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"tieneTextoCompleto" => true "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "619" "paginaFinal" => "620" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Ana Balañá Corberó, Marisol Domínguez-Álvarez, Esther Barreiro" "autores" => array:3 [ 0 => array:4 [ "nombre" => "Ana" "apellidos" => "Balañá Corberó" "email" => array:1 [ 0 => "60355@parcdesalutmar.cat" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Marisol" "apellidos" => "Domínguez-Álvarez" "referencia" => array:3 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">d</span>" "identificador" => "aff0020" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] 2 => array:3 [ "nombre" => "Esther" "apellidos" => "Barreiro" "referencia" => array:4 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] 2 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">c</span>" "identificador" => "aff0015" ] 3 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">e</span>" "identificador" => "aff0025" ] ] ] ] "afiliaciones" => array:5 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital del Mar-Institut de Recerca de l’Hospital del Mar (IMIM), Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología-Debilidad muscular y caquexia en las enfermedades respiratorias crónicas y el cáncer de pulmón, IMIM-Hospital del Mar, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] 2 => array:3 [ "entidad" => "Departament de Ciències Experimentals i de la Salut (CEXS), Universitat Pompeu Fabra (UPF), Parc de Recerca Biomédica de Barcelona (PRBB), Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Universidad Autónoma Barcelona (UAB), Barcelona, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Centro de Investigación en Red de Enfermedades Respiratorias (CIBERES), Instituto de Salud Carlos III (ISCIII), Barcelona, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "La fisioterapia respiratoria en el síndrome de <span class="elsevierStyleItalic">Lady Windermere</span>: ¿el eslabón perdido?" ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lady Windermere syndrome was first described in 1992 by Reich and Johnson.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> It was named after the female character in Oscar Wilde's play – Lady Windermere – who hid behind her fan to voluntarily inhibit coughing, since it was not socially acceptable for “ladies” to clear secretions in public. This syndrome was described in non-smoking women, with a mean age of 60–70 years, no underlying lung disease, growth of <span class="elsevierStyleItalic">Mycobacterium avium</span> complex in respiratory samples, and development of bronchiectasis mainly involving the middle lobe and/or the lingula. Other phenotypic characteristics associated with the disease have been described, such as pectus excavatum, scoliosis, mitral valve prolapse, and a slender body habitus.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> One of the etiological factors involved in its pathophysiology is the voluntary suppression of cough, which, coupled with anatomical peculiarities of both the middle lobe and the lingula and long narrow bronchi, would favor the accumulation of secretions in these lung regions. In addition, a slender body habitus, with a narrow anteroposterior diameter of the chest, increases this regional susceptibility, and together with pectus excavatum can limit the drainage of secretions. The existence of a genetic predisposition for the presence of allelic variants of the gene regulating the transmembrane conductibility of cystic fibrosis and its phenotypic similarity with inherited connective tissue disorders can also contribute to its pathogenesis.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,4</span></a> Other factors such as alterations in systemic leptin or adiponectin levels and menopause may also play a role in pathogenesis.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">The presence of <span class="elsevierStyleItalic">Mycobacterium avium</span> complex usually precedes the development of bronchiectasis, so it is important to assess whether it meets criteria for treatment,<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> which is long (minimum 1 year) and complex due to the potential side effects of the drugs used. Initial combined treatment with clarithromycin/azithromycin, rifampicin, and ethambutol is the right approach in most patients. Given the high estimated health resources needed<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a> and effects of long-term antibiotic treatment, the development of non-pharmacological therapies that support conventional treatments but do not cause adverse effects is being encouraged.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The latest national and international pulmonology guidelines<a class="elsevierStyleCrossRefs" href="#bib0040"><span class="elsevierStyleSup">8,9</span></a> recommend drainage of secretions in patients with bronchiectasis from the early stages, so it is clear that respiratory physiotherapy (RP) would benefit these patients and hospitals need to make adequate provision for efficient RP programs with specialized physiotherapists. Indeed, a recent survey conducted in Belgium reported that up to 84% of patients with bronchiectasis were seen by a respiratory physiotherapist for bronchial hygiene.<a class="elsevierStyleCrossRef" href="#bib0050"><span class="elsevierStyleSup">10</span></a> Therefore, drug treatment aside, in patients with Lady Windermere syndrome, as in patients with bronchiectasis, the drainage of mucopurulent secretions that can favor infection or colonization by pathogenic organisms may be crucial to breaking the circle described by Cole et al. in 1986.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> In this entity, as in any other non-tuberculous mycobacterial (NTM) infection, it is unclear whether it is the chronic NTM infection that causes bronchiectasis, or whether the previous presence of bronchiectasis facilitates colonization by NTM. Whatever the case, the inability to eradicate NTM from the bronchial tree causes a chronic granulomatous inflammatory response with increased inflammatory cytokines, chemokines, and neutrophil recruitment. These release proteolytic enzymes leading to destruction and damage of the bronchial wall, with the formation of new bronchiectasis. Moreover, this inflammatory cascade causes greater changes in mucociliary clearance, favoring the formation of mucous plugs and perpetuating chronic airway inflammation.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">12</span></a> Thus, in this population with a high inflammatory burden and voluntary suppression of the cough mechanism, priority must be given to RF techniques that facilitate the drainage of secretions, although other techniques also exist.</p><p id="par0020" class="elsevierStylePara elsevierViewall">In order to ensure airway patency, physiotherapists apply two types of techniques: manual and instrumental. The manual techniques are: autogenous drainage, total slow expiration with open glottis in lateral decubitus (ELTGOL, from the French Expiration Lente Totale Glotte Ouverte en décubitus Latéral), active ventilatory cycle, and cough itself; while the instrumental techniques are performed using positive oscillating and non-oscillating expiratory pressure devices, most often external high-frequency oscillating-compression devices on the chest wall and percussive intrapulmonary ventilation.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">13</span></a> Treatment should begin with manual techniques that allow good bronchial hygiene to be maintained by modulating the expiratory flow (laminar or turbulent) depending on the location of the secretions. Thus, low expiratory (laminar) flow techniques will be applied for distal secretions, and as these move towards more central airways (assessed by respiratory auscultation), high expiratory (turbulent) flow techniques will be applied. This sequence of maneuvers will make it easier for the patient to finally be able to cough.</p><p id="par0025" class="elsevierStylePara elsevierViewall">Scientific evidence currently underlines the utility of ELTGOL among bronchial hygiene maneuvers. ELTGOL involves the patient being be placed in lateral decubitus, on the affected lung, thus favoring maximum deflation and gas-liquid interaction. The patient is then asked to breath normally at tidal volumes, and then breathe out the air with the glottis open, producing a laminar flow until the end of the expiratory reserve volume is reached, preferably with the manual assistance of the physiotherapist.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In 2018, Muñoz et al.<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">15</span></a> provided more evidence on this technique with the publication of a randomized study which concluded that applying ELTGOL twice a day for 1 year not only produced an increase in the amount of sputum mobilized, but also reduced the number of exacerbations, improving quality of life in patients with bronchiectasis.</p><p id="par0030" class="elsevierStylePara elsevierViewall">Today, as in the case of bronchiectasis, RP combined with long antibiotic treatments to reduce the inflammatory burden in the bronchial tree play a fundamental role in improving clinical management of patients with Lady Windermere syndrome. More randomized studies are needed to identify the effects of RP and the best bronchial hygiene techniques in these patients.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-08-30" "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Balañá Corberó A, Domínguez-Álvarez M, Barreiro E. La fisioterapia respiratoria en el síndrome de <span class="elsevierStyleItalic">Lady Windermere</span>: ¿el eslabón perdido? 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 7 | 4 | 11 |
2024 October | 47 | 21 | 68 |
2024 September | 54 | 22 | 76 |
2024 August | 66 | 48 | 114 |
2024 July | 52 | 19 | 71 |
2024 June | 66 | 33 | 99 |
2024 May | 76 | 22 | 98 |
2024 April | 35 | 34 | 69 |
2024 March | 42 | 20 | 62 |
2024 February | 31 | 15 | 46 |
2023 March | 14 | 3 | 17 |
2023 February | 78 | 16 | 94 |
2023 January | 50 | 29 | 79 |
2022 December | 86 | 24 | 110 |
2022 November | 67 | 24 | 91 |
2022 October | 76 | 30 | 106 |
2022 September | 42 | 19 | 61 |
2022 August | 48 | 45 | 93 |
2022 July | 43 | 37 | 80 |
2022 June | 47 | 34 | 81 |
2022 May | 38 | 40 | 78 |
2022 April | 44 | 27 | 71 |
2022 March | 46 | 36 | 82 |
2022 February | 19 | 25 | 44 |
2021 November | 1 | 0 | 1 |
2021 September | 1 | 2 | 3 |
2021 May | 0 | 1 | 1 |
2020 November | 1 | 0 | 1 |
2020 October | 1 | 0 | 1 |