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FPI: fibrosis pulmonar idiopática; NIU: neumonía intersticial usual; TCAR: tomografía computarizada de alta resolución.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Diego Castillo, Albert Sánchez-Font, Virginia Pajares, Tomás Franquet, Roger Llatjós, Irene Sansano, Jacobo Sellarés, Carmen Centeno, Juan J. 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Asociación Latinoamericana de Tórax (ALAT) 2019" ] ] "contieneResumen" => array:2 [ "en" => true "es" => true ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1724 "Ancho" => 2559 "Tamanyo" => 276783 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0105" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Inhaled treatment depending on the severity of COPD. ALAT-2019.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Maria Montes de Oca, Maria Victorina López Varela, Agustín Acuña, Eduardo Schiavi, Alejandro Casas, Antonio Tokumoto, Carlos A. 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Barcelona, Spain" "etiqueta" => "c" "identificador" => "aff0015" ] 3 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Hospital de Bellvitge, Hospitalet de Llobregat, Spain" "etiqueta" => "d" "identificador" => "aff0020" ] 4 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital de Vall d’Hebron, Barcelona, Spain" "etiqueta" => "e" "identificador" => "aff0025" ] 5 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Clínic, IDIBAPS, Barcelona, Spain" "etiqueta" => "f" "identificador" => "aff0030" ] 6 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Germans Trias i Pujol, Barcelona, Spain" "etiqueta" => "g" "identificador" => "aff0035" ] 7 => array:3 [ "entidad" => "Servicio de Cirugía Torácica. Hospital del Sagrat Cor, Barcelona, Spain" "etiqueta" => "h" "identificador" => "aff0040" ] 8 => array:3 [ "entidad" => "Servicio de Radiología. Hospital Clínic, Barcelona, Spain" "etiqueta" => "i" "identificador" => "aff0045" ] 9 => array:3 [ "entidad" => "Servicio de Anatomía Patológica. Hospital Clínic, Universitat de Barcelona, IDIBAPS, Barcelona, Spain" "etiqueta" => "j" "identificador" => "aff0050" ] 10 => array:3 [ "entidad" => "Servicio de Neumología. Hospital Parc Taulí, Sabadell, Spain" "etiqueta" => "k" "identificador" => "aff0055" ] 11 => array:3 [ "entidad" => "Servicio de Cirugía Torácica. Hospital de la Santa Creu i Sant Pau, Barcelona, Spain" "etiqueta" => "l" "identificador" => "aff0060" ] 12 => array:3 [ "entidad" => "Unitat de Pneumologia. Hospital Universitari General de Granollers, Granollers, Spain" "etiqueta" => "m" "identificador" => "aff0065" ] 13 => array:3 [ "entidad" => "Servicio de Neumología. Hospital de Bellvitge. IDIBELL, Hospitalet de Llobregat, Spain" "etiqueta" => "n" "identificador" => "aff0070" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Propuesta multidisciplinar respecto al algoritmo diagnóstico de la fibrosis pulmonar idiopática: papel de la criobiopsia transbronquial" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1826 "Ancho" => 1492 "Tamanyo" => 160623 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0195" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Proposed amendment of the diagnostic algorithm for idiopathic pulmonary fibrosis. HRCT: high-resolution computed tomography; IPF: idiopathic pulmonary fibrosis; UIP: usual interstitial pneumonia.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><span id="sec0005" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0025">Introduction</span><p id="par0005" class="elsevierStylePara elsevierViewall">The diagnosis of idiopathic interstitial pneumonias (IIP) is based on the multidisciplinary analysis of clinical, radiological and histologic data.<a class="elsevierStyleCrossRef" href="#bib0005"><span class="elsevierStyleSup">1</span></a> The conventional procedure of choice for obtaining samples of lung tissue is surgical lung biopsy (SLB) because specimens obtained using standard transbronchial biopsy (TBB) are unsuitable for the diagnosis of these pathologies.<a class="elsevierStyleCrossRef" href="#bib0010"><span class="elsevierStyleSup">2</span></a> Transbronchial cryobiopsy (TBCB) is a method for obtaining lung tissue using endoscopic cryoprobes.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The use of this technique in the study of IIP has expanded in recent years as an alternative to SLB.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> It has also been proposed in patients with idiopathic pulmonary fibrosis (IPF), but the recently published ATS/ERS/JRS/ALAT clinical practice guidelines conclude that scientific evidence is insufficient to recommend its use.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">In this article we aim to initiate a broader, multidisciplinary discussion on the value of TBCB in patients with suspected IPF and to propose a possible diagnostic schema incorporating this technique.</p><span id="sec0010" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0030">Diagnosis of idiopathic pulmonary fibrosis. What do the current guidelines propose?</span><span id="sec0015" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0035">The diagnostic process in idiopathic pulmonary fibrosis</span><p id="par0015" class="elsevierStylePara elsevierViewall">Two major documents were published on the diagnosis of IPF in 2018: the updated ATS/ERS/ALAT/JRS diagnostic guidelines and the Fleischner Society White Paper.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> According to current recommendations, the diagnosis of IPF is based on the findings of a multidisciplinary assessment, the appropriate clinical context (more prevalent in patients older than 60 years, men, and former smokers), and a pattern of usual interstitial pneumonia (UIP), either on high-resolution computed tomography (HRCT) or analysis of the histologic material obtained by needle biopsy of the lung.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> The process, therefore, aims to:<ul class="elsevierStyleList" id="lis0005"><li class="elsevierStyleListItem" id="lsti0005"><span class="elsevierStyleLabel">•</span><p id="par0020" class="elsevierStylePara elsevierViewall">Rule out other possible causes of the origin of the lung disease through a comprehensive clinical history and complementary tests, and exclude systemic autoimmune disease, occupational or domestic exposures, and drugs with potential pneumotoxicity<a class="elsevierStyleCrossRef" href="#bib0035"><span class="elsevierStyleSup">7</span></a>;</p></li><li class="elsevierStyleListItem" id="lsti0010"><span class="elsevierStyleLabel">•</span><p id="par0025" class="elsevierStylePara elsevierViewall">Confirm the presence of a pattern of UIP according to accepted radiological and histologic criteria<a class="elsevierStyleCrossRef" href="#bib0010">2</a>.</p></li></ul></p><p id="par0030" class="elsevierStylePara elsevierViewall">An important feature of the 2002 guidelines that has been given particular emphasis in the most recent versions is that multidisciplinary assessment is the “gold standard” in the diagnostic process. This reflects a fundamental change from the previously established criteria in which the histologic pattern was given greater weight than all other factors.<a class="elsevierStyleCrossRef" href="#bib0040"><span class="elsevierStyleSup">8</span></a> Furthermore, priority is given to less invasive diagnostic processes, with biopsy being reserved for cases that are inconclusive after the initial multidisciplinary assessment.</p></span><span id="sec0020" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0040">Role of high-resolution computed tomography in the diagnosis of idiopathic pulmonary fibrosis</span><p id="par0035" class="elsevierStylePara elsevierViewall">Leading clinical guidelines regard HRCT as an essential component in the diagnosis of IPF, as it can identify UIP from: (a) evidence of fibrotic changes in both lungs, predominantly in the lung bases and subpleural regions, despite a frequent patchy pattern; (b) reticular opacities, often associated with traction bronchiectasis; (c) honeycombing manifested as clumped cystic spaces (diameters of between 3 and 10<span class="elsevierStyleHsp" style=""></span>mm); and (d) the absence of other findings listed as inconsistent for UIP.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a></p><p id="par0040" class="elsevierStylePara elsevierViewall">The first step in the diagnosis of IPF, then, is the use of an appropriate technique that allows us to obtain images of high diagnostic quality. The essential differences between conventional CT and HRCT reside in the slice thickness used in the acquisition and reconstruction of the images.<a class="elsevierStyleCrossRefs" href="#bib0045"><span class="elsevierStyleSup">9,10</span></a> In HRCT, images are obtained from 1<span class="elsevierStyleHsp" style=""></span>mm slices, and (as in conventional CT) with the patient in a supine position at deep inspiration. A high frequency algorithm and a field of vision limited to the pulmonary parenchyma are used for image reconstruction.<a class="elsevierStyleCrossRef" href="#bib0055"><span class="elsevierStyleSup">11</span></a> Intravenous contrast is not administered during the HRCT. The images obtained in expiratory series are very useful for demonstrating air trapping.<a class="elsevierStyleCrossRefs" href="#bib0060"><span class="elsevierStyleSup">12,13</span></a></p><p id="par0045" class="elsevierStylePara elsevierViewall">Due to inter-observer variability and discrepancies, and advances in disease characterization, imaging techniques, and the collection of histologic samples using cryobiopsy, the Fleischner Society has published a number of new radiological criteria for diagnosing IPF and facilitating access to treatment.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a> In this review, 4 new categories differentiating UIP patterns in HRCT have been proposed: typical, probable, and indeterminate UIP patterns, and alternative diagnoses to IPF (<a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>). The “possible” pattern has been changed with respect to the previous classification to “probable” UIP, and “inconsistent” has been changed to “indeterminate”.</p><elsevierMultimedia ident="tbl0005"></elsevierMultimedia><p id="par0050" class="elsevierStylePara elsevierViewall">According to our review, an accurate diagnosis of IPF can be made when HRCT images show a pattern of typical or probable UIP.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> If the clinical context is indeterminate for IPF or the HRCT pattern is not indicative of typical or probable UIP, completing the diagnostic process with lung biopsy should be considered.</p><p id="par0055" class="elsevierStylePara elsevierViewall">The updated ATS/ERS/JRS/ALAT guidelines also propose 4 radiological patterns in the diagnosis of IPF that are similar but not identical to those proposed by the Fleischner Society.<a class="elsevierStyleCrossRefs" href="#bib0025"><span class="elsevierStyleSup">5,6</span></a> The basic findings of UIP and probable UIP patterns are similar, but the indeterminate pattern differs by including the presence of predominantly basal subpleural reticulation (also known as “early UIP”), along with the true indeterminate pattern (a pattern of fibrosing interstitial lung disease with findings that really do not guide the clinician towards any etiology).</p><p id="par0060" class="elsevierStylePara elsevierViewall">One of the main differences between the ATS/ERS guidelines and the Fleischner Society document lies in the recommendation for performing or not performing lung biopsy in patients with a pattern of possible UIP in a clinical context consistent with IPF: the ATS/ESR guidelines make a conditional recommendation in favor of this procedure.<a class="elsevierStyleCrossRef" href="#bib0070"><span class="elsevierStyleSup">14</span></a> In short, then, for the authors of the Fleischner guidelines, the risk of comorbidities associated with SLB is greater than the benefit of finding an alternative diagnosis in patients with a high clinical suspicion of IPF and HRCT showing a pattern of probable UIP. This is based on various studies published in recent years that have analyzed the correlation between the probable UIP pattern and the presence of UIP in lung biopsy.<a class="elsevierStyleCrossRefs" href="#bib0075"><span class="elsevierStyleSup">15,16</span></a> As the study of Brownell et al. clearly shows, in cohorts with a high prevalence of histologic UIP, the pattern of possible UIP on HRCT is sufficient to predict this diagnosis and hence avoid SLB.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">17</span></a> However, in other situations, the positive predictive value is lower, so we need other clinical variables (such as sex, age, or presence of traction bronchiectasis) to identify groups of subjects with a high positive predictive value for histologic UIP. As such, the pretest probability is very important for evaluating the radiological pattern of possible UIP. TBCB could be an excellent alternative in this situation, since it has less comorbidity than SLB, and while the diagnostic yield is lower than that of SLB, it may be sufficient to substantiate the diagnosis of IPF in cases with a pattern of probable UIP.</p></span><span id="sec0025" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0045">Histologic diagnostic criteria for usual interstitial pneumonia</span><p id="par0065" class="elsevierStylePara elsevierViewall">The characteristics of pulmonary parenchyma in a biopsy with a UIP pattern were established in various consensus documents, and have been slightly modified in subsequent updates published in 2011, 2013, and most recently, 2018.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,5,18</span></a> The latest 2018 guidelines describe the following histologic characteristics:<ul class="elsevierStyleList" id="lis0010"><li class="elsevierStyleListItem" id="lsti0015"><span class="elsevierStyleLabel">•</span><p id="par0070" class="elsevierStylePara elsevierViewall">Evidence of interstitial fibrosis associated with marked distortion of the lung architecture with a characteristic distribution of predominantly peripheral involvement in the secondary lobule, i.e. paraseptal or subpleural.</p></li><li class="elsevierStyleListItem" id="lsti0020"><span class="elsevierStyleLabel">•</span><p id="par0075" class="elsevierStylePara elsevierViewall">Presence of fibroblast foci in areas of interface of fibrosis with normal parenchyma.</p></li><li class="elsevierStyleListItem" id="lsti0025"><span class="elsevierStyleLabel">•</span><p id="par0080" class="elsevierStylePara elsevierViewall">Presence of heterogeneous lesions that result in a combination of fibrotic areas of advanced involvement and areas with normal alveolar septa.</p></li><li class="elsevierStyleListItem" id="lsti0030"><span class="elsevierStyleLabel">•</span><p id="par0085" class="elsevierStylePara elsevierViewall">Absence of features inconsistent with a diagnosis of UIP, suggesting an alternative diagnosis. Despite showing all the histologic characteristics of UIP, the presence of granulomas or other specific features that correspond to another entity rule out the diagnosis.</p></li></ul></p><p id="par0090" class="elsevierStylePara elsevierViewall">These characteristics can be difficult to comprehend, so the above-mentioned 2018 guidelines provide 4 options on the probability of a UIP diagnosis. These are listed in <a class="elsevierStyleCrossRef" href="#tbl0010">Table 2</a> following the same format as <a class="elsevierStyleCrossRef" href="#tbl0005">Table 1</a>.</p><elsevierMultimedia ident="tbl0010"></elsevierMultimedia></span></span><span id="sec0030" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0050">Invasive diagnostic techniques</span><span id="sec0035" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0055">Transbronchial cryobiopsy</span><p id="par0095" class="elsevierStylePara elsevierViewall">The concept of TBCB arose from the introduction of modified flexible cryotherapy probes and the need to improve the diagnostic yield of TBBs, whose role in the diagnosis of certain diffuse interstitial lung diseases (ILD) was often questioned.<a class="elsevierStyleCrossRefs" href="#bib0005"><span class="elsevierStyleSup">1,18</span></a> With regard to standardization of the procedure, a recently published expert consensus analyzes the scientific evidence on the diagnostic yield and safety of TBCB in the most relevant published studies.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> In this review, the diagnostic yield of TBCB was within the range of 50.6 %–100 % compared to the 25 %–65 % yield obtained with conventional forceps; pneumothorax occurred in 1.4 %–26 % of cases and bleeding in 1 %–12 %. The authors recommend performing the technique with orotracheal intubation under deep sedation or general anesthesia, using an occlusion balloon to control bleeding under fluoroscopic guidance. They also recommend obtaining 3–5 biopsies in different lung segments, at least 1<span class="elsevierStyleHsp" style=""></span>cm from the pleura.</p><p id="par0100" class="elsevierStylePara elsevierViewall">The first study to demonstrate the viability of TBCB in the diagnosis of ILD was published in 2009, and showed that larger and better quality lung parenchyma samples were obtained compared with TBB. In this initial study, the mean size of the samples was 15.11<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> compared with 5.82 mm<span class="elsevierStyleSup">2</span> for samples obtained with the conventional technique.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">3</span></a> The first Spanish study on the use of TBCB appeared in 2010.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">20</span></a> The diagnostic yield of TBCB vs TBB in ILD was subsequently evaluated in a randomized, prospective study.<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">21</span></a> A histopathologic diagnosis was reached in more cases in the TBCB group (74.4 %) than in the TBB group (34.1 %, p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.001), and the final multidisciplinary diagnosis was higher (51.3 % versus 29.1 %, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.038). With regard to IPF, Tomassetti et al. retrospectively assessed the impact of TBCB versus SLB in the multidisciplinary diagnosis of IPF.<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">22</span></a> The study showed that the increase in diagnostic precision achieved with the addition of TBCB was similar to that achieved with surgical biopsy in the diagnosis of IPF (SLB from 29 % to 63 %, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0003 and TBCB from 30 % to 65 %, p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.0016).</p><p id="par0105" class="elsevierStylePara elsevierViewall">Iftikhar et al. conducted a review of 16 studies with TBCB versus 14 studies with SBL that included more than 2200 patients.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> In this meta-analysis, a lower diagnostic yield was observed in the TBCB group (83 %) than in the VATS-SLB group (92 %). In a prospective study, Romagnoli et al. analyzed the diagnostic concordance of TBCB compared to SLB.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">24</span></a> In this study, 21 patients underwent both techniques on the same day, in the same operating room, during the same anesthesia. The results of this study show that the same histologic diagnosis was obtained with both procedures in only 8 out of 21 patients (38 %): SLB yielded larger specimens and was superior in establishing useful histologic patterns in multidisciplinary diagnostics. However, it should be noted that the primary outcome (histologic diagnostic concordance) was obtained from a pathology evaluation that was “blind” to the clinical and radiological information, which is not standard clinical practice. Another significant point is that in this study only 21 of the 61 selected patients were included. That is to say, 40 patients could not be included in the study, either because they refused an SLB or because they were ruled out due to comorbidities.</p><p id="par0110" class="elsevierStylePara elsevierViewall">Another argument in favor of TBCB is the reduced cost compared to SLB by video-assisted thoracoscopy (VATS). Cost analyses found a potential cost savings for TBCB compared to VATS-SLB of between £210-£647 per patient/year<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> or between €953.09/patient when the VATS-SLB is performed on an outpatient basis and a maximum of €1,925.29/patient when the SLB involves a 48<span class="elsevierStyleHsp" style=""></span>-h admission.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">26</span></a></p><p id="par0115" class="elsevierStylePara elsevierViewall">With regard to the contraindications for the test, according to the expert consensus, there is no age limit for TBCB, provided it is not ruled out due to comorbidities and lack of fitness for anesthesia.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a> It has also been reported that patients with worse lung function have more complications. FVC<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>50 % predicted or DLCO<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>35 % predicted, if present, are recommended as relative contraindications. The presence of pulmonary arterial hypertension (PAH) may increase the risk of bleeding, and in some series PAH greater than 40−45<span class="elsevierStyleHsp" style=""></span>mmHg has been regarded as a relative contraindication.<a class="elsevierStyleCrossRefs" href="#bib0015"><span class="elsevierStyleSup">3,21</span></a></p><p id="par0120" class="elsevierStylePara elsevierViewall">Therefore, although SLB is the method of first choice, TBCB is an alternative when a patient refuses SLB or when SLB is inadvisable.</p></span><span id="sec0040" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0060">Surgical lung biopsy</span><p id="par0125" class="elsevierStylePara elsevierViewall">SLB is still the “gold standard” for the histologic diagnosis of diffuse ILD. Currently, the approach of choice is VATS, using 1, 2, or 3 ports of entry for introducing the camera and instruments.<a class="elsevierStyleCrossRef" href="#bib0135"><span class="elsevierStyleSup">27</span></a> The implementation of minimally invasive surgery has helped simplify the technique.<a class="elsevierStyleCrossRef" href="#bib0140"><span class="elsevierStyleSup">28</span></a> With the help of HRCT, the biopsy site is selected by multidisciplinary decision, thus improving the cost-effectiveness of the technique. The resection is performed using mechanical endosutures, a technique that is increasingly safe and allows the parenchyma to be simultaneously sectioned and sealed. Samples are sent for histopathological study and microbiological culture. A sample should generally measure about 3<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>2<span class="elsevierStyleHsp" style=""></span>×<span class="elsevierStyleHsp" style=""></span>1<span class="elsevierStyleHsp" style=""></span>cm<span class="elsevierStyleSup">3</span>, although some authors recommend a diameter of more than 2<span class="elsevierStyleHsp" style=""></span>cm. SLB is usually performed under general anesthesia with selective intubation, although it is true that there is a growing trend towards performing the procedure with orotracheal intubation or even under sedation with a laryngeal mask.<a class="elsevierStyleCrossRefs" href="#bib0145"><span class="elsevierStyleSup">29,30</span></a> Endosutures are so safe that postoperative air leak has been reduced to a minimum, so systematic pleural drainage placement is not required.<a class="elsevierStyleCrossRefs" href="#bib0155"><span class="elsevierStyleSup">31,32</span></a> In outpatient surgery programs, patients are admitted 1−2<span class="elsevierStyleHsp" style=""></span>hours before surgery and discharged about 4−6<span class="elsevierStyleHsp" style=""></span>hours after the procedure. Publications on outpatient surgery programs have reported admission rates of 3 % (mostly due to air leakage) and readmission rates of 3 %, also for pneumothorax.<a class="elsevierStyleCrossRef" href="#bib0165"><span class="elsevierStyleSup">33</span></a> A recent prospective, multicenter study involving 224 patients and 13 thoracic surgery departments assessed the feasibility of the outpatient approach in VATS-SLB in the diagnosis of diffuse ILD. The results showed that the anatomical site and the number of biopsies do not influence the diagnosis of ILD: a specific diagnosis was obtained in 87 % of cases (of which 26.1 % were IPF), and morbidity rates after discharge were comparable among patients who were admitted (9/154: 5.8 %) and those who were treated as outpatients (3/70: 4.3 %).<a class="elsevierStyleCrossRef" href="#bib0170"><span class="elsevierStyleSup">34</span></a></p></span></span><span id="sec0045" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0065">Open questions</span><span id="sec0050" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0070">Can a diagnosis of usual interstitial pneumonia in a biopsy be diagnosed by cryobiopsy?</span><p id="par0130" class="elsevierStylePara elsevierViewall">TBCB is especially useful in diseases with peribronchovascular and lymphangitic distribution and in diseases with very specific or characteristic features, but it is of little (or less) use in diseases where a pattern must be identified, such as IPF. Despite this, TBCB is gaining utility.</p><p id="par0135" class="elsevierStylePara elsevierViewall">The histologic criteria for UIP were established with SLB, but these features can also be identified in TBCB. The presence of pleura or septum in the sample is necessary to determine the UIP pattern, since the distribution of fibrosis is 1 of the 4 requirements. Therefore, cryobiopsies that do not contain these structures will only be able to establish a “probable UIP pattern”. However, a patchy distribution and higher proliferation of fibroblast foci are easily identifiable in TBCB. Another very characteristic morphological element of the UIP pattern is honeycombing. The presence of honeycombing has been much debated in the literature, as it cannot always be detected. A recent study concluded that areas of histologic honeycombing can be detected in TBCB when more than 2 fragments containing pleura are obtained. The size of the fragments may make it difficult to differentiate between honeycombing and bronchiolar metaplasia.</p><p id="par0140" class="elsevierStylePara elsevierViewall">TBCB, therefore, might not satisfy all the criteria needed to definitively establish a pattern of UIP, but it can still be very useful for identifying histologic characteristics of probable or possible UIP pattern, and for detecting other histologic features that will exclude UIP. For this reason, minimum quality criteria must be established in terms of the number and size of samples, their distribution, and histologic findings. At the microscopic level, some authors suggest that a minimum sample size of 5<span class="elsevierStyleHsp" style=""></span>mm of well expanded parenchyma is needed identify a pattern, and although smaller fragments may contain all the elements, this would be the optimal size.<a class="elsevierStyleCrossRef" href="#bib0175"><span class="elsevierStyleSup">35</span></a></p></span><span id="sec0055" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0075">Safety</span><p id="par0145" class="elsevierStylePara elsevierViewall">In terms of safety, the complications most frequently described in association with TBCB are severe bleeding and pneumothorax.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a> With regard to bleeding after the procedure, there is no consensus on the definition and quantification of bleeding, so this outcome is very heterogeneous in the literature. In general, studies comparing this technique with TBB have shown a higher percentage of moderate bleeding in the TBCB group than in the SLB group. Johannson et al. performed a meta-analysis in which they found an overall frequency of moderate/severe bleeding of 39 %, with a range of 0%–78%, demonstrating wide heterogeneity.<a class="elsevierStyleCrossRef" href="#bib0180"><span class="elsevierStyleSup">36</span></a> In their systematic review, Ganganah et al. compared TBCB with TBB and identified 3 studies that compared directly in terms of frequency of bleeding; bleeding was significantly greater in TBCB in only 1 of the 3.<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">25</span></a> Rates of moderate bleeding of 20.99 % (5.6 %–42.8 %) associated with TBCB have also been reported, including 3 deaths (0.5 % of the group).<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> In this respect, the recommendation on standardization of the TBCB procedure includes the use of an occlusion balloon to control possible bleeding.<a class="elsevierStyleCrossRef" href="#bib0095"><span class="elsevierStyleSup">19</span></a></p><p id="par0150" class="elsevierStylePara elsevierViewall">Sharp et al. conclude that pneumothorax is the most common adverse effect in TBCB, occurring in 20 % of cases (15 % required drainage).<a class="elsevierStyleCrossRef" href="#bib0185"><span class="elsevierStyleSup">37</span></a> The total combined probability of presenting pneumothorax was 0.06 (95 % CI: 0.02–0.11), while the probability of pneumothorax with chest tube placement was 0.03 (95 % CI: 0.01–0.08). In studies that show a higher rate of pneumothorax, this finding may be related to the characteristics of the study patients (patients with interstitial lung disease and fibrotic pattern) and the collection of a greater number of subpleural biopsies (<1<span class="elsevierStyleHsp" style=""></span>cm).<a class="elsevierStyleCrossRefs" href="#bib0110"><span class="elsevierStyleSup">22,38</span></a></p><p id="par0155" class="elsevierStylePara elsevierViewall">With regard to SLB, the incidence of complications in the published series varies widely, the most frequent being postoperative pain, and the most feared being exacerbation of the underlying disease. Both pain and exacerbations have diminished with the implementation of minimally invasive techniques.<a class="elsevierStyleCrossRefs" href="#bib0195"><span class="elsevierStyleSup">39,40</span></a> In 2007, Kreider et al. reported that the implementation of VATS programs did not reduce morbidity or mortality associated with SLB.<a class="elsevierStyleCrossRef" href="#bib0205"><span class="elsevierStyleSup">41</span></a> Careful selection of patients and the time when biopsy is indicated appear to be important factors in reducing complications. Hutchinson et al. published a retrospective analysis which found that mortality associated with non-elective surgery was as high as 16 %, but fell to 1.7 % in elective surgery.<a class="elsevierStyleCrossRef" href="#bib0210"><span class="elsevierStyleSup">42</span></a></p><p id="par0160" class="elsevierStylePara elsevierViewall">In meta-analysis reviewing both techniques, the incidence of grade 2 (moderate to severe) bleeding in the TBCB group was 4.9 % (2.2 %–10.7 %).<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">23</span></a> In the studies that evaluated VATS-SLB, only 5 reported persistent air leak, at an incidence of 2 % (0.9 %–4 %). In these studies, mortality at 30–60 days post-procedure was 0.7 % (0.4 %–1.2 %) after TBCB and 1.8 % (1.0 %–3 %) after VATS-SLB. Other safety indicators in the comparison of TBCB versus VATS-SLB were the frequency of adverse events (excluding pneumothorax) (2 % versus 13.3 % [p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001]), mean length of hospital stay (2.6 days [range 0–17] versus 6.1 [range 3–48] [p<span class="elsevierStyleHsp" style=""></span><<span class="elsevierStyleHsp" style=""></span>0.0001]), and mortality (0.3 % versus 2.7 % [p<span class="elsevierStyleHsp" style=""></span>=<span class="elsevierStyleHsp" style=""></span>0.045]), respectively.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">4</span></a></p></span></span></span><span id="sec0060" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0080">Conclusion: a multidisciplinary proposal on the role of cryobiopsy in the diagnosis of idiopathic pulmonary fibrosis</span><p id="par0165" class="elsevierStylePara elsevierViewall">Two alternatives for the diagnosis of IPF in cases that require lung biopsy are currently available. Although no adequate studies comparing both techniques have yet been conducted, and despite the fact that favorable outcomes have been demonstrated for each method, our impression is that both procedures have distinct characteristics that make them more or less suitable, depending on each clinical situation. The challenge, therefore, is not to decide between 2 competing techniques in the diagnosis of patients with IPF, but to be able to recognize which is best suited to a particular situation.</p><p id="par0170" class="elsevierStylePara elsevierViewall"><a class="elsevierStyleCrossRef" href="#tbl0015">Table 3</a> lists some circumstances that can assist in decision-making. Factors such as comorbidities, lung function, the experience of the bronchoscopy team and the pathologist, the location and extension of the radiological pattern, and the cost of the technique should be carefully assessed. The diagnostic delay must also be evaluated, since each additional procedure in the algorithm increases time to diagnosis. This proposed algorithm must be validated in prospective studies to demonstrate its clinical usefulness.</p><elsevierMultimedia ident="tbl0015"></elsevierMultimedia><p id="par0175" class="elsevierStylePara elsevierViewall">On the basis of all these variables, as shown in <a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>, each site must evaluate on a case-by-case basis which of the 2 procedures offers a better risk-benefit ratio for obtaining a histological diagnosis. Additionally, of course, studies are needed to compare the diagnostic yield and safety of SLB versus TBCB in IPF.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia></span><span id="sec0065" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0085">Authorship</span><p id="par0180" class="elsevierStylePara elsevierViewall">DC and ASF organized the debate and were responsible for proposing the publication of this article. DC, ASF and AT designed the manuscript. All authors contributed to the publication and have reviewed the version submitted for publication.</p></span><span id="sec0070" class="elsevierStyleSection elsevierViewall"><span class="elsevierStyleSectionTitle" id="sect0090">Conflict of interests</span><p id="par0185" class="elsevierStylePara elsevierViewall">DC has received personal honoraria and non-financial support from Boehringer-Ingelheim and Roche, as well as honoraria from Bristol-Myers Squibb, unrelated to this manuscript; JS has received grants and personal honoraria from Boehringer-Ingelheim and Roche, and personal honoraria from Menarini, Glaxo, Novartis and Chiesi, unrelated to this manuscript. MM-M has received grants and personal honoraria from Boehringer-Ingelheim, Esteve-Teijin Healthcare, and Roche, personal honoraria from Chiesi, and grants from GSK, unrelated to this manuscript; the remaining authors declare no conflict of interest with respect to this manuscript.</p></span></span>" "textoCompletoSecciones" => array:1 [ "secciones" => array:10 [ 0 => array:3 [ "identificador" => "xres1304957" "titulo" => "Abstract" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0005" ] ] ] 1 => array:2 [ "identificador" => "xpalclavsec1205126" "titulo" => "Keywords" ] 2 => array:3 [ "identificador" => "xres1304956" "titulo" => "Resumen" "secciones" => array:1 [ 0 => array:1 [ "identificador" => "abst0010" ] ] ] 3 => array:2 [ "identificador" => "xpalclavsec1205127" "titulo" => "Palabras clave" ] 4 => array:3 [ "identificador" => "sec0005" "titulo" => "Introduction" "secciones" => array:3 [ 0 => array:3 [ "identificador" => "sec0010" "titulo" => "Diagnosis of idiopathic pulmonary fibrosis. What do the current guidelines propose?" "secciones" => array:3 [ 0 => array:2 [ "identificador" => "sec0015" "titulo" => "The diagnostic process in idiopathic pulmonary fibrosis" ] 1 => array:2 [ "identificador" => "sec0020" "titulo" => "Role of high-resolution computed tomography in the diagnosis of idiopathic pulmonary fibrosis" ] 2 => array:2 [ "identificador" => "sec0025" "titulo" => "Histologic diagnostic criteria for usual interstitial pneumonia" ] ] ] 1 => array:3 [ "identificador" => "sec0030" "titulo" => "Invasive diagnostic techniques" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0035" "titulo" => "Transbronchial cryobiopsy" ] 1 => array:2 [ "identificador" => "sec0040" "titulo" => "Surgical lung biopsy" ] ] ] 2 => array:3 [ "identificador" => "sec0045" "titulo" => "Open questions" "secciones" => array:2 [ 0 => array:2 [ "identificador" => "sec0050" "titulo" => "Can a diagnosis of usual interstitial pneumonia in a biopsy be diagnosed by cryobiopsy?" ] 1 => array:2 [ "identificador" => "sec0055" "titulo" => "Safety" ] ] ] ] ] 5 => array:2 [ "identificador" => "sec0060" "titulo" => "Conclusion: a multidisciplinary proposal on the role of cryobiopsy in the diagnosis of idiopathic pulmonary fibrosis" ] 6 => array:2 [ "identificador" => "sec0065" "titulo" => "Authorship" ] 7 => array:2 [ "identificador" => "sec0070" "titulo" => "Conflict of interests" ] 8 => array:2 [ "identificador" => "xack449322" "titulo" => "Acknowledgements" ] 9 => array:1 [ "titulo" => "References" ] ] ] "pdfFichero" => "main.pdf" "tienePdf" => true "fechaRecibido" => "2019-05-09" "fechaAceptado" => "2019-07-03" "PalabrasClave" => array:2 [ "en" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Keywords" "identificador" => "xpalclavsec1205126" "palabras" => array:5 [ 0 => "Diffuse interstitial lung disease" 1 => "Idiopathic pulmonary fibrosis" 2 => "Transbronchial cryobiopsy" 3 => "Surgical lung biopsy" 4 => "Diagnosis." ] ] ] "es" => array:1 [ 0 => array:4 [ "clase" => "keyword" "titulo" => "Palabras clave" "identificador" => "xpalclavsec1205127" "palabras" => array:5 [ 0 => "Enfermedad pulmonar intersticial difusa" 1 => "Fibrosis pulmonar idiopática" 2 => "Criobiopsia transbronquial" 3 => "Biopsia pulmonar quirúrgica" 4 => "Diagnóstico." ] ] ] ] "tieneResumen" => true "resumen" => array:2 [ "en" => array:2 [ "titulo" => "Abstract" "resumen" => "<span id="abst0005" class="elsevierStyleSection elsevierViewall"><p id="spar0040" class="elsevierStyleSimplePara elsevierViewall">The diagnosis of idiopathic pulmonary fibrosis (IPF) is a complex process that requires the multidisciplinary integration of clinical, radiological, and histological variables. Due to its diagnostic yield, surgical lung biopsy has been the recommended procedure for obtaining samples of lung parenchyma, when required. However, given the morbidity and mortality of this technique, alternative techniques which carry a lower risk have been explored. The most important of these is transbronchial cryobiopsy—transbronchial biopsy with a cryoprobe—which is useful for obtaining lung tissue with less comorbidity. Yield may be lower than surgical biopsy, but it is higher than with transbronchial biopsy with standard forceps. This option has been discussed in the recent clinical guidelines for the diagnosis of IPF, but the authors do not go so far as recommend it. The aim of this article, the result of a multidisciplinary discussion forum, is to review current evidence and make proposals for the use of transbronchial cryobiopsy in the diagnosis of IPF.</p></span>" ] "es" => array:2 [ "titulo" => "Resumen" "resumen" => "<span id="abst0010" class="elsevierStyleSection elsevierViewall"><p id="spar0045" class="elsevierStyleSimplePara elsevierViewall">El diagnóstico de la fibrosis pulmonar idiopática (FPI) es un proceso complejo que precisa la integración multidisciplicinar de variables clínicas, radiológicas e histológicas. Cuando es preciso obtener muestras de parénquima pulmonar, la biopsia pulmonar quirúrgica ha sido el procedimiento recomendado por su rendimiento diagnóstico. Pero dada la morbi-mortalidad de esta técnica, se han explorado alternativas con menores riesgos.. La más importante es la biopsia transbronquial con criosonda (criobiopsia transbronquial), que permite obtener tejido pulmonar con menor comorbilidad, con un rendimiento inferior a la biopsia quirúrgica pero superior a la biopsia transbronquial con pinza convencional. Por ello, en las recientes guías clínicas para el diagnóstico de la FPI se ha valorado esta opción, sin llegar a obtener una recomendación. En este artículo, resultado de un foro de discusión multidisciplinar, se pretende revisar la evidencia actual y hacer propuestas sobre el uso de la criobiopsia transbronquial para el diagnóstico de la FPI.</p></span>" ] ] "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Castillo D. et al. Propuesta multidisciplinar respecto al algoritmo diagnóstico de la fibrosis pulmonar idiopática: papel de la criobiopsia transbronquial. Arch Bronconeumol. 2020;56:99–105.</p>" ] ] "multimedia" => array:4 [ 0 => array:8 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1826 "Ancho" => 1492 "Tamanyo" => 160623 ] ] "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0195" "detalle" => "Fig. " "rol" => "short" ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Proposed amendment of the diagnostic algorithm for idiopathic pulmonary fibrosis. HRCT: high-resolution computed tomography; IPF: idiopathic pulmonary fibrosis; UIP: usual interstitial pneumonia.</p>" ] ] 1 => array:9 [ "identificador" => "tbl0005" "etiqueta" => "Table 1" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Source: Criteria proposed by the Fleischner Society.<a class="elsevierStyleCrossRef" href="#bib0030"><span class="elsevierStyleSup">6</span></a>" "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0200" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0015" class="elsevierStyleSimplePara elsevierViewall">HRCT: high-resolution computed tomography; IPF: idiopathic pulmonary fibrosis; UIP: usual interstitial pneumonia.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Typical UIP pattern \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Probable UIP pattern \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Indeterminate UIP pattern \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Findings consistent with a diagnosis other than IPF \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Distribution \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Predominantly basal (occasionally diffuse) and subpleural; often heterogeneous \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Predominantly basal and subpleural; often heterogeneous \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Variable or diffuse \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Fibrosis predominantly in upper lobes or upper or middle lung; predominantly peribronchovascular with normal subpleural space. \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Findings \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Honeycombing; reticular pattern with peripheral distribution of traction bronchiectasis or bronchiolectasis; no findings suggestive of an alternative diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Reticular pattern with peripheral distribution of traction bronchiectasis or bronchiolectasis; no honeycombing; no findings suggestive of an alternative diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Evidence of fibrosis with some discrete features suggestive of a non-NIU pattern \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Any of the following: predominant consolidation, ground glass opacity (without acute exacerbation), extensive mosaic attenuation pattern, attenuation with significant lobular air trapping in expiration, diffuse nodules or cysts \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2235545.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">UIP diagnostic categories based on HRCT.</p>" ] ] 2 => array:9 [ "identificador" => "tbl0010" "etiqueta" => "Table 2" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "fuente" => "Source: adapted from the recommendation of the ATS/ERS/JRS/ALAT clinical guidelines.<a class="elsevierStyleCrossRef" href="#bib0025"><span class="elsevierStyleSup">5</span></a>" "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0205" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0025" class="elsevierStyleSimplePara elsevierViewall">LAM: lymphangioleiomyomatosis; LCH: Langerhan’s cell histiocytosis; HP: hypersensitivity pneumonitis; IIP: idiopathic interstitial lung diseases; UIP: interstitial usual pneumonia.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">UIP pattern \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Probable UIP pattern \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Indeterminate UIP pattern \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Alternative diagnosis \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Architectural distortion with dense fibrosis (honeycombing) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Incomplete characteristics of the first column plus absence of findings suggestive of an alternative diagnosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Fibrosis with or without architectural distortion, with characteristics of other patterns or suggestive of other causes \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">1. Findings of other histologic patterns of IIP (e.g., no fibroblast foci or loose fibrosis) in all biopsies \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="2" align="left" valign="middle">2. Prevalence of fibrosis in subpleural or paraseptal area</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">or \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="middle">2. Any characteristic of the first column but with findings suggestive of another diagnosis</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " rowspan="2" align="left" valign="middle">2. Findings suggestive of other disease (e.g., sarcoidosis, HP, LCH, LAM)</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Presence of honeycombing only \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">3. Heterogeneous distribution of fibrosis \t\t\t\t\t\t\n \t\t\t\t</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">4. Fibroblast foci \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t"> \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2235544.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0020" class="elsevierStyleSimplePara elsevierViewall">Classification of lung biopsies.</p>" ] ] 3 => array:8 [ "identificador" => "tbl0015" "etiqueta" => "Table 3" "tipo" => "MULTIMEDIATABLA" "mostrarFloat" => true "mostrarDisplay" => false "detalles" => array:1 [ 0 => array:3 [ "identificador" => "at0210" "detalle" => "Table " "rol" => "short" ] ] "tabla" => array:2 [ "leyenda" => "<p id="spar0035" class="elsevierStyleSimplePara elsevierViewall">HRCT: high-resolution computed tomography; IPF: idiopathic pulmonary fibrosis; TBCB: transbronchial cryobiopsy; UIP: usual interstitial pneumonia.</p>" "tablatextoimagen" => array:1 [ 0 => array:2 [ "tabla" => array:1 [ 0 => """ <table border="0" frame="\n \t\t\t\t\tvoid\n \t\t\t\t" class=""><thead title="thead"><tr title="table-row"><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black"> \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Cryobiopsy \t\t\t\t\t\t\n \t\t\t\t\t\t</th><th class="td" title="\n \t\t\t\t\ttable-head\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t" scope="col" style="border-bottom: 2px solid black">Surgical lung biopsy \t\t\t\t\t\t\n \t\t\t\t\t\t</th></tr></thead><tbody title="tbody"><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="5" align="left" valign="middle">Pros</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Experience of bronchoscopy team \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Experience of surgical team \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Low comorbidity of the technique \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diagnostic yield \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cost \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Macroscopic visualization of the area to be biopsied \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Site of HRCT findings: central \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Site of HRCT findings: peripheral \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Probable UIP pattern in context of high probability of IPF \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Probable UIP pattern in context of low probability of IPF \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead rowgroup " rowspan="4" align="left" valign="middle">Cons</td><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Risk of pneumothorax (severe emphysema, lesion in upper lobes) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Patient- and procedure-related comorbidities \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Risk of hemorrhage (associated with pulmonary hypertension) \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Diminished lung function values \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Low radiological representation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Time on procedure waiting list \t\t\t\t\t\t\n \t\t\t\t</td></tr><tr title="table-row"><td class="td-with-role" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t ; entry_with_role_rowhead " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Pathologist’s experience in the TBCB interpretation \t\t\t\t\t\t\n \t\t\t\t</td><td class="td" title="\n \t\t\t\t\ttable-entry\n \t\t\t\t " align="left" valign="\n \t\t\t\t\ttop\n \t\t\t\t">Cost \t\t\t\t\t\t\n \t\t\t\t</td></tr></tbody></table> """ ] "imagenFichero" => array:1 [ 0 => "xTab2235546.png" ] ] ] ] "descripcion" => array:1 [ "en" => "<p id="spar0030" class="elsevierStyleSimplePara elsevierViewall">Factors to consider in each patient and site when deciding between transbronchial cryobiopsy and surgical lung biopsy.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0005" "bibliografiaReferencia" => array:42 [ 0 => array:3 [ "identificador" => "bib0005" "etiqueta" => "[1]" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "An official American Thoracic Society/European Respiratory Society statement: Update of the international multidisciplinary classification of the idiopathic interstitial pneumonias" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "W.D. 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Year/Month | Html | Total | |
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2024 November | 8 | 3 | 11 |
2024 October | 59 | 23 | 82 |
2024 September | 64 | 17 | 81 |
2024 August | 78 | 36 | 114 |
2024 July | 52 | 29 | 81 |
2024 June | 59 | 31 | 90 |
2024 May | 103 | 36 | 139 |
2024 April | 56 | 39 | 95 |
2024 March | 52 | 33 | 85 |
2024 February | 45 | 32 | 77 |
2023 December | 1 | 2 | 3 |
2023 August | 1 | 2 | 3 |
2023 June | 4 | 2 | 6 |
2023 May | 4 | 2 | 6 |
2023 April | 3 | 3 | 6 |
2023 March | 28 | 8 | 36 |
2023 February | 71 | 17 | 88 |
2023 January | 51 | 34 | 85 |
2022 December | 79 | 32 | 111 |
2022 November | 82 | 33 | 115 |
2022 October | 66 | 39 | 105 |
2022 September | 53 | 26 | 79 |
2022 August | 49 | 32 | 81 |
2022 July | 53 | 52 | 105 |
2022 June | 54 | 31 | 85 |
2022 May | 46 | 40 | 86 |
2022 April | 59 | 40 | 99 |
2022 March | 47 | 40 | 87 |
2022 February | 42 | 39 | 81 |
2021 June | 2 | 2 | 4 |
2021 March | 1 | 2 | 3 |
2021 February | 1 | 2 | 3 |
2020 April | 3 | 4 | 7 |