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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lymphoepithelioma is an undifferentiated carcinoma characterized by stromal infiltration due to the presence of atypical epithelial cells&#44; associated with a dense benign reactive inflammatory infiltrate&#44; rich in lymphocytes and plasma cells&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> The vast majority of cases occur in the nasopharynx and characteristically in Asian patients&#44; and an etiopathogenic association with Epstein&#8211;Barr virus &#40;EBV&#41; has been suggested&#46; When lymphoepithelioma affects other anatomical sites &#40;mostly the parotid salivary glands or the thymus&#41;&#44; it is called lymphoepithelioma-like carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2&#8211;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 66-year-old Caucasian male&#44; ex-smoker of 22 pack-years&#44; with a history of untreated chronic obstructive pulmonary disease GOLD grade 2&#46; As a result of a persistent cough of several weeks&#8217; duration&#44; computed tomography &#40;CT&#41; was performed that showed an irregular consolidation in the middle lobe &#40;ML&#41;&#44; multiple bilateral pulmonary nodules&#44; and bilateral hilar and mediastinal lymphadenopathies of significant size&#44; along with moderate pericardial effusion&#46; Blood tests were significant only for raised CYFRA 21&#46;1 &#40;27&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; and neuron-specific enolase &#40;50<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; A positron emission tomography &#40;PET&#41; showed increased uptake of <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose both in the ML consolidation and in the mediastinal and hilar lymphadenopathies and lung nodules observed on CT&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fiberoptic bronchoscopy performed before the PET showed thickened irregular mucosa suggestive of neoplastic infiltration at the entrance of the ML bronchus&#46; The biopsy samples obtained &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; confirmed the diagnosis of lymphoepithelioma-like carcinoma of the lung&#46; An assessment was carried out by the ENT department that ruled out the presence of a primary lymphoepithelioma-like carcinoma of the nasopharynx&#46; Three weeks after the first visit&#44; the patient was referred to the medical oncology department with a diagnosis of stage IVA lymphoepithelioma-like carcinoma of the lung &#40;T4N3M1a&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> where he began treatment with carboplatin and pemetrexed&#46; After 2 cycles of chemotherapy&#44; the patient presented both pulmonary and pancreatic disease progression&#46; Finally&#44; a second treatment scheme with carboplatin and gemcitabine began&#44; and he remained clinically stable&#44; with metabolic response according to Response Evaluation Criteria In Solid Tumors &#40;RECIST&#41; criteria&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Lymphoepithelioma-like carcinoma of the lung&#44; first described in 1987&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> is one of the most infrequent pulmonary histologic subtypes&#46; Given that the vast majority of cases of lymphoepithelioma-like carcinoma affect the nasopharynx&#44; its presence at this level must be ruled out before pulmonary involvement can be considered to be primary&#46; One of the most important aspects of this type of carcinoma is the potential carcinogenic action of EBV&#46; In fact&#44; the laboratory test used to demonstrate the role of this virus in the genesis of lymphoepithelioma-like carcinoma identifies fractions of non-coding RNA located in the nucleus of cells infected with the virus &#40;Epstein&#8211;Barr virus-encoded small RNAs &#91;EBERs&#93;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> It is believed that EBER particles&#44; first described in 1981&#44; interact with a variety of host proteins to form ribonucleoprotein complexes&#46; Although the specific function of EBERs is still not resolved&#44; it is believed that they could play an important role in the oncogenesis of this tumor&#46; Xie et al&#46; propose that the concentration of EBV DNA in blood might be a useful marker in lymphoepithelioma-like carcinoma of the lung&#44; since patients who present high levels in pre-treatment blood appear to have lower survival rates&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> Most patients with lymphoepithelioma are from East Asia &#40;an area of endemic nasopharyngeal carcinoma&#41; and&#44; although it is more common in non-smokers&#44; it appears to be more associated with smoking in the Caucasian population&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10&#8211;12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given that the lymphoepithelioma-like carcinoma of the lung is a rare entity&#44; hardly any prospective studies have evaluated the different therapeutic options&#46; In principle&#44; the treatment strategy is the same as for non-small cell lung cancer &#40;NSCLC&#41;&#44; with surgical resection as the therapeutic option of choice&#46; In inoperable cases&#44; cisplatin-based chemotherapy would be the alternative to surgery&#46; Some authors have suggested that it is more sensitive to chemotherapy than NSCLC and propose a neoadjuvant regimen in selected cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13&#44;14</span></a> The role of immunotherapy in this type of tumor is currently unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; lymphoepithelioma-like carcinoma of the lung is a very rare tumor&#44; especially in the Caucasian population&#46; EBV probably plays an important pathogenic role&#44; as demonstrated by the identification of EBERs in tumor cells&#46; Therapeutic management is similar to that of NSCLC&#46;</p></span>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Hematoxylin&#8211;eosin staining 100&#215;&#44; showing clear areas of epithelial differentiation with large cytoplasms and eosinophils&#44; and very abundant lymphocytes in the stroma&#46; &#40;B&#41; Immunohistochemical study positive for cytokeratin AE1&#47;AE3&#46; &#40;C&#41; Marked positivity of all atypical epithelial cells for EBER &#40;EBV-encoded small nuclear RNA&#41;&#46;</p>"
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Scientific Letter
Primary Pulmonary Lymphoepithelioma-Like Carcinoma in a Non-Asian Patient
Linfoepitelioma-like primario pulmonar en paciente no asiático
Marta Llabrés de Pradaa, Roberto Martin-Deleona,
Corresponding author
robermartin48@gmail.com

Corresponding author.
, Daniel Martinezb, Carmen M. Lucenaa, Carles Agustía
a Servicio de Neumología y Alergia Respiratoria, Instituto Clínico Respiratorio, Hospital Clínic, Barcelona, Spain
b Servicio de Anatomía Patológica, Centro de Diagnóstico Biomédico, Hospital Clínic, Barcelona, Spain
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    "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lymphoepithelioma is an undifferentiated carcinoma characterized by stromal infiltration due to the presence of atypical epithelial cells&#44; associated with a dense benign reactive inflammatory infiltrate&#44; rich in lymphocytes and plasma cells&#46;<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> The vast majority of cases occur in the nasopharynx and characteristically in Asian patients&#44; and an etiopathogenic association with Epstein&#8211;Barr virus &#40;EBV&#41; has been suggested&#46; When lymphoepithelioma affects other anatomical sites &#40;mostly the parotid salivary glands or the thymus&#41;&#44; it is called lymphoepithelioma-like carcinoma&#46;<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2&#8211;7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 66-year-old Caucasian male&#44; ex-smoker of 22 pack-years&#44; with a history of untreated chronic obstructive pulmonary disease GOLD grade 2&#46; As a result of a persistent cough of several weeks&#8217; duration&#44; computed tomography &#40;CT&#41; was performed that showed an irregular consolidation in the middle lobe &#40;ML&#41;&#44; multiple bilateral pulmonary nodules&#44; and bilateral hilar and mediastinal lymphadenopathies of significant size&#44; along with moderate pericardial effusion&#46; Blood tests were significant only for raised CYFRA 21&#46;1 &#40;27&#46;5<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41; and neuron-specific enolase &#40;50<span class="elsevierStyleHsp" style=""></span>ng&#47;ml&#41;&#46; A positron emission tomography &#40;PET&#41; showed increased uptake of <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose both in the ML consolidation and in the mediastinal and hilar lymphadenopathies and lung nodules observed on CT&#46;</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fiberoptic bronchoscopy performed before the PET showed thickened irregular mucosa suggestive of neoplastic infiltration at the entrance of the ML bronchus&#46; The biopsy samples obtained &#40;<a class="elsevierStyleCrossRef" href="#fig0005">Fig&#46; 1</a>&#41; confirmed the diagnosis of lymphoepithelioma-like carcinoma of the lung&#46; An assessment was carried out by the ENT department that ruled out the presence of a primary lymphoepithelioma-like carcinoma of the nasopharynx&#46; Three weeks after the first visit&#44; the patient was referred to the medical oncology department with a diagnosis of stage IVA lymphoepithelioma-like carcinoma of the lung &#40;T4N3M1a&#41;&#44;<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> where he began treatment with carboplatin and pemetrexed&#46; After 2 cycles of chemotherapy&#44; the patient presented both pulmonary and pancreatic disease progression&#46; Finally&#44; a second treatment scheme with carboplatin and gemcitabine began&#44; and he remained clinically stable&#44; with metabolic response according to Response Evaluation Criteria In Solid Tumors &#40;RECIST&#41; criteria&#46;</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Lymphoepithelioma-like carcinoma of the lung&#44; first described in 1987&#44;<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> is one of the most infrequent pulmonary histologic subtypes&#46; Given that the vast majority of cases of lymphoepithelioma-like carcinoma affect the nasopharynx&#44; its presence at this level must be ruled out before pulmonary involvement can be considered to be primary&#46; One of the most important aspects of this type of carcinoma is the potential carcinogenic action of EBV&#46; In fact&#44; the laboratory test used to demonstrate the role of this virus in the genesis of lymphoepithelioma-like carcinoma identifies fractions of non-coding RNA located in the nucleus of cells infected with the virus &#40;Epstein&#8211;Barr virus-encoded small RNAs &#91;EBERs&#93;&#41;&#46;<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> It is believed that EBER particles&#44; first described in 1981&#44; interact with a variety of host proteins to form ribonucleoprotein complexes&#46; Although the specific function of EBERs is still not resolved&#44; it is believed that they could play an important role in the oncogenesis of this tumor&#46; Xie et al&#46; propose that the concentration of EBV DNA in blood might be a useful marker in lymphoepithelioma-like carcinoma of the lung&#44; since patients who present high levels in pre-treatment blood appear to have lower survival rates&#46;<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> Most patients with lymphoepithelioma are from East Asia &#40;an area of endemic nasopharyngeal carcinoma&#41; and&#44; although it is more common in non-smokers&#44; it appears to be more associated with smoking in the Caucasian population&#46;<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10&#8211;12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given that the lymphoepithelioma-like carcinoma of the lung is a rare entity&#44; hardly any prospective studies have evaluated the different therapeutic options&#46; In principle&#44; the treatment strategy is the same as for non-small cell lung cancer &#40;NSCLC&#41;&#44; with surgical resection as the therapeutic option of choice&#46; In inoperable cases&#44; cisplatin-based chemotherapy would be the alternative to surgery&#46; Some authors have suggested that it is more sensitive to chemotherapy than NSCLC and propose a neoadjuvant regimen in selected cases&#46;<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13&#44;14</span></a> The role of immunotherapy in this type of tumor is currently unknown&#46;<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion&#44; lymphoepithelioma-like carcinoma of the lung is a very rare tumor&#44; especially in the Caucasian population&#46; EBV probably plays an important pathogenic role&#44; as demonstrated by the identification of EBERs in tumor cells&#46; Therapeutic management is similar to that of NSCLC&#46;</p></span>"
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        "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as&#58; Llabr&#233;s de Prada M&#44; Martin-Deleon R&#44; Martinez D&#44; Lucena CM&#44; Agust&#237; C&#46; Linfoepitelioma-like primario pulmonar en paciente no asi&#225;tico&#46; Arch Bronconeumol&#46; 2019&#59;55&#58;600&#8211;601&#46;</p>"
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          "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">&#40;A&#41; Hematoxylin&#8211;eosin staining 100&#215;&#44; showing clear areas of epithelial differentiation with large cytoplasms and eosinophils&#44; and very abundant lymphocytes in the stroma&#46; &#40;B&#41; Immunohistochemical study positive for cytokeratin AE1&#47;AE3&#46; &#40;C&#41; Marked positivity of all atypical epithelial cells for EBER &#40;EBV-encoded small nuclear RNA&#41;&#46;</p>"
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Article information
ISSN: 15792129
Original language: English
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