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B) El estudio inmunohistoquímico es positivo para citoqueratina AE1/AE3. C) Llamativa positividad de todas las células epiteliales atípicas para EBER (VEB-encoded small nuclear RNA).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Marta Llabrés de Prada, Roberto Martin-Deleon, Daniel Martinez, Carmen M. Lucena, Carles Agustí" "autores" => array:5 [ 0 => array:2 [ "nombre" => "Marta" "apellidos" => "Llabrés de Prada" ] 1 => array:2 [ "nombre" => "Roberto" "apellidos" => "Martin-Deleon" ] 2 => array:2 [ "nombre" => "Daniel" "apellidos" => "Martinez" ] 3 => array:2 [ "nombre" => "Carmen M." "apellidos" => "Lucena" ] 4 => array:2 [ "nombre" => "Carles" "apellidos" => "Agustí" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212919302630" "doi" => "10.1016/j.arbr.2019.03.011" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919302630?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619302194?idApp=UINPBA00003Z" "url" => "/03002896/0000005500000011/v4_202003140718/S0300289619302194/v4_202003140718/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S1579212919303015" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.04.013" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "2146" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 0 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:602-3" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Acquired T790M-positive Squamous Cell Lung Carcinoma that Responded to Osimertinib" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "602" "paginaFinal" => "603" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Carcinoma pulmonar de células escamosas con mutación T790M adquirida que respondió a osimertinib" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 899 "Ancho" => 1255 "Tamanyo" => 194073 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Computed tomography (CT) scan showed a mass lesion in the right hilar region of the lower lobe of the right lung. (B) Haematoxylin and eosin staining of the biopsy specimen. Histopathological findings of the biopsy specimen showed squamous cell carcinoma (magnification 200×). (C) CT scan showed regrowth of the tumour (arrow). (D) The tumour showed shrinkage after osimertinib administration (arrow).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Masahiro Yamasaki, Kunihiko Funaishi, Wakako Daido, Noboru Hattori" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Masahiro" "apellidos" => "Yamasaki" ] 1 => array:2 [ "nombre" => "Kunihiko" "apellidos" => "Funaishi" ] 2 => array:2 [ "nombre" => "Wakako" "apellidos" => "Daido" ] 3 => array:2 [ "nombre" => "Noboru" "apellidos" => "Hattori" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0300289619302200" "doi" => "10.1016/j.arbres.2019.04.004" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619302200?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919303015?idApp=UINPBA00003Z" "url" => "/15792129/0000005500000011/v1_201911020900/S1579212919303015/v1_201911020900/en/main.assets" ] "itemAnterior" => array:19 [ "pii" => "S1579212919303003" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.04.012" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "2144" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:600" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Cerebral Air Embolism After CT-guided Lung Biopsy: A Case of Early Diagnosis and Successful Treatment" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:1 [ "paginaInicial" => "600" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Embolismo aéreo cerebral tras una biopsia pulmonar guiada por CT: un caso de diagnóstico temprano y tratamiento exitoso" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 1663 "Ancho" => 1733 "Tamanyo" => 206486 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Chest CT prior biopsy. The white arrow indicates the target lesion in the right upper lobe, in close proximity to the main fissure. (B) Chest CT during the biopsy. An 18-gauge Tru-Cut needle is successfully advanced through the target nodule under continuous CT-fluoroscopy guidance, as indicated by the white arrow. (C) Brain CT 19<span class="elsevierStyleHsp" style=""></span>min after the biopsy. The white arrows indicate air in the right superior frontal, precentral, central (A) and superior temporal (B) sulci, consistent with cerebral venous air embolism. (D) Brain CT 3 days after biopsy showing complete resorption of the air bubbles. The white arrowhead indicates the external ventricular derivation.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Francesca Piccoli, Ezio Lanza, Romano Fabio Lutman" "autores" => array:3 [ 0 => array:2 [ "nombre" => "Francesca" "apellidos" => "Piccoli" ] 1 => array:2 [ "nombre" => "Ezio" "apellidos" => "Lanza" ] 2 => array:2 [ "nombre" => "Romano Fabio" "apellidos" => "Lutman" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0300289619302182" "doi" => "10.1016/j.arbres.2019.04.003" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619302182?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919303003?idApp=UINPBA00003Z" "url" => "/15792129/0000005500000011/v1_201911020900/S1579212919303003/v1_201911020900/en/main.assets" ] "en" => array:15 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Primary Pulmonary Lymphoepithelioma-Like Carcinoma in a Non-Asian Patient" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "600" "paginaFinal" => "601" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Marta Llabrés de Prada, Roberto Martin-Deleon, Daniel Martinez, Carmen M. Lucena, Carles Agustí" "autores" => array:5 [ 0 => array:3 [ "nombre" => "Marta" "apellidos" => "Llabrés de Prada" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 1 => array:4 [ "nombre" => "Roberto" "apellidos" => "Martin-Deleon" "email" => array:1 [ 0 => "robermartin48@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 2 => array:3 [ "nombre" => "Daniel" "apellidos" => "Martinez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Carmen M." "apellidos" => "Lucena" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 4 => array:3 [ "nombre" => "Carles" "apellidos" => "Agustí" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología y Alergia Respiratoria, Instituto Clínico Respiratorio, Hospital Clínic, Barcelona, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Anatomía Patológica, Centro de Diagnóstico Biomédico, Hospital Clínic, Barcelona, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Linfoepitelioma-like primario pulmonar en paciente no asiático" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 335 "Ancho" => 1405 "Tamanyo" => 211702 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Hematoxylin–eosin staining 100×, showing clear areas of epithelial differentiation with large cytoplasms and eosinophils, and very abundant lymphocytes in the stroma. (B) Immunohistochemical study positive for cytokeratin AE1/AE3. (C) Marked positivity of all atypical epithelial cells for EBER (EBV-encoded small nuclear RNA).</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Lymphoepithelioma is an undifferentiated carcinoma characterized by stromal infiltration due to the presence of atypical epithelial cells, associated with a dense benign reactive inflammatory infiltrate, rich in lymphocytes and plasma cells.<a class="elsevierStyleCrossRef" href="#bib0080"><span class="elsevierStyleSup">1</span></a> The vast majority of cases occur in the nasopharynx and characteristically in Asian patients, and an etiopathogenic association with Epstein–Barr virus (EBV) has been suggested. When lymphoepithelioma affects other anatomical sites (mostly the parotid salivary glands or the thymus), it is called lymphoepithelioma-like carcinoma.<a class="elsevierStyleCrossRefs" href="#bib0085"><span class="elsevierStyleSup">2–7</span></a></p><p id="par0010" class="elsevierStylePara elsevierViewall">We report the case of a 66-year-old Caucasian male, ex-smoker of 22 pack-years, with a history of untreated chronic obstructive pulmonary disease GOLD grade 2. As a result of a persistent cough of several weeks’ duration, computed tomography (CT) was performed that showed an irregular consolidation in the middle lobe (ML), multiple bilateral pulmonary nodules, and bilateral hilar and mediastinal lymphadenopathies of significant size, along with moderate pericardial effusion. Blood tests were significant only for raised CYFRA 21.1 (27.5<span class="elsevierStyleHsp" style=""></span>ng/ml) and neuron-specific enolase (50<span class="elsevierStyleHsp" style=""></span>ng/ml). A positron emission tomography (PET) showed increased uptake of <span class="elsevierStyleSup">18</span>F-fluorodeoxyglucose both in the ML consolidation and in the mediastinal and hilar lymphadenopathies and lung nodules observed on CT.</p><p id="par0015" class="elsevierStylePara elsevierViewall">Fiberoptic bronchoscopy performed before the PET showed thickened irregular mucosa suggestive of neoplastic infiltration at the entrance of the ML bronchus. The biopsy samples obtained (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>) confirmed the diagnosis of lymphoepithelioma-like carcinoma of the lung. An assessment was carried out by the ENT department that ruled out the presence of a primary lymphoepithelioma-like carcinoma of the nasopharynx. Three weeks after the first visit, the patient was referred to the medical oncology department with a diagnosis of stage IVA lymphoepithelioma-like carcinoma of the lung (T4N3M1a),<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">8</span></a> where he began treatment with carboplatin and pemetrexed. After 2 cycles of chemotherapy, the patient presented both pulmonary and pancreatic disease progression. Finally, a second treatment scheme with carboplatin and gemcitabine began, and he remained clinically stable, with metabolic response according to Response Evaluation Criteria In Solid Tumors (RECIST) criteria.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0020" class="elsevierStylePara elsevierViewall">Lymphoepithelioma-like carcinoma of the lung, first described in 1987,<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">9</span></a> is one of the most infrequent pulmonary histologic subtypes. Given that the vast majority of cases of lymphoepithelioma-like carcinoma affect the nasopharynx, its presence at this level must be ruled out before pulmonary involvement can be considered to be primary. One of the most important aspects of this type of carcinoma is the potential carcinogenic action of EBV. In fact, the laboratory test used to demonstrate the role of this virus in the genesis of lymphoepithelioma-like carcinoma identifies fractions of non-coding RNA located in the nucleus of cells infected with the virus (Epstein–Barr virus-encoded small RNAs [EBERs]).<a class="elsevierStyleCrossRef" href="#bib0125"><span class="elsevierStyleSup">10</span></a> It is believed that EBER particles, first described in 1981, interact with a variety of host proteins to form ribonucleoprotein complexes. Although the specific function of EBERs is still not resolved, it is believed that they could play an important role in the oncogenesis of this tumor. Xie et al. propose that the concentration of EBV DNA in blood might be a useful marker in lymphoepithelioma-like carcinoma of the lung, since patients who present high levels in pre-treatment blood appear to have lower survival rates.<a class="elsevierStyleCrossRef" href="#bib0130"><span class="elsevierStyleSup">11</span></a> Most patients with lymphoepithelioma are from East Asia (an area of endemic nasopharyngeal carcinoma) and, although it is more common in non-smokers, it appears to be more associated with smoking in the Caucasian population.<a class="elsevierStyleCrossRefs" href="#bib0125"><span class="elsevierStyleSup">10–12</span></a></p><p id="par0025" class="elsevierStylePara elsevierViewall">Given that the lymphoepithelioma-like carcinoma of the lung is a rare entity, hardly any prospective studies have evaluated the different therapeutic options. In principle, the treatment strategy is the same as for non-small cell lung cancer (NSCLC), with surgical resection as the therapeutic option of choice. In inoperable cases, cisplatin-based chemotherapy would be the alternative to surgery. Some authors have suggested that it is more sensitive to chemotherapy than NSCLC and propose a neoadjuvant regimen in selected cases.<a class="elsevierStyleCrossRefs" href="#bib0140"><span class="elsevierStyleSup">13,14</span></a> The role of immunotherapy in this type of tumor is currently unknown.<a class="elsevierStyleCrossRef" href="#bib0150"><span class="elsevierStyleSup">15</span></a></p><p id="par0030" class="elsevierStylePara elsevierViewall">In conclusion, lymphoepithelioma-like carcinoma of the lung is a very rare tumor, especially in the Caucasian population. EBV probably plays an important pathogenic role, as demonstrated by the identification of EBERs in tumor cells. Therapeutic management is similar to that of NSCLC.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Llabrés de Prada M, Martin-Deleon R, Martinez D, Lucena CM, Agustí C. Linfoepitelioma-like primario pulmonar en paciente no asiático. Arch Bronconeumol. 2019;55:600–601.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 335 "Ancho" => 1405 "Tamanyo" => 211702 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">(A) Hematoxylin–eosin staining 100×, showing clear areas of epithelial differentiation with large cytoplasms and eosinophils, and very abundant lymphocytes in the stroma. (B) Immunohistochemical study positive for cytokeratin AE1/AE3. (C) Marked positivity of all atypical epithelial cells for EBER (EBV-encoded small nuclear RNA).</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:15 [ 0 => array:3 [ "identificador" => "bib0080" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Lymphoepithelial carcinoma of the larynx" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "B.U. Coskun" 1 => "U. Cinar" 2 => "B.M. Sener" 3 => "B. 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Year/Month | Html | Total | |
---|---|---|---|
2024 November | 4 | 2 | 6 |
2024 October | 37 | 16 | 53 |
2024 September | 35 | 15 | 50 |
2024 August | 52 | 27 | 79 |
2024 July | 43 | 21 | 64 |
2024 June | 72 | 25 | 97 |
2024 May | 62 | 26 | 88 |
2024 April | 37 | 25 | 62 |
2024 March | 37 | 18 | 55 |
2024 February | 30 | 18 | 48 |
2023 March | 11 | 4 | 15 |
2023 February | 39 | 19 | 58 |
2023 January | 27 | 31 | 58 |
2022 December | 54 | 25 | 79 |
2022 November | 44 | 15 | 59 |
2022 October | 47 | 35 | 82 |
2022 September | 28 | 17 | 45 |
2022 August | 30 | 39 | 69 |
2022 July | 27 | 38 | 65 |
2022 June | 27 | 33 | 60 |
2022 May | 29 | 32 | 61 |
2022 April | 34 | 28 | 62 |
2022 March | 30 | 29 | 59 |
2022 February | 37 | 32 | 69 |
2022 January | 32 | 24 | 56 |
2021 December | 26 | 33 | 59 |
2021 November | 34 | 33 | 67 |
2020 April | 1 | 0 | 1 |
2020 March | 1 | 0 | 1 |