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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years&#44; we have seen the emergence of different methods of smoking tobacco and other substances that are increasing in popularity&#44; mainly among young people and adolescents&#46; Despite the messages propagated among the population&#44; the safety of the fumes and smoke generated by these systems and their usefulness in smoking cessation have not been demonstrated&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this context&#44; we present the case of a 33-year-old man&#44; former smoker of 10 cigarettes&#47;day from the age of 19 until 2 months previously&#44; when he began to vape nicotine-free products &#40;3&#8239;ml in 3 doses per day&#41;&#46; He was receiving sertraline for an anxiety-depressive disorder&#44; practiced sports regularly&#44; and had no occupational risk exposure&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He presented in the emergency department with sudden onset of bloody expectoration after excessive consumption of vaping fluid &#40;almost 30&#8239;ml&#44; higher than usual&#41; with a new flavoring agent&#46; Upon arrival&#44; the patient was hemodynamically stable&#44; breathing normally&#44; with a baseline oxygen saturation of 95&#37;&#46; Lab tests were performed&#44; showing leukocytosis 12&#44;230&#8239;cells&#47;mm<span class="elsevierStyleSup">3</span>&#46; All other parameters were normal &#40;platelets&#44; coagulation&#44; CRP&#44; liver and renal profile&#44; and later&#44; autoimmune tests&#41; and Ziehl staining in sputum was negative&#46; Chest X-ray findings showed pathological changes&#46; A CT scan was then performed&#44; showing a ground glass infiltrate in the left upper lobe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Under observation&#44; the patient produced 40&#8239;ml bloody expectoration in 12&#8239;hours12&#8239;h&#44; but after admission to the ward&#44; he produced 50&#8239;ml in 1&#8239;h&#46; An arteriography was performed&#44; and a tortuous right bronchial artery was observed&#44; which was embolized&#44; reducing the bleeding&#46; Despite this procedure&#44; the patient continued to expectorate blood in smaller amounts&#44; so a bronchoscopy was performed&#44; showing active diffuse capillary bleeding in both sides&#44; with no clear source&#44; which could not be controlled with cold serum or adrenaline&#46; He was then admitted to the ICU for monitoring and was treated with low-flow oxygen therapy through nasal prongs&#44; antibiotics &#40;levofloxacin&#41;&#44; and corticosteroids &#40;methylprednisolone&#41;&#46; Fortunately&#44; his progress was favorable&#59; he did not require intubation and was moved to the ward within 48&#8239;h&#46; When the patient was stable&#44; bronchoscopy was performed&#44; which ruled out any endobronchial lesion&#46; Abundant siderophages were observed in bronchoalveolvar lavage&#44; but no foamy macrophages were present and no microorganism was isolated&#46; One month later&#44; the patient was re-admitted to hospital-at-home&#44; due to superinfection&#44; for which he received another cycle of intravenous antibiotics&#46; He subsequently remained asymptomatic until discharge from follow-up months later&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">This is a case of special interest that can be added to the cases of lung damage associated with vaping&#44; called e-cigarette or vaping product use associated lung injury &#40;EVALI&#41;&#44; that have recently been described&#46; Nearly 3000 cases have been reported to the Centers for Disease Control in the United States&#44; and the largest published cohort comprises 60 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> For this reason&#44; in September 2019&#44; the Centers for Disease Control published a guide collating the available scientific evidence&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of a &#8220;confirmed&#8221; case is based on 4 criteria&#58; 1&#41; electronic cigarette use in the previous 90 days&#59; 2&#41; pulmonary opacities&#59; 3&#41; exclusion of lung infection &#40;respiratory virus&#44; influenza PCR&#44; antigenuria for <span class="elsevierStyleItalic">Legionella</span> and <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#58; negative&#59; blood cultures&#47;sputum culture&#47;bronchoalveolar lavage&#44; detection of opportunistic germs&#44; if performed&#58; negative&#41;&#59; and 4&#41; no alternative diagnosis&#46; A case would be designated as &#8220;probable&#8221; if no microbiological tests were carried out to rule out infection&#44; or if any of these tests were positive but not considered clinically to be the only cause of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient is therefore a &#8220;probable&#8221; case of vaping-related lung disease&#44; since the cause-effect relationship &#40;use-hemoptysis&#41; is very clear and only one sputum culture was available&#46; Other causes of hemoptysis were ruled out by the laboratory tests&#58; pulmonary-renal syndromes&#44; bleeding disorders&#44; and autoimmune diseases &#40;normal labs&#41;&#44; parenchymal lesions &#40;infiltrate&#44; tumors&#44; cavities&#44; bronchiectasis&#44; etc&#46;&#44; by CT scan&#41;&#44; pulmonary thromboembolism&#44; arteriovenous malformations&#44; and endobronchial lesions &#40;e&#46;g&#46;&#44; tumor or foreign body&#44; by bronchoscopy&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">It should be noted that no cases have been previously reported in Spain&#44; and that our patient inhaled a flavoring substance that did not contain nicotine&#44; tetrahydrocannabinol or cannabidiol&#44; as was the case for all patients previously published&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#8211;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The form of presentation with very acute hemoptysis after excessive consumption of the inhaled substance is also noteworthy&#44; when compared with the mean 6-day duration of symptoms in other series &#40;in the cohort of 53 patients&#41;&#46; Hemoptysis is the least frequent of all symptoms presented &#40;occurring in 11&#37; of the series<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a>&#41;&#46; Different forms of presentation have been described&#58; organizing pneumonia&#44; lipoid pneumonia&#44; hypersensitivity pneumonitis&#44; respiratory bronchiolitis&#44; giant cell pneumonia&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> diffuse alveolar hemorrhage&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and diffuse alveolar damage&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In terms of treatment&#44; antibiotics covering the most common microorganisms in community-acquired pneumonia have been prescribed empirically in most patients&#46; Corticosteroids are not routinely recommended&#44; except in life-threatening cases&#44; in patients suffering from clinical deterioration and hypoxemia&#44; and if eosinophilic or cryptogenic organizing pneumonia is observed&#44; in line with standard care&#46; The recommended treatment is methylprednisolone 0&#46;5&#8722;1&#8239;mg&#47;kg&#47;day for 5&#8722;10 days&#44; depending on the patient&#8217;s response and progress&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">With regard to disease course&#44; series published so far &#40;n&#8239;&#61;&#8239;53<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and n&#8239;&#61;&#8239;60<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#41; report that more than half of the patients were admitted to the ICU&#44; but less than one third required orotracheal intubation&#44; and 3 deaths were recorded&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In short&#44; as professionals we must be alert to new patterns of inhaled drug use&#44; because of our profound lack of knowledge of the short- and long-term effects&#46; Cases like ours are beginning to reveal some of the consequences of short-term consumption&#44; but the pathophysiological mechanism by which the lung injury occurs&#44; the substances responsible for it&#44; and its correct treatment are still unknown&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A patient registry&#44; as proposed by SEPAR&#44; is now urgently needed to enable us to carry out a thorough analysis of the cases and shed light on this new entity&#46; We must establish more precise diagnostic criteria&#44; identify the substances responsible for lung damage&#44; and produce solid scientific evidence to guide the proper management of these patients and to convey a clear message to the general population and health authorities about these devices&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Cano Aguirre M d P&#44; Esperanza Barrios A&#44; Mart&#237;nez Mu&#241;iz F&#44; Alonso Viteri S&#44; Mu&#241;iz Gonz&#225;lez F&#44; Segoviano Mateo R&#44; et al&#46; Hemoptisis secundaria a vapeo&#46; Arch Bronconeumol&#46; 2021&#59;57&#58;505&#8211;506&#46;</p>"
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Scientific Letter
Hemoptysis induced by vaping
Hemoptisis secundaria a vapeo
María del Puerto Cano Aguirrea,e,
Corresponding author
mpcano@torrejonsalud.com

Corresponding author.
, Alba Esperanza Barriosa,e, Francisco Martínez Muñiza, Soledad Alonso Viteria,e, Francisco Muñiz Gonzálezb, Rocío Segoviano Mateoc, Ángela Algaba Calderónd,e
a Servicio de Neumología, Hospital Universitario de Torrejón, Torrejónde Ardoz, Madrid, Spain
b Servicio de Neumología, Hospital Recoletas Campo Grande, Valladolid, Spain
c Servicio de Medicina Interna, Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, Spain
d Servicio de Medicina Intensiva, Hospital Universitario de Torrejón, Torrejón de Ardoz, Madrid, Spain
e Universidad Francisco de Vitoria, Madrid, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">In recent years&#44; we have seen the emergence of different methods of smoking tobacco and other substances that are increasing in popularity&#44; mainly among young people and adolescents&#46; Despite the messages propagated among the population&#44; the safety of the fumes and smoke generated by these systems and their usefulness in smoking cessation have not been demonstrated&#46;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this context&#44; we present the case of a 33-year-old man&#44; former smoker of 10 cigarettes&#47;day from the age of 19 until 2 months previously&#44; when he began to vape nicotine-free products &#40;3&#8239;ml in 3 doses per day&#41;&#46; He was receiving sertraline for an anxiety-depressive disorder&#44; practiced sports regularly&#44; and had no occupational risk exposure&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">He presented in the emergency department with sudden onset of bloody expectoration after excessive consumption of vaping fluid &#40;almost 30&#8239;ml&#44; higher than usual&#41; with a new flavoring agent&#46; Upon arrival&#44; the patient was hemodynamically stable&#44; breathing normally&#44; with a baseline oxygen saturation of 95&#37;&#46; Lab tests were performed&#44; showing leukocytosis 12&#44;230&#8239;cells&#47;mm<span class="elsevierStyleSup">3</span>&#46; All other parameters were normal &#40;platelets&#44; coagulation&#44; CRP&#44; liver and renal profile&#44; and later&#44; autoimmune tests&#41; and Ziehl staining in sputum was negative&#46; Chest X-ray findings showed pathological changes&#46; A CT scan was then performed&#44; showing a ground glass infiltrate in the left upper lobe &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41;&#46; Under observation&#44; the patient produced 40&#8239;ml bloody expectoration in 12&#8239;hours12&#8239;h&#44; but after admission to the ward&#44; he produced 50&#8239;ml in 1&#8239;h&#46; An arteriography was performed&#44; and a tortuous right bronchial artery was observed&#44; which was embolized&#44; reducing the bleeding&#46; Despite this procedure&#44; the patient continued to expectorate blood in smaller amounts&#44; so a bronchoscopy was performed&#44; showing active diffuse capillary bleeding in both sides&#44; with no clear source&#44; which could not be controlled with cold serum or adrenaline&#46; He was then admitted to the ICU for monitoring and was treated with low-flow oxygen therapy through nasal prongs&#44; antibiotics &#40;levofloxacin&#41;&#44; and corticosteroids &#40;methylprednisolone&#41;&#46; Fortunately&#44; his progress was favorable&#59; he did not require intubation and was moved to the ward within 48&#8239;h&#46; When the patient was stable&#44; bronchoscopy was performed&#44; which ruled out any endobronchial lesion&#46; Abundant siderophages were observed in bronchoalveolvar lavage&#44; but no foamy macrophages were present and no microorganism was isolated&#46; One month later&#44; the patient was re-admitted to hospital-at-home&#44; due to superinfection&#44; for which he received another cycle of intravenous antibiotics&#46; He subsequently remained asymptomatic until discharge from follow-up months later&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">This is a case of special interest that can be added to the cases of lung damage associated with vaping&#44; called e-cigarette or vaping product use associated lung injury &#40;EVALI&#41;&#44; that have recently been described&#46; Nearly 3000 cases have been reported to the Centers for Disease Control in the United States&#44; and the largest published cohort comprises 60 patients&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> For this reason&#44; in September 2019&#44; the Centers for Disease Control published a guide collating the available scientific evidence&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">The diagnosis of a &#8220;confirmed&#8221; case is based on 4 criteria&#58; 1&#41; electronic cigarette use in the previous 90 days&#59; 2&#41; pulmonary opacities&#59; 3&#41; exclusion of lung infection &#40;respiratory virus&#44; influenza PCR&#44; antigenuria for <span class="elsevierStyleItalic">Legionella</span> and <span class="elsevierStyleItalic">Streptococcus pneumoniae</span>&#58; negative&#59; blood cultures&#47;sputum culture&#47;bronchoalveolar lavage&#44; detection of opportunistic germs&#44; if performed&#58; negative&#41;&#59; and 4&#41; no alternative diagnosis&#46; A case would be designated as &#8220;probable&#8221; if no microbiological tests were carried out to rule out infection&#44; or if any of these tests were positive but not considered clinically to be the only cause of the disease&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">Our patient is therefore a &#8220;probable&#8221; case of vaping-related lung disease&#44; since the cause-effect relationship &#40;use-hemoptysis&#41; is very clear and only one sputum culture was available&#46; Other causes of hemoptysis were ruled out by the laboratory tests&#58; pulmonary-renal syndromes&#44; bleeding disorders&#44; and autoimmune diseases &#40;normal labs&#41;&#44; parenchymal lesions &#40;infiltrate&#44; tumors&#44; cavities&#44; bronchiectasis&#44; etc&#46;&#44; by CT scan&#41;&#44; pulmonary thromboembolism&#44; arteriovenous malformations&#44; and endobronchial lesions &#40;e&#46;g&#46;&#44; tumor or foreign body&#44; by bronchoscopy&#41;&#46;</p><p id="par0035" class="elsevierStylePara elsevierViewall">It should be noted that no cases have been previously reported in Spain&#44; and that our patient inhaled a flavoring substance that did not contain nicotine&#44; tetrahydrocannabinol or cannabidiol&#44; as was the case for all patients previously published&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4&#8211;6</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The form of presentation with very acute hemoptysis after excessive consumption of the inhaled substance is also noteworthy&#44; when compared with the mean 6-day duration of symptoms in other series &#40;in the cohort of 53 patients&#41;&#46; Hemoptysis is the least frequent of all symptoms presented &#40;occurring in 11&#37; of the series<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a>&#41;&#46; Different forms of presentation have been described&#58; organizing pneumonia&#44; lipoid pneumonia&#44; hypersensitivity pneumonitis&#44; respiratory bronchiolitis&#44; giant cell pneumonia&#44;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> diffuse alveolar hemorrhage&#44;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> and diffuse alveolar damage&#44; among others&#46;<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9&#8211;11</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">In terms of treatment&#44; antibiotics covering the most common microorganisms in community-acquired pneumonia have been prescribed empirically in most patients&#46; Corticosteroids are not routinely recommended&#44; except in life-threatening cases&#44; in patients suffering from clinical deterioration and hypoxemia&#44; and if eosinophilic or cryptogenic organizing pneumonia is observed&#44; in line with standard care&#46; The recommended treatment is methylprednisolone 0&#46;5&#8722;1&#8239;mg&#47;kg&#47;day for 5&#8722;10 days&#44; depending on the patient&#8217;s response and progress&#46;<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p><p id="par0050" class="elsevierStylePara elsevierViewall">With regard to disease course&#44; series published so far &#40;n&#8239;&#61;&#8239;53<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> and n&#8239;&#61;&#8239;60<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a>&#41; report that more than half of the patients were admitted to the ICU&#44; but less than one third required orotracheal intubation&#44; and 3 deaths were recorded&#46;<a class="elsevierStyleCrossRefs" href="#bib0010"><span class="elsevierStyleSup">2&#44;4</span></a></p><p id="par0055" class="elsevierStylePara elsevierViewall">In short&#44; as professionals we must be alert to new patterns of inhaled drug use&#44; because of our profound lack of knowledge of the short- and long-term effects&#46; Cases like ours are beginning to reveal some of the consequences of short-term consumption&#44; but the pathophysiological mechanism by which the lung injury occurs&#44; the substances responsible for it&#44; and its correct treatment are still unknown&#46;</p><p id="par0060" class="elsevierStylePara elsevierViewall">A patient registry&#44; as proposed by SEPAR&#44; is now urgently needed to enable us to carry out a thorough analysis of the cases and shed light on this new entity&#46; We must establish more precise diagnostic criteria&#44; identify the substances responsible for lung damage&#44; and produce solid scientific evidence to guide the proper management of these patients and to convey a clear message to the general population and health authorities about these devices&#46;</p></span>"
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Article information
ISSN: 15792129
Original language: English
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