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following rupture of the left lung hydatid cyst (B); air-fluid level after placement of ECMO, showing opacification of the entire left hemithorax and air in the left lung base (C); and after withdrawal of ventilatory support and ECMO (D).</p>" ] ] ] "autores" => array:5 [ 0 => array:2 [ "autoresLista" => "María Teresa Gómez-Hernández" "autores" => array:1 [ 0 => array:2 [ "nombre" => "María Teresa" "apellidos" => "Gómez-Hernández" ] ] ] 1 => array:2 [ "autoresLista" => "Ernest J. Martínez" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Ernest J." "apellidos" => "Martínez" ] ] ] 2 => array:2 [ "autoresLista" => "Marta G. Fuentes" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Marta G." "apellidos" => "Fuentes" ] ] ] 3 => array:2 [ "autoresLista" => "Marta Paz" "autores" => array:1 [ 0 => array:2 [ "nombre" => "Marta" "apellidos" => "Paz" ] ] ] 4 => array:2 [ "autoresLista" => "Israel Rodríguez, Nuria M. Novoa, Marcelo F. Jiménez" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Israel" "apellidos" => "Rodríguez" ] 1 => array:2 [ "nombre" => "Nuria M." "apellidos" => "Novoa" ] 2 => array:2 [ "nombre" => "Marcelo F." "apellidos" => "Jiménez" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212921001658?idApp=UINPBA00003Z" "url" => "/15792129/0000005700000007/v1_202107020656/S1579212921001658/v1_202107020656/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Hemoptysis induced by vaping" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "505" "paginaFinal" => "506" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "María del Puerto Cano Aguirre, Alba Esperanza Barrios, Francisco Martínez Muñiz, Soledad Alonso Viteri, Francisco Muñiz González, Rocío Segoviano Mateo, Ángela Algaba Calderón" "autores" => array:7 [ 0 => array:4 [ "nombre" => "María del Puerto" "apellidos" => "Cano Aguirre" "email" => array:1 [ 0 => "mpcano@torrejonsalud.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Alba" "apellidos" => "Esperanza Barrios" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 2 => array:3 [ "nombre" => "Francisco" "apellidos" => "Martínez Muñiz" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "Soledad" "apellidos" => "Alonso Viteri" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 4 => array:3 [ "nombre" => "Francisco" "apellidos" => "Muñiz González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:3 [ "nombre" => "Rocío" "apellidos" => "Segoviano Mateo" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] 6 => array:3 [ "nombre" => "Ángela" "apellidos" => "Algaba Calderón" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario de Torrejón, Torrejónde Ardoz, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Recoletas Campo Grande, Valladolid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Medicina Interna, Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Medicina Intensiva, Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Universidad Francisco de Vitoria, Madrid, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemoptisis secundaria a vapeo" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 748 "Ancho" => 750 "Tamanyo" => 42512 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT scan showing infiltrate in the left upper lobe.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years, we have seen the emergence of different methods of smoking tobacco and other substances that are increasing in popularity, mainly among young people and adolescents. Despite the messages propagated among the population, the safety of the fumes and smoke generated by these systems and their usefulness in smoking cessation have not been demonstrated.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this context, we present the case of a 33-year-old man, former smoker of 10 cigarettes/day from the age of 19 until 2 months previously, when he began to vape nicotine-free products (3 ml in 3 doses per day). He was receiving sertraline for an anxiety-depressive disorder, practiced sports regularly, and had no occupational risk exposure.</p><p id="par0015" class="elsevierStylePara elsevierViewall">He presented in the emergency department with sudden onset of bloody expectoration after excessive consumption of vaping fluid (almost 30 ml, higher than usual) with a new flavoring agent. Upon arrival, the patient was hemodynamically stable, breathing normally, with a baseline oxygen saturation of 95%. Lab tests were performed, showing leukocytosis 12,230 cells/mm<span class="elsevierStyleSup">3</span>. All other parameters were normal (platelets, coagulation, CRP, liver and renal profile, and later, autoimmune tests) and Ziehl staining in sputum was negative. Chest X-ray findings showed pathological changes. A CT scan was then performed, showing a ground glass infiltrate in the left upper lobe (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). Under observation, the patient produced 40 ml bloody expectoration in 12 hours12 h, but after admission to the ward, he produced 50 ml in 1 h. An arteriography was performed, and a tortuous right bronchial artery was observed, which was embolized, reducing the bleeding. Despite this procedure, the patient continued to expectorate blood in smaller amounts, so a bronchoscopy was performed, showing active diffuse capillary bleeding in both sides, with no clear source, which could not be controlled with cold serum or adrenaline. He was then admitted to the ICU for monitoring and was treated with low-flow oxygen therapy through nasal prongs, antibiotics (levofloxacin), and corticosteroids (methylprednisolone). Fortunately, his progress was favorable; he did not require intubation and was moved to the ward within 48 h. When the patient was stable, bronchoscopy was performed, which ruled out any endobronchial lesion. Abundant siderophages were observed in bronchoalveolvar lavage, but no foamy macrophages were present and no microorganism was isolated. One month later, the patient was re-admitted to hospital-at-home, due to superinfection, for which he received another cycle of intravenous antibiotics. He subsequently remained asymptomatic until discharge from follow-up months later.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">This is a case of special interest that can be added to the cases of lung damage associated with vaping, called e-cigarette or vaping product use associated lung injury (EVALI), that have recently been described. Nearly 3000 cases have been reported to the Centers for Disease Control in the United States, and the largest published cohort comprises 60 patients.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> For this reason, in September 2019, the Centers for Disease Control published a guide collating the available scientific evidence.</p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of a “confirmed” case is based on 4 criteria: 1) electronic cigarette use in the previous 90 days; 2) pulmonary opacities; 3) exclusion of lung infection (respiratory virus, influenza PCR, antigenuria for <span class="elsevierStyleItalic">Legionella</span> and <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>: negative; blood cultures/sputum culture/bronchoalveolar lavage, detection of opportunistic germs, if performed: negative); and 4) no alternative diagnosis. A case would be designated as “probable” if no microbiological tests were carried out to rule out infection, or if any of these tests were positive but not considered clinically to be the only cause of the disease.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient is therefore a “probable” case of vaping-related lung disease, since the cause-effect relationship (use-hemoptysis) is very clear and only one sputum culture was available. Other causes of hemoptysis were ruled out by the laboratory tests: pulmonary-renal syndromes, bleeding disorders, and autoimmune diseases (normal labs), parenchymal lesions (infiltrate, tumors, cavities, bronchiectasis, etc., by CT scan), pulmonary thromboembolism, arteriovenous malformations, and endobronchial lesions (e.g., tumor or foreign body, by bronchoscopy).</p><p id="par0035" class="elsevierStylePara elsevierViewall">It should be noted that no cases have been previously reported in Spain, and that our patient inhaled a flavoring substance that did not contain nicotine, tetrahydrocannabinol or cannabidiol, as was the case for all patients previously published.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4–6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The form of presentation with very acute hemoptysis after excessive consumption of the inhaled substance is also noteworthy, when compared with the mean 6-day duration of symptoms in other series (in the cohort of 53 patients). Hemoptysis is the least frequent of all symptoms presented (occurring in 11% of the series<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4</span></a>). Different forms of presentation have been described: organizing pneumonia, lipoid pneumonia, hypersensitivity pneumonitis, respiratory bronchiolitis, giant cell pneumonia,<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> diffuse alveolar hemorrhage,<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and diffuse alveolar damage, among others.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9–11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In terms of treatment, antibiotics covering the most common microorganisms in community-acquired pneumonia have been prescribed empirically in most patients. Corticosteroids are not routinely recommended, except in life-threatening cases, in patients suffering from clinical deterioration and hypoxemia, and if eosinophilic or cryptogenic organizing pneumonia is observed, in line with standard care. The recommended treatment is methylprednisolone 0.5−1 mg/kg/day for 5−10 days, depending on the patient’s response and progress.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">With regard to disease course, series published so far (n = 53<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and n = 60<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>) report that more than half of the patients were admitted to the ICU, but less than one third required orotracheal intubation, and 3 deaths were recorded.<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2,4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In short, as professionals we must be alert to new patterns of inhaled drug use, because of our profound lack of knowledge of the short- and long-term effects. Cases like ours are beginning to reveal some of the consequences of short-term consumption, but the pathophysiological mechanism by which the lung injury occurs, the substances responsible for it, and its correct treatment are still unknown.</p><p id="par0060" class="elsevierStylePara elsevierViewall">A patient registry, as proposed by SEPAR, is now urgently needed to enable us to carry out a thorough analysis of the cases and shed light on this new entity. We must establish more precise diagnostic criteria, identify the substances responsible for lung damage, and produce solid scientific evidence to guide the proper management of these patients and to convey a clear message to the general population and health authorities about these devices.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Cano Aguirre M d P, Esperanza Barrios A, Martínez Muñiz F, Alonso Viteri S, Muñiz González F, Segoviano Mateo R, et al. Hemoptisis secundaria a vapeo. Arch Bronconeumol. 2021;57:505–506.</p>" ] ] "multimedia" => array:1 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 748 "Ancho" => 750 "Tamanyo" => 42512 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0005" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">CT scan showing infiltrate in the left upper lobe.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:11 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Official statement of the Spanish Society of Pulmonology and Thoracic Surgery (SEPAR) on Electronic Cigarettes and IQOS®" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "J. 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Year/Month | Html | Total | |
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2024 November | 87 | 7 | 94 |
2024 October | 723 | 47 | 770 |
2024 September | 596 | 18 | 614 |
2024 August | 493 | 44 | 537 |
2024 July | 664 | 19 | 683 |
2024 June | 558 | 27 | 585 |
2024 May | 586 | 33 | 619 |
2024 April | 513 | 24 | 537 |
2024 March | 553 | 17 | 570 |
2024 February | 550 | 21 | 571 |
2024 January | 606 | 31 | 637 |
2023 December | 633 | 31 | 664 |
2023 November | 802 | 39 | 841 |
2023 October | 960 | 47 | 1007 |
2023 September | 919 | 37 | 956 |
2023 August | 674 | 35 | 709 |
2023 July | 666 | 18 | 684 |
2023 June | 604 | 18 | 622 |
2023 May | 655 | 34 | 689 |
2023 April | 902 | 21 | 923 |
2023 March | 717 | 26 | 743 |
2023 February | 710 | 39 | 749 |
2023 January | 331 | 24 | 355 |
2022 December | 175 | 23 | 198 |
2022 November | 199 | 27 | 226 |
2022 October | 216 | 34 | 250 |
2022 September | 101 | 29 | 130 |
2022 August | 80 | 41 | 121 |
2022 July | 98 | 44 | 142 |
2022 June | 83 | 43 | 126 |
2022 May | 78 | 34 | 112 |
2022 April | 40 | 15 | 55 |
2022 March | 43 | 39 | 82 |
2022 February | 13 | 17 | 30 |
2021 August | 2 | 4 | 6 |
2021 July | 2 | 0 | 2 |