by intrinsic vasoconstrictions&#44; given the intrinsic hypoxic status of the neoproliferative lesion&#46; Benign lesions&#44; in contrast&#44; receive blood from both the pulmonary and bronchial arteries&#44; and therefore show early enhancement<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Thus&#44; in the case of passive atelectasis&#44; B-mode shows a homogeneous consolidation containing hyperechoic air bronchogram and early arterial enhancement that persists throughout the examination and may remain for longer than 5&#8239;min<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; The findings for areas of pulmonary infarction will be similar to those of atelectasis in B-mode and we can identify hypoechoic nodules within the area of collapse&#46; After the administration of contrast agent&#44; we will see an absence of enhancement in the infarcted areas<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; Pulmonary abscesses show delayed enhancement &#40;&#62;6&#8239;s&#41; with hypoechoic and hypodense central areas corresponding to necrosis&#44; which may appear in preexisting tumors<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Pneumonia and metastatic lesions and malignant lesions are a diagnostic challenge&#44; especially in cases where both entities coexist&#46; Pneumonias in general show early &#40;&#60;6&#8239;s&#41; homogeneous arterial enhancement&#46; However&#44; in some cases both pathologies show delayed enhancement &#40;&#62;6&#8239;s&#41;&#46; They differ in that in pneumonia&#44; homogeneous enhancement is maintained in late phases with late washout &#40;&#62;60&#8239;s&#41;&#44; while metastatic lesions will show faster washout &#40;&#60;60&#8239;s&#41; of the lesion than the surrounding parenchyma<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We report the case of a 79-year-old woman with a history of papillary thyroid carcinoma who attended the emergency room for dyspnea that had worsened progressively until it appeared with minimal exertion&#46; Chest X-ray revealed multiple foci of consolidation&#46; A computed tomography &#40;CT&#41; scan was performed that ruled out pulmonary thromboembolism but revealed heterogeneous consolidations in both lower lobes along with areas suggestive of infectious bronchiolitis and some solid nodules &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; A positive test was obtained for tumor markers &#40;CA 19-9 and CYFRA 21-1&#41; and&#44; in view of a suspected malignant origin&#44; a positron emission tomography &#40;PET&#47;CT&#41; with fluorodeoxyglucose was performed&#44; which showed probable pancreatic cancer and possible metastatic consolidations in the lungs&#46; Since the largest consolidation&#44; located in the lower right lobe&#44; was in extensive contact with the peripheral pleura&#44; we decided to perform ultrasound-guided biopsy&#46; We administered 2&#46;4&#8239;mL of ultrasound contrast agent &#40;SonoVue&#44; Rovi&#44; Pozuelo de Alarc&#243;n&#44; Madrid&#44; Spain&#41; and two distinct areas were observed&#44; differentiated by their uptake pattern&#58; a peripheral area with delayed enhancement &#40;&#62;6&#8239;s post-injection&#41; and early washout &#40;disappearance of contrast uptake within a few seconds of uptake&#41;&#44; while the remaining consolidation showed early homogeneous enhancement &#40;&#60;6&#8239;s&#41; and delayed washout &#40;&#62;1&#8239;min&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#8211;F&#41;&#46; In view of these findings&#44; we decided to biopsy the first of these areas with a 22&#8239;G fine needle&#59; it was reported as alveolar metastasis of pancreatic adenocarcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>G&#41;&#46; Because the rest of the consolidation showed suggestive characteristics of a pneumonia process&#44; we decided to perform fiberoptic bronchoscopy&#59; samples obtained showed a fungal infection &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>H&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient we were able to differentiate between pneumonia and metastasis&#44; as she presented pre-existing pulmonary consolidation containing a hypoechoic area&#46; On contrast-enhanced ultrasound&#44; the consolidation showed late homogeneous uptake with delayed washout&#44; with the exception of the central and peripheral areas that showed late enhancement but early washout&#44; suggestive of malignancy&#46; This enhancement pattern also helped guide the percutaneous biopsy to the most suspicious target area to improve the diagnostic yield of the samples collected&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Ultrasound-guided biopsy is an alternative to CT-guided biopsy for peripheral or pleural lung lesions<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> and achieves a similar diagnostic effectiveness and yield as CT<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Additionally&#44; ultrasound-guided percutaneous procedures offer certain advantages&#44; such as real-time monitoring of the procedure&#44; absence of radiation&#44; lower costs and duration of the procedure&#44; and the complication rates are similar to or lower than with CT-guided biopsy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; In many cases&#44; contrast-enhanced chest ultrasound helps clarify the nature of the lesion under study and&#44; if necessary&#44; guides the biopsy needle towards areas of interest&#44; avoiding necrotic foci<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> and targeting areas with a greater suspicion of malignancy&#44; as in the case presented&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Isus Oliv&#233; G&#44; P&#225;ez Carpio A&#44; Mart&#237;nez D&#44; Vollmer I&#46; Papel de la ecograf&#237;a con contraste en la diferenciaci&#243;n entre una neumon&#237;a y una neoplasia en el seno de una consolidaci&#243;n pulmonar&#46; Arch Bronconeumol&#46; 2021&#59;57&#58;605&#8211;607&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; CT after intravenous iodinated contrast agent&#46; Axial slices are shown in the mediastinum window &#40;left&#41; and pulmonary parenchyma window &#40;right&#41; where heterogeneous consolidation is observed in the right lower lobe with hypodense areas &#40;circle&#41; and areas of ground glass and tree-in-bud pattern &#40;arrow&#41;&#46; Some bilateral solid pulmonary nodules &#40;arrowhead&#41; probably associated with metastases are also observed&#46; &#40;B&#41; B-mode ultrasound performed in the same patient showing heterogeneous consolidation without air bronchogram and anechoic subpleural area &#40;oval&#41;&#46; &#40;C&#8211;F&#41; Ultrasound image after injection of contrast agent showing homogeneous but delayed enhancement &#40;star&#41; of the consolidated pulmonary parenchyma &#40;pneumonia pattern&#41;&#46; A subpleural triangular area is observed that shows more delayed enhancement than the surrounding consolidated parenchyma &#40;oval&#41;&#46; Moreover&#44; washout of this area is rapid&#44; suggesting malignancy&#46; An ultrasound-guided biopsy of the suspicious area was subsequently performed with histological results confirming pancreatic adenocarcinoma metastases&#46; Later&#44; a fiberoptic bronchoscopy confirmed fungal superinfection in the surrounding parenchyma&#46; &#40;G&#41; Large atypical and vacuolated epithelial cell groups associated with metastatic pancreatic adenocarcinoma&#46; &#40;H&#41; Microbiological analysis of the bronchoalveolar lavage sample from the consolidation area showing branched structures corresponding to hyphae&#46;</p>"
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Scientific Letter
Role of contrast-enhanced ultrasound in the differentiation between pneumonia and neoplasia within a lung consolidation
Papel de la ecografía con contraste en la diferenciación entre una neumonía y una neoplasia en el seno de una consolidación pulmonar
Gemma Isus Olivé, Alfredo Páez Carpio, Daniel Martínez, Ivan Vollmer
Corresponding author
vollmer@clinic.cat

Corresponding author.
Servicio de Radiodiagnóstico (CDIC), Hospital Clínic, Barcelona, Spain
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; CT after intravenous iodinated contrast agent&#46; Axial slices are shown in the mediastinum window &#40;left&#41; and pulmonary parenchyma window &#40;right&#41; where heterogeneous consolidation is observed in the right lower lobe with hypodense areas &#40;circle&#41; and areas of ground glass and tree-in-bud pattern &#40;arrow&#41;&#46; Some bilateral solid pulmonary nodules &#40;arrowhead&#41; probably associated with metastases are also observed&#46; &#40;B&#41; B-mode ultrasound performed in the same patient showing heterogeneous consolidation without air bronchogram and anechoic subpleural area &#40;oval&#41;&#46; &#40;C&#8211;F&#41; Ultrasound image after injection of contrast agent showing homogeneous but delayed enhancement &#40;star&#41; of the consolidated pulmonary parenchyma &#40;pneumonia pattern&#41;&#46; A subpleural triangular area is observed that shows more delayed enhancement than the surrounding consolidated parenchyma &#40;oval&#41;&#46; Moreover&#44; washout of this area is rapid&#44; suggesting malignancy&#46; An ultrasound-guided biopsy of the suspicious area was subsequently performed with histological results confirming pancreatic adenocarcinoma metastases&#46; Later&#44; a fiberoptic bronchoscopy confirmed fungal superinfection in the surrounding parenchyma&#46; &#40;G&#41; Large atypical and vacuolated epithelial cell groups associated with metastatic pancreatic adenocarcinoma&#46; &#40;H&#41; Microbiological analysis of the bronchoalveolar lavage sample from the consolidation area showing branched structures corresponding to hyphae&#46;</p>"
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contrast-enhanced ultrasound is of great utility in evaluating lung lesions that are in peripheral locations or contained within a consolidation<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a>&#44; since it helps identify areas of necrosis and thus improves diagnostic accuracy when obtaining samples<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46; Similarly&#44; contrast-enhanced studies help reach a differential diagnosis&#44; as they highlight specific characteristics of certain diseases&#44; such as pulmonary infarction&#44; atelectasis&#44; aggressive cancers&#44; and obstructive atelectasis due to central lesions<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">The time to enhancement of the parenchyma or lung lesion varies&#44; depending on whether the vascular component is supplied from the pulmonary arteries &#40;&#60;6&#8239;s&#41; or from the bronchial arteries &#40;&#62;6&#8239;s&#41;&#46; Similarly&#44; the pattern and extent of enhancement as well as the washout time &#40;greater than 60&#8239;s&#41; in a consolidated focus or lung lesion helps differentiate between lung collapse&#44; infectious process&#47;abscess&#44; infarction&#44; and tumor&#46; In general&#44; tumors receive arterial vascular supply from the bronchial arteries&#44; as the pulmonary arteries are incapable of neoangiogenesis&#46; The delay in uptake by malignant lesions is explained by intrinsic vasoconstrictions&#44; given the intrinsic hypoxic status of the neoproliferative lesion&#46; Benign lesions&#44; in contrast&#44; receive blood from both the pulmonary and bronchial arteries&#44; and therefore show early enhancement<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a>&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Thus&#44; in the case of passive atelectasis&#44; B-mode shows a homogeneous consolidation containing hyperechoic air bronchogram and early arterial enhancement that persists throughout the examination and may remain for longer than 5&#8239;min<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; The findings for areas of pulmonary infarction will be similar to those of atelectasis in B-mode and we can identify hypoechoic nodules within the area of collapse&#46; After the administration of contrast agent&#44; we will see an absence of enhancement in the infarcted areas<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46; Pulmonary abscesses show delayed enhancement &#40;&#62;6&#8239;s&#41; with hypoechoic and hypodense central areas corresponding to necrosis&#44; which may appear in preexisting tumors<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">Pneumonia and metastatic lesions and malignant lesions are a diagnostic challenge&#44; especially in cases where both entities coexist&#46; Pneumonias in general show early &#40;&#60;6&#8239;s&#41; homogeneous arterial enhancement&#46; However&#44; in some cases both pathologies show delayed enhancement &#40;&#62;6&#8239;s&#41;&#46; They differ in that in pneumonia&#44; homogeneous enhancement is maintained in late phases with late washout &#40;&#62;60&#8239;s&#41;&#44; while metastatic lesions will show faster washout &#40;&#60;60&#8239;s&#41; of the lesion than the surrounding parenchyma<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a>&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">We report the case of a 79-year-old woman with a history of papillary thyroid carcinoma who attended the emergency room for dyspnea that had worsened progressively until it appeared with minimal exertion&#46; Chest X-ray revealed multiple foci of consolidation&#46; A computed tomography &#40;CT&#41; scan was performed that ruled out pulmonary thromboembolism but revealed heterogeneous consolidations in both lower lobes along with areas suggestive of infectious bronchiolitis and some solid nodules &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>A&#41;&#46; A positive test was obtained for tumor markers &#40;CA 19-9 and CYFRA 21-1&#41; and&#44; in view of a suspected malignant origin&#44; a positron emission tomography &#40;PET&#47;CT&#41; with fluorodeoxyglucose was performed&#44; which showed probable pancreatic cancer and possible metastatic consolidations in the lungs&#46; Since the largest consolidation&#44; located in the lower right lobe&#44; was in extensive contact with the peripheral pleura&#44; we decided to perform ultrasound-guided biopsy&#46; We administered 2&#46;4&#8239;mL of ultrasound contrast agent &#40;SonoVue&#44; Rovi&#44; Pozuelo de Alarc&#243;n&#44; Madrid&#44; Spain&#41; and two distinct areas were observed&#44; differentiated by their uptake pattern&#58; a peripheral area with delayed enhancement &#40;&#62;6&#8239;s post-injection&#41; and early washout &#40;disappearance of contrast uptake within a few seconds of uptake&#41;&#44; while the remaining consolidation showed early homogeneous enhancement &#40;&#60;6&#8239;s&#41; and delayed washout &#40;&#62;1&#8239;min&#41; &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>B&#8211;F&#41;&#46; In view of these findings&#44; we decided to biopsy the first of these areas with a 22&#8239;G fine needle&#59; it was reported as alveolar metastasis of pancreatic adenocarcinoma &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>G&#41;&#46; Because the rest of the consolidation showed suggestive characteristics of a pneumonia process&#44; we decided to perform fiberoptic bronchoscopy&#59; samples obtained showed a fungal infection &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>H&#41;&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In our patient we were able to differentiate between pneumonia and metastasis&#44; as she presented pre-existing pulmonary consolidation containing a hypoechoic area&#46; On contrast-enhanced ultrasound&#44; the consolidation showed late homogeneous uptake with delayed washout&#44; with the exception of the central and peripheral areas that showed late enhancement but early washout&#44; suggestive of malignancy&#46; This enhancement pattern also helped guide the percutaneous biopsy to the most suspicious target area to improve the diagnostic yield of the samples collected&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">Ultrasound-guided biopsy is an alternative to CT-guided biopsy for peripheral or pleural lung lesions<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;3</span></a> and achieves a similar diagnostic effectiveness and yield as CT<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>&#46; Additionally&#44; ultrasound-guided percutaneous procedures offer certain advantages&#44; such as real-time monitoring of the procedure&#44; absence of radiation&#44; lower costs and duration of the procedure&#44; and the complication rates are similar to or lower than with CT-guided biopsy<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a>&#46; In many cases&#44; contrast-enhanced chest ultrasound helps clarify the nature of the lesion under study and&#44; if necessary&#44; guides the biopsy needle towards areas of interest&#44; avoiding necrotic foci<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2&#44;6</span></a> and targeting areas with a greater suspicion of malignancy&#44; as in the case presented&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Isus Oliv&#233; G&#44; P&#225;ez Carpio A&#44; Mart&#237;nez D&#44; Vollmer I&#46; Papel de la ecograf&#237;a con contraste en la diferenciaci&#243;n entre una neumon&#237;a y una neoplasia en el seno de una consolidaci&#243;n pulmonar&#46; Arch Bronconeumol&#46; 2021&#59;57&#58;605&#8211;607&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; CT after intravenous iodinated contrast agent&#46; Axial slices are shown in the mediastinum window &#40;left&#41; and pulmonary parenchyma window &#40;right&#41; where heterogeneous consolidation is observed in the right lower lobe with hypodense areas &#40;circle&#41; and areas of ground glass and tree-in-bud pattern &#40;arrow&#41;&#46; Some bilateral solid pulmonary nodules &#40;arrowhead&#41; probably associated with metastases are also observed&#46; &#40;B&#41; B-mode ultrasound performed in the same patient showing heterogeneous consolidation without air bronchogram and anechoic subpleural area &#40;oval&#41;&#46; &#40;C&#8211;F&#41; Ultrasound image after injection of contrast agent showing homogeneous but delayed enhancement &#40;star&#41; of the consolidated pulmonary parenchyma &#40;pneumonia pattern&#41;&#46; A subpleural triangular area is observed that shows more delayed enhancement than the surrounding consolidated parenchyma &#40;oval&#41;&#46; Moreover&#44; washout of this area is rapid&#44; suggesting malignancy&#46; An ultrasound-guided biopsy of the suspicious area was subsequently performed with histological results confirming pancreatic adenocarcinoma metastases&#46; Later&#44; a fiberoptic bronchoscopy confirmed fungal superinfection in the surrounding parenchyma&#46; &#40;G&#41; Large atypical and vacuolated epithelial cell groups associated with metastatic pancreatic adenocarcinoma&#46; &#40;H&#41; Microbiological analysis of the bronchoalveolar lavage sample from the consolidation area showing branched structures corresponding to hyphae&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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