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ratio of 0&#46;6&#44; with FEV<span class="elsevierStyleInf">1</span> 75&#37;&#44; and FVC 101&#37;&#46; A diagnosis of chronic obstructive pulmonary disease &#40;COPD&#41; was given and treatment started with tiotropium&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">One week after bronchoscopy&#44; the patient attended the emergency department with a fever of 39<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; cough and a 6-day history of purulent expectoration that did not improve after treatment with amoxicillin&#8211;clavulanic acid&#46; She was admitted and treated with levofloxacin and imipenem&#46; Sputum analysis showed the presence of alcohol-resistant bacilli&#44; so given the possibility of pulmonary tuberculosis&#44; treatment was changed to rifampicin&#44; isoniazid&#44; pyrazinamide&#44; and ethambutol&#46; Polymerase chain reaction &#40;PCR&#41; for <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> was negative&#44; so pending mycobacteria culture results&#44; and after clinical and radiological improvement&#44; the patient was discharged with the same treatment&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">One month later&#44; growth of <span class="elsevierStyleItalic">Mycobacterium malmoense</span> was observed in the culture of 3 different sputum samples and in bronchoalveolar lavage&#46; These were inoculated into solid &#40;Lowein-Jensen and Coletsos&#41; and liquid &#40;Versatrek system&#41; media&#46; The microorganism was identified using the GenoType CM&#47;as kit&#46; The antibiogram showed sensitivity to rifampicin&#44; clarithromycin&#44; and streptomycin&#44; and resistance to isoniazid and pyrazinamide&#46; In view of these results&#44; treatment was changed to rifabutin&#44; ethambutol&#44; and clarithromycin&#46; After beginning this regimen&#44; the patient reported asthenia&#44; hyporexia&#44; and vomiting&#44; so the treatment schedule was changed to daily rifampicin&#44; and ethambutol on Monday&#44; Wednesday and Friday&#46; The patient&#39;s side effects resolved&#44; so the dose of ethambutol was gradually increased to a daily dose&#44; with adequate clinical tolerance&#46; The treatment continued for 2 years&#44; after which the patient remained asymptomatic with radiological improvement&#46; Residual lesions persisted in the chest CT&#44; but the size of the right upper cavity and lung nodules decreased&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">M&#46; malmoense</span> is the most common non-tuberculous mycobacteria in northern European countries&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> In other European countries&#44; a limited number of cases have been published&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> but in Spain&#44; series of only 5<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> to 20 cases have been described in the last 35 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;6</span></a> Risk factors for infection are the same as for any other mycobacteria&#58; immunosuppression&#44; previous respiratory diseases&#44; smoking&#44; and alcohol abuse&#44; all of which were present in our patient&#46; Since there are a greater numbers of patients with underlying lung diseases or immunosuppressive treatments&#44; the incidence of <span class="elsevierStyleItalic">M&#46; malmoense</span> infection is likely to continue to increase&#46; Infection with this mycobacteria is clinically significant in about 70&#37;&#8211;80&#37; of patients with lung disease&#46; It is also the most important pathogen after <span class="elsevierStyleItalic">Mycobacterium avium</span> complex&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The isolation of <span class="elsevierStyleItalic">M&#46; malmoense</span> in respiratory samples is probably indicative of infection&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> In our patient&#44; we reached a diagnosis after observing <span class="elsevierStyleItalic">M&#46; malmoense</span> growth in sputum and bronchoalveolar lavage cultures&#46; The microorganism was identified using a molecular technique &#40;GenoType CM&#47;as&#41; that&#44; due to its speed and effectiveness&#44; has now replaced conventional biochemical tests in most laboratories&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> More recently&#44; the MALDI-TOF technique has been introduced for the identification of microorganisms&#44; including mycobacteria&#46; Although it was not used in this case&#44; this technique has already proved its usefulness&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> A 2-year course of a combination of rifampicin &#40;or rifabutin&#41; and ethambutol is recommended for the treatment of these infections&#44; and clarithromycin may be added on a case-by-case basis&#46; Triple therapy has not been shown to be superior to dual therapy&#44; so sometimes the latter is preferred due to frequent adverse effects associated with clarithromycin&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> In our case&#44; the determination of antimicrobial sensitivity was also of great help in deciding on treatment&#46; This was achieved using the broth microdilution technique&#44; using cut-off points established by the Clinical and Laboratory Standards Institute &#40;CLSI&#41; for <span class="elsevierStyleItalic">M&#46; avium</span> complex&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We conclude that although the frequency of respiratory infections caused by <span class="elsevierStyleItalic">M&#46; malmoense</span> in Spain is low&#44; it is probably increasing and is here to stay&#46; Unfortunately&#44; there is little evidence regarding the effectiveness of treatment&#44; although long-term dual therapy seems to be effective in managing this pathology&#46; As with other mycobacteria&#44; microbiological study is important for the management of these infections&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Laso del Hierro FJ&#44; L&#243;pez Yeste P&#44; Naya Prieto A&#44; Carballosa de Miguel MdP&#44; Esteban Moreno J&#44; Villar &#193;lvarez F&#46; <span class="elsevierStyleItalic">Mycobacterium malmoense</span>&#44; &#191;ha llegado para quedarse&#63; Arch Bronconeumol&#46; 2020&#59;56&#58;401&#8211;402&#46;</p>"
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Scientific Letter
Mycobacterium malmoense. Is It Here to Stay?
Mycobacterium malmoense, ¿ha llegado para quedarse?
Francisco José Laso del Hierroa, Pablo López Yestea, Alba Naya Prietoa, María del Pilar Carballosa de Miguela, Jaime Esteban Morenob, Felipe Villar Álvareza,
Corresponding author
fvillarleon@yahoo.es

Corresponding author.
a Servicio de Neumología, IIS Fundación Jiménez Díaz, CIBERES, UAM, Madrid, Spain
b Servicio de Microbiología Clínica, IIS Fundación Jiménez Díaz, UAM, Madrid, Spain
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ratio of 0&#46;6&#44; with FEV<span class="elsevierStyleInf">1</span> 75&#37;&#44; and FVC 101&#37;&#46; A diagnosis of chronic obstructive pulmonary disease &#40;COPD&#41; was given and treatment started with tiotropium&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">One week after bronchoscopy&#44; the patient attended the emergency department with a fever of 39<span class="elsevierStyleHsp" style=""></span>&#176;C&#44; cough and a 6-day history of purulent expectoration that did not improve after treatment with amoxicillin&#8211;clavulanic acid&#46; She was admitted and treated with levofloxacin and imipenem&#46; Sputum analysis showed the presence of alcohol-resistant bacilli&#44; so given the possibility of pulmonary tuberculosis&#44; treatment was changed to rifampicin&#44; isoniazid&#44; pyrazinamide&#44; and ethambutol&#46; Polymerase chain reaction &#40;PCR&#41; for <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> was negative&#44; so pending mycobacteria culture results&#44; and after clinical and radiological improvement&#44; the patient was discharged with the same treatment&#46;</p><p id="par0020" class="elsevierStylePara elsevierViewall">One month later&#44; growth of <span class="elsevierStyleItalic">Mycobacterium malmoense</span> was observed in the culture of 3 different sputum samples and in bronchoalveolar lavage&#46; These were inoculated into solid &#40;Lowein-Jensen and Coletsos&#41; and liquid &#40;Versatrek system&#41; media&#46; The microorganism was identified using the GenoType CM&#47;as kit&#46; The antibiogram showed sensitivity to rifampicin&#44; clarithromycin&#44; and streptomycin&#44; and resistance to isoniazid and pyrazinamide&#46; In view of these results&#44; treatment was changed to rifabutin&#44; ethambutol&#44; and clarithromycin&#46; After beginning this regimen&#44; the patient reported asthenia&#44; hyporexia&#44; and vomiting&#44; so the treatment schedule was changed to daily rifampicin&#44; and ethambutol on Monday&#44; Wednesday and Friday&#46; The patient&#39;s side effects resolved&#44; so the dose of ethambutol was gradually increased to a daily dose&#44; with adequate clinical tolerance&#46; The treatment continued for 2 years&#44; after which the patient remained asymptomatic with radiological improvement&#46; Residual lesions persisted in the chest CT&#44; but the size of the right upper cavity and lung nodules decreased&#46;</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">M&#46; malmoense</span> is the most common non-tuberculous mycobacteria in northern European countries&#46;<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> In other European countries&#44; a limited number of cases have been published&#44;<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3&#44;4</span></a> but in Spain&#44; series of only 5<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> to 20 cases have been described in the last 35 years&#46;<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5&#44;6</span></a> Risk factors for infection are the same as for any other mycobacteria&#58; immunosuppression&#44; previous respiratory diseases&#44; smoking&#44; and alcohol abuse&#44; all of which were present in our patient&#46; Since there are a greater numbers of patients with underlying lung diseases or immunosuppressive treatments&#44; the incidence of <span class="elsevierStyleItalic">M&#46; malmoense</span> infection is likely to continue to increase&#46; Infection with this mycobacteria is clinically significant in about 70&#37;&#8211;80&#37; of patients with lung disease&#46; It is also the most important pathogen after <span class="elsevierStyleItalic">Mycobacterium avium</span> complex&#46;<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The isolation of <span class="elsevierStyleItalic">M&#46; malmoense</span> in respiratory samples is probably indicative of infection&#46;<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> In our patient&#44; we reached a diagnosis after observing <span class="elsevierStyleItalic">M&#46; malmoense</span> growth in sputum and bronchoalveolar lavage cultures&#46; The microorganism was identified using a molecular technique &#40;GenoType CM&#47;as&#41; that&#44; due to its speed and effectiveness&#44; has now replaced conventional biochemical tests in most laboratories&#46;<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> More recently&#44; the MALDI-TOF technique has been introduced for the identification of microorganisms&#44; including mycobacteria&#46; Although it was not used in this case&#44; this technique has already proved its usefulness&#46;<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> A 2-year course of a combination of rifampicin &#40;or rifabutin&#41; and ethambutol is recommended for the treatment of these infections&#44; and clarithromycin may be added on a case-by-case basis&#46; Triple therapy has not been shown to be superior to dual therapy&#44; so sometimes the latter is preferred due to frequent adverse effects associated with clarithromycin&#46;<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> In our case&#44; the determination of antimicrobial sensitivity was also of great help in deciding on treatment&#46; This was achieved using the broth microdilution technique&#44; using cut-off points established by the Clinical and Laboratory Standards Institute &#40;CLSI&#41; for <span class="elsevierStyleItalic">M&#46; avium</span> complex&#46;<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We conclude that although the frequency of respiratory infections caused by <span class="elsevierStyleItalic">M&#46; malmoense</span> in Spain is low&#44; it is probably increasing and is here to stay&#46; Unfortunately&#44; there is little evidence regarding the effectiveness of treatment&#44; although long-term dual therapy seems to be effective in managing this pathology&#46; As with other mycobacteria&#44; microbiological study is important for the management of these infections&#46;</p></span>"
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ISSN: 15792129
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