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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contacts tracing of patients with tuberculosis &#40;TB&#41; is a priority for the control of the disease in countries with low prevalence and high economic resources&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> as stated in the Plan for the Prevention and Control of Tuberculosis in Spain&#44; which underlines the need to intensify contact tracing and coordination among all the health centers and teams involved&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; few studies in Spain have analyzed the organization of contacts tracing programs&#58; most have been performed in specific geographical areas and focus on evaluating such programs to identify their weaknesses and work towards improving them&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This prospective&#44; observational cohort study of the contacts of tuberculosis patients was therefore aimed at describing the organization of these programs in Spain and the prevalence of latent tuberculous infection among the contacts studied&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Contacts of patients diagnosed with TB between January 2018 and December 2019 were identified and included in the national registry of SEPAR&#8217;s Integrated Tuberculosis Research Program &#40;PII-TB&#41;&#44; which is accessed by user names and passwords provided to the members of the PII-TB Task Force The study was approved by the Research Ethics Committee of all participating centers&#46; Twelve centers from 6 Spanish autonomous communities participated in the study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The following definitions were established&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Initial index case</span>&#58; a person of any age diagnosed with TB in a specific household or other comparable environment in which others may have been exposed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Contact</span>&#58; any person who has been exposed to an index case and classified according to the time of exposure as&#58; 1&#41; habitual&#58; contact was repeated and occurred more than once a week&#59; and 2&#41; sporadic&#58; only one contact occurred or&#44; if repeated&#44; occurred less than once a week&#46; In any case&#44; to be sporadic&#44; the period of contact had to be less than 6&#160;h&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secondary case</span>&#58; a person diagnosed with TB who was identified from among the individuals studied as contacts&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Latent tuberculosis infection &#40;LTBI&#41;&#58;</span> tuberculin skin test &#40;TST&#41; with induration diameter of 5&#160;mm or more and&#47;or positive interferon-&#947; release assay &#40;IGRA&#41;&#44; with no evidence of active disease&#46; The QuantiFERON-TB GOLD in-Tube IGRA was used with a cut-off point of 0&#46;35&#160;IU&#47;ml&#46; The responsible investigator determined which TST and IGRA were to be used and the order in which they were performed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">e&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Dual strategy</span>&#58; use of both diagnostic techniques&#44; TST and IGRA&#44; regardless of the sequence&#46;</p></li></ul></p><p id="par0050" class="elsevierStylePara elsevierViewall">Proportions were compared between groups using the Chi-square test and the 2-tailed Fisher test when the expected values were less than 5&#46; Quantitative variables were compared using the Student&#8217;s t-test or its non-parametric equivalent&#44; the Mann&#8211;Whitney U test&#46; The prevalence of LTBI among contacts was calculated taking into account the total number of contacts&#46; A p-value of less than 0&#46;05 was considered significant&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We analyzed 1035 contacts from 265 index cases&#44; 525 women and 510 men&#44; with a mean age of 37&#46;96&#160;&#177;&#160;20&#46;13 years&#59; 777 &#40;75&#46;1&#37;&#41; were Spanish natives and 413 &#40;39&#46;9&#37;&#41; were household contacts&#46; Contacts tracing was conducted in specialist tuberculosis clinics in 769 cases &#40; 74&#44;2&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the differences between different healthcare sites where the tracing study was performed&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">TST was performed in 844 contacts &#40;81&#46;5&#37;&#41; and IGRA in 469 &#40;45&#46;3&#37;&#41;&#44; while both tests were performed in 348 &#40;33&#46;6&#37;&#41;&#46; Of the 444 in whom the TST was negative&#44; a second determination was made in 90&#46;7&#37; with a conversion rate of 2&#46;7&#37;&#59; these percentages were 58&#46;8&#37; and 5&#46;2&#37; &#40;9&#47;289&#41;&#44; respectively&#44; for the IGRAs&#46; LTBI was diagnosed in 346 &#40;33&#46;4&#37;&#41; and depending on the diagnostic strategy&#44; the prevalence was 48&#46;2&#37; if both TST and IGRA were performed&#44; 27&#46;4&#37; if TST was used alone&#44; and 40&#46;4&#37; if IGRA was used alone &#40;p&#160;&#61;&#160;0&#46;01&#41;&#46; In 126 contacts&#44; the index case had negative sputum smear and culture or extrapulmonary disease&#46; Of these&#44; 97 &#40;76&#46;9&#37;&#41; were seen in specialist tuberculosis clinics&#44; and LTBI was detected in 24&#46;6&#37; &#40;31&#47;126&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">TB was diagnosed in 17 contacts &#40;1&#46;6&#37;&#41;&#58; in all of these&#44; the index case had a positive culture&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In our series&#44; LTBI is slightly less prevalent than the 40&#37; to 57&#37; reported in previous studies published in Spain&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a> We believe that this may be partly due to the uneven use of diagnostic techniques&#44; since LTBI rates were significantly higher in cases in which a dual strategy was used&#46; Although there is no clear advantage of TST over IGRA&#44; or vice versa&#44; performing both tests together to establish the diagnosis of LTBI improves diagnostic sensitivity&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In addition the conversion rate of the IGRA is also higher than that of TST&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> We found that TST and IGRA were performed simultaneously in only 33&#37; of patients&#44; and if the initial test was negative&#44; a second determination was made in a higher percentage of patients undergoing TST than IGRA&#46; We therefore believe that the dual strategy is the most appropriate&#44; and if the initial tests are negative&#44; they should be repeated 8&#8211;12 weeks later to determine whether there are conversions&#59; this is one of the aspects to be improved in the performance of contact tracing studies&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Another interesting finding of our study is that tracing of more than 2&#47;3 of the contacts was conducted by a specialist tuberculosis clinic&#46; These facilities differ clearly from other healthcare sites&#58; they perform a higher percentage of dual diagnostic techniques&#44; track contacts outside the family setting&#44; and follow up index cases with negative or extrapulmonary culture &#40;86&#46;1&#37; and 76&#46;9&#37;&#44; respectively&#41;&#44; with the resulting impact on the detection of infected individuals&#44; the main objective of the contact study&#46; Although contacts tracing in cases of extrapulmonary TB is controversial unless there is another added risk factor&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> we believe that there are arguments in favor of this approach&#44; including the sizeable proportion of LTBI detected &#40;25&#37; in our study and as high as 35&#37; in others<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#41; and the active TB load detected in previous series&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Finally&#44; it is also worth noting that&#44; in line with previous reports&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> care in specialist tuberculosis clinics improved the follow-up of contacts&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Our study has limitations&#46; First&#44; this was an observational study in which several researchers participated&#44; so errors might have been made in some of the variables collected&#44; thus implying a selection bias&#46; However&#44; we should point out that all the researchers were tuberculosis experts actively involved in the PII-TB program&#44; which we believe improved the quality of data collection and reduced this risk&#44; thus endorsing the validity of the results obtained&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We conclude that the dual use of TST and IGRA testing in contacts tracing is recommended to improve sensitivity in the diagnosis of infected individuals&#46; There are also differences between study sites&#44; with specialist tuberculosis units showing better results&#44; suggesting that the process should be centralized in these clinics to offer more homogeneous care&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authorship</span><p id="par0090" class="elsevierStylePara elsevierViewall">Jos&#233; Antonio Gull&#243;n Blanco participated in the conception and design of the study&#44; data collection&#44; analysis and interpretation&#44; and writing of the article&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Teresa Rodrigo Sanz&#44; Jos&#233; Mar&#237;a Garc&#237;a Garc&#237;a and the PII-TB participated in the critical review of the intellectual content and final approval of the submitted manuscript&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Fernando &#193;lvarez Navascu&#233;s&#44; Eva Tabernero Huguet and Josefina Sabr&#237;a Mestres collaborated in the final approval of the submitted manuscript&#46; The Task Force of the Integrated Research Program in Tuberculosis &#40;PII-TB&#41; has been involved in data collection&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0105" class="elsevierStylePara elsevierViewall">This study was funded by the <span class="elsevierStyleGrantSponsor" id="gs0005">Instituto de la Salud Carlos III-Fondos FEDER</span> grant <span class="elsevierStyleGrantNumber" refid="gs0005">PI17&#47;00724</span> and by the <span class="elsevierStyleGrantSponsor" id="gs0010">Spanish Society of Pulmonology and Thoracic Surgery &#40;SEPAR&#41;</span> grant <span class="elsevierStyleGrantNumber" refid="gs0010">378&#47;2017</span>&#46;</p></span></span>"
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            "apendice" => "<p id="par0110" class="elsevierStylePara elsevierViewall">Manuel &#193;ngel Villanueva Montes &#40;Pneumology&#44; Universitty Hospital San Agust&#237;n&#44; Avil&#233;s&#41;&#44; Isabel L&#243;pez Aranaga &#40;Pneumology&#44; University Hospital of Cruces&#44; Baracaldo&#41;&#44; Juan Diego &#193;lvarez Mavarez &#40;Pneumology&#44; Carmen and Severo Ochoa Hospital&#44; Cangas del Narcea&#41;&#44; Mar&#237;a Somoza Gonz&#225;lez &#40; Pneumology&#44; Consorcio Sanitario de Terrassa&#44; Terrassa&#41;&#44; Luis Anibarro Garc&#237;a &#40;Internal Medicine Complejo Hospitalario Universitario de Pontevedera&#41;&#44; Christian Anchorena &#40;Pneumology&#44; Complejo Hospitalario Universitario de Pontevedera&#41;&#44; Isabel Mir Viladrich &#40;Pneumology&#44; Son Llatzer Hospital Palma de Mallorca&#41;&#44; &#193;ngel Dom&#237;nguez Castellano &#40;Infectious Diseases Service&#44; University Hospital Virgen Macarena&#44; Seville&#41;&#44; Ant&#243;n Penas Truque &#40;Pneumology&#44; University Hospital Lucus Augusti&#44; Lugo&#41;&#44; Silvia Dorronsoro Quintana &#40;Pneumology&#44; Hospital of Zum&#225;rraga&#44; Zum&#225;rraga&#41;&#44; Juan Francisco Medina Gallardo &#40;Pneumology&#44; University Hospital Virgen del Roc&#237;o&#44; Seville&#41;&#44; Lander Altube Urrengoetxea &#40;Pneumology&#44; University Hospital of Galdakao&#44; Galdakao&#41;&#44; Mar&#237;a Otero Santiago &#40;University Hospital of &#241;&#241; A Coru&#241;a&#44; A Coru&#241;&#241;na&#41;&#44; Concepci&#243;n Rodr&#237;guez Garc&#237;a &#40;Pneumology&#44; Universitary Hospital San Agust&#237;n&#44; Avil&#233;s&#41; and Juan Rodr&#237;guez L&#243;pez &#40;Pneumology&#44; Grande Covian Hospital&#44; Arriondas&#41;&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Members of the PII-TB Research Group &#40;TB Integrated Research Program&#41;&#241;"
            "identificador" => "sec0015"
          ]
        ]
      ]
    ]
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      0 => array:8 [
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        "etiqueta" => "Table 1"
        "tipo" => "MULTIMEDIATABLA"
        "mostrarFloat" => true
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        "detalles" => array:1 [
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#43;&#58; positive&#59; &#8211;&#58; negative&#59; Dx strategy&#58; diagnostic strategy&#59; EP&#58; extrapulmonary&#59; IGRA&#58; interferon-g release assays&#59; LTBI&#58; latent tuberculous infection&#59; LTBI-T&#58; latent tuberculous infection treatment completed&#59; TB clinic&#58; specialist tuberculosis clinic&#59; TST&#58; tuberculin skin test&#46;</p>"
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Scientific Letter
Tuberculosis contacts study: Organization and prevalence of latent tuberculosis infection
Estudio de contactos de pacientes con tuberculosis: organización y prevalencia de la infección tuberculosa latente
José Antonio Gullón Blancoa,b,
Corresponding author
josegubl@gmail.com

Corresponding author.
, Teresa Rodrigo Sanzb, Fernando Álvarez Navascuesa,b, Eva Tabernero Huguetb,c, Josefina Sabría Mestresb,d, José-María García-Garcíab, Integrated Tuberculosis Research Program (PII-TB) Working group
a Pneumology, University Hospital San Agustín, Avilés, Spain
b Integrated Tuberculosis Research Program (PII-TB) SEPAR, Barcelona, Spain
c Pneumology, University Hospital of Cruces, Baracaldo, Spain
d Pneumology, University Hospital Moisés Broggi, Sant Joan Despí, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Contacts tracing of patients with tuberculosis &#40;TB&#41; is a priority for the control of the disease in countries with low prevalence and high economic resources&#44;<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1&#44;2</span></a> as stated in the Plan for the Prevention and Control of Tuberculosis in Spain&#44; which underlines the need to intensify contact tracing and coordination among all the health centers and teams involved&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> However&#44; few studies in Spain have analyzed the organization of contacts tracing programs&#58; most have been performed in specific geographical areas and focus on evaluating such programs to identify their weaknesses and work towards improving them&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">This prospective&#44; observational cohort study of the contacts of tuberculosis patients was therefore aimed at describing the organization of these programs in Spain and the prevalence of latent tuberculous infection among the contacts studied&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Contacts of patients diagnosed with TB between January 2018 and December 2019 were identified and included in the national registry of SEPAR&#8217;s Integrated Tuberculosis Research Program &#40;PII-TB&#41;&#44; which is accessed by user names and passwords provided to the members of the PII-TB Task Force The study was approved by the Research Ethics Committee of all participating centers&#46; Twelve centers from 6 Spanish autonomous communities participated in the study&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">The following definitions were established&#58;<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">a&#41;</span><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Initial index case</span>&#58; a person of any age diagnosed with TB in a specific household or other comparable environment in which others may have been exposed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">b&#41;</span><p id="par0030" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Contact</span>&#58; any person who has been exposed to an index case and classified according to the time of exposure as&#58; 1&#41; habitual&#58; contact was repeated and occurred more than once a week&#59; and 2&#41; sporadic&#58; only one contact occurred or&#44; if repeated&#44; occurred less than once a week&#46; In any case&#44; to be sporadic&#44; the period of contact had to be less than 6&#160;h&#46;</p></li><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">c&#41;</span><p id="par0035" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Secondary case</span>&#58; a person diagnosed with TB who was identified from among the individuals studied as contacts&#46;</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">d&#41;</span><p id="par0040" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Latent tuberculosis infection &#40;LTBI&#41;&#58;</span> tuberculin skin test &#40;TST&#41; with induration diameter of 5&#160;mm or more and&#47;or positive interferon-&#947; release assay &#40;IGRA&#41;&#44; with no evidence of active disease&#46; The QuantiFERON-TB GOLD in-Tube IGRA was used with a cut-off point of 0&#46;35&#160;IU&#47;ml&#46; The responsible investigator determined which TST and IGRA were to be used and the order in which they were performed&#46;</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">e&#41;</span><p id="par0045" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">Dual strategy</span>&#58; use of both diagnostic techniques&#44; TST and IGRA&#44; regardless of the sequence&#46;</p></li></ul></p><p id="par0050" class="elsevierStylePara elsevierViewall">Proportions were compared between groups using the Chi-square test and the 2-tailed Fisher test when the expected values were less than 5&#46; Quantitative variables were compared using the Student&#8217;s t-test or its non-parametric equivalent&#44; the Mann&#8211;Whitney U test&#46; The prevalence of LTBI among contacts was calculated taking into account the total number of contacts&#46; A p-value of less than 0&#46;05 was considered significant&#46;</p><p id="par0055" class="elsevierStylePara elsevierViewall">We analyzed 1035 contacts from 265 index cases&#44; 525 women and 510 men&#44; with a mean age of 37&#46;96&#160;&#177;&#160;20&#46;13 years&#59; 777 &#40;75&#46;1&#37;&#41; were Spanish natives and 413 &#40;39&#46;9&#37;&#41; were household contacts&#46; Contacts tracing was conducted in specialist tuberculosis clinics in 769 cases &#40; 74&#44;2&#37;&#41;&#46; <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a> shows the differences between different healthcare sites where the tracing study was performed&#46;</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0060" class="elsevierStylePara elsevierViewall">TST was performed in 844 contacts &#40;81&#46;5&#37;&#41; and IGRA in 469 &#40;45&#46;3&#37;&#41;&#44; while both tests were performed in 348 &#40;33&#46;6&#37;&#41;&#46; Of the 444 in whom the TST was negative&#44; a second determination was made in 90&#46;7&#37; with a conversion rate of 2&#46;7&#37;&#59; these percentages were 58&#46;8&#37; and 5&#46;2&#37; &#40;9&#47;289&#41;&#44; respectively&#44; for the IGRAs&#46; LTBI was diagnosed in 346 &#40;33&#46;4&#37;&#41; and depending on the diagnostic strategy&#44; the prevalence was 48&#46;2&#37; if both TST and IGRA were performed&#44; 27&#46;4&#37; if TST was used alone&#44; and 40&#46;4&#37; if IGRA was used alone &#40;p&#160;&#61;&#160;0&#46;01&#41;&#46; In 126 contacts&#44; the index case had negative sputum smear and culture or extrapulmonary disease&#46; Of these&#44; 97 &#40;76&#46;9&#37;&#41; were seen in specialist tuberculosis clinics&#44; and LTBI was detected in 24&#46;6&#37; &#40;31&#47;126&#41;&#46;</p><p id="par0065" class="elsevierStylePara elsevierViewall">TB was diagnosed in 17 contacts &#40;1&#46;6&#37;&#41;&#58; in all of these&#44; the index case had a positive culture&#46;</p><p id="par0070" class="elsevierStylePara elsevierViewall">In our series&#44; LTBI is slightly less prevalent than the 40&#37; to 57&#37; reported in previous studies published in Spain&#46;<a class="elsevierStyleCrossRefs" href="#bib0020"><span class="elsevierStyleSup">4&#44;6</span></a> We believe that this may be partly due to the uneven use of diagnostic techniques&#44; since LTBI rates were significantly higher in cases in which a dual strategy was used&#46; Although there is no clear advantage of TST over IGRA&#44; or vice versa&#44; performing both tests together to establish the diagnosis of LTBI improves diagnostic sensitivity&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> In addition the conversion rate of the IGRA is also higher than that of TST&#46;<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8&#44;9</span></a> We found that TST and IGRA were performed simultaneously in only 33&#37; of patients&#44; and if the initial test was negative&#44; a second determination was made in a higher percentage of patients undergoing TST than IGRA&#46; We therefore believe that the dual strategy is the most appropriate&#44; and if the initial tests are negative&#44; they should be repeated 8&#8211;12 weeks later to determine whether there are conversions&#59; this is one of the aspects to be improved in the performance of contact tracing studies&#46;</p><p id="par0075" class="elsevierStylePara elsevierViewall">Another interesting finding of our study is that tracing of more than 2&#47;3 of the contacts was conducted by a specialist tuberculosis clinic&#46; These facilities differ clearly from other healthcare sites&#58; they perform a higher percentage of dual diagnostic techniques&#44; track contacts outside the family setting&#44; and follow up index cases with negative or extrapulmonary culture &#40;86&#46;1&#37; and 76&#46;9&#37;&#44; respectively&#41;&#44; with the resulting impact on the detection of infected individuals&#44; the main objective of the contact study&#46; Although contacts tracing in cases of extrapulmonary TB is controversial unless there is another added risk factor&#44;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> we believe that there are arguments in favor of this approach&#44; including the sizeable proportion of LTBI detected &#40;25&#37; in our study and as high as 35&#37; in others<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>&#41; and the active TB load detected in previous series&#46;<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Finally&#44; it is also worth noting that&#44; in line with previous reports&#44;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> care in specialist tuberculosis clinics improved the follow-up of contacts&#44; as shown in <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>&#46;</p><p id="par0080" class="elsevierStylePara elsevierViewall">Our study has limitations&#46; First&#44; this was an observational study in which several researchers participated&#44; so errors might have been made in some of the variables collected&#44; thus implying a selection bias&#46; However&#44; we should point out that all the researchers were tuberculosis experts actively involved in the PII-TB program&#44; which we believe improved the quality of data collection and reduced this risk&#44; thus endorsing the validity of the results obtained&#46;</p><p id="par0085" class="elsevierStylePara elsevierViewall">We conclude that the dual use of TST and IGRA testing in contacts tracing is recommended to improve sensitivity in the diagnosis of infected individuals&#46; There are also differences between study sites&#44; with specialist tuberculosis units showing better results&#44; suggesting that the process should be centralized in these clinics to offer more homogeneous care&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authorship</span><p id="par0090" class="elsevierStylePara elsevierViewall">Jos&#233; Antonio Gull&#243;n Blanco participated in the conception and design of the study&#44; data collection&#44; analysis and interpretation&#44; and writing of the article&#46;</p><p id="par0095" class="elsevierStylePara elsevierViewall">Teresa Rodrigo Sanz&#44; Jos&#233; Mar&#237;a Garc&#237;a Garc&#237;a and the PII-TB participated in the critical review of the intellectual content and final approval of the submitted manuscript&#46;</p><p id="par0100" class="elsevierStylePara elsevierViewall">Fernando &#193;lvarez Navascu&#233;s&#44; Eva Tabernero Huguet and Josefina Sabr&#237;a Mestres collaborated in the final approval of the submitted manuscript&#46; The Task Force of the Integrated Research Program in Tuberculosis &#40;PII-TB&#41; has been involved in data collection&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Funding</span><p id="par0105" class="elsevierStylePara elsevierViewall">This study was funded by the <span class="elsevierStyleGrantSponsor" id="gs0005">Instituto de la Salud Carlos III-Fondos FEDER</span> grant <span class="elsevierStyleGrantNumber" refid="gs0005">PI17&#47;00724</span> and by the <span class="elsevierStyleGrantSponsor" id="gs0010">Spanish Society of Pulmonology and Thoracic Surgery &#40;SEPAR&#41;</span> grant <span class="elsevierStyleGrantNumber" refid="gs0010">378&#47;2017</span>&#46;</p></span></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Gull&#243;n Blanco JA&#44; Rodrigo Sanz T&#44; &#193;lvarez Navascues F&#44; Tabernero Huguet E&#44; Sabr&#237;a Mestres J&#44; Garc&#237;a-Garc&#237;a J-M et al&#46; Estudio de contactos de pacientes con tuberculosis&#58; organizaci&#243;n y prevalencia de la infecci&#243;n tuberculosa latente&#46; Arch Bronconeumol&#46; 2021&#59;57&#58;509&#8211;511&#46;</p>"
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            "apendice" => "<p id="par0110" class="elsevierStylePara elsevierViewall">Manuel &#193;ngel Villanueva Montes &#40;Pneumology&#44; Universitty Hospital San Agust&#237;n&#44; Avil&#233;s&#41;&#44; Isabel L&#243;pez Aranaga &#40;Pneumology&#44; University Hospital of Cruces&#44; Baracaldo&#41;&#44; Juan Diego &#193;lvarez Mavarez &#40;Pneumology&#44; Carmen and Severo Ochoa Hospital&#44; Cangas del Narcea&#41;&#44; Mar&#237;a Somoza Gonz&#225;lez &#40; Pneumology&#44; Consorcio Sanitario de Terrassa&#44; Terrassa&#41;&#44; Luis Anibarro Garc&#237;a &#40;Internal Medicine Complejo Hospitalario Universitario de Pontevedera&#41;&#44; Christian Anchorena &#40;Pneumology&#44; Complejo Hospitalario Universitario de Pontevedera&#41;&#44; Isabel Mir Viladrich &#40;Pneumology&#44; Son Llatzer Hospital Palma de Mallorca&#41;&#44; &#193;ngel Dom&#237;nguez Castellano &#40;Infectious Diseases Service&#44; University Hospital Virgen Macarena&#44; Seville&#41;&#44; Ant&#243;n Penas Truque &#40;Pneumology&#44; University Hospital Lucus Augusti&#44; Lugo&#41;&#44; Silvia Dorronsoro Quintana &#40;Pneumology&#44; Hospital of Zum&#225;rraga&#44; Zum&#225;rraga&#41;&#44; Juan Francisco Medina Gallardo &#40;Pneumology&#44; University Hospital Virgen del Roc&#237;o&#44; Seville&#41;&#44; Lander Altube Urrengoetxea &#40;Pneumology&#44; University Hospital of Galdakao&#44; Galdakao&#41;&#44; Mar&#237;a Otero Santiago &#40;University Hospital of &#241;&#241; A Coru&#241;a&#44; A Coru&#241;&#241;na&#41;&#44; Concepci&#243;n Rodr&#237;guez Garc&#237;a &#40;Pneumology&#44; Universitary Hospital San Agust&#237;n&#44; Avil&#233;s&#41; and Juan Rodr&#237;guez L&#243;pez &#40;Pneumology&#44; Grande Covian Hospital&#44; Arriondas&#41;&#46;</p>"
            "etiqueta" => "Appendix A"
            "titulo" => "Members of the PII-TB Research Group &#40;TB Integrated Research Program&#41;&#241;"
            "identificador" => "sec0015"
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          "leyenda" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">&#43;&#58; positive&#59; &#8211;&#58; negative&#59; Dx strategy&#58; diagnostic strategy&#59; EP&#58; extrapulmonary&#59; IGRA&#58; interferon-g release assays&#59; LTBI&#58; latent tuberculous infection&#59; LTBI-T&#58; latent tuberculous infection treatment completed&#59; TB clinic&#58; specialist tuberculosis clinic&#59; TST&#58; tuberculin skin test&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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