was read the article
array:24 [ "pii" => "S1579212920302809" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.06.007" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "2546" "copyright" => "SEPAR" "copyrightAnyo" => "2020" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2020;56:766-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0300289620302192" "issn" => "03002896" "doi" => "10.1016/j.arbres.2020.06.016" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "2546" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2020;56:766-7" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "es" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta al Director</span>" "titulo" => "Respuesta a «Dual antibiotic therapy for outpatient management of community-acquired pneumonia?»" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "766" "paginaFinal" => "767" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Reply to “Dual Antibiotic Therapy for Outpatient Management of Community-Acquired Pneumonia?”" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Rosario Menéndez, Raúl Méndez, Antoni Torres" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Rosario" "apellidos" => "Menéndez" ] 1 => array:2 [ "nombre" => "Raúl" "apellidos" => "Méndez" ] 2 => array:2 [ "nombre" => "Antoni" "apellidos" => "Torres" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212920302809" "doi" => "10.1016/j.arbr.2020.06.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920302809?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620302192?idApp=UINPBA00003Z" "url" => "/03002896/0000005600000011/v2_202011100719/S0300289620302192/v2_202011100719/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S1579212920302937" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.05.012" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "2509" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2020;56:767-8" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "When the Need is Greater Than Feasible" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "767" "paginaFinal" => "768" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cuando la necesidad es mayor de lo factible" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1268 "Ancho" => 1250 "Tamanyo" => 69894 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Fissios App Logo.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carlos Alfredo Fraile Olivero, José Ramón Jarabo Sarceda, Carlos Cerdán Santacruz, Passio Santos Capa, Pedro Daniel Arribas Manzanal, Rafael Barriuso, Florentino Hernando Trancho" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Carlos Alfredo" "apellidos" => "Fraile Olivero" ] 1 => array:2 [ "nombre" => "José Ramón" "apellidos" => "Jarabo Sarceda" ] 2 => array:2 [ "nombre" => "Carlos" "apellidos" => "Cerdán Santacruz" ] 3 => array:2 [ "nombre" => "Passio" "apellidos" => "Santos Capa" ] 4 => array:2 [ "nombre" => "Pedro Daniel" "apellidos" => "Arribas Manzanal" ] 5 => array:2 [ "nombre" => "Rafael" "apellidos" => "Barriuso" ] 6 => array:2 [ "nombre" => "Florentino" "apellidos" => "Hernando Trancho" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920302937?idApp=UINPBA00003Z" "url" => "/15792129/0000005600000011/v1_202011120627/S1579212920302937/v1_202011120627/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212920302949" "issn" => "15792129" "doi" => "10.1016/j.arbr.2020.05.013" "estado" => "S300" "fechaPublicacion" => "2020-11-01" "aid" => "2505" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "cor" "cita" => "Arch Bronconeumol. 2020;56:765-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Dual Antibiotic Therapy for Outpatient Management of Community-acquired Pneumonia?" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "765" "paginaFinal" => "766" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "¿Tratamiento antibiótico dual en el manejo ambulatorio de la neumonía adquirida en la comunidad?" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Carles Llor, Ana Moragas, Kristin Vevatne" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Carles" "apellidos" => "Llor" ] 1 => array:2 [ "nombre" => "Ana" "apellidos" => "Moragas" ] 2 => array:2 [ "nombre" => "Kristin" "apellidos" => "Vevatne" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920302949?idApp=UINPBA00003Z" "url" => "/15792129/0000005600000011/v1_202011120627/S1579212920302949/v1_202011120627/en/main.assets" ] "en" => array:13 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Letter to the Editor</span>" "titulo" => "Reply to “Dual antibiotic therapy for outpatient management of community-acquired pneumonia?”" "tieneTextoCompleto" => true "saludo" => "To the Editor:" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "766" "paginaFinal" => "767" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Rosario Menéndez, Raúl Méndez, Antoni Torres" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Rosario" "apellidos" => "Menéndez" "email" => array:1 [ 0 => "rosmenend@gmail.com" ] "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Raúl" "apellidos" => "Méndez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Antoni" "apellidos" => "Torres" "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] ] ] ] "afiliaciones" => array:3 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario y Politécnico La Fe, Valencia, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "CIBER Enfermedades Respiratorias (CIBERES), Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Clínic, Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Respuesta a «Dual antibiotic therapy for outpatient management of community-acquired pneumonia?»" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">One of the most controversial topics in the recommendations and consensus documents on antibiotic treatment in respiratory infections is the choice of outpatient treatment of pneumonia. The debate between monotherapy with a beta-lactam or combination with a macrolide leads to differences of opinion among clinicians, and even among scientific societies.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,2</span></a> There is some logic to the arguments, and several reasons to justify both approaches in the treatment of mild pneumonia. The first and most important is that no randomized trials with sufficient patient numbers have been conducted in different geographical areas and over long periods that include different seasons, comparing the use of a beta-lactam alone versus the combination of a beta-lactam with a macrolide. The few studies in non-hospitalized patients use mortality as a study variable, which is unhelpful since death rates are very low in this setting, and it is unlikely that significant differences will be detected. Other outcomes, such as therapeutic failure, complications or need for later admission, would be of greater interest. Secondly, because microbiological studies are not performed, there is a shortage of etiological information in mild pneumonia, so the percentage of intracellular microorganisms in which macrolides play an obvious role is unknown. The few studies that use microbiological molecular diagnostic techniques show that the prevalence of these intracellular bacteria, in particular <span class="elsevierStyleItalic">Legionella pneumophila</span>, is underestimated. Moreover, in the early stages of infection, urinary antigen testing for <span class="elsevierStyleItalic">Legionella pneumophila</span> may give false negatives, and this technique also only recognizes serotype <span class="elsevierStyleSmallCaps">i</span>. In Spain<span class="elsevierStyleItalic">, Legionella pneumophila</span> occurs in up to 6% of cases in the outpatient setting and a beta-lactam in monotherapy is insufficient.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> Microbiological point-of-care testing in the outpatient setting that covers a range of bacteria and viruses would be very useful for improving etiological information; however, we are aware that these services are not available in standard practice and conventional microbiological studies are not recommended in the guidelines. The third factor is the possibility of pneumonia caused by mixed etiologies such as pneumococcus and intracellular bacteria or the possibility of bacteremia in mild pneumonias.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> For all these reasons, the therapeutic approach to mild pneumonias should always include a regimen offering complete cover that always includes pneumococcus and intracellular bacteria, in order to reduce the chance of failure. Efforts must be made to avoid continuing the macrolide for more than 3 or 5 days if the response is good.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Horita et al. published a meta-analysis<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a> analyzing the impact of the combination of beta-lactams and macrolides on mortality, but only 3 studies were included in the mild/moderate pneumonia subgroup. This is insufficient to properly address mortality, and the authors recognize the shortage of randomized and observational studies in their paper. Asadi et al.,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> in an observational study of 2,845 patients, compared macrolides with quinolones, and found fewer hospital admissions and lower mortality (0.2 vs. 3.0%, p = 0.02) in the macrolide group. In fact, macrolides have even shown good outcomes in patients with risk factors for pneumococcal resistance.<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a></p><p id="par0015" class="elsevierStylePara elsevierViewall">When the decision has to be made between using fewer antibiotics or offering complete coverage of the most common microorganisms of mild pneumonia, the SEPAR update of the CAP guidelines leans towards the second option. We agree that a very large, well-designed randomized trial may provide an answer to this unresolved issue.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Menéndez R, Méndez R, Torres A. Respuesta a «Dual antibiotic therapy for outpatient management of community-acquired pneumonia?». Arch Bronconeumol. 2020;56:766–767.</p>" ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:7 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Neumonía adquirida en la comunidad. Normativa de la SEPAR. Actualización 2020" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R Menéndez" 1 => "C. Cilloniz" 2 => "P.P. España" 3 => "J. Almirall" 4 => "A. Uranga" 5 => "R. Méndez" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2020.05.017" "Revista" => array:8 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2020" "volumen" => "56" "numero" => "Supl 1" "paginaInicial" => "1" "paginaFinal" => "10" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/32586707" "web" => "Medline" ] ] "itemHostRev" => array:3 [ "pii" => "S1473309914708278" "estado" => "S300" "issn" => "14733099" ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0010" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Dual antibiotic therapy for outpatient management of community-acquired pneumonia?" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:3 [ 0 => "C. Llor" 1 => "A. Moragas" 2 => "K. Vevatne" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2020.05.016" "Revista" => array:2 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2020" ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0015" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Microbial aetiology of community-acquired pneumonia and its relation to severity" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "C Cilloniz" 1 => "S Ewig" 2 => "E Polverino" 3 => "MA Marcos" 4 => "C Esquinas" 5 => "A Gabarrus" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2010.143982" "Revista" => array:6 [ "tituloSerie" => "Thorax" "fecha" => "2011" "volumen" => "66" "paginaInicial" => "340" "paginaFinal" => "346" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21257985" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0020" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Polymicrobial community-acquired pneumonia: An emerging entity" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "C. Cillóniz" 1 => "R. Civljak" 2 => "A. Nicolini" 3 => "A. Torres" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/resp.12663" "Revista" => array:6 [ "tituloSerie" => "Respirology" "fecha" => "2016" "volumen" => "21" "paginaInicial" => "65" "paginaFinal" => "75" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26494527" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0025" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Beta-lactam plus macrolideor beta-lactam alone for community-acquired pneumonia: A systematic review and meta-analysis" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "N. Horita" 1 => "T. Otska" 2 => "S. Haranaga" 3 => "H. Namkoong" 4 => "M. Miki" 5 => "N. Miyashita" ] ] ] ] ] "host" => array:1 [ 0 => array:1 [ "Revista" => array:5 [ "tituloSerie" => "Respirology" "fecha" => "2016" "volumen" => "21" "paginaInicial" => "1193" "paginaFinal" => "1200" ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0030" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Guideline adherence and macrolides reduced mortality in outpatients with pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "L. Asadi" 1 => "D.T. Eurich" 2 => "J.M. Gamble" 3 => "J.K. Minhas-Sandhu" 4 => "T.J. Marrie" 5 => "S.R. Majumdar" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.rmed.2011.11.017" "Revista" => array:6 [ "tituloSerie" => "Respir Med" "fecha" => "2012" "volumen" => "106" "paginaInicial" => "451" "paginaFinal" => "458" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22182341" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0035" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Risk factors for drug-resistant Streptococcus pneumoniae and antibiotic prescribing practices in outpatient community-acquired pneumonia" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "T.C. Jenkins" 1 => "J. Sakai" 2 => "B.C. Knepper" 3 => "C.J. Swartwood" 4 => "J.S. Haukoos" 5 => "J.A. Long" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1111/j.1553-2712.2012.01365.x" "Revista" => array:6 [ "tituloSerie" => "Acad Emerg Med" "fecha" => "2012" "volumen" => "19" "paginaInicial" => "703" "paginaFinal" => "706" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22632455" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005600000011/v1_202011120627/S1579212920302809/v1_202011120627/en/main.assets" "Apartado" => array:4 [ "identificador" => "45358" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Letters to the Editor" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005600000011/v1_202011120627/S1579212920302809/v1_202011120627/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920302809?idApp=UINPBA00003Z" ]
Year/Month | Html | Total | |
---|---|---|---|
2024 November | 3 | 2 | 5 |
2024 October | 38 | 17 | 55 |
2024 September | 46 | 20 | 66 |
2024 August | 59 | 40 | 99 |
2024 July | 38 | 18 | 56 |
2024 June | 54 | 44 | 98 |
2024 May | 77 | 34 | 111 |
2024 April | 30 | 27 | 57 |
2024 March | 36 | 20 | 56 |
2024 February | 38 | 25 | 63 |
2023 October | 4 | 2 | 6 |
2023 March | 3 | 6 | 9 |
2023 February | 29 | 22 | 51 |
2023 January | 27 | 30 | 57 |
2022 December | 42 | 18 | 60 |
2022 November | 55 | 27 | 82 |
2022 October | 50 | 24 | 74 |
2022 September | 34 | 25 | 59 |
2022 August | 36 | 43 | 79 |
2022 July | 39 | 47 | 86 |
2022 June | 34 | 31 | 65 |
2022 May | 27 | 34 | 61 |
2022 April | 41 | 30 | 71 |
2022 March | 36 | 41 | 77 |
2022 February | 18 | 15 | 33 |
2021 March | 3 | 0 | 3 |
2020 December | 1 | 0 | 1 |