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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Malignant pleural effusion &#40;MPE&#41; is the second most common cause of pleural effusion&#44; affecting 15&#37; of cancer patients&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and its presence confirms advanced disease&#46; Survival of cancer patients with MPE ranges from 3&#8211;12 months&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Most MPEs are symptomatic and usually present with dyspnea&#44; chest pain&#44; anorexia&#44; weight loss&#44; and significant loss of quality of life&#46; Management of symptomatic MPE is palliative and should focus on relieving symptoms&#44; mainly dyspnea&#46; Management options include repeated therapeutic thoracentesis&#44; chest drainage with chemical pleurodesis &#40;CP&#41;&#44; tunneled pleural catheter &#40;TPC&#41; placement&#44; or surgery&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Therapeutic thoracentesis is recommended in patients with dyspnea and MPE occupying &#62;50&#37; of the hemithorax&#44; followed by a definitive palliative intervention &#40;CP or TPC&#41;&#46; Repeated therapeutic thoracentesis should be reserved for patients with a life expectancy limited to a few days or weeks&#46; However&#44; the available evidence is still insufficient to determine which definitive palliative treatment is the best option for the initial management of MPEs&#44; since studies to date confirm that both procedures are effective in controlling dyspnea&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The choice may then depend on certain individual clinical factors &#40;comorbidities&#44; recurrence of effusion&#44; presence of septa or trapped lung&#44; tumor characteristics&#44; type of cancer&#44; or estimated survival&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> that should prompt us to evaluate other factors&#44; such as hospital stay&#44; the need for general anesthesia or repeat procedures&#44; side effects&#44; and final cost&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">CP induces an inflammatory pleural response that binds the pleural layers&#44; preventing fluid buildup&#46; Results show that it improves dyspnea and survival&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and reduces hospital stay and the need for future interventions&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The chance of success increases if pH is &#60;7&#46;20 or effusion occupies &#62;50&#37; of the hemitorax&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Issues that have not yet been sufficiently clarified are the appropriate sclerosing agent&#44; the size of the drainage tubes&#44; and the administration of non-steroidal anti-inflammatory drugs to control pain&#46; To date&#44; the most widely used agent is talc&#44; administered either via the thoracoscope using an atomizer &#40;talc poudrage&#41;&#44; or via an intercostal tube in the form of a suspension &#40;talc slurry&#41;&#44; but neither technique has shown superiority over the other&#46; In a recent study&#44; the failure rates of pleurodesis at 90 days were 22&#37; &#40;36&#47;161&#41; and 24&#37; &#40;38&#47;159&#41; for poudrage and slurry&#44; respectively &#40;OR 0&#46;91&#59; 95&#37; CI&#58; 0&#46;54&#8211;1&#46;55&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;74&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The British Thoracic Society states that both approaches have similar efficacy&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Moreover&#44; the size of the drainage tube does not appear to influence the success rate of pleurodesis&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> although smaller tubes &#40;10&#8211;14<span class="elsevierStyleHsp" style=""></span>F&#41; are more comfortable for the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> One of the advantages of pleurodesis is the greater likelihood of rapid resolution of pleural effusion with limited intervention over time&#46; Nevertheless&#44; this procedure is not recommended in the case of trapped lung<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> or multiple septa&#44; as it is only effective if the talc comes into contact with both pleural layers&#46; The procedure is invasive and additional pleural interventions may be required&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">TPC consists of a fenestrated tube that is introduced into the pleural cavity and tunneled through the subcutaneous cell tissue&#59; it terminates in a one-way valve that permits drainage when connected to a vacuum recipient&#44; helping achieve control of the patient&#39;s symptoms&#46; It has shown similar efficacy to talc pleurodesis&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> but requires fewer days of hospitalization&#44; offers more advantages in patients with trapped lung&#44; and is better tolerated by patients with a poor functional status&#46; Pleurodesis is also achieved spontaneously in 46&#37;&#8211;70&#37; of patients with complete pulmonary reexpansion &#40;the effect is greater if drainage is performed on a daily basis than only when symptoms appear&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> However&#44; long-term drainage is required and the complication rate &#40;mainly cellulitis&#41; is high&#44; but tolerance is generally good and significant morbidity is rare&#46; TPCs appear to be more cost-effective in patients with limited survival &#40;&#60;3 months&#41;&#44; while talc pleurodesis may be more cost-effective in patients with a longer life expectancy&#44; although this observation has not yet been confirmed in clinical trials&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A recent study examined a combination of both techniques&#58; CP via TPC&#46; A TPC was placed in 154 patients with MPE and the fluid was drained on an outpatient basis&#46; If there was no substantial trapped lung&#44; patients were randomly assigned to receive talc or placebo via the TPC&#46; The results showed that pleurodesis was achieved in 43&#37; &#40;30&#47;69&#41; of those receiving talc and in 23&#37; &#40;16&#47;70&#41; of those in the placebo group &#40;HR 2&#46;20&#59; 95&#37; CI&#58; 1&#46;23&#8211;3&#46;92&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#41;&#44; with no adverse effects in either group&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Using this combination&#44; the tube could be removed earlier&#44; with the corresponding reduction in drainage discomfort&#44; possible mechanical failure&#44; infection risks&#44; and cost&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; another novel alternative to managing recurrent MPE is to move pleural fluid into the urinary bladder using a pump system&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Surgical pleurectomy has a limited role in the management of MPE and the potential benefits might not warrant the perioperative mortality and loss of quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In short&#44; current evidence suggests that both talc pleurodesis &#40;in poudrage or slurry&#41; and TPCs are effective in the management of symptomatic MPEs&#44; so the choice will depend on factors such as the experience of the medical team&#44; the patient&#39;s decision and their functional status and life expectancy&#44; the tumor type&#44; and the existence of a trapped lung&#46; In our view&#44; the combination of both procedures &#40;pleurodesis by TPC&#41; is the most effective alternative&#44; and one that takes advantage of the benefits of both methods &#40;outpatient management and faster resolution of the effusion&#41;&#44; while minimizing both the discomfort and the cost of this disease&#46; New clinical trials are needed to respond to current controversies and provide more evidence on the effective and standardized management of this disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors contribution</span><p id="par0040" class="elsevierStylePara elsevierViewall">All authors contributed in the same way to the conception&#44; design&#44; writing and final approval of the manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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Editorial
Malignant pleural effusion management
Manejo del derrame pleural maligno
Lucía Ferreiroa,b,
Corresponding author
lucia.ferreiro.fernandez@sergas.es

Corresponding author at: Hospital Clínico Universitario de Santiago, Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, España.
a Hospital Clínico Universitario de Santiago, Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, España
b Hospital Clínico Universitario de Santiago, Santiago de Compostela, España
Juan Suárez-Antelo
Hospital Clínico Universitario de Santiago, Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, España
y Luis Valdésa,b
a Hospital Clínico Universitario de Santiago, Grupo Interdisciplinar de Investigación en Neumología, Instituto de Investigaciones Sanitarias de Santiago (IDIS), Santiago de Compostela, España
b Hospital Clínico Universitario de Santiago, Santiago de Compostela, España
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Malignant pleural effusion &#40;MPE&#41; is the second most common cause of pleural effusion&#44; affecting 15&#37; of cancer patients&#44;<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> and its presence confirms advanced disease&#46; Survival of cancer patients with MPE ranges from 3&#8211;12 months&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Most MPEs are symptomatic and usually present with dyspnea&#44; chest pain&#44; anorexia&#44; weight loss&#44; and significant loss of quality of life&#46; Management of symptomatic MPE is palliative and should focus on relieving symptoms&#44; mainly dyspnea&#46; Management options include repeated therapeutic thoracentesis&#44; chest drainage with chemical pleurodesis &#40;CP&#41;&#44; tunneled pleural catheter &#40;TPC&#41; placement&#44; or surgery&#46;</p><p id="par0010" class="elsevierStylePara elsevierViewall">Therapeutic thoracentesis is recommended in patients with dyspnea and MPE occupying &#62;50&#37; of the hemithorax&#44; followed by a definitive palliative intervention &#40;CP or TPC&#41;&#46; Repeated therapeutic thoracentesis should be reserved for patients with a life expectancy limited to a few days or weeks&#46; However&#44; the available evidence is still insufficient to determine which definitive palliative treatment is the best option for the initial management of MPEs&#44; since studies to date confirm that both procedures are effective in controlling dyspnea&#46;<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3&#44;4</span></a> The choice may then depend on certain individual clinical factors &#40;comorbidities&#44; recurrence of effusion&#44; presence of septa or trapped lung&#44; tumor characteristics&#44; type of cancer&#44; or estimated survival&#41;<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> that should prompt us to evaluate other factors&#44; such as hospital stay&#44; the need for general anesthesia or repeat procedures&#44; side effects&#44; and final cost&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">CP induces an inflammatory pleural response that binds the pleural layers&#44; preventing fluid buildup&#46; Results show that it improves dyspnea and survival&#44;<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> and reduces hospital stay and the need for future interventions&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The chance of success increases if pH is &#60;7&#46;20 or effusion occupies &#62;50&#37; of the hemitorax&#46;<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> Issues that have not yet been sufficiently clarified are the appropriate sclerosing agent&#44; the size of the drainage tubes&#44; and the administration of non-steroidal anti-inflammatory drugs to control pain&#46; To date&#44; the most widely used agent is talc&#44; administered either via the thoracoscope using an atomizer &#40;talc poudrage&#41;&#44; or via an intercostal tube in the form of a suspension &#40;talc slurry&#41;&#44; but neither technique has shown superiority over the other&#46; In a recent study&#44; the failure rates of pleurodesis at 90 days were 22&#37; &#40;36&#47;161&#41; and 24&#37; &#40;38&#47;159&#41; for poudrage and slurry&#44; respectively &#40;OR 0&#46;91&#59; 95&#37; CI&#58; 0&#46;54&#8211;1&#46;55&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;74&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> The British Thoracic Society states that both approaches have similar efficacy&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Moreover&#44; the size of the drainage tube does not appear to influence the success rate of pleurodesis&#44;<a class="elsevierStyleCrossRef" href="#bib0045"><span class="elsevierStyleSup">9</span></a> although smaller tubes &#40;10&#8211;14<span class="elsevierStyleHsp" style=""></span>F&#41; are more comfortable for the patient&#46;<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> One of the advantages of pleurodesis is the greater likelihood of rapid resolution of pleural effusion with limited intervention over time&#46; Nevertheless&#44; this procedure is not recommended in the case of trapped lung<a class="elsevierStyleCrossRefs" href="#bib0055"><span class="elsevierStyleSup">11&#44;12</span></a> or multiple septa&#44; as it is only effective if the talc comes into contact with both pleural layers&#46; The procedure is invasive and additional pleural interventions may be required&#46;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a></p><p id="par0020" class="elsevierStylePara elsevierViewall">TPC consists of a fenestrated tube that is introduced into the pleural cavity and tunneled through the subcutaneous cell tissue&#59; it terminates in a one-way valve that permits drainage when connected to a vacuum recipient&#44; helping achieve control of the patient&#39;s symptoms&#46; It has shown similar efficacy to talc pleurodesis&#44;<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> but requires fewer days of hospitalization&#44; offers more advantages in patients with trapped lung&#44; and is better tolerated by patients with a poor functional status&#46; Pleurodesis is also achieved spontaneously in 46&#37;&#8211;70&#37; of patients with complete pulmonary reexpansion &#40;the effect is greater if drainage is performed on a daily basis than only when symptoms appear&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> However&#44; long-term drainage is required and the complication rate &#40;mainly cellulitis&#41; is high&#44; but tolerance is generally good and significant morbidity is rare&#46; TPCs appear to be more cost-effective in patients with limited survival &#40;&#60;3 months&#41;&#44; while talc pleurodesis may be more cost-effective in patients with a longer life expectancy&#44; although this observation has not yet been confirmed in clinical trials&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall">A recent study examined a combination of both techniques&#58; CP via TPC&#46; A TPC was placed in 154 patients with MPE and the fluid was drained on an outpatient basis&#46; If there was no substantial trapped lung&#44; patients were randomly assigned to receive talc or placebo via the TPC&#46; The results showed that pleurodesis was achieved in 43&#37; &#40;30&#47;69&#41; of those receiving talc and in 23&#37; &#40;16&#47;70&#41; of those in the placebo group &#40;HR 2&#46;20&#59; 95&#37; CI&#58; 1&#46;23&#8211;3&#46;92&#59; p<span class="elsevierStyleHsp" style=""></span>&#61;<span class="elsevierStyleHsp" style=""></span>0&#46;008&#41;&#44; with no adverse effects in either group&#46;<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> Using this combination&#44; the tube could be removed earlier&#44; with the corresponding reduction in drainage discomfort&#44; possible mechanical failure&#44; infection risks&#44; and cost&#46;</p><p id="par0030" class="elsevierStylePara elsevierViewall">Finally&#44; another novel alternative to managing recurrent MPE is to move pleural fluid into the urinary bladder using a pump system&#46;<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> Surgical pleurectomy has a limited role in the management of MPE and the potential benefits might not warrant the perioperative mortality and loss of quality of life&#46;<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">In short&#44; current evidence suggests that both talc pleurodesis &#40;in poudrage or slurry&#41; and TPCs are effective in the management of symptomatic MPEs&#44; so the choice will depend on factors such as the experience of the medical team&#44; the patient&#39;s decision and their functional status and life expectancy&#44; the tumor type&#44; and the existence of a trapped lung&#46; In our view&#44; the combination of both procedures &#40;pleurodesis by TPC&#41; is the most effective alternative&#44; and one that takes advantage of the benefits of both methods &#40;outpatient management and faster resolution of the effusion&#41;&#44; while minimizing both the discomfort and the cost of this disease&#46; New clinical trials are needed to respond to current controversies and provide more evidence on the effective and standardized management of this disease&#46;</p><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0005">Authors contribution</span><p id="par0040" class="elsevierStylePara elsevierViewall">All authors contributed in the same way to the conception&#44; design&#44; writing and final approval of the manuscript&#46;</p></span><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0010">Conflict of interests</span><p id="par0045" class="elsevierStylePara elsevierViewall">The authors state that they have no conflict of interests&#46;</p></span></span>"
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Article information
ISSN: 15792129
Original language: English
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