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array:24 [ "pii" => "S1579212919302563" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.04.005" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "2141" "copyright" => "SEPAR" "copyrightAnyo" => "2019" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:594-6" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 2 "HTML" => 2 ] "Traduccion" => array:1 [ "es" => array:19 [ "pii" => "S0300289619302157" "issn" => "03002896" "doi" => "10.1016/j.arbres.2019.04.002" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "2141" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:594-6" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:2 [ "total" => 194 "formatos" => array:2 [ "HTML" => 150 "PDF" => 44 ] ] "es" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Carta científica</span>" "titulo" => "Fibrinólisis ambulatoria en el manejo del derrame maligno multiseptado" "tienePdf" => "es" "tieneTextoCompleto" => "es" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "594" "paginaFinal" => "596" ] ] "titulosAlternativos" => array:1 [ "en" => array:1 [ "titulo" => "Ambulatory Fibrinolysis in the Management of Septated Malignant Effusions" ] ] "contieneTextoCompleto" => array:1 [ "es" => true ] "contienePdf" => array:1 [ "es" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Figura 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 950 "Ancho" => 2500 "Tamanyo" => 167948 ] ] "descripcion" => array:1 [ "es" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Paciente de 61 años, con derrame pleural maligno secundario a neoplasia renal estadio <span class="elsevierStyleSmallCaps">iv</span>, que acude por cese del drenaje a través de catéter tunelizado. Se realiza una ecografía torácica en la que se objetivan numerosos septos que impiden el drenaje del líquido pleural (A). Se procede a la instilación de una única dosis de uroquinasa 100.000 UI y se deja actuar durante 2<span class="elsevierStyleHsp" style=""></span>h; posteriormente, se repite la ecografía torácica, en la que se observa un derrame pleural libre con detritus en su interior y una lisis de los septos (B). Se procede entonces a su drenaje con un débito de 750<span class="elsevierStyleHsp" style=""></span>ml de líquido pleural serohemático y una mejoría sintomática posterior del paciente.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Julia Herrero Huertas, Francisco Julián López González, Lucía García Alfonso, Ana Isabel Enríquez Rodríguez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Julia" "apellidos" => "Herrero Huertas" ] 1 => array:2 [ "nombre" => "Francisco Julián" "apellidos" => "López González" ] 2 => array:2 [ "nombre" => "Lucía" "apellidos" => "García Alfonso" ] 3 => array:2 [ "nombre" => "Ana Isabel" "apellidos" => "Enríquez Rodríguez" ] ] ] ] ] "idiomaDefecto" => "es" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S1579212919302563" "doi" => "10.1016/j.arbr.2019.04.005" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919302563?idApp=UINPBA00003Z" ] ] "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S0300289619302157?idApp=UINPBA00003Z" "url" => "/03002896/0000005500000011/v4_202003140718/S0300289619302157/v4_202003140718/es/main.assets" ] ] "itemSiguiente" => array:19 [ "pii" => "S157921291930299X" "issn" => "15792129" "doi" => "10.1016/j.arbr.2019.03.015" "estado" => "S300" "fechaPublicacion" => "2019-11-01" "aid" => "2142" "copyright" => "SEPAR" "documento" => "simple-article" "crossmark" => 1 "subdocumento" => "crp" "cita" => "Arch Bronconeumol. 2019;55:596-7" "abierto" => array:3 [ "ES" => false "ES2" => false "LATM" => false ] "gratuito" => false "lecturas" => array:2 [ "total" => 6 "formatos" => array:2 [ "HTML" => 3 "PDF" => 3 ] ] "en" => array:11 [ "idiomaDefecto" => true "cabecera" => "<span class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Lung Cancer Invading a Coronary Artery Bypass Graft and Presenting as Refractory Atrial Flutter" "tienePdf" => "en" "tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "596" "paginaFinal" => "597" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Cáncer de pulmón que invade un bypass aortocoronario y produce un flúter auricular refractario" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0010" "etiqueta" => "Fig. 2" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr2.jpeg" "Alto" => 463 "Ancho" => 1505 "Tamanyo" => 102581 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0010" class="elsevierStyleSimplePara elsevierViewall">Axial fused PET/CT image (A) demonstrates a hypermetabolic mass (asterisk). Axial CT image (mediastinal window) from the CT portion of the PET/CT (B) study shows an increase in the size of the left hilar mass (asterisk) and a greater secondary encasement of the left internal mammary artery graft (arrow) with respect to the previous imaging study. Coronal CT image (mediastinal window) from the CT portion of the PET/CT (C) better depicts the encasement of the coronary artery bypass graft (arrows) by the mass (asterisk).</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "Luis Gorospe, Ana María Ayala-Carbonero, Odile Ajuria-Illarramendi, Alberto Cabañero-Sánchez" "autores" => array:4 [ 0 => array:2 [ "nombre" => "Luis" "apellidos" => "Gorospe" ] 1 => array:2 [ "nombre" => "Ana María" "apellidos" => "Ayala-Carbonero" ] 2 => array:2 [ "nombre" => "Odile" "apellidos" => "Ajuria-Illarramendi" ] 3 => array:2 [ "nombre" => "Alberto" "apellidos" => "Cabañero-Sánchez" ] ] ] ] ] "idiomaDefecto" => "en" "Traduccion" => array:1 [ "en" => array:9 [ "pii" => "S0300289619302169" "doi" => "10.1016/j.arbres.2019.03.018" "estado" => "S300" "subdocumento" => "" "abierto" => array:3 [ "ES" => true "ES2" => true "LATM" => true ] "gratuito" => true "lecturas" => array:1 [ "total" => 0 ] "idiomaDefecto" => "en" "EPUB" => 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"tieneTextoCompleto" => "en" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "593" "paginaFinal" => "594" ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Hemangiopericitoma pulmonar primario" ] ] "contieneTextoCompleto" => array:1 [ "en" => true ] "contienePdf" => array:1 [ "en" => true ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 790 "Ancho" => 750 "Tamanyo" => 80507 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Image obtained during bronchoscopy highlighting the presence of a polylobulated tumor at the entrance to the left main bronchus.</p>" ] ] ] "autores" => array:1 [ 0 => array:2 [ "autoresLista" => "José María Hernández Pérez, Lorenzo Pérez Negrín, Claudia Viviana 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class="elsevierStyleTextfn">Scientific Letter</span>" "titulo" => "Ambulatory Fibrinolysis in the Management of Septated Malignant Effusions" "tieneTextoCompleto" => true "saludo" => "<span class="elsevierStyleItalic">Dear Editor:</span>" "paginas" => array:1 [ 0 => array:2 [ "paginaInicial" => "594" "paginaFinal" => "596" ] ] "autores" => array:1 [ 0 => array:4 [ "autoresLista" => "Julia Herrero Huertas, Francisco Julián López González, Lucía García Alfonso, Ana Isabel Enríquez Rodríguez" "autores" => array:4 [ 0 => array:4 [ "nombre" => "Julia" "apellidos" => "Herrero Huertas" "email" => array:1 [ 0 => "herrerohuertas@gmail.com" ] "referencia" => array:2 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] 1 => array:2 [ "etiqueta" => "*" "identificador" => "cor0005" ] ] ] 1 => array:3 [ "nombre" => "Francisco Julián" "apellidos" => "López González" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] 2 => array:3 [ "nombre" => "Lucía" "apellidos" => "García Alfonso" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">b</span>" "identificador" => "aff0010" ] ] ] 3 => array:3 [ "nombre" => "Ana Isabel" "apellidos" => "Enríquez Rodríguez" "referencia" => array:1 [ 0 => array:2 [ "etiqueta" => "<span class="elsevierStyleSup">a</span>" "identificador" => "aff0005" ] ] ] ] "afiliaciones" => array:2 [ 0 => array:3 [ "entidad" => "Servicio de Neumología, Hospital Universitario Central de Asturias, Oviedo, Asturias, Spain" "etiqueta" => "a" "identificador" => "aff0005" ] 1 => array:3 [ "entidad" => "Servicio de Neumología, Complexo Hospitalario Universitario A Coruña, A Coruña, Spain" "etiqueta" => "b" "identificador" => "aff0010" ] ] "correspondencia" => array:1 [ 0 => array:3 [ "identificador" => "cor0005" "etiqueta" => "⁎" "correspondencia" => "Corresponding author." ] ] ] ] "titulosAlternativos" => array:1 [ "es" => array:1 [ "titulo" => "Fibrinólisis ambulatoria en el manejo del derrame maligno multiseptado" ] ] "resumenGrafico" => array:2 [ "original" => 0 "multimedia" => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 950 "Ancho" => 2500 "Tamanyo" => 167948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patient, 61 years of age, with malignant pleural effusion due to stage IV kidney cancer, presenting with non-draining tunneled catheter. Chest ultrasound showing abundant septa preventing drainage of pleural fluid (A). A single dose of 100<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase was instilled and left to act for 2<span class="elsevierStyleHsp" style=""></span>h; the thoracic ultrasound was then repeated, revealing pleural effusion containing detritus and lysis of the septa (B). The effusion was than drained, obtaining 750<span class="elsevierStyleHsp" style=""></span>ml of serosanguineous pleural fluid and subsequent symptomatic improvement.</p>" ] ] ] "textoCompleto" => "<span class="elsevierStyleSections"><p id="par0005" class="elsevierStylePara elsevierViewall">Malignant pleural effusion (MPE) is a complication of advanced cancer, and has an estimated incidence of 1/1000 people per year.<a class="elsevierStyleCrossRef" href="#bib0065"><span class="elsevierStyleSup">1</span></a> It is predicted that the prevalence of MPE will increase in the next few years due to the greater survival of patients with active tumors.</p><p id="par0010" class="elsevierStylePara elsevierViewall">Cure rates in MPE are low, and in most cases the effusion is recurrent. Onset occurs with increasing dyspnea, cough, chest pain, and loss of quality of life, so different therapeutic techniques with palliative intent are used. Pleurodesis was the technique of choice for many years, but tunneled pleural drainage (TPD) is now gaining more prominence in clinical practice.<a class="elsevierStyleCrossRefs" href="#bib0070"><span class="elsevierStyleSup">2–4</span></a> In the follow-up of tunneled catheters, formation of fibrinous septa in the interior of the effusion can be observed in up to 14% of patients.<a class="elsevierStyleCrossRef" href="#bib0085"><span class="elsevierStyleSup">5</span></a> This is the result of procoagulant activity and the decline of fibrinolytic activity of MPEs, which contributes to the deposit of fibrin in the pleural space, creating septa that make it difficult to perform pleural effusion drainage in the patient's home. The benefit of urokinase instillation in these cases has been reported by several authors,<a class="elsevierStyleCrossRefs" href="#bib0090"><span class="elsevierStyleSup">6,7</span></a> some of whom opt for high doses over prolonged periods.<a class="elsevierStyleCrossRef" href="#bib0100"><span class="elsevierStyleSup">8</span></a> Hsu et al., in 2006, recommended repeated instillations of 100<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase daily for at least 3 days (up to a maximum of 9 days and 900<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase)<a class="elsevierStyleCrossRef" href="#bib0105"><span class="elsevierStyleSup">9</span></a>; in contrast, other authors such as Mishra et al., in 2018,<a class="elsevierStyleCrossRef" href="#bib0110"><span class="elsevierStyleSup">10</span></a> used 3 doses of 100<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase instilled at 12-h intervals for a total dose of 300<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU, with monitoring 24<span class="elsevierStyleHsp" style=""></span>h after the last dose, but reported no significant benefit in the urokinase group.</p><p id="par0015" class="elsevierStylePara elsevierViewall">We present a clinical case treated according to our hospital protocol for septated MPEs that are not effectively drained.</p><p id="par0020" class="elsevierStylePara elsevierViewall">This was a 61-year-old man, referred to the respiratory medicine outpatient department for generalized constitutional symptoms, dyspnea on minimal effort and recurrent pleural effusion. He underwent 2 thoracenteses in the emergency department, for diagnosis and evacuation; a total of 2700<span class="elsevierStyleHsp" style=""></span>ml lymphocytic exudate was extracted, and cytology was negative for malignancy. In the respiratory medicine clinic, we performed a chest ultrasound which revealed pleural thickening. A computed tomography (CT) scan of the chest was requested, showing grade III/IV right pleural effusion causing right lower lobe atelectasis that contained a 2<span class="elsevierStyleHsp" style=""></span>cm nodular image and multiple foci of tumor-like pleural nodular thickening. The abdomen was significant for a pathological retroperitoneal lymphadenopathy measuring 2<span class="elsevierStyleHsp" style=""></span>cm in its greatest diameter. A right pleural ultrasound-guided biopsy was performed and thoracentesis for drainage was repeated (the third within a week, extracting 2000<span class="elsevierStyleHsp" style=""></span>ml). The pathology study reported renal cell carcinoma metastasis as a primary neoplasm.</p><p id="par0025" class="elsevierStylePara elsevierViewall">A diagnosis of MPE due to stage IV kidney cancer was made, and in view of the persisting pleural effusion, we decided, after explaining the different therapeutic alternatives to the patient, to place a TPD catheter (IPC™ Rocket Medical©, Watford, United Kingdom), and both the patient and his family members were instructed how to perform drainage at home. About 30 days after TPD placement, the patient attended the clinic with dyspnea on minimal effort (visual analog scale [VAS]: 8/10, modified Medical Research Council dyspnea grade: III), with ineffective TPD draining. Chest X-ray revealed grade II/IV right pleural effusion, unchanged from previous studies, with the catheter placed correctly in the right hemithorax. A chest ultrasound showed grade II/IV effusion containing multiple septa and detritus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>A). An intrapleural instillation of 100<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase was administered and left to act for 2<span class="elsevierStyleHsp" style=""></span>h, after which chest ultrasound was repeated, according to our protocol; this showed total lysis of the septa and persistent pleural effusion with detritus (<a class="elsevierStyleCrossRef" href="#fig0005">Fig. 1</a>B). This effusion was drained, obtaining 750<span class="elsevierStyleHsp" style=""></span>ml of serosanguineous fluid; no associated complications were reported, and the patient showed significant symptomatic relief.</p><elsevierMultimedia ident="fig0005"></elsevierMultimedia><p id="par0030" class="elsevierStylePara elsevierViewall">In October 2017, we implemented our protocol for home-managed MPE that does not drain after connecting the TPD tube to the vacuum bottle. This protocol consists of an initial chest X-ray and pleural ultrasound and, if intrapleural septa are observed on the latter, a single dose of 100<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase is instilled and the patient is reevaluated at 2<span class="elsevierStyleHsp" style=""></span>h by repeating the ultrasound to visualize the effect of the urokinase (lysis of the septa), and then immediately performing drainage through the tunneled catheter.<a class="elsevierStyleCrossRef" href="#bib0115"><span class="elsevierStyleSup">11</span></a> A third pleural ultrasound is performed to confirm the reduction of the pleural effusion and the absence of immediate complications. The procedure takes less than 10<span class="elsevierStyleHsp" style=""></span>min from the time of the initial ultrasound to the intrapleural administration of the fibrinolytic agent, and another 10<span class="elsevierStyleHsp" style=""></span>min between subsequently visualizing septal lysis and draining the effusion. On discharge, the patient is given a contact telephone number to report any possible complications (effusion becoming hemorrhagic, principally, or onset of dyspnea or chest pain).</p><p id="par0035" class="elsevierStylePara elsevierViewall">Fifteen patients have been included in this protocol to date, 53.8% men, with an average age (standard deviation, SD) of 68.5 (13.9) years, and an average (SD) of 584 (199) cc drained after the procedure. Clear symptomatic relief (reduction of >2 points on VAS) was obtained in 73.3% of cases, and no complications have been observed so far.</p><p id="par0040" class="elsevierStylePara elsevierViewall">The dose of urokinase required in MPE is not clearly established, and in our experience a high success rate is achieved in septal lysis with a single dose. As previously mentioned, recent studies published in the literature support the instillation of fibrinolytic agents over several consecutive days with subsequent assessments; however, this approach requires several visits and increases costs, and the patient is obliged to spend more time in the hospital.<a class="elsevierStyleCrossRef" href="#bib0120"><span class="elsevierStyleSup">12</span></a> Since most patients with advanced disease are receiving palliative care, one of the main objectives should be to prioritize the well-being of the patient and reduce the number of visits to the hospital. With this systematic intervention, effective septal fibrinolysis is achieved in a single visit, without affecting the main objective of the procedure, which is to optimize pulmonary reexpansion, reduce pleural effusion, and improve the patient's dyspnea.</p></span>" "pdfFichero" => "main.pdf" "tienePdf" => true "NotaPie" => array:1 [ 0 => array:2 [ "etiqueta" => "☆" "nota" => "<p class="elsevierStyleNotepara" id="npar0005">Please cite this article as: Herrero Huertas J, López González FJ, García Alfonso L, Enríquez Rodríguez AI. Fibrinólisis ambulatoria en el manejo del derrame maligno multiseptado. Arch Bronconeumol. 2019;55:594–596.</p>" ] ] "multimedia" => array:1 [ 0 => array:7 [ "identificador" => "fig0005" "etiqueta" => "Fig. 1" "tipo" => "MULTIMEDIAFIGURA" "mostrarFloat" => true "mostrarDisplay" => false "figura" => array:1 [ 0 => array:4 [ "imagen" => "gr1.jpeg" "Alto" => 950 "Ancho" => 2500 "Tamanyo" => 167948 ] ] "descripcion" => array:1 [ "en" => "<p id="spar0005" class="elsevierStyleSimplePara elsevierViewall">Patient, 61 years of age, with malignant pleural effusion due to stage IV kidney cancer, presenting with non-draining tunneled catheter. Chest ultrasound showing abundant septa preventing drainage of pleural fluid (A). A single dose of 100<span class="elsevierStyleHsp" style=""></span>000<span class="elsevierStyleHsp" style=""></span>IU urokinase was instilled and left to act for 2<span class="elsevierStyleHsp" style=""></span>h; the thoracic ultrasound was then repeated, revealing pleural effusion containing detritus and lysis of the septa (B). The effusion was than drained, obtaining 750<span class="elsevierStyleHsp" style=""></span>ml of serosanguineous pleural fluid and subsequent symptomatic improvement.</p>" ] ] ] "bibliografia" => array:2 [ "titulo" => "References" "seccion" => array:1 [ 0 => array:2 [ "identificador" => "bibs0015" "bibliografiaReferencia" => array:12 [ 0 => array:3 [ "identificador" => "bib0065" "etiqueta" => "1" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of a malignant pleural effusion: British Thoracic Society Pleural Disease Guideline 2010" "autores" => array:1 [ 0 => array:3 [ "colaboracion" => "BTS Pleural Disease Guideline Group" "etal" => false "autores" => array:5 [ 0 => "M.E. Roberts" 1 => "E. Neville" 2 => "R.G. Berrisford" 3 => "G. Antunes" 4 => "N.J. Ali" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1136/thx.2010.136994" "Revista" => array:7 [ "tituloSerie" => "Thorax" "fecha" => "2010" "volumen" => "65" "numero" => "Suppl. 2" "paginaInicial" => "ii32" "paginaFinal" => "ii40" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/20696691" "web" => "Medline" ] ] ] ] ] ] ] ] 1 => array:3 [ "identificador" => "bib0070" "etiqueta" => "2" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Uso del drenaje pleural permanente en el manejo ambulatorio del derrame pleural maligno recidivante" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E. Cases" 1 => "L. Seijo" 2 => "C. Disdier" 3 => "M.J. Lorenzo" 4 => "R. Cordovilla" 5 => "F. Sanchis" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.arbres.2009.09.009" "Revista" => array:6 [ "tituloSerie" => "Arch Bronconeumol" "fecha" => "2009" "volumen" => "45" "paginaInicial" => "591" "paginaFinal" => "596" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/19879036" "web" => "Medline" ] ] ] ] ] ] ] ] 2 => array:3 [ "identificador" => "bib0075" "etiqueta" => "3" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Management of pleural effusion in the cancer patient" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:1 [ 0 => "P. Doelken" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1055/s-0030-1269833" "Revista" => array:6 [ "tituloSerie" => "Semin Respir Crit Care Med" "fecha" => "2010" "volumen" => "31" "paginaInicial" => "734" "paginaFinal" => "742" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21213205" "web" => "Medline" ] ] ] ] ] ] ] ] 3 => array:3 [ "identificador" => "bib0080" "etiqueta" => "4" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Home-management of malignant pleural effusion with an indwelling pleural catheter: ten years experience" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L. Bertolaccini" 1 => "A. Viti" 2 => "A. Gorla" 3 => "A. Terzi" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/j.ejso.2012.08.021" "Revista" => array:6 [ "tituloSerie" => "Eur J Surg Oncol" "fecha" => "2012" "volumen" => "38" "paginaInicial" => "1161" "paginaFinal" => "1164" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22959168" "web" => "Medline" ] ] ] ] ] ] ] ] 4 => array:3 [ "identificador" => "bib0085" "etiqueta" => "5" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Indwelling pleural catheters reduce inpatient days over pleurodesis for malignant pleural effusion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.T.H. Fysh" 1 => "G.W. Waterer" 2 => "P.A. Kendall" 3 => "P.R. Bremner" 4 => "S. Dina" 5 => "E. Geelhoed" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.11-2657" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2012" "volumen" => "142" "paginaInicial" => "394" "paginaFinal" => "400" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/22406960" "web" => "Medline" ] ] ] ] ] ] ] ] 5 => array:3 [ "identificador" => "bib0090" "etiqueta" => "6" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrapleural fibrinolysis for the treatment of indwelling pleural catheter-related symptomatic loculations" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "R. Thomas" 1 => "F. Piccolo" 2 => "D. Miller" 3 => "P.R. MacEachern" 4 => "A.C. Chee" 5 => "T. Huseini" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1378/chest.14-2401" "Revista" => array:6 [ "tituloSerie" => "Chest" "fecha" => "2015" "volumen" => "148" "paginaInicial" => "746" "paginaFinal" => "751" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/25742001" "web" => "Medline" ] ] ] ] ] ] ] ] 6 => array:3 [ "identificador" => "bib0095" "etiqueta" => "7" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrapleural fibrinolytic therapy in patients with nondraining indwelling pleural catheters" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "M.R. Vial" 1 => "D.E. Ost" 2 => "G.A. Eapen" 3 => "C.A. Jimenez" 4 => "R.C. Morice" 5 => "O. O’Connell" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1097/LBR.0000000000000265" "Revista" => array:5 [ "tituloSerie" => "J Bronchol Interv Pulmonol" "fecha" => "2016" "volumen" => "23" "paginaInicial" => "98" "paginaFinal" => "105" ] ] ] ] ] ] 7 => array:3 [ "identificador" => "bib0100" "etiqueta" => "8" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Streptokinase for malignant pleural effusions: a randomized controlled study" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:6 [ 0 => "E. Okur" 1 => "V. Baysungur" 2 => "C. Tezel" 3 => "G. Ergene" 4 => "H.K. Okur" 5 => "S. Halezeroglu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1177/0218492311410874" "Revista" => array:6 [ "tituloSerie" => "Asian Cardiovasc Thorac Ann" "fecha" => "2011" "volumen" => "19" "paginaInicial" => "238" "paginaFinal" => "243" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/21885549" "web" => "Medline" ] ] ] ] ] ] ] ] 8 => array:3 [ "identificador" => "bib0105" "etiqueta" => "9" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Intrapleural urokinase for the treatment of loculated malignant pleural effusions and trapped lungs in medically inoperable cancer patients" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:4 [ 0 => "L.-H. Hsu" 1 => "T.C. Soong" 2 => "A.-C. Feng" 3 => "M.-C. Liu" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1016/S1556-0864(15)31612-9" "Revista" => array:6 [ "tituloSerie" => "J Thorac Oncol" "fecha" => "2006" "volumen" => "1" "paginaInicial" => "460" "paginaFinal" => "467" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/17409900" "web" => "Medline" ] ] ] ] ] ] ] ] 9 => array:3 [ "identificador" => "bib0110" "etiqueta" => "10" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Randomized controlled trial of urokinase versus placebo for nondraining malignant pleural effusion" "autores" => array:1 [ 0 => array:2 [ "etal" => true "autores" => array:6 [ 0 => "E.K. Mishra" 1 => "A.O. Clive" 2 => "G.H. Wills" 3 => "H.E. Davies" 4 => "A.E. Stanton" 5 => "M. al-Aloul" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1164/rccm.201704-0809OC" "Revista" => array:6 [ "tituloSerie" => "Am J Respir Crit Care Med" "fecha" => "2018" "volumen" => "197" "paginaInicial" => "502" "paginaFinal" => "508" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/28926296" "web" => "Medline" ] ] ] ] ] ] ] ] 10 => array:3 [ "identificador" => "bib0115" "etiqueta" => "11" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Effect of intrapleural streptokinase on a loculated malignant pleural effusion" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:2 [ 0 => "N.A. Maskell" 1 => "F.V. Gleeson" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1056/ENEJMicm020531" "Revista" => array:5 [ "tituloSerie" => "N Engl J Med" "fecha" => "2003" "volumen" => "348" "paginaInicial" => "e4" "link" => array:1 [ 0 => array:2 [ "url" => "https://www.ncbi.nlm.nih.gov/pubmed/12672879" "web" => "Medline" ] ] ] ] ] ] ] ] 11 => array:3 [ "identificador" => "bib0120" "etiqueta" => "12" "referencia" => array:1 [ 0 => array:2 [ "contribucion" => array:1 [ 0 => array:2 [ "titulo" => "Malignant pleural effusion: from bench to bedside" "autores" => array:1 [ 0 => array:2 [ "etal" => false "autores" => array:5 [ 0 => "I. Psallidas" 1 => "I. Kalomenidis" 2 => "J.M. Porcel" 3 => "B.W. Robinson" 4 => "G.T. Stathopoulos" ] ] ] ] ] "host" => array:1 [ 0 => array:2 [ "doi" => "10.1183/16000617.0019-2016" "Revista" => array:5 [ "tituloSerie" => "Eur Respir Rev" "fecha" => "2016" "volumen" => "25" "paginaInicial" => "189" "paginaFinal" => "198" ] ] ] ] ] ] ] ] ] ] ] "idiomaDefecto" => "en" "url" => "/15792129/0000005500000011/v1_201911020900/S1579212919302563/v1_201911020900/en/main.assets" "Apartado" => array:4 [ "identificador" => "49861" "tipo" => "SECCION" "en" => array:2 [ "titulo" => "Scientific letters" "idiomaDefecto" => true ] "idiomaDefecto" => "en" ] "PDF" => "https://static.elsevier.es/multimedia/15792129/0000005500000011/v1_201911020900/S1579212919302563/v1_201911020900/en/main.pdf?idApp=UINPBA00003Z&text.app=https://archbronconeumol.org/" "EPUB" => "https://multimedia.elsevier.es/PublicationsMultimediaV1/item/epub/S1579212919302563?idApp=UINPBA00003Z" ]
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