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A) Imagen de secuelas de proceso tuberculoso previo, con signos de pérdida de volumen de ambos lóbulos superiores y cicatrices parenquimatosas con gran cavidad en vértice derecho. B) Visión de múltiples nódulos bilaterales y difusos, algunos cavitados, y patrón micronodular de distribución en árbol en brote en lóbulo inferior derecho y lóbulo medio, en relación con el proceso infeccioso actual.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francisco José Laso del Hierro, Pablo López Yeste, Alba Naya Prieto, María del Pilar Carballosa de Miguel, Jaime Esteban Moreno, Felipe Villar Álvarez" "autores" => array:6 [ 0 => array:2 [ "nombre" => "Francisco José" "apellidos" => "Laso del Hierro" ] 1 => array:2 [ "nombre" => "Pablo" "apellidos" => "López Yeste" ] 2 => array:2 [ "nombre" => "Alba" "apellidos" => "Naya Prieto" ] 3 => array:2 [ "nombre" => "María del Pilar" "apellidos" => "Carballosa de Miguel" ] 4 => array:2 [ "nombre" => "Jaime" "apellidos" => "Esteban Moreno" ] 5 => array:2 [ "nombre" => "Felipe" "apellidos" => "Villar Álvarez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S157921292030094X" "doi" => "10.1016/j.arbr.2019.12.007" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921292030094X?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300053?idApp=UINPBA00003Z" "url" => "/03002896/0000005600000006/v3_202010110737/S0300289620300053/v3_202010110737/es/main.assets" ] ] "itemSiguiente" => array:18 [ "pii" => "S157921292030118X" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.12.011" "estado" => "S300" "fechaPublicacion" => "2020-06-01" "aid" => "2386" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2020;56:403-5" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:10 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Functional Endoscopic Sinus Surgery for Nasal Polyposis in Asthma Patients: Impact on Bronchial Inflammation" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "403" "paginaFinal" => "405" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cirugía endoscópica nasosinusal para la poliposis nasal en pacientes con asma: impacto en la inflamación bronquial" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Vicente Plaza, Alfonso del Cuvillo, Lorena Soto-Retes, Joan Ramón Gras, Carolina Cisneros, Silvia Sánchez-Cuellar, Ana Gómez-Bastero, Eva Martínez-Moragón, Carles Sabadell, Santiago Quirce, Francisco Álvarez, Ana Rosado, Inmaculada Lluch, Gregorio Soto" "autores" => array:14 [ 0 => array:2 [ "nombre" => "Vicente" "apellidos" => "Plaza" ] 1 => array:2 [ "nombre" => "Alfonso" "apellidos" => "del Cuvillo" ] 2 => array:2 [ "nombre" => "Lorena" "apellidos" => "Soto-Retes" ] 3 => array:2 [ "nombre" => "Joan Ramón" "apellidos" => "Gras" ] 4 => array:2 [ "nombre" => "Carolina" "apellidos" => "Cisneros" ] 5 => array:2 [ "nombre" => "Silvia" "apellidos" => "Sánchez-Cuellar" ] 6 => array:2 [ "nombre" => "Ana" "apellidos" => "Gómez-Bastero" ] 7 => array:2 [ "nombre" => "Eva" "apellidos" => "Martínez-Moragón" ] 8 => array:2 [ "nombre" => "Carles" "apellidos" => "Sabadell" ] 9 => array:2 [ "nombre" => "Santiago" "apellidos" => "Quirce" ] 10 => array:2 [ "nombre" => "Francisco" "apellidos" => "Álvarez" ] 11 => array:2 [ "nombre" => "Ana" "apellidos" => "Rosado" ] 12 => array:2 [ "nombre" => "Inmaculada" "apellidos" => "Lluch" ] 13 => array:2 [ "nombre" => "Gregorio" "apellidos" => "Soto" ] ] ] ] ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S157921292030118X?idApp=UINPBA00003Z" "url" => "/15792129/0000005600000006/v1_202006030729/S157921292030118X/v1_202006030729/en/main.assets" ] "itemAnterior" => array:18 [ "pii" => "S1579212920300938" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.12.006" "estado" => "S300" "fechaPublicacion" => "2020-06-01" "aid" => "2375" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2020;56:399-401" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Foreign Body in the Airways. 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Distal granuloma that trapped the cannula tube in the lung base.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Fernando Revuelta-Salgado, Ricardo García-Luján, Isabel Pina-Maiquez, Juan Margallo-Iribarnegaray, Miguel Angel Verdejo-Gómez, Borja de Miguel-Campo, Eduardo de Miguel-Poch" "autores" => array:7 [ 0 => array:2 [ "nombre" => "Fernando" "apellidos" => "Revuelta-Salgado" ] 1 => array:2 [ "nombre" => "Ricardo" "apellidos" => "García-Luján" ] 2 => array:2 [ "nombre" => "Isabel" "apellidos" => "Pina-Maiquez" ] 3 => array:2 [ "nombre" => "Juan" "apellidos" => "Margallo-Iribarnegaray" ] 4 => array:2 [ "nombre" => "Miguel Angel" "apellidos" => "Verdejo-Gómez" ] 5 => array:2 [ "nombre" => "Borja" "apellidos" => "de Miguel-Campo" ] 6 => array:2 [ "nombre" => "Eduardo" "apellidos" => "de Miguel-Poch" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "es" => array:9 [ "pii" => "S0300289620300028" "doi" => "10.1016/j.arbres.2019.12.019" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "es" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289620300028?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212920300938?idApp=UINPBA00003Z" "url" => "/15792129/0000005600000006/v1_202006030729/S1579212920300938/v1_202006030729/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "<span class="elsevierStyleItalic">Mycobacterium malmoense</span>. Is It Here to Stay?" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">To the Editor</span>," "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "401" "paginaFinal" => "402" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Francisco José Laso del Hierro, Pablo López Yeste, Alba Naya Prieto, María del Pilar Carballosa de Miguel, Jaime Esteban Moreno, Felipe Villar Álvarez" "autores" => array:6 [ 0 => array:3 [ "nombre" => "Francisco José" "apellidos" => "Laso del Hierro" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:3 [ "nombre" => "Pablo" "apellidos" => "López Yeste" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Alba" "apellidos" => "Naya Prieto" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 3 => array:3 [ "nombre" => "María del Pilar" "apellidos" => "Carballosa de Miguel" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Jaime" "apellidos" => "Esteban Moreno" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 5 => array:4 [ "nombre" => "Felipe" "apellidos" => "Villar Álvarez" "email" => array:1 [ 0 => "fvillarleon@yahoo.es" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, IIS Fundación Jiménez Díaz, CIBERES, UAM, Madrid, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Microbiología Clínica, IIS Fundación Jiménez Díaz, UAM, Madrid, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "<span class="elsevierStyleItalic">Mycobacterium malmoense</span>, ¿ha llegado para quedarse?" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1411 "Ancho" => 955 "Tamanyo" => 107736 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest CT. (A) Image of sequelae from previous tuberculous process, with signs of volume loss in both upper lobes and parenchymal scars with large cavitation in right apex. (B) View of multiple bilateral and diffuse nodules, some cavitated, and micronodular tree-in-bud pattern in right lower lobe and middle lobe, associated with the current infectious process.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">The lung is one of the organs most affected by infections caused by non-tuberculous mycobacteria, and patients with comorbidities or immunosuppressive therapy are more susceptible.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> Given the increased incidence of these risk factors, diseases caused by non-tuberculous mycobacteria are likely to become more frequent in the future. The microbiological study of these species is essential to design the most appropriate treatments.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 69-year-old woman who consulted with chronic lumbar pain as her only symptom. Her case history recorded a personal history of a former smoking habit (75 pack-year index), chronic alcoholism, and pulmonary tuberculosis at 41 years of age. After bilateral lung nodules were observed on chest X-ray, a chest computed tomography (CT) was performed, in which sequelae of a previous tuberculous process were visualized, with parenchymal scars and signs of loss of volume in both upper lobes, together with a large cavity and granulomas in the right apex. CT also revealed multiple bilateral and diffuse nodules; the larger nodules (15<span class="elsevierStyleHsp" style=""></span>mm) in the right lower lobe were cavitary, and a micronodular pattern with tree-in-bud distribution was observed in the right middle and lower lobes (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>). A diagnostic bronchoscopy was then performed, with benign cellularity in bronchoalveolar lavage. Microbiological cultures were negative, while results of mycobacteria cultures were pending. Spirometry testing showed a peak expiratory volume in 1 second (FEV<span class="elsevierStyleInf">1</span>)/post-bronchodilator forced vital capacity (FVC) ratio of 0.6, with FEV<span class="elsevierStyleInf">1</span> 75%, and FVC 101%. A diagnosis of chronic obstructive pulmonary disease (COPD) was given and treatment started with tiotropium.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0015" class="elsevierStylePara elsevierViewall">One week after bronchoscopy, the patient attended the emergency department with a fever of 39<span class="elsevierStyleHsp" style=""></span>°C, cough and a 6-day history of purulent expectoration that did not improve after treatment with amoxicillin–clavulanic acid. She was admitted and treated with levofloxacin and imipenem. Sputum analysis showed the presence of alcohol-resistant bacilli, so given the possibility of pulmonary tuberculosis, treatment was changed to rifampicin, isoniazid, pyrazinamide, and ethambutol. Polymerase chain reaction (PCR) for <span class="elsevierStyleItalic">Mycobacterium tuberculosis</span> was negative, so pending mycobacteria culture results, and after clinical and radiological improvement, the patient was discharged with the same treatment.</p><p id="par0020" class="elsevierStylePara elsevierViewall">One month later, growth of <span class="elsevierStyleItalic">Mycobacterium malmoense</span> was observed in the culture of 3 different sputum samples and in bronchoalveolar lavage. These were inoculated into solid (Lowein-Jensen and Coletsos) and liquid (Versatrek system) media. The microorganism was identified using the GenoType CM/as kit. The antibiogram showed sensitivity to rifampicin, clarithromycin, and streptomycin, and resistance to isoniazid and pyrazinamide. In view of these results, treatment was changed to rifabutin, ethambutol, and clarithromycin. After beginning this regimen, the patient reported asthenia, hyporexia, and vomiting, so the treatment schedule was changed to daily rifampicin, and ethambutol on Monday, Wednesday and Friday. The patient's side effects resolved, so the dose of ethambutol was gradually increased to a daily dose, with adequate clinical tolerance. The treatment continued for 2 years, after which the patient remained asymptomatic with radiological improvement. Residual lesions persisted in the chest CT, but the size of the right upper cavity and lung nodules decreased.</p><p id="par0025" class="elsevierStylePara elsevierViewall"><span class="elsevierStyleItalic">M. malmoense</span> is the most common non-tuberculous mycobacteria in northern European countries.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">2</span></a> In other European countries, a limited number of cases have been published,<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">3,4</span></a> but in Spain, series of only 5<a class="elsevierStyleCrossRef" href="#bib0075"><span class="elsevierStyleSup">4</span></a> to 20 cases have been described in the last 35 years.<a class="elsevierStyleCrossRefs" href="#bib0080"><span class="elsevierStyleSup">5,6</span></a> Risk factors for infection are the same as for any other mycobacteria: immunosuppression, previous respiratory diseases, smoking, and alcohol abuse, all of which were present in our patient. Since there are a greater numbers of patients with underlying lung diseases or immunosuppressive treatments, the incidence of <span class="elsevierStyleItalic">M. malmoense</span> infection is likely to continue to increase. Infection with this mycobacteria is clinically significant in about 70%–80% of patients with lung disease. It is also the most important pathogen after <span class="elsevierStyleItalic">Mycobacterium avium</span> complex.<a class="elsevierStyleCrossRef" href="#bib0090"><span class="elsevierStyleSup">7</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">The isolation of <span class="elsevierStyleItalic">M. malmoense</span> in respiratory samples is probably indicative of infection.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">8</span></a> In our patient, we reached a diagnosis after observing <span class="elsevierStyleItalic">M. malmoense</span> growth in sputum and bronchoalveolar lavage cultures. The microorganism was identified using a molecular technique (GenoType CM/as) that, due to its speed and effectiveness, has now replaced conventional biochemical tests in most laboratories.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">9</span></a> More recently, the MALDI-TOF technique has been introduced for the identification of microorganisms, including mycobacteria. Although it was not used in this case, this technique has already proved its usefulness.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">10</span></a> A 2-year course of a combination of rifampicin (or rifabutin) and ethambutol is recommended for the treatment of these infections, and clarithromycin may be added on a case-by-case basis. Triple therapy has not been shown to be superior to dual therapy, so sometimes the latter is preferred due to frequent adverse effects associated with clarithromycin.<a class="elsevierStyleCrossRef" href="#bib0060"><span class="elsevierStyleSup">1</span></a> In our case, the determination of antimicrobial sensitivity was also of great help in deciding on treatment. This was achieved using the broth microdilution technique, using cut-off points established by the Clinical and Laboratory Standards Institute (CLSI) for <span class="elsevierStyleItalic">M. avium</span> complex.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">11</span></a></p><p id="par0035" class="elsevierStylePara elsevierViewall">We conclude that although the frequency of respiratory infections caused by <span class="elsevierStyleItalic">M. malmoense</span> in Spain is low, it is probably increasing and is here to stay. Unfortunately, there is little evidence regarding the effectiveness of treatment, although long-term dual therapy seems to be effective in managing this pathology. As with other mycobacteria, microbiological study is important for the management of these infections.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Laso del Hierro FJ, López Yeste P, Naya Prieto A, Carballosa de Miguel MdP, Esteban Moreno J, Villar Álvarez F. <span class="elsevierStyleItalic">Mycobacterium malmoense</span>, ¿ha llegado para quedarse? Arch Bronconeumol. 2020;56:401–402.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1411 "Ancho" => 955 "Tamanyo" => 107736 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Chest CT. (A) Image of sequelae from previous tuberculous process, with signs of volume loss in both upper lobes and parenchymal scars with large cavitation in right apex. 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