Clinical Image
Endoscopic Management of Tracheal Neurofibroma
Tratamiento endoscópico de neurofibroma traqueal
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(B) Tumor cells showing strong, diffuse staining for β-catenin. β-Catenin 400×. (C) Diffuse staining of tumor cell nuclei with thyroid transcription factor (TTF-1). TTF-1, 200×. (D) Tumor cells showing diffuse, strong staining with progesterone receptors. 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(B) Proliferation of spindle cells, cigar-shaped nuclei, and elongated cytoplasms, below the bronchial epithelium, H–E ×20. (C) S100 positivity for in these cells, ×40.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">We report the case of a 24-year-old patient with a finding of a tracheal mass, seen in the respiratory medicine department for a study of probable asthma. He had been diagnosed with neurofibromatosis type 1 in childhood.</p><p id="par0010" class="elsevierStylePara elsevierViewall">During the exploration of a 12-month history of progressive dyspnea, an alteration was observed in the image of the trachea on chest X-ray, and flattening of the F/V curves was detected. Bronchoscopy revealed a tracheal sessile mass, 5<span class="elsevierStyleHsp" style=""></span>cm from the vocal cords, with 90% blockage of the lumen.</p><p id="par0015" class="elsevierStylePara elsevierViewall">The tracheal tumor was removed under general anesthesia and rigid bronchoscopy using mechanical resection and Nd-YAG laser coagulation (<a class="elsevierStyleCrossRef" href="#fig0005">Image 1</a>A).</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">The pathological study revealed myxoid tissue with spindle cells, cigar-shaped nuclei, and elongated cytoplasms. The immunohistochemical study showed an abundant presence of S100 protein. The diagnosis was endotracheal neurofibroma (<a class="elsevierStyleCrossRef" href="#fig0005">Image 1</a> B and C).</p><p id="par0025" class="elsevierStylePara elsevierViewall">The patient remains asymptomatic and free of recurrence 14 months after the intervention.</p><p id="par0030" class="elsevierStylePara elsevierViewall">The bronchoscopic treatment of neurogenic tumors was first reported in 1983.<a class="elsevierStyleCrossRef" href="#bib0015"><span class="elsevierStyleSup">1</span></a> Endoscopic treatment without surgery can be considered definitive in benign polypoid tumors with a lesion base of less than 15<span class="elsevierStyleHsp" style=""></span>mm<span class="elsevierStyleSup">2</span> and a strictly intraluminal component, since the risk of recurrence is extremely low.<a class="elsevierStyleCrossRef" href="#bib0020"><span class="elsevierStyleSup">2</span></a></p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Cilleruelo Ramos A, Borrego Pintado H, Castanedo Allende M. Tratamiento endoscópico de neurofibroma traqueal. Arch Bronconeumol. 2020;56:116.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Image 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 558 "Ancho" => 1250 "Tamanyo" => 119990 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Image of the endotracheal tumor via the rigid bronchoscope, with the Nd:YAG laser fiber and aspiration probe. (B) Proliferation of spindle cells, cigar-shaped nuclei, and elongated cytoplasms, below the bronchial epithelium, H–E ×20. (C) S100 positivity for in these cells, ×40.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:2 [ 0 => array:3 [ "identificador" => "bib0015" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Endobronchial neurogenic tumors treated by transbronchial electrical snaring and Nd-YAG laser abrasion: report of three cases" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "H. Suzuki" 1 => "Y. Sekine" 2 => "H. Motohashi" 3 => "M. Chiyo" 4 => "M. Suzuki" 5 => "Y. Haga" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1007/s00595-004-2900-8" "Revista" => array:6 [ "tituloSerie" => "Surg Today" "fecha" => "2005" "volumen" => "35" "paginaInicial" => "243" "paginaFinal" => "246" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/15772797" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0020" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Bronchoscopic multimodal management of tracheal neurofibroma" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "A. Rabeau" 1 => "J. Mazieres" 2 => "C. Hermant" 3 => "F. Projetti" 4 => "A. Didier" 5 => "N. Guibert" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/LBR.0000000000000220" "Revista" => array:6 [ "tituloSerie" => "J Bronchology Interv Pulmonol" "fecha" => "2016" "volumen" => "23" "paginaInicial" => "340" "paginaFinal" => "342" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/26496086" "web" => "Medline" ] ] ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005600000002/v2_202002112050/S1579212919304148/v2_202002112050/en/main.assets" "Apartado" => array:4 [ "identificador" => "21342" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Clinical Image" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005600000002/v2_202002112050/S1579212919304148/v2_202002112050/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919304148?idApp=UINPBA00003Z" ]
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